专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006126069A2 A METHOD FOR THE PRODUCTION OF A MONOCLONAL ANTIBODY TO CD20 FOR THE TREATMENT OF B-CELL LYMPHOMA 审中-公开
标题翻译：用于生产CD20单克隆抗体用于治疗B细胞淋巴瘤的方法
公开(公告)号：WO2006126069A2
公开(公告)日：2006-11-30
申请号：PCT/IB2006/001358
申请日：2006-05-24
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT LTD. , MORAWALA, Patell, Villoo
发明人： MORAWALA, Patell, Villoo
CPC分类号： C07K16/2887 , C07K2317/24
摘要： The present invention relates to the recombinant method used for the production of soluble form of an antibody that binds to CD20 for treatment of patients with relapsed or refractory, low-grade or follicular, CD20-positive, B-cell non-Hodgkin's lymphoma (NHL). The treatment will comprise the use of immunologically active anti-CD20 antibodies; or radiolabeled anti-CD20 antibodies and or cooperative strategies where both labeled and non-labeled antibodies will be used for treatment of NHL. The procedure describes the de novo synthesis of the nucleic acid sequence encoding anti-CD20, transformation of the constructed nucleic acid sequences into competent bacteria and the sub-cloning of the same into mammalian expression vectors for expression of the desired protein. DNA constructs comprising the control elements associated with the gene of interest has been disclosed. The nucleic acid sequence of interest has been codon optimized to permit expression in the suitable mammalian host cells.
摘要翻译：本发明涉及用于生产结合CD20的抗体可溶形式的重组方法，用于治疗复发性或难治性，低级或滤泡型CD20阳性，B细胞非霍奇金淋巴瘤（NHL）的患者）。治疗将包括使用免疫活性的抗CD20抗体; 或放射性标记的抗CD20抗体和/或协同策略，其中标记和未标记的抗体将用于治疗NHL。该方法描述了编码抗CD20的核酸序列的从头合成，将构建的核酸序列转化为感受态细菌，并将其亚克隆至用于表达所需蛋白质的哺乳动物表达载体中。已经公开了包含与感兴趣的基因相关的对照元件的DNA构建体。感兴趣的核酸序列已被密码子优化以允许在合适的哺乳动物宿主细胞中表达。

2. 发明申请

WO2006126066A2 A RECOMBINANT METHOD FOR PRODUCTION OF AN ERYTHROPOIESIS STIMULATING PROTEIN 审中-公开
标题翻译：一种用于生产红细胞生成素刺激蛋白的重组方法
公开(公告)号：WO2006126066A2
公开(公告)日：2006-11-30
申请号：PCT/IB2006/001353
申请日：2006-05-24
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT LTD. , MORAWALA, Patell, Villoo
发明人： MORAWALA, Patell, Villoo
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to the recombinant method used for the production of a highly glycosylated form (in total five N linked glycosylations as opposed to three N linked glyosylations in the natural EPO) of erythropoietin. The added sites for glycosylation will result in greater number of carbohydrate chains, and higher sialic acid content than human EPO, which in turn would impart to the recombinant molecule a longer half-life. The invention further relates to the construction of expression cassettes comprising nucleic acid sequences encoding for the highly glycosylated form of Erythropoietin and stable expression in the host cells. The invention further relates to the optimized method for purification of the erythropoiesis stimulating protein. The recombinant EPO according to the invention, and the salts and functional derivatives thereof, may comprise the active ingredient of pharmaceutical compositions for an increase in the hematocrit for treatment of anemia and for restoration of patient well being and quality of life.
摘要翻译：本发明涉及用于生产高度糖基化形式（在天然EPO中与三个N连接的糖基化相反的总共5个N连接的糖基化）促红细胞生成素的重组方法。糖基化的添加位点将导致比人EPO更多的碳水化合物链和更高的唾液酸含量，其又赋予重组分子更长的半衰期。本发明还涉及包含编码高糖基化形式的红细胞生成素的核酸序列并在宿主细胞中稳定表达的表达盒的构建。本发明还涉及促红细胞生成蛋白的纯化的优化方法。根据本发明的重组EPO及其盐和功能衍生物可以包含药物组合物的活性成分，用于增加用于治疗贫血的血细胞比容和恢复患者的生活质量和生活质量。

3. 发明公开

EP1979482A1 NOVEL EFFICIENT TRANSFORMATION METHOD FOR SUNFLOWER AND OIL SEEDS BASED ON POSITIVE SELECTION 审中-公开
标题翻译：新的高效，ON正选择基于变换方法和向日葵种子油
公开(公告)号：EP1979482A1
公开(公告)日：2008-10-15
申请号：EP06710510.6
申请日：2006-01-12
申请人： Avestha Gengraine Technologies PVT Ltd
发明人： MORAWALA, Patell, Villoo , RAJYASHRI, K., R.
IPC分类号： C12N15/82 , C12N9/92 , C12N15/61
CPC分类号： C12N15/821 , C12N9/92
摘要： The invention describes a highly improved, reproducible and a consistent method of transformation and regeneration that results in obtaining 12-15% transgenic plants. The present invention relates to a method of selecting genetically transformed Sunflower explants based on their ability to utilize Xylose as a sole carbohydrate source. Further disclosed is the nucleic acid sequence of the Xylose Isomerase gene, vector construction for incorporation of the selection marker gene and the process of Agrobacterium Mediated Transformation of target host plant with the vector comprising the gene encoding the enzyme Xylose isomerase under the functional combination of the heterologous regulatory sequences. Also disclosed is the method of selecting the putative transformants post transformation with the said vector that possess a metabolic advantage of utilizing Xylose as a sole carbon source. Increased efficiency of regeneration, better growth and survival has been observed on subjection to the described method of positive selection. The subject invention alleviates the disadvantages of negative selection methods such as the undesired elimination of the transformed cells and the potential environmental harm caused due to the dispersal of the antibiotic and the herbicide resistant genes.

4. 发明申请

WO2008029191A1 WATER EXTRACTS FROM EUGENIA AND THEIR APPLICATION IN DIABETES RELATED CONDITIONS 审中-公开
标题翻译：来自欧盟的水提取物及其在糖尿病患者中的应用相关条件
公开(公告)号：WO2008029191A1
公开(公告)日：2008-03-13
申请号：PCT/IB2006/002732
申请日：2006-09-08
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT. LTD , MORAWALA, Patell, Villoo
发明人： MORAWALA, Patell, Villoo
IPC分类号： A61K36/00
CPC分类号： A61K36/61
摘要： The present invention relates to herbal extracts from Eugenia jambolana species with hypoglycemic activity, which is characterized in delaying of onset and / or management of diabetes by inhibiting the glucose absorption in the intestine and by mimicking and potentiating the insulin activity and also to a method for producing the extract and the use of the extract in the treatment of diabetes. The invention relates to the extraction process of derivation of the extract from Eugenia jambolana, which is characterized in that the solvent used is water. The herbal extracts comprise active ingredients that delay saccharide digestion or absorption thereby suppressing a rise in post-prandial and / or fasting blood glucose levels.
摘要翻译：本发明涉及具有低血糖活性的金丝桃属植物的草药提取物，其特征在于通过抑制肠内的葡萄糖吸收来延迟糖尿病的发作和/或控制，并且通过模拟和增强胰岛素活性，产生提取物和使用提取物治疗糖尿病。本发明涉及从金银花提取物的提取方法，其特征在于使用的溶剂是水。草药提取物包含延迟糖消化或吸收的活性成分，从而抑制餐后和/或空腹血糖水平的升高。

5. 发明申请

WO2008062245A1 EUGENIA JAMBOLANA PLANT EXTRACTS FOR THE TREATMENT OF DIABETES AND THE EXTRACTION PROCESS THEREOF 审中-公开
标题翻译：用于治疗糖尿病的EUGENIA JAMBOLANA植物提取物及其提取方法
公开(公告)号：WO2008062245A1
公开(公告)日：2008-05-29
申请号：PCT/IB2006/002733
申请日：2006-09-08
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT. LTD , MORAWALA, Patell, Villoo
发明人： MORAWALA, Patell, Villoo
IPC分类号： A61K36/61 , A61K131/00
CPC分类号： A61K36/61
摘要： The present invention relates to herbal extracts from Eugenia jambolana species with hypoglycemic activity, which is characterized in delaying of onset and / or management of diabetes by inhibiting the glucose absorption in the intestine and by mimicking and potentiating the insulin activity and also to a method for producing the extract and the use of the extract in the treatment of diabetes.
摘要翻译：本发明涉及具有低血糖活性的金丝桃属植物的草药提取物，其特征在于通过抑制肠内的葡萄糖吸收来延迟糖尿病的发作和/或控制，并且通过模拟和增强胰岛素活性，产生提取物和使用提取物治疗糖尿病。

6. 发明申请

WO2007080440A1 NOVEL EFFICIENT TRANSFORMATION METHOD FOR SUNFLOWER AND OIL SEEDS BASED ON POSITIVE SELECTION 审中-公开
标题翻译：基于积极选择的新品种和油种的高效转化方法
公开(公告)号：WO2007080440A1
公开(公告)日：2007-07-19
申请号：PCT/IB2006/000491
申请日：2006-01-12
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT.LTD. , MORAWALA, Patell, Villoo , RAJYASHRI, K., R.
发明人： MORAWALA, Patell, Villoo , RAJYASHRI, K., R.
IPC分类号： C12N15/82 , C12N9/92 , C12N15/61
CPC分类号： C12N15/821 , C12N9/92
摘要： The invention describes a highly improved, reproducible and a consistent method of transformation and regeneration that results in obtaining 12-15% transgenic plants. The present invention relates to a method of selecting genetically transformed Sunflower explants based on their ability to utilize Xylose as a sole carbohydrate source. Further disclosed is the nucleic acid sequence of the Xylose Isomerase gene, vector construction for incorporation of the selection marker gene and the process of Agrobacterium Mediated Transformation of target host plant with the vector comprising the gene encoding the enzyme Xylose isomerase under the functional combination of the heterologous regulatory sequences. Also disclosed is the method of selecting the putative transformants post transformation with the said vector that possess a metabolic advantage of utilizing Xylose as a sole carbon source. Increased efficiency of regeneration, better growth and survival has been observed on subjection to the described method of positive selection. The subject invention alleviates the disadvantages of negative selection methods such as the undesired elimination of the transformed cells and the potential environmental harm caused due to the dispersal of the antibiotic and the herbicide resistant genes.
摘要翻译：本发明描述了高度改进的，可重复的和一致的转化和再生方法，其导致获得12-15％的转基因植物。本发明涉及一种基于其利用木糖作为唯一碳水化合物来源的能力来选择遗传转化的向日葵外植体的方法。进一步公开的是，在包含编码酶木糖异构酶的基因的载体的功能组合下，将木糖异构酶基因的核酸序列，掺入选择标记基因的载体构建和农杆菌介导的靶宿主植物转化过程异源调控序列。还公开了使用具有利用木糖作为唯一碳源的代谢优势的所述载体选择转化后的推定转化体的方法。对于所选择的阳性选择方法，观察到提高再生效率，更好的生长和生存。本发明减轻了阴性选择方法的缺点，例如不希望地消除转化细胞，以及由于抗生素和除草剂抗性基因的分散引起的潜在的环境危害。

7. 发明申请

WO2007113608A1 PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN BRASSICA USING NOVEL DELTA-6-DESATURASE 审中-公开
标题翻译：使用新的DELTA-6-去饱和酶在BRASSICA中生产聚氨酯脂肪酸
公开(公告)号：WO2007113608A1
公开(公告)日：2007-10-11
申请号：PCT/IB2006/001023
申请日：2006-04-06
申请人： AVESTHA GENGRAINE TECHNOLGIES PVT LTD. , MORAWALA, Patell, Villoo , RAJZASHRI, K., R.
发明人： MORAWALA, Patell, Villoo , RAJZASHRI, K., R.
IPC分类号： C12N15/10 , A01H5/00 , C12N15/53 , C12N15/82 , A23D9/013 , C11C1/00
CPC分类号： C12N9/0083 , C12N15/8247
摘要： The invention relates to a method of producing polyunsaturated fatty acids in transgenic Brassica plants by the Agrobacterium mediated gene transfer of genes involved in the desaturation of the polyunsaturated fatty acids and thereby encoding for polypeptides involved in the biosynthesis of polyunsaturated fatty acids based on the expression of the said genes. The invention additionally relates to the construction of expression cassettes comprising nucleic acid sequences encoding delta-6 desaturase enzyme obtained from Schizochytrium SC-I and the host cells into which the vectors have been introduced. The further aspects relate to the selection and regeneration of the putative transformants based on a method of positive selection.
摘要翻译：本发明涉及通过土壤杆菌介导的参与多不饱和脂肪酸去饱和的基因的基因转移，从而编码参与多不饱和脂肪酸生物合成的多肽的转基因芸苔属植物中的多不饱和脂肪酸的方法，其基于所述基因。本发明还涉及包含编码从裂殖壶菌SC-1获得的δ-6去饱和酶的核酸序列的表达盒和已导入载体的宿主细胞的表达盒的构建。进一步的方面涉及基于正选择方法的推定转化体的选择和再生。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式