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1. 发明申请

WO2008089452A2 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
标题翻译：改善心肌梗塞扩张的方法
公开(公告)号：WO2008089452A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051505
申请日：2008-01-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , MICHAL, Eugene, T. , BASU, Shubhayu , SHEEHY, Alexander, J. , SPINALE, Francis, G. , MUKHERJEE, Rupak
发明人： MICHAL, Eugene, T. , BASU, Shubhayu , SHEEHY, Alexander, J. , SPINALE, Francis, G. , MUKHERJEE, Rupak
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架以引起左后壁厚度的增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

2. 发明申请

WO2008008139A3 METHODS AND DEVICES FOR FORMING TREATMENT AGENT CARRIERS 审中-公开
公开(公告)号：WO2008008139A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/013315
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , BASU, Shubhayu , MICHAL, Eugene, T.
发明人： BASU, Shubhayu , MICHAL, Eugene, T.
IPC分类号： A61K9/14 , B05B5/00
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

3. 发明申请

WO2008013743A2 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , MICHAL, Eugene, T. , CALLAS, Peter, L. , LUDWIG, Florian, N.
发明人： MICHAL, Eugene, T. , CALLAS, Peter, L. , LUDWIG, Florian, N.
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，其包括将导管组件引入血管内腔的阻塞区域并且用导管组件再通过阻塞区域。在再通之前或期间，处理剂可以通过导管组件递送到阻塞区域下游的血管区域。处理剂可具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且与医疗装置再通的阻塞区域。处理剂可以被输送到阻塞区域下游的容器区域。处理剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其它方法中，输送插管可以被引入封闭血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤的性质的治疗剂可通过输送导管输送到未灌注区域。在递送治疗剂之后，通过将血管成形术装置推入闭塞的血管中，封闭的血管可以再通。

4. 发明申请

WO2011133436A1 COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 审中-公开
标题翻译：包含乳酸聚合物的可植入装置的涂料及其制造方法
公开(公告)号：WO2011133436A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/032790
申请日：2011-04-15
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , HOSSAINY, Syed F.A. , TANG, Yiwen , MICHAL, Eugene, T. , GLAUSER, Thierry , PACETTI, Stephen, D. , DESNOYER, Jessica
发明人： HOSSAINY, Syed F.A. , TANG, Yiwen , MICHAL, Eugene, T. , GLAUSER, Thierry , PACETTI, Stephen, D. , DESNOYER, Jessica
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。

5. 发明授权

EP1689462B1 COATINGS FOR IMPLANTABLE DEVICES COMPRISING BLOCK COPOLYMERS OF LACTIC ACID AND ETHYLENE GLYCOL 有权
标题翻译：涂料可植入设备含乙二醇酸与奶块共聚物
公开(公告)号：EP1689462B1
公开(公告)日：2008-03-19
申请号：EP04811546.3
申请日：2004-11-17
申请人： Abbott Cardiovascular Systems Inc.
发明人： HOSSAINY, Syed, F.A. , TANG, Yiwen , MICHAL, Eugene, T. , GLAUSER, Thierry , PACETTI, Stephen, D. , DESNOYER, Jessica, R.
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/06 , A61F2/06 , A61M29/02
CPC分类号： A61L31/10 , A61F2/86 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.

6. 发明授权

EP2560699B1 COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 有权
标题翻译：涂料用牛奶酸聚合物和工艺可植入设备及其
公开(公告)号：EP2560699B1
公开(公告)日：2014-02-12
申请号：EP11719689.9
申请日：2011-04-15
申请人： Abbott Cardiovascular Systems Inc.
发明人： HOSSAINY, Syed F.A. , TANG, Yiwen , MICHAL, Eugene, T. , GLAUSER, Thierry , PACETTI, Stephen, D. , DESNOYER, Jessica
IPC分类号： A61L31/16 , A61L31/10
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04

7. 发明公开

EP2560699A1 COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 有权
标题翻译：涂料用牛奶酸聚合物和工艺可植入设备及其
公开(公告)号：EP2560699A1
公开(公告)日：2013-02-27
申请号：EP11719689.9
申请日：2011-04-15
申请人： Abbott Cardiovascular Systems Inc.
发明人： HOSSAINY, Syed F.A. , TANG, Yiwen , MICHAL, Eugene, T. , GLAUSER, Thierry , PACETTI, Stephen, D. , DESNOYER, Jessica
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.

8. 发明公开

EP2109469A2 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 有权
标题翻译：方法进行修改心肌梗死扩张
公开(公告)号：EP2109469A2
公开(公告)日：2009-10-21
申请号：EP08727952.7
申请日：2008-01-18
申请人： Abbott Cardiovascular Systems, Inc.
发明人： MICHAL, Eugene, T. , BASU, Shubhayu , SHEEHY, Alexander, J. , SPINALE, Francis, G. , MUKHERJEE, Rupak
IPC分类号： A61L26/00
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

9. 发明授权

EP1517716B1 POLYACRYLATES COATINGS FOR IMPLANTABLE MEDICAL DEVICES 失效转让
标题翻译：聚丙烯酸酯表层植入式医疗器械
公开(公告)号：EP1517716B1
公开(公告)日：2009-07-29
申请号：EP03738930.1
申请日：2003-05-14
申请人： Abbott Cardiovascular Systems Inc.
发明人： ROORDA, Wouter, E. , DING, Ni , PACETTI, Stephen, D. , MICHAL, Eugene, T. , SHAH, Ashok, A. , HOSSAINY, Syed F.A.
IPC分类号： A61L31/10 , A61L27/34
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06

10. 发明授权

EP2109469B1 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 有权
标题翻译：方法进行修改心肌梗死扩张
公开(公告)号：EP2109469B1
公开(公告)日：2014-06-04
申请号：EP08727952.7
申请日：2008-01-18
申请人： Abbott Cardiovascular Systems Inc.
发明人： MICHAL, Eugene, T. , BASU, Shubhayu , SHEEHY, Alexander , SPINALE, Francis, G. , MUKHERJEE, Rupak
IPC分类号： A61L27/20 , A61L27/26 , A61L27/50 , A61L27/52
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

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