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1. 发明申请

WO1995004283A1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES 审中-公开
标题翻译：流体样品中TESTOSTERONE检测和定量的试剂和方法
公开(公告)号：WO1995004283A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008604
申请日：1994-08-01
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ADAMCZYK, Maciej , CHEN, Yon-Yih , WALLING, John, A. , JAMES, Bryan, D. , ARTRIP, Sharon, G.
IPC分类号： G01N33/74
CPC分类号： G01N33/53 , C07J1/0022 , C07K16/26 , G01N33/743 , Y02P20/55 , Y10S435/81 , Y10S435/962 , Y10S435/968 , Y10S436/817 , Y10S436/822 , Y10S530/812
摘要： The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.
摘要翻译：本发明公开了由免疫原制备的新型免疫原，抗体以及用于免疫测定的标记试剂，用于检测和定量测试样品中的睾酮。还公开了使用这些试剂的免疫测定法和合成这些试剂的方法。免疫测定优选为微粒酶免疫测定（MEIAs）和荧光偏振免疫测定（FPIAs）。进一步揭示了制备上述新型免疫原和标记试剂的新型起始材料。还公开了从新型起始材料制备新型免疫原和标记试剂的方法。

2. 发明申请

WO1992012975A1 HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR COTININE 审中-公开
标题翻译：生活习惯，追踪者，免疫球蛋白和抗体免疫免疫
公开(公告)号：WO1992012975A1
公开(公告)日：1992-08-06
申请号：PCT/US1992000382
申请日：1992-01-16
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , WALLING, John, A. , HU, Hsiang-Yun , HASZ, Barbara, E.
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , G01N33/5308
摘要： Disclosed is a substantially optically pure hapten, useful in an immunoassay for cotinine. The hapten corresponds to a specified structural formula (I). In formula (I) X is a straight or branched chain, saturated or unsaturated, divalent radical covalently bonded to a pyridyl ring at the number 2-, 4-, 5- or 6- position. The divalent radical, X, has from 1 to 10 carbon atoms wherein the chain of the divalent radical optionally may contain 1 or 2 hetero atoms selected from members of the group consisting of S, O and NZ in which Z represents a C1 to C3 alkyl group. In formula (I), n = 1 or 0, and Q is a functional group selected from -COOH, -NH2 (provided that n does not equal 0), -C(O)NHNH2, -O(CO)Cl, -CHO, -NCS or -NCO. Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten. Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for cotinine. Also disclosed is an improved immunoassay for determining cotinine in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining cotinine involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.

3. 发明授权

EP0712497B1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES 失效
标题翻译：试剂和方法检测和睾酮的液体样品定量测定方法
公开(公告)号：EP0712497B1
公开(公告)日：2001-11-07
申请号：EP94927907.9
申请日：1994-08-01
申请人： Abbott Laboratories
发明人： ADAMCZYK, Maciej , CHEN, Yon-Yih , WALLING, John, A. , JAMES, Bryan, D. , ARTRIP, Sharon, G.
IPC分类号： G01N33/74 , G01N33/531 , G01N33/58 , C07K16/24 , C07J1/00 , A61K31/565 , A61K31/58
CPC分类号： G01N33/53 , C07J1/0022 , C07K16/26 , G01N33/743 , Y02P20/55 , Y10S435/81 , Y10S435/962 , Y10S435/968 , Y10S436/817 , Y10S436/822 , Y10S530/812
摘要： The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

4. 发明公开

EP0712497A1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES 失效
标题翻译：试剂和方法检测和睾酮的液体样品定量测定方法
公开(公告)号：EP0712497A1
公开(公告)日：1996-05-22
申请号：EP94927907.0
申请日：1994-08-01
申请人： Abbott Laboratories
发明人： ADAMCZYK, Maciej , CHEN, Yon-Yih , WALLING, John, A. , JAMES, Bryan, D. , ARTRIP, Sharon, G.
IPC分类号： C07J1 , C07K16 , G01N33
CPC分类号： G01N33/53 , C07J1/0022 , C07K16/26 , G01N33/743 , Y02P20/55 , Y10S435/81 , Y10S435/962 , Y10S435/968 , Y10S436/817 , Y10S436/822 , Y10S530/812
摘要： The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

5. 发明公开

EP0569490A1 HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR COTININE 失效
标题翻译：半抗原，示踪剂，为NINE CONTI免疫免疫原性的抗体。
公开(公告)号：EP0569490A1
公开(公告)日：1993-11-18
申请号：EP92904991.0
申请日：1992-01-16
申请人： ABBOTT LABORATORIES
发明人： WALLING, John, A. , HU, Hsiang-Yun , HASZ, Barbara, E.
IPC分类号： C07D401 , G01N33
CPC分类号： C07D401/04 , G01N33/5308
摘要： L'invention décrit un haptène pratiquement pur optiquement, efficace dans une immuno-analyse sur la cotinine. L'haptène correspond à une formule structurelle spécifique (I). Dans ladite formule (I), X représente un radical divalent, à chaîne droite ou ramifiée, saturé ou insaturé, à liaison covalente avec un composé cyclique de pyridyle sur les positions numéros 2-, 4-, 5- et 6-. Le radical divalent X possède entre 1 et 10 atomes de carbone, où la chaîne dudit radical peut éventuellement contenir 1 ou 2 hétéroatomes sélectionnés à partir d'éléments du groupe constitué par S, O et NZ dans lequel Z représente un groupe alkyle C1 à C3. Dans la formule (I), n = 1 ou 0 et Q représente un groupe fonctionnel sélectionné à partir de -COOH, -NH2 (dans la mesure où n n'est pas égal à 0), -C(O)NHNH2, -O(CO)Cl, -CHO, -NCS et -NCO. L'invention décrit également un immunogène dérivé de l'haptène, ainsi qu'un anticorps créé en réaction à l'immunogène dérivé de l'haptène. L'invention décrit également un traceur fluorescent dérivé d'un composé pratiquement pur optiquement correspondant à l'haptène, ledit traceur s'utilisant dans une immuno-analyse sur la cotinine. L'invention décrit également une immuno-analyse améliorée servant à déterminer la cotinine dans un prélèvement biologique et comportant les étapes de mise en contact du prélèvement avec des anticorps créés en réaction à l'immunogène. L'invention décrit également une immuno-analyse de polarisation par fluorescence (FPIA) servant à déterminer la présence de cotinine et comprenant l'étape de mise en contact du prélèvement avec les anticorps créés en réaction à l'immunogène et/ou comprenant une étape de mise en contact du prélèvement avec un traceur fluorescent.

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