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1. 发明申请

US20050209589A1 Assessment of lesion transmurality 失效
标题翻译：病变透壁性评估
公开(公告)号：US20050209589A1
公开(公告)日：2005-09-22
申请号：US11133900
申请日：2005-05-19
申请人： Adam Berman , Gregory Brucker , Robert Svenson
发明人： Adam Berman , Gregory Brucker , Robert Svenson
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00029 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. Transmurality can be assessed to approximate a location of non-transmurality in a formed lesion.
摘要翻译：一种用于原位处理身体组织（例如，心脏的心房组织以治疗）心房颤动的方法和装置包括将病变形成工具定位在心脏表面上。损伤形成工具包括具有用于放置在心脏表面上的组织相对表面的引导构件。消融构件联接到引导构件以相对于引导构件在纵向路径中移动。消融构件具有消融元件，用于将发射方向上的消融能量远离组织相对表面。引导构件可以是柔性的，以调节用于纵向路径的引导构件的形状以接近所需的消融路径，同时将组织相对表面保持抵靠心脏表面。在一个实施例中，消融构件包括设置成在纵向通路中行进的至少一个辐射发射构件。透视性可以被评估以在形成的病变中近似非透壁的位置。

2. 发明申请

US20070073280A1 End-fire guided ablation 审中-公开
标题翻译：终火引导消融
公开(公告)号：US20070073280A1
公开(公告)日：2007-03-29
申请号：US11385316
申请日：2006-03-20
申请人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
发明人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B90/11 , A61B2018/00023 , A61B2018/00196 , A61B2018/2288
摘要： An apparatus for forming a lesion in tissue along a desired ablation path includes a guide member having a tissue-opposing surface for placement against a heart surface. A guide carriage is sized to be received within the guide member and moveable therein along a longitudinal axis. The carriage is configured to receive an optical fiber extending substantially axially within the carriage and bend the fiber for a discharge tip of the fiber to aim through a bottom wall of the guide member. The carriage is further configured to bend the fiber toward said discharge tip with a curved portion subject to mechanical stress and a straight portion at the fiber discharge tip. The straight portion is selected to have a length to dissipate thermal stress arising from reflectance of light from the tissue back into the discharge tip.
摘要翻译：用于沿着期望的消融路径在组织中形成病变的装置包括具有用于放置在心脏表面上的组织相对表面的引导构件。引导托架的尺寸被设计成被容纳在引导构件内并沿着纵向轴线在其中可移动。滑架被构造成接收在滑架内基本上轴向延伸的光纤，并且弯曲光纤以使纤维的放电尖端瞄准穿过引导构件的底壁。托架进一步构造成使纤维朝着所述排出端弯曲，具有受到机械应力的弯曲部分和在纤维排出端部处的直线部分。直线部分被选择为具有消散由来自组织的光的反射率引起的放电尖端的热应力的长度。

3. 发明申请

US20070198046A1 Surgical visualization tool 审中-公开
标题翻译：手术可视化工具
公开(公告)号：US20070198046A1
公开(公告)日：2007-08-23
申请号：US11356581
申请日：2006-02-17
申请人： Edwin Hlavka , Gregory Brucker , Steven Savage , Adam Berman
发明人： Edwin Hlavka , Gregory Brucker , Steven Savage , Adam Berman
IPC分类号： A61M29/00
CPC分类号： A61B1/00165 , A61B1/00082 , A61B1/018 , A61B1/3132
摘要： The tool for enhancing visualization during surgery includes a shaft having a balloon member at a distal end. A fluid conduit through the shaft permits passing and inflation fluid into the balloon to selectively inflate the balloon. The balloon is formed of a material transparent to a wavelength of interest. A waveguide extends within the shaft into the interior of the balloon to visualize anatomical features external to the balloon.
摘要翻译：用于在手术期间增强可视化的工具包括在远端具有气囊构件的轴。通过轴的流体导管允许通过和充气流体进入球囊以选择性地使球囊膨胀。气球由对感兴趣的波长透明的材料形成。波导在轴内延伸到气囊的内部，以可视化气球外部的解剖特征。

4. 发明申请

US20050182392A1 Apparatus and method for guided ablation treatment 失效
标题翻译：引导消融治疗的装置和方法
公开(公告)号：US20050182392A1
公开(公告)日：2005-08-18
申请号：US11102091
申请日：2005-04-08
申请人： Gregory Brucker , Adam Berman , Damian Jelich , Dana Mester , Robert Clapp
发明人： Gregory Brucker , Adam Berman , Damian Jelich , Dana Mester , Robert Clapp
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. In another embodiment, the guide member has a plurality of longitudinally spaced apart tissue attachment locations with at least two being separately activated at the selection of an operator to be attached and unattached to an opposing tissue surface. Various means are described for the attachment including vacuum and mechanical attachment. The guide member may have a steering mechanism to remotely manipulate the shape of the guide member.
摘要翻译：一种用于原位处理身体组织（例如，心脏的心房组织以治疗）心房颤动的方法和装置包括将病变形成工具定位在心脏表面上。损伤形成工具包括具有用于放置在心脏表面上的组织相对表面的引导构件。消融构件联接到引导构件以相对于引导构件在纵向路径中移动。消融构件具有消融元件，用于将发射方向上的消融能量远离组织相对表面。引导构件可以是柔性的，以调节用于纵向路径的引导构件的形状以接近所需的消融路径，同时将组织相对表面保持抵靠心脏表面。在一个实施例中，消融构件包括设置成在纵向通路中行进的至少一个辐射发射构件。在另一个实施例中，引导构件具有多个纵向间隔开的组织附接位置，其中至少两个组织附接位置在选择要附接并未附接到相对组织表面的操作者处被单独激活。描述了用于附件的各种装置，包括真空和机械附件。引导构件可以具有用于远程地操纵引导构件的形状的转向机构。

5. 发明申请

US20070073281A1 Guided ablation with motion control 审中-公开
标题翻译：引导消融与运动控制
公开(公告)号：US20070073281A1
公开(公告)日：2007-03-29
申请号：US11385358
申请日：2006-03-20
申请人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
发明人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B18/02 , A61B18/1492 , A61B90/11 , A61B2017/00243 , A61B2018/00196 , A61B2018/2288
摘要： An apparatus for forming a lesion in tissue along a desired ablation path includes a guide member having a tissue-opposing surface for placement against a heart surface. A guide carriage is sized to be received within the guide member and moveable therein along a longitudinal axis. A flexible tubular member extends from a proximal end of said carriage and through a length of the guide member with the tubular member adapted to move the carriage within the guide member upon application of a force to the tubular member. A system urges the carriage to move in a path along an axis of the guide member by amount substantially identical to a displacement of a force application location on the flexible tubular member.
摘要翻译：用于沿着期望的消融路径在组织中形成病变的装置包括具有用于放置在心脏表面上的组织相对表面的引导构件。引导托架的尺寸被设计成被容纳在引导构件内并沿着纵向轴线在其中可移动。柔性管状构件从所述托架的近端延伸并且穿过引导构件的长度，其中管状构件适于在对管状构件施加力时将托架移动到引导构件内。系统促使滑架沿着引导构件的轴线的路径移动，其量基本上与柔性管状构件上的施力位置的位移相同。

6. 发明申请

US20070073277A1 Controlled guided ablation treatment 审中-公开
标题翻译：受控引导消融治疗
公开(公告)号：US20070073277A1
公开(公告)日：2007-03-29
申请号：US11385317
申请日：2006-03-20
申请人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
发明人： Kevin Johnson , Dana Mester , Gregory Brucker , Paul Asselin , Robert Clapp , Adam Berman
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B5/053 , A61B5/0538 , A61B5/117 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00084 , A61B2017/00115 , A61B2017/00243 , A61B2017/00247 , A61B2017/0243 , A61B2017/306 , A61B2017/3488 , A61B2018/00011 , A61B2018/00196 , A61B2018/00392 , A61B2018/00577 , A61B2018/00636 , A61B2018/2288 , A61B2090/064
摘要： An apparatus for forming a lesion in tissue along a desired ablation path includes a guide member having a tissue-opposing surface for placement against a heart surface. A guide carriage is sized to be received within the guide member and moveable along a longitudinal axis of the guide member. A tubular member extends from a proximal end of the carriage and out a proximal end of the guide member. An ablation element is carried in the carriage for movement. The ablation member is connected to a source of ablation energy through the tubular member. A sensor is provided for sensing a safety condition. The sensor is connected to a monitor external the guide member.
摘要翻译：用于沿着期望的消融路径在组织中形成病变的装置包括具有用于放置在心脏表面上的组织相对表面的引导构件。导向架的尺寸被设计成被容纳在引导构件内并且可以沿着引导构件的纵向轴线移动。管状构件从托架的近端延伸并且从引导构件的近端延伸出来。在滑架中携带消融元件用于移动。消融构件通过管状构件连接到消融能量源。提供传感器用于感测安全条件。传感器连接到引导构件外部的监视器。

7. 发明申请

US20050171521A1 Cardiac lesions with continuity testing 失效
标题翻译：具有连续性测试的心脏病变
公开(公告)号：US20050171521A1
公开(公告)日：2005-08-04
申请号：US11066959
申请日：2005-02-25
申请人： Gregory Brucker , Robert Svenson
发明人： Gregory Brucker , Robert Svenson
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the tissue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.
摘要翻译：用于治疗原位生物组织的方法和装置包括通过在组织中形成病变并进入组织的表面来识别具有易于治疗的病症的患者。病变形成工具抵靠所访问的表面定位。该工具包括用于将所选波长的相干波形引导到光纤尖端的光纤，用于从光纤尖端排出光能。选择波长以使光能穿透组织的整个厚度，以通过组织的厚度形成一定数量的坏死组织。该工具还包括连接到纤维尖端的引导尖端。引导尖端适于具有与纤维末端对准的排出孔，以限定从纤维尖端到组织表面的无阻碍的光路径。引导尖端进一步适于放置在组织表面上，其中引导尖端沿组织表面滑动，与组织表面相对的排出孔以无创的方式滑动接合。操纵损伤形成工具以将引导尖端在通道中的组织表面上拉伸，同时保持排出孔与组织表面相对，以在组织中形成延伸通路长度的跨壁损伤。

8. 发明申请

US20050096643A1 Apparatus and method for laser treatment 失效
标题翻译：用于激光治疗的装置和方法
公开(公告)号：US20050096643A1
公开(公告)日：2005-05-05
申请号：US10975674
申请日：2004-10-28
申请人： Gregory Brucker , Robert Svenson
发明人： Gregory Brucker , Robert Svenson
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the tissue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.
摘要翻译：用于治疗原位生物组织的方法和装置包括通过在组织中形成病变并进入组织的表面来识别具有易于治疗的病症的患者。病变形成工具抵靠所访问的表面定位。该工具包括用于将所选波长的相干波形引导到光纤尖端的光纤，用于从光纤尖端排出光能。选择波长以使光能穿透组织的整个厚度，以通过组织的厚度形成一定数量的坏死组织。该工具还包括连接到纤维尖端的引导尖端。引导尖端适于具有与纤维末端对准的排出孔，以限定从纤维尖端到组织表面的无阻碍的光路径。引导尖端进一步适于放置在组织表面上，其中引导尖端沿组织表面滑动，与组织表面相对的排出孔以无创的方式滑动接合。操纵损伤形成工具以将引导尖端在通道中的组织表面上拉伸，同时保持排出孔与组织表面相对，以在组织中形成延伸通路长度的跨壁损伤。

9. 发明申请

US20050159734A1 Atraumatic laser tip for atrial fibrillation treatment 失效
标题翻译：无创激光尖端用于房颤治疗
公开(公告)号：US20050159734A1
公开(公告)日：2005-07-21
申请号：US11080855
申请日：2005-03-15
申请人： Gregory Brucker , Robert Svenson
发明人： Gregory Brucker , Robert Svenson
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the issue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.
摘要翻译：用于治疗原位生物组织的方法和装置包括通过在组织中形成病变并进入组织的表面来识别具有易于治疗的病症的患者。病变形成工具抵靠所访问的表面定位。该工具包括用于将所选波长的相干波形引导到光纤尖端的光纤，用于从光纤尖端排出光能。选择波长以使光能穿透组织的整个厚度，以通过组织的厚度形成一定数量的坏死组织。该工具还包括连接到纤维尖端的引导尖端。引导尖端适于具有与纤维末端对准的排出孔，以限定从纤维尖端到组织表面的无阻碍的光路径。引导尖端进一步适于被放置在组织表面上，其中引导尖端可沿组织表面滑动，与与检查表面相对的排出孔无创伤滑动接合。操纵损伤形成工具以将引导尖端在通道中的组织表面上拉伸，同时保持排出孔与组织表面相对，以在组织中形成延伸通路长度的跨壁损伤。

10. 发明申请

US20050143722A1 Laser-based maze procedure for atrial fibrillation 失效
标题翻译：用于心房颤动的基于激光的迷宫程序
公开(公告)号：US20050143722A1
公开(公告)日：2005-06-30
申请号：US11067131
申请日：2005-02-25
申请人： Gregory Brucker , Robert Svenson
发明人： Gregory Brucker , Robert Svenson
IPC分类号： A61B17/00 , A61B17/30 , A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the tissue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.
摘要翻译：用于治疗原位生物组织的方法和装置包括通过在组织中形成病变并进入组织的表面来识别具有易于治疗的病症的患者。病变形成工具抵靠所访问的表面定位。该工具包括用于将所选波长的相干波形引导到光纤尖端的光纤，用于从光纤尖端排出光能。选择波长以使光能穿透组织的整个厚度，以通过组织的厚度形成一定数量的坏死组织。该工具还包括连接到纤维尖端的引导尖端。引导尖端适于具有与纤维末端对准的排出孔，以限定从纤维尖端到组织表面的无阻碍的光路径。引导尖端进一步适于放置在组织表面上，其中引导尖端沿组织表面滑动，与组织表面相对的排出孔以无创的方式滑动接合。操纵损伤形成工具以将引导尖端在通道中的组织表面上拉伸，同时保持排出孔与组织表面相对，以在组织中形成延伸通路长度的跨壁损伤。

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