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1. 发明公开

EP2478370A2 DUAL FLUORESCENCE ASSAY FOR DETERMINING VIABILITY OF PARASITIC OR NON-PARASITIC WORMS 审中-公开
标题翻译：双荧光试验测定寄生或非寄生虫的存活
公开(公告)号：EP2478370A2
公开(公告)日：2012-07-25
申请号：EP10763844.7
申请日：2010-09-13
申请人： Aberystwyth University
发明人： PEAK, Emily , HOFFMANN, Karl Francis
IPC分类号： G01N33/569 , G01N33/53
CPC分类号： G01N33/5308 , G01N33/5085 , G01N2021/6441 , G01N2333/43526
摘要： A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.

2. 发明申请

WO2016097759A1 ANTHELMINTIC COMPOUNDS 审中-公开
标题翻译： ANTHELMINTIC化合物
公开(公告)号：WO2016097759A1
公开(公告)日：2016-06-23
申请号：PCT/GB2015/054078
申请日：2015-12-18
申请人： ABERYSTWYTH UNIVERSITY
发明人： HOFFMANN, Karl Francis , NASH, Robert James , PEAK, Emily
IPC分类号： A61K31/00 , A61K31/122 , A61K31/4184 , A61K31/4985 , A61P33/10
CPC分类号： A61K31/00 , A61K31/122 , A61K31/4184 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compounds, in particular derivatives of the diterpenoids sempervirol and 7‐keto‐sempervirol, and their use in therapy, including in pharmaceutical compositions and combinations, especially in the treatment and/or prophylaxis of the tropical diseases schistosomiasis and/or fascioliasis, for example in humans or in non‐human land mammals such as sheep, cattle, other ruminants, or goats.
摘要翻译：本发明涉及化合物，特别是二萜类化合物sempervirol和7-酮基半胱氨酸的衍生物及其在治疗中的用途，包括药物组合物和组合，特别是治疗和/或预防热带病血吸虫病和/或 fascioliasis，例如在人类或非人类陆地哺乳动物如绵羊，牛，其他反刍动物或山羊中。

3. 发明申请

WO2011033290A2 DUAL-FLUORESCENCE ASSAY 审中-公开
标题翻译：双色荧光测定
公开(公告)号：WO2011033290A2
公开(公告)日：2011-03-24
申请号：PCT/GB2010/051527
申请日：2010-09-13
申请人： ABERYSTWYTH UNIVERSITY , PEAK, Emily , HOFFMANN, Karl Francis
发明人： PEAK, Emily , HOFFMANN, Karl Francis
IPC分类号： G01N33/569
CPC分类号： G01N33/5308 , G01N33/5085 , G01N2021/6441 , G01N2333/43526
摘要： A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.
摘要翻译：描述了双色荧光测定和试剂盒，其允许测定活的和死的寄生虫或非寄生虫，例如蠕虫。该测定允许筛选一种或多种试剂或事件对寄生虫或非寄生虫的活力的影响。在一个实例中，测定包括（a）提供包含一种或多种寄生虫或非寄生虫的样品 ; （b）将寄生虫或非寄生虫与一种浓度的荧光素二乙酸酯接触，足以在样品中存在的任何活的寄生虫或非寄生虫中产生可检测的绿色荧光，以及足以产生任何可检测的红色荧光的碘化丙啶浓度存在于样品中的死寄生虫或非寄生虫; 和（c）检测寄生虫或非寄生虫的红色和绿色荧光。该测定还包括将寄生虫或非寄生虫与一种或多种测试试剂接触，或将寄生虫或非寄生虫蠕虫接触事件。该测定允许寄生虫或非寄生虫蠕虫死亡和存活的快速客观评分，并且能够实现高通量筛选用于鉴定针对诸如血吸虫病的疾病的潜在药剂。还描述了使用FTIR分析对寄生虫或非寄生虫表型和/或代谢物进行鉴别分析的方法和试剂盒。

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