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1. 发明专利

HU0204524A2 NUCLEIC AND PROTEINIC ACIDS CORRESPONDING TO HUMAN GENE ABC1 未知
公开(公告)号：HU0204524A2
公开(公告)日：2003-04-28
申请号：HU0204524
申请日：2000-06-08
申请人： AVENTIS PHARMA SA
发明人： ARNOULD-REGUIGNE ISABELLE , ASSMANN GERD , BREWER H BRYAN , DENEFLE PATRICE , DUVERGER NICOLAS , FUNKE HARALD , LEMOINE CENDRINE , NAUDIN LAURENT , PRADES CATHERINE , ROSIER-MONTUS MARIE-FRANCOISE , RUST STEPHAN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/52
摘要： The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

2. 发明专利

NO20016089A 未知
公开(公告)号：NO20016089A
公开(公告)日：2002-02-15
申请号：NO20016089
申请日：2001-12-13
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER-MONTUS MARIE-FRANCOISE , ARNOULD-REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN , FUNKE HARALD , BREWER H BRYAN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K14/775 , A61K38/17 , A61P7/00
CPC分类号： C07K14/705

3. 发明专利

FR2795091B1 未知
公开(公告)号：FR2795091B1
公开(公告)日：2003-10-31
申请号：FR9907684
申请日：1999-06-17
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER MONTUS MARIE FRANCOISE , ARNOULD REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN
IPC分类号： A61P9/10 , C07K14/705 , C12N15/12 , A61K38/17 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/861 , C12Q1/68 , G01N33/68

4. 发明专利

BR0011724A 未知
公开(公告)号：BR0011724A
公开(公告)日：2002-03-26
申请号：BR0011724
申请日：2000-06-08
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER-MONTUS MARIE-FRANCOISE , ARNOULD-REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , RUST STEPHAN , ASSMANN GERD , FUNKE HARALD , BREWER H BRYAN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/52
摘要： The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

5. 发明专利

NO20016089L 未知
公开(公告)号：NO20016089L
公开(公告)日：2002-02-15
申请号：NO20016089
申请日：2001-12-13
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER-MONTUS MARIE-FRANCOISE , ARNOULD-REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN , FUNKE HARALD , BREWER H BRYAN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K14/775 , A61K38/17 , A61P7/00
摘要： The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

6. 发明专利

FR2795091A1 New nucleic acid and proteins from the human ABC1 gene, useful for treating and preventing diseases associated with abnormal reverse transport of cholesterol 未知
公开(公告)号：FR2795091A1
公开(公告)日：2000-12-22
申请号：FR9907684
申请日：1999-06-17
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER MONTUS MARIE FRANCOISE , ARNOULD REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN
IPC分类号： A61P9/10 , C07K14/705 , C12N15/12 , A61K38/17 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/861 , C12Q1/68 , G01N33/68
摘要： Nucleic acid (I) comprising at least 245 consecutive nucleotides (nt) from any one of the 14 sequences, designated (S1)-(S14), defined in the specification, or their complements, representing intron/exon combinations from the human ABC1 gene, is new. Independent claims are also included for the following: (1) nucleic acid (Ia) comprising any one of the 33 sequences (S15 to S47; all sequences defined in the specification) or their complements, representing individual exons of the ABC1 gene; (2) nucleic acid (Ib) comprising at least 8 consecutive nt from any of 43 sequences (S48 to S90; all sequences defined in the specification) or their complements, representing introns of the ABC1 gene; (3) nucleic acid (Ic) at least 80% identical with the sequences of (Ib) or their complements; (4) nucleic acid (Id) that hybridizes under highly stringent conditions with the sequences of (Ib) or their complements; (5) nucleic acid (Ie) of 9497 basepair (bp) (S91; defined in the specification), representing the cDNA of the human ABC1 gene or its complement; (6) nucleic acid (If) comprising at least 8 nt from the 2617 bp (S92), 302 bp (S93), 9593 bp (S94), 173 bp (S95) or 9495 bp (S95) (all sequences defined in the specification), or their biologically active fragments or complements; (7) nucleic acid (Ig) at least 80% identical with (S92)-(S96), their biologically active fragments or complements; (8) nucleic acid (Ih) that hybridizes under highly stringent conditions with (S92)-(S96), their biologically active fragments or complements; (9) nucleic acid (Ii) comprising at least 8 nucleotides from any of sequences (S97)-(S108), containing a polymorphic base, or their complements; (10) probes and primers specific for the ABC1 gene containing at least 15 nt from (I)-(Ii); (11) a method for amplification and detection of (I)-(Ii); (12) a kit for detection or amplification of (I)-(Ii); (13) a recombinant vector containing (I)-(Ii); (14) recombinant host cells containing (I)-(Ii) or the vector of (13); (15) mutated ABC1 polypeptides of 2233 (S140) or 574 (S141) amino acids (aa) (both sequences defined in the specification); (16) antibodies (Ab) directed against the mutants of (15); (17) a kit for detecting the mutants of (15) containing Ab and detection reagents; and (18) a method of screening to identify compounds (A) that act on the metabolism of cholesterol and are agonists or antagonists of ABC1 polypeptide.

7. 发明专利

ZA200110545B Nucleic and proteinic acids corresponding to human gene ABC1. 未知
公开(公告)号：ZA200110545B
公开(公告)日：2003-07-30
申请号：ZA200110545
申请日：2001-12-21
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ARNOULD-REGUIGNE ISABELLE , NAUDIN LAURENT , DUVERGER NICOLAS , RUST STEPHAN , BREWER H BRYAN , ROSIER-MONTUS MARIE-FRANCOISE , PRADES CATHERINE , LEMOINE CENDRINE , ASSMANN GERD , FUNKE HARALD
IPC分类号： A61P9/10 , C07K14/705 , C12N15/12 , C12N , C07K , C12Q

8. 发明专利

NO20016089D0 未知
公开(公告)号：NO20016089D0
公开(公告)日：2001-12-13
申请号：NO20016089
申请日：2001-12-13
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER-MONTUS MARIE-FRANCOISE , ARNOULD-REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN , FUNKE HARALD , BREWER H BRYAN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N
摘要： The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

9. 发明专利

AU5540800A Nucleic and proteinic acids corresponding to human gene abc1 未知
公开(公告)号：AU5540800A
公开(公告)日：2001-01-09
申请号：AU5540800
申请日：2000-06-08
申请人： AVENTIS PHARMA SA
发明人： DENEFLE PATRICE , ROSIER-MONTUS MARIE-FRANCOISE , ARNOULD-REGUIGNE ISABELLE , PRADES CATHERINE , NAUDIN LAURENT , LEMOINE CENDRINE , DUVERGER NICOLAS , ASSMANN GERD , RUST STEPHAN , FUNKE HARALD , BREWER H BRYAN JR
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P9/04 , A61P9/10 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/52
摘要： The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

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