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1. 发明专利

JP2009185042A Protein stabilized pharmacologically activated drug, process for its production and method for use thereof 有权
标题翻译：蛋白质稳定的药物活化药物及其生产方法及其使用方法
公开(公告)号：JP2009185042A
公开(公告)日：2009-08-20
申请号：JP2009089303
申请日：2009-04-01
申请人： Abraxis Bioscience Llc , アブラクシスバイオサイエンス, エルエルシー
发明人： DESAI NEIL P , TAO CHUNLIN , YANG ANDREW , LOUIE LESLIE , ZHENG TIANLI , YAO ZHIWEN , SOON-SHIONG PATRICK , MAGDASSI SHLOMO
IPC分类号： A61J3/00 , A61K47/42 , A23L33/00 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/38 , A61K9/50 , A61K9/51 , A61K31/05 , A61K31/337 , A61K31/52 , A61K31/706 , A61K38/00 , A61K38/22 , A61K45/00 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61K51/00 , A61P29/00 , A61P35/00
CPC分类号： A61K9/5169 , A23L33/40 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K9/5192 , B82Y5/00 , Y10S977/907 , Y10S977/915 , Y10S977/927
摘要： PROBLEM TO BE SOLVED: To provide a useful composition and a method for in vivo transfer of a substantially water insoluble pharmacologically active substance. SOLUTION: The composition contains protein coated solid or liquid substantially water insoluble pharmacologically active drug particles with average sizes of less than 200 nm wherein the protein coating has a free protein bound with it; a part of the above substantially water insoluble pharmacologically active drug is contained in the above protein coating; a part of the above substantially water insoluble pharmacologically active drug is bound with the above free protein surrounded with the above free protein coating and the above particles can be filtered using a filter of 0.22 micron. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于体内转移基本上不溶于水的药理活性物质的有用组合物和方法。该组合物含有平均尺寸小于200nm的蛋白质包被的固体或液体基本上不溶于水的药理学活性药物颗粒，其中蛋白质包衣具有与其结合的游离蛋白质; 上述基本上不溶于水的药理活性药物的一部分包含在上述蛋白质包衣中; 上述基本上不溶于水的药理活性药物的一部分与上述游离蛋白质结合，上述游离蛋白质被上述游离蛋白质涂层包围，并且可以使用0.22微米的过滤器过滤上述颗粒。版权所有（C）2009，JPO＆INPIT

2. 发明专利

CY1114717T1 ΝΕΕΣ ΦΑΡΜΑΚΟΤΕΧΝΙΚΕΣ ΜΟΡΦΕΣ ΦΑΡΜΑΚΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ, ΜΕΘΟΔΟΙ ΠΑΡΑΣΚΕΥΗΣ ΑΥΤΩΝ ΚΑΙ ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΧΡΗΣΗ ΑΥΤΩΝ 未知
公开(公告)号：CY1114717T1
公开(公告)日：2016-10-05
申请号：CY131101125
申请日：2013-12-12
申请人： ABRAXIS BIOSCIENCE LLC
发明人： DESAI NEIL P , SOON-SHIONG PATRICK , MAGDASSI SHLOMO , SAHADEVAN DAVID C
IPC分类号： A61K9/22
摘要： Σύμφωναμετηνπαρούσαεφεύρεση, παρέχονταισυνθέσειςκαιμέθοδοιχρήσιμοιγια in vivo απελευθέρωσηουσιαστικώςαδιάλυτωνστονερόφαρμακολογικώςδραστικώνπαραγόντων (όπωςτοαντικαρκινικόφάρμακοπακλιταξέλη), όπουο φαρμακολογικώςδραστικόςπαράγωναπελευθερώνεταιστηνμορφήεναιωρημένωνσωματιδίωνεπικαλυμμένωνμεπρωτεΐνη (πουδραωςσταθεροποιητικόςπαράγων). Ειδικότερα, πρωτεΐνηκαιφαρμακολογικώςδραστικόςπαράγωνσεέναβιοσυμβατόμέσοδιασποράςυποβάλλονταισευψηλήδιάτμηση, απουσίαοιωνδήποτεσυνηθισμένωνεπιφανειοδραστικών, καθώςεπίσηςαπουσίαοιουδήποτευλικούπολυμερικούπυρήναγιατασωματίδια. Ηπορείααποδίδεισωματίδιαμεδιάμετρομικρότερηαπόπερίπου 1 μικρό. Ηχρήσημιαςειδικήςσύνθεσηςκαιοισυνθήκεςπαρασκευής (π.χ. προσθήκηενόςπολικούδιαλύτηστηνοργανικήφάση) καιπροσεκτικήεπιλογήτηςκατάλληληςοργανικήςφάσηςκαικλάσματοςφάσης, επιτρέπειτηνεπαναλήψιμηπαραγωγήασυνήθισταμικρώννανοσωματιδίωνμικρότερωναπό 200 nm σεδιάμετρο, πουμπορείνααποστειρώνονταιμεδιήθηση. Τοσωματιδιακόσύστημαπουπαράγεταισύμφωναπροςτηνεφεύρεσημπορείναμετατρέπεταισεεπαναδιασπειρόμενηξηρήσκόνηπουπεριλαμβάνεινανοσωματίδιααδιάλυτουστονερόφαρμάκουεπικαλυμμέναμεμιαπρωτεΐνηκαιελεύθερηπρωτεΐνηπροςτηνοποίασυνδέονταιμόριατουφαρμακολογικούπαράγοντα. Αυτόέχειωςαποτέλεσμαμοναδικόσύστημααπελευθέρωσης, όπουτμήματουφαρμακολογικώςδραστικούπαράγονταείναιευκόλωςβιοδιαθέσιμο (στηνμορφήμορίωνπουσυνδέονταιπροςτηνπρωτεΐνη) καιτμήματουπαράγονταυπάρχειεντόςτωνσωματιδίωνχωρίςοποιαδήποτεπολυμερικήμήτρασεαυτά.

3. 发明专利

BRPI9711856B1 métodos para preparação de um agente ativo, substancialmente insolúvel em água e composição para liberação in vivo de um agente ativo 未知
公开(公告)号：BRPI9711856B1
公开(公告)日：2016-07-12
申请号：BR9711856
申请日：1997-09-24
申请人： ABRAXIS BIOSCIENCE INC , ABRAXIS BIOSCIENCE LLC , AMERICAN BIOSCIENCE INC , VIVORX PHARMACEUTICALS INC
发明人： YANG ANDREW , TAO CHUNLIN , LOUIE LESLIE , DESAI NEIL P , SOON-SHIONG PATRICK , MAGDASSI SHLOMO , ZHENG TIANLI , YAO ZHIWEN
IPC分类号： A61J3/00 , A61K9/14 , A23L33/00 , A61K9/00 , A61K9/38 , A61K9/50 , A61K9/51 , A61K31/337 , A61K45/00 , A61K47/30 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61P29/00 , A61P35/00
摘要： patente de invenção: "agentes farmacologicamente ativos estabilizados com proteína, processos para a sua preparação e processos para o seu uso". de acordo com a presente invenção são providos composições e processos para liberação in vivo de agentes farmacologicamente ativos substancialmente insolúveis em água (tais como paclitaxel de drogas anticâncer) nos quais o agente farmacologicamente ativo é liberado na forma de partículas suspensas revestidas com proteína (que agem como um agente estabilizador) . em particular, a proteína e o agente farmacologicamente ativo em um meio dispersante biocompatível são submetidos a alto cisalhamento, na ausência de qualquer tensoativo convencional e também na ausência de qualquer material de núcleo polimérico para as partículas. o procedimento produz partículas com diâmetro menor do que 1 mícron. o uso de composição e de preparação específicas (por exemplo, adição de um solvente polar à fase orgânica) e uma seleção cuidadosa da fase orgânica apropriada permite a produção reproduzível de nanopartículas especialmente pequenas de menos do que 200 nm de diâmetro, as quais podem ser filtradas sob condições estéreis. o sistema de partícula produzido de acordo com a presente invenção pode ser convertido em um pó seco redispersável compreendendo nanopartículas de droga insolúvel em água revestidas com proteína e uma proteína livre à qual as moléculas do referido agente farmacologicamente ativo está associado. isto resulta em um sistema único de liberação no qual parte do agente farmacologicamente ativo está rapidamente biodisponível (na forma de moléculas ligadas a uma proteína) e parte do agente está presente dentro de partículas sem qualquer matriz polimérica.

4. 发明专利

MX337149B NUEVAS FORMULACIONES DE AGENTES FARMACOLOGICOS, METODOS PARA SU PREPARACION Y METODOS PARA EL USO DE LOS MISMOS. 未知
公开(公告)号：MX337149B
公开(公告)日：2016-02-15
申请号：MX12014591
申请日：1998-06-26
申请人： ABRAXIS BIOSCIENCE LLC
发明人： DESAI NEIL P , SOON-SHIONG PATRICK , MAGDASSI SHLOMO , SAHADEVAN DAVID C
IPC分类号： A01N43/02 , A61K9/107 , A61K9/14 , A61K9/51 , A61K31/335 , A61K31/337 , A61P35/00
摘要： De conformidad con la presente invención, se proporcionan composiciones y métodos útiles para la liberación n vivo de agentes farmacológicamente activos sustancialmente insolubles en agua (tales como el fármaco anti-cáncer paclitaxel), en los cuales el agente farmacológicamente activo es liberado en forma de partículas suspendidas recubiertas con proteína (la cual actúa como un agente estabilizante). En particular, la proteína y el agente farmacológicamente activo en un medio dispersante biocompatible, están sujetos a un gran esfuerzo cortante, en ausencia de cualquier surfactante convencional y también en ausencia de cualquier material polimérico para el núcleo de las partículas. El procedimiento produce partículas con un diámetro de menos de aproximadamente 1 micron. El uso de una composición específica y condiciones de preparación (por ejemplo, adición de un solvente polar a la fase orgánica) y la selección cuidadosa de la fase orgánica apropiada y la fracción de la fase, facilita la producción reproducible de nanopartículas inusualmente pequeñas de menos de 200 nm de diámetro que pueden ser filtradas estériles. El sistema particulado producido de conformidad con la invención puede convertirse en un polvo seco redispersable que comprende nanopartículas de fármaco insoluble en agua recubierto con una proteína y proteína libre a la cual se enlazan las moléculas del agente farmacológico. Esto resulta en un sistema único de liberación, en el cual, parte del agente farmacológicamente activo es fácilmente biodisponible (en forma de moléculas enlazadas a la proteína) y parte del agente está presente dentro de las partículas sin ninguna matriz polimérica.

5. 发明专利

PT1023050E NOVAS FORMULAÇÕES DE AGENTES FARMACOLÓGICOS, MÉTODOS PARA A SUA PREPARAÇÃO E MÉTODOS PARA A SUA UTILIZAÇÃO 未知
公开(公告)号：PT1023050E
公开(公告)日：2013-12-04
申请号：PT09893287
申请日：1998-06-26
申请人： ABRAXIS BIOSCIENCE LLC
发明人： MAGDASSI SHLOMO , SOON-SHIONG PATRICK , DESAI NEIL P , SAHADEVAN DAVID C
IPC分类号： A61K9/107 , A61K9/22 , A61K9/14 , A61K9/51 , A61K31/335 , A61K31/337 , A61P35/00

6. 发明专利

SG165156A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF 未知
公开(公告)号：SG165156A1
公开(公告)日：2010-10-28
申请号：SG2006069470
申请日：1998-06-26
申请人： ABRAXIS BIOSCIENCE LLC
发明人： DESAI NEIL P , SHIONG PATRICK SOON , MAGDASSI SHLOMO , SHADEVAN DAVID C
IPC分类号： A61K9/107 , A61K9/51 , A61K31/337 , A61P35/00 , A61P9/10
摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein. (No suitable figure)

7. 发明专利

NO328689B1 未知
公开(公告)号：NO328689B1
公开(公告)日：2010-04-26
申请号：NO991620
申请日：1999-04-06
申请人： ABRAXIS BIOSCIENCE LLC
发明人： SOON-SHIONG PATRICK , DESAI NEIL P , TAO CHUNLIN , YANG ANDREW , LOUIE LESLIE , ZHENG TIANLI , YAO ZHIWEN , MAGDASSI SHLOMO
IPC分类号： A61J3/00 , A61K9/14 , A23L33/00 , A61K9/00 , A61K9/38 , A61K9/50 , A61K9/51 , A61K31/337 , A61K45/00 , A61K47/30 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61P29/00 , A61P35/00
摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water-insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The use of specific composition and preparation conditions enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered.

8. 发明专利

AU2006202836B2 Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof 未知
公开(公告)号：AU2006202836B2
公开(公告)日：2009-10-08
申请号：AU2006202836
申请日：2006-06-30
申请人： ABRAXIS BIOSCIENCE LLC
发明人： TAO CHUNLIN , YAO ZHIWEN , MAGDASSI SHLOMO , LOUIE LESLIE , DESAI NEIL P , SOON-SHIONG PATRICK , YANG ANDREW
IPC分类号： A61K9/107 , A61K9/51 , A61K31/337

9. 发明专利

HK1024866A1 PROTEIN STABILIZED PHARMACOLOGICALLY ACTIVE AGENTS AND THEIR USE 未知
公开(公告)号：HK1024866A1
公开(公告)日：2000-10-27
申请号：HK00103153
申请日：2000-05-27
申请人： ABRAXIS BIOSCIENCE LLC
发明人： LOUIE LESLIE , DESAI NEIL P , SOON-SHIONG PATRICK , TAO CHUNLIN , ZHENG TIANTLI , YANG ANDREW , MAGDASSI SHLOMO , YAO ZHIWEN
IPC分类号： A61J3/00 , A23L33/00 , A61K20090101 , A61K9/00 , A61K9/14 , A61K9/38 , A61K9/50 , A61K9/51 , A61K31/337 , A61K45/00 , A61K47/30 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61P29/00 , A61P35/00
摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water-insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The use of specific composition and preparation conditions enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered.

10. 发明专利

NO340319B1 Sammensetning som omfatter nanopartikler som omfatter taxan for cancerbehandling. 未知
公开(公告)号：NO340319B1
公开(公告)日：2017-03-27
申请号：NO20120338
申请日：2012-03-22
申请人： ABRAXIS BIOSCIENCE LLC
发明人： SOON-SHIONG PATRICK , DESAI NEIL P , MAGDASSI SHLOMO , SAHADEVAN DAVID C
IPC分类号： A61K9/107 , A61K31/337 , A61K9/14 , A61K9/51 , A61K31/335 , A61P35/00

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