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1. 发明申请

WO9952923A3 METHOD FOR THE PRODUCTION OF PENTOPYRANOSYL NUCLEOSIDES 审中-公开
标题翻译：用于生产pentopyranosylnucleosides
公开(公告)号：WO9952923A3
公开(公告)日：2000-01-13
申请号：PCT/EP9902356
申请日：1999-04-07
申请人： AVENTIS RES & TECH GMBH & CO , ESCHENMOSER ALBERT , PITSCH STEFAN , WENDEBORN SEBASTIAN
发明人： ESCHENMOSER ALBERT , PITSCH STEFAN , WENDEBORN SEBASTIAN
IPC分类号： C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00
CPC分类号： C07H19/04 , Y10S977/915
摘要： The invention relates to a method for the production of a pentopyranosyl nucleoside 3', 4'-cyclic acetal, whereby a pentopyranosyl nucleoside is made to react with an aldehyde, ketone, acetal or ketal under a vacuum.
摘要翻译：本发明涉及一种用于制备pentopyranosylnucleoside的3”，4'-环状缩醛的方法，其中一个pentopyranosylnucleoside与减压醛，酮，缩醛或缩酮反应的方法。

2. 发明申请

WO9915509A3 CYCLOHEXYL AND HETEROCYCLYL NUCLEOSIDE DERIVATIVES, METHOD FOR PRODUCING THESE DERIVATIVES, AND THE USE OF THE DERIVATIVES AND THEIR OLIGOMERS OR CONJUGATES IN PAIRING AND/OR TESTING SYSTEMS 审中-公开
标题翻译：环己基和杂环核苷衍生物的生产和使用本衍生品，它们的低聚物或在配对和/或测试系统中共轭
公开(公告)号：WO9915509A3
公开(公告)日：1999-06-24
申请号：PCT/EP9806002
申请日：1998-09-21
申请人： AVENTIS RES & TECH GMBH & CO , MICULKA CHRISTIAN , WINDHAB NORBERT , ESCHENMOSER ALBERT , SCHERER STEFAN , QUINKERT GERHARD
发明人： MICULKA CHRISTIAN , WINDHAB NORBERT , ESCHENMOSER ALBERT , SCHERER STEFAN , QUINKERT GERHARD
IPC分类号： C07D239/54 , A61K47/42 , A61K47/48 , C07D473/18 , C07D473/34 , C12N7/01 , C12Q1/68 , C07K7/06
CPC分类号： C12Q1/68
摘要： The invention relates to a compound of formula (I), wherein R is NR R , OR or SR with R and R being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R is equal to CmH2m-C(X)-Y with X being =O, =S or =N, Y being equal to OR , NR R or SR , R and R having the same meaning given above, and m being a whole number from 1 to 4; or R is equal to CmH2m-Z-Y' with Z being a sulfonyl, phosphonyl, ether or amine group, Y' being equal to H, CnH2n+1, OR , NR R or SR then Z is sulphonyl or phosphonyl group, n, R and R having the meaning given above, and Y' being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR R , O, NR ou S independently of each other with R , R and R being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR or N with R having the meaning of R independently, A-B, B-C or C-D not being two identical heteroatoms; and nucleobase means thymine, uracile, adénine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.
摘要翻译：本发明涉及式（I）的化合物，其中R <1>是NR <3> [R <4>或<3>，或SR <3>为R <3>和R <4>彼此独立地，等于或不同的H或C n H 2n + 1，其中n是1-12的整数; R 2等于C m H 2m -C（X）-Y，其中X等于= O，= S或= N; Y是OR 3，NR 3 R 4或SR 3，其中R 3和R 4如上所定义; m是1-4的整数，或者R 2是C m H 2m -ZY'，Z是磺酰基，膦酰基，醚或胺基，其中Z是磺酰基或膦酰基，Y“是H，为C n H 2n + 1个，或者<3>，NR <3> [R <4>，或者SR <3>，其中n，R <3>和R <4>具有上文给出的含义，并且，当Z是醚或胺基时，Y'是C n H 2n + 1; A，B和d彼此独立地相同或不同的，CR <5> - [R <6>，O，NR <7>或S，其中R <5> - [R <6> - [R <7>独立地是H或为CnH2n +1，其中n如上所定义且C为CR 8或N为R 8，独立于R 5的含义，但AB，BC或CD不代表两个相同的杂原子; 核碱基是指胸腺嘧啶，尿嘧啶，腺嘌呤，胞嘧啶，鸟嘌呤，异胞嘧啶，异鸟嘌呤，黄嘌呤或次黄嘌呤; 他们在配套和/或测试系统中的制造和使用。

3. 发明专利

CA2327436A1 PROCESS FOR THE PREPARATION OF PENTOPYRANOSYLNUCLEOSIDES 未知
公开(公告)号：CA2327436A1
公开(公告)日：1999-10-21
申请号：CA2327436
申请日：1999-04-07
申请人： AVENTIS RES & TECH GMBH & CO
发明人： PITSCH STEFAN , ESCHENMOSER ALBERT , WENDEBORN SEBASTIAN
IPC分类号： C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00
摘要： The invention relates to a method for the production of a pentopyranosyl nucleoside 3', 4'-cyclic acetal, whereby a pentopyranosyl nucleoside is made to react with an aldehyde, ketone, acetal or ketal under a vacuum.

4. 发明专利

BR9714393A 未知
公开(公告)号：BR9714393A
公开(公告)日：2000-05-16
申请号：BR9714393
申请日：1997-12-10
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , MICULKA CHRISTIAN , WINDHAB NORBERT , HOPPE HANS-ULRICH
IPC分类号： C07B61/00 , C07H21/00
摘要： The invention relates to a supramolecular nanosystem containing at least one substantially non-helical oligomer (oligomer A) and one or more identical or different, substantially non-helical oligomers which do not pair with each other, with identical or different functional units (oligomer B), in which the oligomer A can pair specifically non-covalently, and oligomer B is determinable by its monomers.

5. 发明专利

BR9909909A 未知
公开(公告)号：BR9909909A
公开(公告)日：2000-12-26
申请号：BR9909909
申请日：1999-04-07
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , PITSCH STEFAN , WENDEBORN SEBASTIAN
IPC分类号： C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00
摘要： Processes for the preparation of 3',4'-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pressure of less than about 500 mbar.

6. 发明专利

BR9812375A 未知
公开(公告)号：BR9812375A
公开(公告)日：2000-09-19
申请号：BR9812375
申请日：1998-09-21
申请人： AVENTIS RES & TECH GMBH & CO
发明人： MICULKA CHRISTIAN , WINDHAB NORBERT , ESCHENMOSER ALBERT , SCHERER STEFAN , QUINKERT GERHARD
IPC分类号： C07D239/54 , A61K47/42 , A61K47/48 , C07D473/18 , C07D473/34 , C12N7/01 , C12Q1/68 , C07K7/06
摘要： The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof.

7. 发明专利

DE19815901A1 未知
公开(公告)号：DE19815901A1
公开(公告)日：1999-10-14
申请号：DE19815901
申请日：1998-04-08
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , PITSCH STEFAN , WENDEBORN SEBASTIAN
IPC分类号： C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00 , C07H19/00 , C07H1/00
摘要： The invention relates to a method for the production of a pentopyranosyl nucleoside 3', 4'-cyclic acetal, whereby a pentopyranosyl nucleoside is made to react with an aldehyde, ketone, acetal or ketal under a vacuum.

8. 发明专利

CA2301641A1 SUPRAMOLECULAR PAIRING SYSTEM, ITS PREPARATION AND USE 未知
公开(公告)号：CA2301641A1
公开(公告)日：1999-04-01
申请号：CA2301641
申请日：1998-09-21
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , SCHERER STEFAN , WINDHAB NORBERT , QUINKERT GERHARD , MICULKA CHRISTIAN
IPC分类号： C07D239/54 , A61K47/42 , A61K47/48 , C07D473/18 , C07D473/34 , C12N7/01 , C12Q1/68 , C07K7/06
摘要： The invention relates to a compound of formula (I), wherein R1 is NR3R4, OR3 or SR3 with R3 and R4 being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R2 is equal to CmH2m-C(X)-Y with X being =O, =S or =N, Y being equal to OR3, NR3R4 or SR3, R3 and R4 having the same meaning given above, and m being a whole number from 1 to 4; or R2 is equal to CmH2m-Z-Y' with Z being a sulfonyl, phosphonyl, ether or amine group, Y' being equal to H, CnH2n+1, OR3, NR3R4 or SR3 then Z is sulphonyl or phosphonyl group, n, R3 and R4 having the meaning given above, and Y' being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR5R6, O, NR7 ou S independently of each other with R5, R6 and R7 being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR8 or N with R8 having the meaning of R5 independently, A-B, B-C or C-D not being two identical heteroatoms; and nucleobase means thymine, uracile, adénine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.

9. 发明专利

AU734804B2 Non-helical supramolecular nanosystems 未知
公开(公告)号：AU734804B2
公开(公告)日：2001-06-21
申请号：AU5661298
申请日：1997-12-10
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , MICULKA CHRISTIAN , WINDHAB NORBERT , HOPPE HANS-ULRICH
IPC分类号： C07B61/00 , C07H21/00
摘要： The invention relates to a supramolecular nanosystem containing at least one substantially non-helical oligomer (oligomer A) and one or more identical or different, substantially non-helical oligomers which do not pair with each other, with identical or different functional units (oligomer B), in which the oligomer A can pair specifically non-covalently, and oligomer B is determinable by its monomers.

10. 发明专利

AU3706499A Method for the production of pentopyranosyl nucleosides 未知
公开(公告)号：AU3706499A
公开(公告)日：1999-11-01
申请号：AU3706499
申请日：1999-04-07
申请人： AVENTIS RES & TECH GMBH & CO
发明人： ESCHENMOSER ALBERT , PITSCH STEFAN , WENDEBORN SEBASTIAN
IPC分类号： C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00
摘要： Processes for the preparation of 3',4'-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pressure of less than about 500 mbar.

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