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1. 发明授权

US09434713B2 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressin-dependent diseases 有权
公开(公告)号：US09434713B2
公开(公告)日：2016-09-06
申请号：US14040412
申请日：2013-09-27
申请人： ABBVIE DEUTSCHLAND GMBH & CO KG , Andrea Hager-Wernet
发明人： Wilfried Braje , Thorsten Oost , Astrid Netz , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/497 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel 5,6-disubstituted oxindole derivatives and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such derivatives, and to the use of such derivatives for the manufacture of a medicament, and methods of treating disorders in a subject in need thereof, such as vasopressin-dependent disorders, using 5,6-disubstituted oxindole derivatives.

2. 发明授权

US09422264B2 Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases 有权
标题翻译：氨基甲酸酯取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途
公开(公告)号：US09422264B2
公开(公告)日：2016-08-23
申请号：US14252425
申请日：2014-04-14
申请人： AbbVie Deutschland GmbH & Co. KG , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译：本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。

3. 发明授权

US09487505B2 Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them 有权
标题翻译：杂芳基取代的1,3-二氢吲哚-2-酮衍生物和含有它们的药物
公开(公告)号：US09487505B2
公开(公告)日：2016-11-08
申请号：US14037026
申请日：2013-09-25
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , Andrea Hager-Wernet
发明人： Wilfried Lubisch , Wilfried Hornberger , Thorsten K. Oost , Daryl Richard Sauer , Liliane Unger , Wolfgang Wernet , Hervé Geneste
IPC分类号： A01N43/38 , C07D403/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6 and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.

4. 发明申请

US20140315914A1 CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES 有权
标题翻译：碳水化合物取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途
公开(公告)号：US20140315914A1
公开(公告)日：2014-10-23
申请号：US14252425
申请日：2014-04-14
申请人： Andrea Hager-Wernet , AbbVie Deutschland GmbH & Co. KG
发明人： Astrid Netz , Thorsten Oost , Hervé Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译：本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。

5. 发明申请

US20140303138A1 SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES 有权
标题翻译：取代的氧化衍生物及其用于治疗依赖于依赖性依赖性的药物
公开(公告)号：US20140303138A1
公开(公告)日：2014-10-09
申请号：US14095162
申请日：2013-12-03
申请人： Andrea Hager-Wernet , ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： Wilfried Braje , Astrid Netz , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14 , C07D209/34 , C07D401/04
CPC分类号： C07D401/14 , C07D209/34 , C07D401/04
摘要： The present invention relates to novel substituted oxindole derivatives of the formula (I), pharmaceutical agents containing said derivatives, and the use thereof for the treatment of vasopressin-dependent illnesses.
摘要翻译：本发明涉及式（I）的新型取代羟吲哚衍生物，含有所述衍生物的药物及其用于治疗加压素依赖性疾病的用途。

6. 发明授权

US09388141B2 Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor 有权
标题翻译：适用于治疗对多巴胺D3受体调节作用的疾病的酰氨基环烷基化合物
公开(公告)号：US09388141B2
公开(公告)日：2016-07-12
申请号：US14213720
申请日：2014-03-14
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： Andreas Haupt , Jürgen Dinges , Liliane Unger , Karsten Wicke , Robert Van Waterschoot , Karla Drescher , Ana Relo
IPC分类号： C07D239/42 , C07D403/04 , A61K31/506
CPC分类号： C07D239/42 , A61K31/506 , C07D403/04
摘要： The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is an oxygen containing cyclic radical selected such as C3-C6 cycloalkyl, which carries one or two oxygen containing radicals selected from the group consisting of OH, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, and a carbonyl oxygen, R2 is selected from the group consisting of hydrogen, OH and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, etc.
摘要翻译：本发明涉及新的酰氨基环烷基化合物，特别是涉及本文所述的式I化合物及其盐和N-氧化物。该化合物具有有价值的治疗特性，特别适用于治疗对多巴胺D3受体调节作出反应的疾病。在式I中，变量具有以下含义：m为1或2，n为1或2，A选自CH 2，CH 2 CH 2，CHFCH 2和CF 2 CH 2，R 1为选自氧的环状基团，例如C 3 -C 6环烷基，其携带一个或两个选自OH，C 1 -C 2烷氧基，氟化C 1 -C 2烷氧基和羰基氧的含氧基团，R 2选自氢，OH和氟，R 3a选自氢和甲基，R 3b选自氢和甲基，R 4是支链C 4 -C 6烷基或支链氟化C 4 -C 6烷基，R 5尤其是C 1 -C 6烷基氟化C 1 -C 3烷基，C 1 -C 2烷氧基-C 1 -C 4烷基，氟化C 1 -C 2烷氧基-C 1 -C 4 - 烷基，羟基-C 1 -C 4 - 烷基，氟化羟基-C 1 -C 4烷基，氧杂环丁烷基，氟化氧杂环丁烷基，氧杂环戊烷基，氟代氧杂环戊烷基，C3-C5环烷基，氟化C3-C5环烷基等

7. 发明申请

US20150175570A1 BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 审中-公开
标题翻译：适用于治疗多巴胺D3受体调节障碍的苯并呋喃半导体化合物
公开(公告)号：US20150175570A1
公开(公告)日：2015-06-25
申请号：US14553923
申请日：2014-11-25
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： Sean Colm Turner , Andreas Haupt , Wilfried Braje , Udo Lange , Karla Drescher , Liliane Unger , Ana Lucia Jongen-Relo , Anton Bespalov
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D213/76
摘要： The invention relates to compounds of the formula R1 is selected from the group consisting of hydrogen, linear C1-C3 alkyl and fluorinated linear C1-C3 alkyl; R2 is hydrogen or methyl; R3 is selected from the group consisting of hydrogen, halogen, C1-C2-alkyl, fluorinated C1-C2-alkyl, C1-C2-alkoxy and fluorinated C1-C2-alkoxy, R4 is C1-C2-alkyl or fluorinated C1-C2-alkyl; n is 0, 1 or 2, and the physiologically tolerated salts of these compounds and the N-oxides thereof. The invention also relates to a pharmaceutical composition that comprises at least one compound of the formula I and/or at least one physiologically tolerated acid addition salt thereof, and further to a method for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one compound or physiologically tolerated acid addition salt of the formula I to a subject in need thereof.
摘要翻译：本发明涉及式R1的化合物选自氢，直链C 1 -C 3烷基和氟化线性C 1 -C 3烷基; R2是氢或甲基; R3选自氢，卤素，C1-C2-烷基，氟化C1-C2-烷基，C1-C2-烷氧基和氟化C1-C2-烷氧基，R4是C1-C2-烷基或氟化C1-C2 -烷基; n为0,1或2，以及这些化合物的生理上耐受的盐及其N-氧化物。本发明还涉及包含至少一种式I化合物和/或其至少一种生理上耐受的酸加成盐的药物组合物，还涉及治疗有益于多巴胺D3受体拮抗剂或多巴胺D3的病症的方法所述方法包括向有需要的受试者施用有效量的至少一种式I化合物或生理学上耐受的酸加成盐。

8. 发明申请

US20150158845A1 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES 审中-公开
标题翻译： 5-取代的氧化衍生物及其用于治疗依赖性依赖性疾病的用途
公开(公告)号：US20150158845A1
公开(公告)日：2015-06-11
申请号：US14554734
申请日：2014-11-26
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： Wilfried Braje , Thorsten Oost , Astrid Netz , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel 5-halogen-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译：本发明涉及新的5-卤素取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。

9. 发明申请

US20140343074A1 Oxindole Derivatives Carrying An Oxetane Substituent and use thereof for Treating Vasopressine-Related Diseases 有权
标题翻译：携带氧杂环丁烷取代基的羟吲哚衍生物及其用于治疗血管加压素相关疾病的用途
公开(公告)号：US20140343074A1
公开(公告)日：2014-11-20
申请号：US14214154
申请日：2014-03-14
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Katja Jantos , Wilfred Braje , Herve Geneste , Andreas Kling , Liliane Unger , Berthold Behl , Marcel van Gaalen , Wilfried Hornberger , Loic Laplanche , Silke Weber
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D487/08
摘要： The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及新型取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素相关病症的用途。

10. 发明申请

US20140315918A1 Oxindole Derivatives Carrying An Oxetane Substituent and Use Thereof For Treating Vassopressin-Related Diseases 有权
标题翻译：携带Oxetane取代基的Oxindole衍生物及其用于治疗加压素相关疾病的用途
公开(公告)号：US20140315918A1
公开(公告)日：2014-10-23
申请号：US14214264
申请日：2014-03-14
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Katja Jantos , Wilfred Braje , Herve Geneste , Andreas Kling , Liliane Unger , Berthold Behl , Marcel van Gaalen , Wilfried Hornberger , Loic Laplanche , Silke Weber
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D487/08
摘要： The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及新型取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素相关病症的用途。

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