专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1995017965A1 DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 审中-公开
标题翻译：具有表面流动的装置及其在诊断测定中的使用
公开(公告)号：WO1995017965A1
公开(公告)日：1995-07-06
申请号：PCT/US1994014510
申请日：1994-12-16
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , BERMAN, Marvin , FORNEY, Kevin, J. , GEIST, Jill, M. , KORN, Jacqueline, J. , LANGNER, Thomas, J. , LOOMIS, Neil, W. , MORICI, Laura, S. , MUETTERTIES, Andrew, J. , PARSONS, Robert, G. , PUTMAN, Jill, M. , ROPELLA, Paul, J. , SCHAPIRA, Thomas, G. , SIEGEL, Neal, A. , WAGNER, Brian, K. , BASORE, Bob, O.
IPC分类号： B01L03/00
CPC分类号： G01N33/521 , B01L3/0241 , B01L3/5023 , B01L3/5027 , B01L2200/027 , B01L2200/16 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406
摘要： The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.
摘要翻译：本发明涉及使用包括与毛细管道（18）液体连通的多孔材料（20）的一次性测定装置来改进测定的性能。特别地，毛细管轨道（18）与固体支持物一起使用，以将测试样品和测定试剂直接引导到多孔材料（20）上或多孔材料（20）中的限定的反应位点（22）。反应位点（22）的信号发育表明测定结果。本发明还涉及包括毛细管轨道（18）的一次性分析装置（10）的构造。特别地，通过在所需毛细管轨迹（18）的反向图像中将薄膜层（23）上的流体不溶性材料（25a）印刷，然后对印刷材料进行封盖来形成毛细管轨迹。或者，毛细管轨道（18）通过在所需毛细管轨道（18）的反向图像（30）中的多孔材料（25b）上印刷流体不溶性材料而形成，然后夹在两个膜层（23 ，26）。本发明还涉及一种液滴形成装置（50），其可以掺入一种或多种测定试剂以允许改进的样品处理和试剂添加，混合和孵育。

2. 发明申请

WO1992008974A1 IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING SELECTIVELY IMPREGNATED POROUS MATERIAL 审中-公开
标题翻译：改进的AGGLUTINATION反应装置利用选择性的多孔材料
公开(公告)号：WO1992008974A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008548
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , FORNEY, Kevin, J. , PARSONS, Robert, G. , ROPELLA, Paul, J. , BASORE, Bob, O. , O'CONNELL, Michael, B.
IPC分类号： G01N33/487
CPC分类号： B01L3/5027 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , G01N33/5302 , G01N33/5304 , G01N33/54313 , G01N33/54366 , Y10T436/112499 , Y10T436/25375 , Y10T436/255
摘要： Disclosed is an improved device for performing agglutination reactions having at least one chamber (25) having a proximate zone (6) and a distal zone (7), in which chamber (25) agglutination reactions can be performed. The improvement comprises utilization in the device of means for controlling overall rate of liquid flow through the chamber (25), the means comprising a layer (2) of liquid absorbent material selectively impregnated with a substance to form an impregnated region (26) and a non-impregnated region (4) wherein the non-impregnated region (4) is liquid absorbent and the impregnated region (26) is liquid-occlusive. The non-impregnated region (4) is in liquid communication with the distal zone (7) of the chamber (25).
摘要翻译：公开了一种用于进行凝集反应的改进装置，其具有至少一个具有邻近区域（6）和远端区域（7）的腔室（25），其中腔室（25）可以进行凝集反应。该改进包括在装置中利用用于控制通过腔室（25）的液体流速的装置的装置，该装置包括选择性浸渍有物质的液体吸收材料层（2）以形成浸渍区域（26）和非浸渍区域（4），其中非浸渍区域（4）是液体吸收剂，并且浸渍区域（26）是液体闭塞的。非浸渍区域（4）与腔室（25）的远端区域（7）液体连通。

3. 发明申请

WO1994009366A1 ASSAY DEVICES USING SUBSURFACE FLOW 审中-公开
标题翻译：使用表面流测定装置
公开(公告)号：WO1994009366A1
公开(公告)日：1994-04-28
申请号：PCT/US1993008751
申请日：1993-09-16
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , FORNEY, Kevin, J. , GEIST, Jill, M. , LOOMIS, Neil, W. , MORICI, Laura, S. , MUETTERTIES, Andrew, J. , PARSONS, Robert, G. , PUTMAN, Jill, M. , ROPELLA, Paul, J. , SCHAPIRA, Thomas, G. , SIEGEL, Neal, A. , WAGNER, Brian, K. , BASORE, Bob, O.
IPC分类号： G01N33/543
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/50273 , B01L2200/16 , B01L2300/069 , B01L2300/0825 , B01L2400/0406 , G01N33/54366 , G01N33/54386
摘要： The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material in liquid communication with a capillary track. In particular, the capillary track is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site on or in the porous material. Signal development at the reaction site indicates the assay result. The present invention is also directed to the construction of a disposable assay device which includes a capillary track. In particular, the cappillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a film layer and then capping the printed material. Alternatively, the capillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a porous material which is then sandwiched between two film layers.
摘要翻译：本发明涉及使用包括与毛细管轨道液体连通的多孔材料的一次性测定装置来改进测定的性能。特别地，毛细管轨道与固体支持物一起使用以将测试样品和测定试剂直接引导至多孔材料上或其中的限定的反应位点。反应位点的信号发育表明测定结果。本发明还涉及包括毛细管轨迹的一次性测定装置的构造。特别地，通过在所需毛细管轨迹的反向图像中将流体不溶性材料印刷在膜层上并且然后对印刷材料进行封盖而形成毛细管轨迹。或者，毛细管轨迹是通过在所需毛细管轨道的反向图像中印刷流体不溶性材料形成在多孔材料上，然后夹在两个膜层之间。

4. 发明申请

WO1992008973A1 IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL 审中-公开
标题翻译：改进的聚合反应装置利用多孔吸收材料
公开(公告)号：WO1992008973A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008573
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ROPELLA, Paul, J. , PARSONS, Robert, G. , FORNEY, Kevin, J. , BASORE, Bob, O. , MUETTERTIES, Andrew, J.
IPC分类号： G01N31/22
CPC分类号： G01N33/5304 , G01N33/54366
摘要： Disclosed is an improved device (10) for performing agglutination reactions having at least one chamber (10) having a reaction zone and a distal zone, in which chamber agglutination reactions can be performed. The improvement comprises utilization in the device of means for controlling the overall rate of liquid flow through the chamber (22), the means comprising a layer of liquid absorbant material (22) selectively impregnated with a substance to form an impregnated region and a non-impregnated region wherein the non-impregnated region is liquid absorbant and the impregnated region is liquid-occlusive. The non-impregnated region is in liquid communication with the distal zone of the chamber (10).
摘要翻译：公开了一种用于进行凝集反应的改进装置（10），其具有至少一个具有反应区和远端区的室（10），其中可以进行腔室凝集反应。该改进包括在装置中利用用于控制通过腔室（22）的液体流速的装置的装置，该装置包括选择性浸渍物质以形成浸渍区域的液体吸收剂材料层（22）浸渍区域，其中非浸渍区域是液体吸收剂，并且浸渍区域是液体闭塞的。非浸渍区域与腔室（10）的远端区域液体连通。

5. 发明申请

WO1992008972A1 IMPROVED AGGLUTINATION REACTION DEVICE HAVING GEOMETRICALLY MODIFIED CHAMBERS 审中-公开
标题翻译：改进的几何改型反应装置
公开(公告)号：WO1992008972A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008549
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , PARSONS, Robert, G. , BASORE, Bob, O. , O'CONNELL, Michael, B. , FORNEY, Kevin, J. , ROPELLA, Paul, J. , MUETTERTIES, Andrew, J.
IPC分类号： G01N31/22
CPC分类号： G01N33/5304 , B01L3/5027 , B01L2300/069 , B01L2300/0803 , B01L2300/0825 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , G01N33/54366
摘要： Disclosed is a device for performing agglutination reactions comprising: in adherent relationship, a first wettable layer (1), a second liquid-occlusive layer (2) parallel to and overlying the first layer (1), and a third layer (3) parallel to and overlying the second layer (2) and having a window for observing particles. The second layer is interposed between, and is in adherent relationship to the first and third layers. The second layer (2) has at least one general slot (25) defining a channel for directing liquid conducted by capillary action through a chamber defined by the slot in conjunction with the first (1) and third (3) layers. The chamber has a proximate zone and a distal zone. The geometry of the chamber is modified to provide flow paths having different rates of flow per unit area along the paths. This arrangement of such different paths in the chamber allows agglutination reactions in the chamber to result in the formation of a non-random pattern of aggregated particles in the distal zone of the chamber. Such a non-random pattern is more readily observable than a random pattern of aggregated particles.
摘要翻译：公开了一种用于进行凝集反应的装置，包括：以粘附关系，平行于第一层（1）的第一可湿性层（1），第二液体闭塞层（2）和第三层（3）平行到达并覆盖第二层（2）并具有用于观察颗粒的窗口。第二层插入在第一和第三层之间并且与第一和第三层呈贴壁关系。第二层（2）具有限定通道的至少一个通用槽（25），该通道用于将通过毛细管作用传导的液体引导通过与第一（1）和第三层（3）层结合的槽限定的室。腔室具有近区域和远端区域。腔室的几何形状被修改以提供具有沿着路径的每单位面积流速不同的流动路径。腔室中这种不同路径的这种布置允许腔室中的凝集反应导致在腔室的远侧区域中形成凝集颗粒的非随机图案。这种非随机图案比聚集颗粒的随机图案更容易观察到。

6. 发明公开

EP0557429A1 IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING SELECTIVELY IMPREGNATED POROUS MATERIAL 失效
标题翻译：改进的凝集反应使用选择性浸渍多孔材料。
公开(公告)号：EP0557429A1
公开(公告)日：1993-09-01
申请号：EP92900648.0
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： FORNEY, Kevin, J. , PARSONS, Robert, G. , ROPELLA, Paul, J. , BASORE, Bob, O. , O'CONNELL, Michael, B.
IPC分类号： B01L3 , G01N33 , G01N37
CPC分类号： B01L3/5027 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , G01N33/5302 , G01N33/5304 , G01N33/54313 , G01N33/54366 , Y10T436/112499 , Y10T436/25375 , Y10T436/255
摘要： Dispositif amélioré permettant de procéder à des réactions d'agglutination et comportant au moins une chambre (25) présentant une zone proximale (6) et une zone distale (7), les réactions d'agglutination intervenant dans ladite chambre (25). L'amélioration comprend l'utilisation dans le dispositif d'un moyen de régulation de la vitesse globale de l'écoulement de liquide à travers ladite chambre (25), le moyen comprenant une couche (2) de matière absorbant du liquide sélectivement imprégnée d'une substance afin de former une région imprégnée (26) ainsi qu'une région non imprégnée (4), ladite région non imprégnée (4) absorbant le liquide et ladite région imprégnée (26) arrêtant le liquide. Ladite région non imprégnée (4) est en communication fluide avec la zone distale (7) de la chambre (25).

7. 发明公开

EP0557447A1 IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL 失效
标题翻译：改进的凝集反应采用多孔吸收材料。
公开(公告)号：EP0557447A1
公开(公告)日：1993-09-01
申请号：EP92901199.0
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： ROPELLA, Paul, J. , PARSONS, Robert, G. , FORNEY, Kevin, J. , BASORE, Bob, O. , MUETTERTIES, Andrew, J.
IPC分类号： G01N33
CPC分类号： G01N33/5304 , G01N33/54366
摘要： Dispositif amélioré (10) permettant de procéder à des réactions d'agglutination, comportant au moins une chambre (10) présentant une zone de réaction et une zone distale, les réactions d'agglutination ayant lieu dans ladite chambre. L'amélioration comprend l'utilisation dans le dispositif d'un moyen de régulation du débit global de liquide dans la chambre (22), le moyen comprenant une couche de matière absorbant le liquide (22) sélectivement imprégnée d'une substance afin de former une région imprégnée ainsi qu'une région non imprégnée, ladite région non imprégnée absorbant le liquide et ladite région imprégnée arrêtant le liquide. Ladite région non imprégnée est en communication liquide avec la zone distale de la chambre (10).

8. 发明公开

EP0737104A1 DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 失效
标题翻译： - 流动在其表面进行诊断分析仪器
公开(公告)号：EP0737104A1
公开(公告)日：1996-10-16
申请号：EP95905970.0
申请日：1994-12-16
申请人： Abbott Laboratories
发明人： BERMAN, Marvin , FORNEY, Kevin, J. , GEIST, Jill, M. , KORN, Jacqueline, J. , LANGNER, Thomas, J. , LOOMIS, Neil, W. , MORICI, Laura, S. , MUETTERTIES, Andrew, J. , PARSONS, Robert, G. , PUTMAN, Jill, M. , ROPELLA, Paul, J. , SCHAPIRA, Thomas, G. , SIEGEL, Neal, A. , WAGNER, Brian, K. , BASORE, Bob, O.
IPC分类号： G01N31 , B01L3 , G01N33
CPC分类号： G01N33/521 , B01L3/0241 , B01L3/5023 , B01L3/5027 , B01L2200/027 , B01L2200/16 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406
摘要： The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

9. 发明公开

EP0664000A1 ASSAY DEVICES USING SUBSURFACE FLOW 失效
标题翻译：测试设备在其表面下的流出使用。
公开(公告)号：EP0664000A1
公开(公告)日：1995-07-26
申请号：EP93921623.0
申请日：1993-09-16
申请人： ABBOTT LABORATORIES
发明人： FORNEY, Kevin, J. , GEIST, Jill, M. , LOOMIS, Neil, W. , MORICI, Laura, S. , MUETTERTIES, Andrew, J. , PARSONS, Robert, G. , PUTMAN, Jill, M. , ROPELLA, Paul, J. , SCHAPIRA, Thomas, G. , SIEGEL, Neal, A. , WAGNER, Brian, K. , BASORE, Bob, O.
IPC分类号： G01N33 , B01L3
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/50273 , B01L2200/16 , B01L2300/069 , B01L2300/0825 , B01L2400/0406 , G01N33/54366 , G01N33/54386
摘要： The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material in liquid communication with a capillary track. In particular, the capillary track is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site on or in the porous material. Signal development at the reaction site indicates the assay result. The present invention is also directed to the construction of a disposable assay device which includes a capillary track. In particular, the cappillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a film layer and then capping the printed material. Alternatively, the capillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a porous material which is then sandwiched between two film layers.

10. 发明公开

EP0557433A1 IMPROVED AGGLUTINATION REACTION DEVICE HAVING GEOMETRICALLY MODIFIED CHAMBERS 失效
标题翻译：具有几何凝集反应修饰的CHAMBERS改善。
公开(公告)号：EP0557433A1
公开(公告)日：1993-09-01
申请号：EP92900764.0
申请日：1991-11-15
申请人： ABBOTT LABORATORIES
发明人： PARSONS, Robert, G. , BASORE, Bob, O. , O'CONNELL, Michael, B. , FORNEY, Kevin, J. , ROPELLA, Paul, J. , MUETTERTIES, Andrew, J.
IPC分类号： B01L3 , G01N33
CPC分类号： G01N33/5304 , B01L3/5027 , B01L2300/069 , B01L2300/0803 , B01L2300/0825 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , G01N33/54366
摘要： Dispositif permettant d'obtenir des réactions d'agglutination et comprenant: dans une relation d'adhérence, une première couche mouillable (1), une seconde arrêtant le liquide (2) parallèle à la première couche (1) qu'elle recouvre, ainsi qu'une troisième couche (3) parallèle à la seconde couche (2) qu'elle recouvre et dotée d'une fenêtre permettant l'observation de particules. La seconde couche est interposée entre les première et troisième couches avec lesquelles elle est en relation d'adhérence. La seconde couche (2) présente au moins une fente générale (25) définissant un canal permettant d'orienter du liquide conduit par capillarité à travers une chambre définie par la fente conjointement avec les première (1) et troisième (3) couches. La chambre présente une zone proximale ainsi qu'une zone distale. La géométrie de ladite chambre est modifiée afin de ménager des chemins d'écoulement ayant différents débits par zone unitaire le long desdits chemins. Cet agencement desdits chemins différents permet d'obtenir des réactions d'agglutination dans ladite chambre avec comme résultat la formation d'une configuration non aléatoire de particules agrégées dans la zone distale de ladite chambre. Ladite configuration non aléatoire est plus facilement observable qu'une configuration aléatoire de particules agrégées.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式