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1. 发明申请

WO2016204841A1 PEPTIDES AND THEIR USE IN THE TREATMENT OF SKIN 审中-公开
标题翻译：皮肤及其在治疗皮肤中的用途
公开(公告)号：WO2016204841A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/023569
申请日：2016-03-22
申请人： AVON PRODUCTS, INC.
发明人： IDKOWIAK BALDYS, Jolanta , LYGA, John W. , SANTHANAM, Uma
IPC分类号： A61K8/64 , A61K38/18 , A61P17/00 , A61Q19/08
CPC分类号： A61K8/64 , A61K8/342 , A61K8/347 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/46 , A61K8/4926 , A61K8/671 , A61K8/675 , A61Q19/08
摘要： Peptides derived from the Growth Differentiation Factor 11 (GDF- 11 ) protein and derivatives thereof, topical compositions, and methods of diminishing signs of aging and/or improving health of human integuments are provided. The present invention provides active agents comprising peptides and topical formulations. One aspect of the invention provides compositions for topical use comprising an active agent comprising one or more GDF-1 1-derived peptides or fragments or derivatives thereof. In another aspect, methods are provided for ameliorating and/or preventing signs of human skin photoaging and intrinsic aging (e.g., diminishing the appearance of wrinkles and/or fine lines, tightening sagging skin, thickening thinning skin, evening skin tone, treating hyperpigmentation, etc.) comprising topically applying to the skin (e.g., skin of the face) a composition comprising, in a topically acceptable vehicle, one or more GDF-11-derived peptides of the invention.
摘要翻译：提供了衍生自生长分化因子11（GDF-11）蛋白及其衍生物的肽，局部组合物和减少老化迹象和/或改善人类皮肤健康的方法。本发明提供包含肽和局部制剂的活性剂。本发明的一个方面提供用于局部使用的组合物，其包含含有一种或多种GDF-11衍生肽或其片段或衍生物的活性剂。另一方面，提供了用于改善和/或预防人皮肤光老化和内在衰老迹象的方法（例如，减少皱纹和/或细纹的出现，紧缩下垂的皮肤，增厚变薄的皮肤，傍晚肤色，治疗色素沉着过度，等），其包括局部施用于皮肤（例如，脸部的皮肤）组合物，其在局部可接受的载体中包含一种或多种本发明的衍生自GDF-11的肽。

2. 发明申请

WO2016053284A1 TOPICAL COMPOSITIONS AND METHODS FOR SKIN LIGHTENING 审中-公开
标题翻译：用于皮肤护理的主题组合物和方法
公开(公告)号：WO2016053284A1
公开(公告)日：2016-04-07
申请号：PCT/US2014/058231
申请日：2014-09-30
申请人： AVON PRODUCTS, INC.
发明人： HU, Hong , YIM, Sunghan , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K8/18 , A61Q19/00 , A61K31/165
CPC分类号： A61K8/4926 , A61K8/42 , A61K8/892 , A61K9/0014 , A61K31/165 , A61K31/203 , A61K31/4453 , A61K47/34 , A61K2800/592 , A61K2800/95 , A61Q19/02 , A61K2300/00
摘要： Embodiments of the invention are generally directed to compositions useful for reducing histamine-induced pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3'-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a cosmetically acceptable vehicle.
摘要翻译：本发明的实施方案通常涉及可用于减少组织胺诱导的皮肤色素沉着的组合物。该组合物还可以包括其它脱色素如烟酰胺及其黑素素转移抑制衍生物，3,3'-硫代二丙酸及其酪氨酸酶抑制衍生物，或间苯二酚及其酪氨酸酶抑制衍生物。

3. 发明申请

WO2016040068A1 GENETIC ASSAY FOR SKIN PIGMENTATION 审中-公开
标题翻译：皮肤染色遗传测定
公开(公告)号：WO2016040068A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/048080
申请日：2015-09-02
申请人： AVON PRODUCTS, INC.
发明人： ZHUANG, Yong , SANTHANAM, Uma , LYGA, John W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K8/64 , A61K2800/78 , A61Q19/02 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates generally to the identification of genes involved in skin pigmentation and to screening methods for identifying cosmetic active agents that modulate skin pigmentation. The invention also relates to compositions for topical application to the skin that comprise modulators (i.e., downregulators and/or upregulators) of genes involved in skin pigmentation, and to methods for increasing or decreasing skin pigmentation by topically administering compositions of the invention to the skin.
摘要翻译：本发明一般涉及涉及皮肤色素沉着的基因的鉴定以及用于鉴定调节皮肤色素沉着的美容活性剂的筛选方法。本发明还涉及用于局部应用于皮肤的组合物，其包含涉及皮肤色素沉着的基因的调节剂（即，下调和/或上调），以及通过将本发明的组合物局部给予皮肤来增加或减少皮肤色素沉着的方法。

4. 发明申请

WO2014164200A1 TYROSINASE INHIBITORS 审中-公开
标题翻译：酪氨酸酶抑制剂
公开(公告)号：WO2014164200A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/021187
申请日：2014-03-06
申请人： AVON PRODUCTS, INC
发明人： HU, Hong , YIM, Sunghan , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K31/175
CPC分类号： A61K8/4973 , A61K8/49 , A61K31/175 , A61K2800/10 , A61K2800/40 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.
摘要翻译：本文所述的组合物和方法包含有效减少不希望的色素沉着的新成分，所述色素沉着例如皮肤变色，雀斑，老年斑，肝斑，日光损伤，晒黑，色素沉着的痤疮痕迹，疤痕，色素胎记，色素沉着过度，炎症后色素沉着过度，伤后色素沉着过度，黄褐斑，牙形刺，烧伤后疤痕，指甲染色，皮肤变黄，眼睛下黑眼圈等。相应地，该组合物可以包括附加的成分用于着色化妆品，保湿剂，清洁剂，调色剂等。

5. 发明申请

WO2014164195A1 TYROSINASE INHIBITORS 审中-公开
标题翻译：酪氨酸酶抑制剂
公开(公告)号：WO2014164195A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/021160
申请日：2014-03-06
申请人： AVON PRODUCTS, INC
发明人： HU, Hong , YIM, Sunghan , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K31/427
CPC分类号： A61K8/494 , A61K8/49 , A61K2800/40 , A61K2800/48 , A61K2800/522 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.
摘要翻译：本文所述的组合物和方法包含有效减少不想要的色素沉着的新成分，例如皮肤变色，雀斑，老年斑，肝斑，太阳损伤，丹参，着色痤疮痕迹，疤痕，色素沉着的胎记，色素沉着过度，发炎后色素沉着过度，损伤后色素沉着，黑斑病，胆固醇，烧伤后疤痕，指甲斑，皮肤泛黄，眼睛黑眼圈等。相应地，组合物可以包含有色化妆品，保湿剂，清洁剂，调色剂等的其它成分。

6. 发明申请

WO2014158685A2 TETRACERA ASIATICA EXTRACTS AND METHODS OF USE 审中-公开
标题翻译：亚美尼亚提取物及其使用方法
公开(公告)号：WO2014158685A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/019269
申请日：2014-02-28
申请人： AVON PRODUCTS, INC
发明人： MEI, Bing C. , LYGA, John W.
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61K2800/20 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： Methods of using extracts of Tetracera asiatica to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin.
摘要翻译：使用积雪草提取物赋予皮肤有益的方法和/或改善由老化或损伤的皮肤引起的皮肤状况。

7. 发明申请

WO2013062667A1 COMPOSITIONS AND METHODS FOR STIMULATING COLLAGEN SYNTHESIS IN THE SKIN 审中-公开
标题翻译：用于刺激皮肤中胶原蛋白合成的组合物和方法
公开(公告)号：WO2013062667A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/051728
申请日：2012-08-21
申请人： AVON PRODUCTS, INC. , HWANG, Cheng S. , LYGA, John W. , HU, Hong
发明人： HWANG, Cheng S. , LYGA, John W. , HU, Hong
IPC分类号： A01N43/56
CPC分类号： A61K8/49 , A61K8/494 , A61K8/4946 , A61K8/496 , A61K31/4155 , A61K31/496 , A61K31/5377 , A61K2800/78 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： Cosmetic compositions comprising substituted carbamoyl heterocyclic analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted carbamoyl heterocyclic analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含取代的氨基甲酰基杂环类似物的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。认为取代的氨基甲酰基杂环类似物对于涉及皮肤老化的一种或多种生物化学途径具有调节活性。

8. 发明申请

WO2017151174A1 HYDROPONIC TILIACORA TRIANDRA AND USE THEREOF 审中-公开
标题翻译： HYDROPONIC TILIACORA TRIANDRA及其用途
公开(公告)号：WO2017151174A1
公开(公告)日：2017-09-08
申请号：PCT/US2016/037995
申请日：2016-06-17
申请人： AVON PRODUCTS, INC.
发明人： HWANG, Cheng S. , LYGA, John W.
IPC分类号： A01G31/00 , A61K8/97 , A61K36/59 , A61Q19/00
摘要： Provided are methods of treating skin with extracts of Tiliacora plants to improve the health and/or diminish signs of aging. In various implementations, the Tiliacora triandra plant is hydroponically grown and/or is capable of stimulating hyaluronic acid production in human fibroblast cells. Skincare compositions comprising the extracts are also provided.
摘要翻译：提供了用Tiliacora植物提取物处理皮肤以改善健康和/或减少衰老迹象的方法。在各种实施方式中，Tiliacora triandra植物水培生长和/或能够刺激人成纤维细胞中的透明质酸产生。还提供了包含提取物的护肤组合物。

9. 发明申请

WO2016068975A1 TOPICAL COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：主题组合物及其使用方法
公开(公告)号：WO2016068975A1
公开(公告)日：2016-05-06
申请号：PCT/US2014/063317
申请日：2014-10-31
申请人： AVON PRODUCTS, INC.
发明人： XI, Kai , IDKOWIAK BALDYS, Jolanta , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K31/4164
CPC分类号： A61K31/4164 , A61K8/4946 , A61K31/4406 , A61K2800/78 , A61Q19/06 , A61Q19/08
摘要： The invention is generally directed to compositions useful for improving the aesthetic appearance of human skin and the use of those compounds for improving the appearance of human skin, including improving skin tone, reducing the appearance of dark circles under the eyes, and reducing inflammation in the skin. The compositions typically comprise adrenergic receptor agonists.
摘要翻译：本发明一般涉及用于改善人体外观美观的组合物，以及这些化合物用于改善人体皮肤外观的用途，包括改善皮肤色调，减少眼睛下方黑眼圈的外观以及减少眼睛中的炎症皮肤。组合物通常包含肾上腺素能受体激动剂。

10. 发明申请

WO2014158877A1 VERNONIA CINEREA EXTRACTS AND METHODS OF USE 审中-公开
标题翻译：维诺氏提取物及其使用方法
公开(公告)号：WO2014158877A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/020641
申请日：2014-03-05
申请人： AVON PRODUCTS, INC
发明人： MEI, Bing C. , LYGA, John W.
IPC分类号： A61K8/04 , A61Q19/00 , A61K36/28
CPC分类号： A61K8/97 , A61K36/28 , A61K2236/333 , A61K2236/39 , A61K2800/78 , A61K2800/782 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention is directed to methods of using extracts of Vernonia cinerea to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin, by increasing glycosaminoglycan production and/or content. The present invention is further directed to a composition for providing an aesthetic improvement of the skin comprising an effective amount of a second aqueous extract of a butanol/water extract of Vernonia cinerea and a cosmetically acceptable vehicle, in the form of a water-in-oil, oil-in- water, silicone-in-water, water-in-silicone, polyol-in-silicone, or silicone-in-polyol emulsion.
摘要翻译：本发明涉及通过增加葡糖胺聚糖的生产和/或含量，使用灰using提取物赋予皮肤益处和/或改善由老化或受损的皮肤引起的皮肤病症的方法。本发明进一步涉及一种用于提供皮肤美学改进的组合物，其包含有效量的呈灰色形式的灰黄色淀的丁醇/水提取物的第二水提取物和化妆品可接受的载体，油，水包油，硅氧烷水溶液，硅酸嵌入硅氧烷，硅氧烷多元醇或聚硅氧烷多元醇乳液。

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