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    • 4. 发明申请
      US20100190224A1 ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF 审中-公开
    • ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF
    • 用于生产甲基亚甲基二甲基丙烯酸酯或其乙烯基 - 苯甲醚的酶及其用途
    • US20100190224A1
    • 2010-07-29
    • US12593090
    • 2008-03-27
    • Markus Poetter , Achim Marx , Georg Fuchs , Birgit Alber , Tobias Juergen Erb
    • Markus Poetter , Achim Marx , Georg Fuchs , Birgit Alber , Tobias Juergen Erb
    • C12P7/42 , C12N15/74 , C12N9/00 , C12N1/21 , C12N15/63 , C07H21/04
    • C12P7/52 , C12N9/506 , C12P7/42
    • The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.
    • 本发明涉及分离的DNA，其选自以下序列：a）根据SEQ ID No 01的序列，b）源自根据a）的序列的内含子序列，并编码它们 蛋白质或肽，其为编码蛋白质或肽的序列，其包含根据SEQ ID No.22的氨基酸序列，d）至少80％相同的序列 根据a）至c）的序列，e）与根据a）至d）中的一个组的序列的反义链杂交的序列或将考虑到遗传密码的变性而杂交，f）a 根据通过一个或多个碱基的取代，添加，倒位和/或缺失得到的a）至e）中的一个序列的序列的衍生物，g）在遗传变性中对应于SEQ ID No 01的序列 代码，h）具有SEQ ID No 01的中性有义突变的序列，和i） 与根据a）至h）中的一个组合的序列互补的序列。 本发明进一步涉及载体，该载体用于转化细胞，转化细胞，多肽，相对于其野生型基因工程改造的细胞，遗传工程细胞的生产方法，可获得的遗传工程改造的细胞 通过该方法，可以使用该细胞和3-羟基异丁酸或其衍生物的制造方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 8. 发明申请
      US20090325248A1 Microbiological Production of 3-Hydroxypropionic Acid 审中-公开
    • Microbiological Production of 3-Hydroxypropionic Acid
    • 微生物生产3-羟基丙酸
    • US20090325248A1
    • 2009-12-31
    • US12067266
    • 2006-10-09
    • Achim Marx , Volker F. Wendisch , Doris Rittmann , Stefan Buchholz
    • Achim Marx , Volker F. Wendisch , Doris Rittmann , Stefan Buchholz
    • C12P7/52 , C12N1/20 , C12N15/74
    • C12P7/40 , C12P7/42 , C12P7/44
    • The present invention relates to a cell which is genetically modified in relation to its wild type and which exhibits at least one of the properties a) or b): a) an increased activity by comparison with its wild type of an enzyme E1 which catalyzes the conversion of pyruvate into oxaloacetate, or of an enzyme E1b which catalyzes the conversion of phosphoenolpyruvate into oxaloacetate, b) an increased activity by comparison with its wild type of an enzyme E2 which catalyzes the conversion of aspartate into beta-alanine, where, besides properties a) or b), the cell is characterized by at least one of the properties c) or d) c) the genetically modified cell is able to export beta-alanine out of the cell, d) the genetically modified cell is able to convert beta-alanine into 3-hydroxypropionic acid. The invention also relates to methods for producing a genetically modified cell, to the genetically modified cells obtainable by this method, to methods for producing 3-hydroxypropionic acid, to a method for producing acrylic acid, to a method for producing polyacrylates, to a method for producing acrylic esters, and to the use of cells for producing 3-hydroxypropionic acid.
    • 本发明涉及一种相对于其野生型进行遗传修饰的细胞，其表现出以下特征中的至少一种：a）或b）：a）通过与其野生型的酶E1相比增加活性，所述酶E1催化 或丙酮酸转化为草酰乙酸的酶E1b或催化磷酸烯醇丙酮酸转化为草酰乙酸的酶E1b; b）通过与其野生型的催化天冬氨酸转化成β-丙氨酸的酶E2的活性相比增加活性， a）或b），所述细胞的特征在于c）或d）中的至少一个c）所述遗传修饰的细胞能够将β-丙氨酸从细胞中出来，d）转基因细胞能够转化 β-丙氨酸转化为3-羟基丙酸。 本发明还涉及生产聚丙烯酸酯的方法，生产丙烯酸的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法 用于制备丙烯酸酯，以及用于生产3-羟基丙酸的细胞。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 10. 发明授权
      US06946271B2 Nucleotide sequences which code for the menE gene 失效
    • Nucleotide sequences which code for the menE gene
    • 编码menE基因的核苷酸序列
    • US06946271B2
    • 2005-09-20
    • US09834722
    • 2001-04-16
    • Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
    • Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
    • C12N9/00 , C12P13/08
    • C12N9/93 , C12P13/08 , C12Y602/01026
    • The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the menE gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    • 本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含SEQ ID NO： 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与 ）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少所述menE 基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
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