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1. 发明申请

US20190177435A1 COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS 审中-公开
公开(公告)号：US20190177435A1
公开(公告)日：2019-06-13
申请号：US16184203
申请日：2018-11-08
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/44 , C07K16/30 , G01N33/574 , C07K16/18
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

2. 发明授权

US09982041B2 Compositions and methods for treatment and detection of cancers 有权
公开(公告)号：US09982041B2
公开(公告)日：2018-05-29
申请号：US14599174
申请日：2015-01-16
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/18 , G01N33/574 , C07K16/30 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/734 , C07K2317/92 , G01N33/57407 , G01N33/57492 , G01N2800/52
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, lung, breast, mouse, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervix, ovary, and/or prostate cancer.

3. 发明申请

US20160274121A1 CANCER MARKERS AND METHODS OF USE THEREOF 审中-公开
标题翻译：癌症标记及其使用方法
公开(公告)号：US20160274121A1
公开(公告)日：2016-09-22
申请号：US15005930
申请日：2016-01-25
申请人： Academia Sinica
发明人： Chi-Huey Wong , Chung-Yi Wu , Sarah K.C. Cheung , Po-Kai Chuang , Tsui-Ling Hsu
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/18 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/734 , C07K2317/92 , G01N33/5073 , G01N33/57407 , G01N2333/70585 , G01N2333/70596 , G01N2405/10 , G01N2500/04 , G01N2500/10 , G01N2800/52
摘要： The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.
摘要翻译：本公开涉及可以调节球形蛋白糖鞘脂合成的方法和组合物。特别地，本公开涉及可以调节生物合成途径中的球形蛋白鞘糖脂SSEA-3 / SSEA-4 / GloboH的合成的糖酵母抑制剂化合物及其组合物和使用方法; 特别是糖酵解抑制剂靶向α-4GalT; β-4GalNAcT-I; 或β-3GalT-V酶在球形蛋白合成途径中。另外，本公开还涉及靶向SSEA-3 / SSEA-4 / GLOBO H相关表位（天然和修饰）的疫苗，抗体和/或免疫原性缀合物组合物，其引发可用于调节的抗体和/或结合片段产生全球糖苷脂蛋白合成。此外，本公开还涉及使用本文所述的组合物治疗或检测过度增殖性疾病和/或病症的方法。此外，本公开还涉及用于预后和治疗用途的癌症干细胞生物标志物。

4. 发明申请

US20150344551A1 COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS 有权
标题翻译：用于治疗和检测癌症的组合物和方法
公开(公告)号：US20150344551A1
公开(公告)日：2015-12-03
申请号：US14599174
申请日：2015-01-16
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/18 , G01N33/574
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/734 , C07K2317/92 , G01N33/57407 , G01N33/57492 , G01N2800/52
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, lung, breast, mouse, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervix, ovary, and/or prostate cancer.
摘要翻译：本文公开了包含与SSEA-4结合的抗体或其抗原结合片段的药物组合物及其使用方法。使用的方法包括但不限于癌症治疗和诊断。本公开的抗体可以结合某些癌细胞表面。本文公开的抗体的示例性靶标可以包括癌，例如脑，肺，乳腺，小鼠，食管，胃，肝，胆管，胰腺，结肠，肾，子宫颈，卵巢和/或前列腺癌中的那些。

5. 发明授权

US10317393B2 Alkynyl sugar analogs for labeling and visualization of glycoconjugates in cells 有权
公开(公告)号：US10317393B2
公开(公告)日：2019-06-11
申请号：US15729317
申请日：2017-10-10
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Sarah R. Hanson , Masaaki Sawa
IPC分类号： G01N33/50 , G01N33/533
摘要： Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

6. 发明申请

US20190085062A1 COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS 审中-公开
公开(公告)号：US20190085062A1
公开(公告)日：2019-03-21
申请号：US15989860
申请日：2018-05-25
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/18 , G01N33/574
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, lung, breast, mouse, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervix, ovary, and/or prostate cancer.

7. 发明授权

US10495645B2 Cancer markers and methods of use thereof 有权
公开(公告)号：US10495645B2
公开(公告)日：2019-12-03
申请号：US15005930
申请日：2016-01-25
申请人： Academia Sinica
发明人： Chi-Huey Wong , Chung-Yi Wu , Sarah K. C. Cheung , Po-Kai Chuang , Tsui-Ling Hsu
IPC分类号： G01N33/574 , C07K16/18 , C07K16/30 , G01N33/50 , A61K39/00
CPC分类号： G01N33/57492 , C07K16/18 , C07K16/3053 , G01N33/5073 , G01N33/57407 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/734 , C07K2317/92 , G01N2333/70585 , G01N2333/70596 , G01N2405/10 , G01N2500/04 , G01N2500/10 , G01N2800/52
摘要： The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.

8. 发明授权

US10150818B2 Compositions and methods for treatment and detection of cancers 有权
公开(公告)号：US10150818B2
公开(公告)日：2018-12-11
申请号：US14798312
申请日：2015-07-13
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/44 , G01N33/574 , C07K16/30 , C07K16/18 , A61K39/00
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

9. 发明授权

US09975965B2 Compositions and methods for treatment and detection of cancers 有权
公开(公告)号：US09975965B2
公开(公告)日：2018-05-22
申请号：US15011543
申请日：2016-01-30
申请人： Academia Sinica
发明人： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC分类号： C07K16/44 , C07K16/18 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/92 , G01N33/57407 , G01N2800/52
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

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