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1. 发明申请

WO2012158991A3 CONTROLLED APPLICATION OF CROSS-LINKING AGENT 审中-公开
标题翻译：交联剂的控制应用
公开(公告)号：WO2012158991A3
公开(公告)日：2013-02-28
申请号：PCT/US2012038483
申请日：2012-05-18
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN , TROKEL STEPHEN L , HERSH PETER , KAMAEV PAVEL
发明人： MULLER DAVID , MARSHALL JOHN , TROKEL STEPHEN L , HERSH PETER , KAMAEV PAVEL
IPC分类号： A61F9/008 , A61F9/007 , A61F9/01
CPC分类号： A61K31/525 , A61F9/0079 , A61F9/008 , A61F9/00804 , A61F2009/00844 , A61F2009/00851 , A61F2009/00853 , A61F2009/00857 , A61F2009/00872
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

2. 发明申请

WO2011130356A2 SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
标题翻译：用于在眼睛中进行交叉连接的系统和方法
公开(公告)号：WO2011130356A2
公开(公告)日：2011-10-20
申请号：PCT/US2011032234
申请日：2011-04-13
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN , TROKEL STEPHEN L , HERSH PETER , KAMAEV PAVEL
发明人： MULLER DAVID , MARSHALL JOHN , TROKEL STEPHEN L , HERSH PETER , KAMAEV PAVEL
IPC分类号： A61F9/00 , A61K31/525 , A61N5/00 , A61N5/08 , A61P27/02
CPC分类号： A61K31/525 , A61F9/008 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

3. 发明申请

WO2011116306A2 SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
标题翻译：用于应用和监测眼睛治疗的系统和方法
公开(公告)号：WO2011116306A2
公开(公告)日：2011-09-22
申请号：PCT/US2011029033
申请日：2011-03-18
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN , FRIEDMAN MARC , BLINN STEPHEN , SCHARF RONALD , KAMAEV PAVEL , PERTAUB RADHA
发明人： MULLER DAVID , MARSHALL JOHN , FRIEDMAN MARC , BLINN STEPHEN , SCHARF RONALD , KAMAEV PAVEL , PERTAUB RADHA
IPC分类号： A61F9/00 , A61B3/10 , A61B3/107 , A61M35/00 , A61N5/06
CPC分类号： A61N5/0625 , A61B3/10 , A61B3/107 , A61F9/00 , A61F9/0079 , A61F9/008 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062 , A61N2005/0643 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
摘要翻译：用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。提供反馈系统以获取测量并将反馈信息传递给控制器。反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。还提供反馈系统的方面来监测和诊断眼睛的特征1.还提供了根据由反馈系统提供的信息激活交联以提高交联疗法的准确性和安全性的方法。

4. 发明申请

WO2011053768A3 SYSTEM AND METHOD FOR STABILIZING CORNEAL TISSUE AFTER TREATMENT 审中-公开
标题翻译：治疗后稳定角膜组织的系统和方法
公开(公告)号：WO2011053768A3
公开(公告)日：2011-11-24
申请号：PCT/US2010054673
申请日：2010-10-29
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN
发明人： MULLER DAVID , MARSHALL JOHN
IPC分类号： A61N5/02 , A61F7/00 , A61F9/007 , A61K38/18 , A61K38/20 , A61M35/00 , A61P27/02
CPC分类号： A61F9/007 , A61B18/1815 , A61B2018/00029 , A61F9/0079 , A61F9/013 , A61F2009/00872 , A61K38/1841 , A61M35/00 , A61M2210/0612
摘要： Embodiments according to aspects of the present invention provide systems and methods for stabilizing corneal tissue after treatment of the corneal tissue. For example, thermokeratoplasty may be applied to the corneal tissue to address disorders associated with abnormal shaping of the cornea. To stabilize the desired structural changes caused by the treatment, embodiments apply ophthalmic formulations that help to inhibit wound healing. Wound healing may occur in response to the application of the treatment and may produce further structural changes that mitigate or alter the desired effects of the treatment.
摘要翻译：根据本发明的方面的实施例提供了用于在角膜组织处理之后稳定角膜组织的系统和方法。例如，热角膜成形术可以应用于角膜组织以解决与角膜异常成形相关的疾病。为了稳定由治疗引起的期望的结构变化，实施方案应用有助于抑制伤口愈合的眼用制剂。伤口愈合可能会因应用治疗而发生，并可能产生进一步的结构变化，从而减轻或改变预期的治疗效果。

5. 发明申请

WO2009134953A2 SYSTEM AND METHOD FOR APPLYING THERAPY TO AN EYE USING ENERGY CONDUCTION 审中-公开
标题翻译：使用能量诱导将眼部应用于眼睛的系统和方法
公开(公告)号：WO2009134953A2
公开(公告)日：2009-11-05
申请号：PCT/US2009042204
申请日：2009-04-30
申请人： AVEDRO INC , MULLER DAVID
发明人： MULLER DAVID
IPC分类号： A61B18/18 , A61F9/007
CPC分类号： A61F9/00 , A61B18/18 , A61B18/1815 , A61F9/0079 , A61F9/013
摘要： Thermokeratoplasty is applied to achieve a customized reshaping of a cornea, especially, for the treatment of astigmatism. Energy is applied to the cornea in a customized pattern using a specific configuration of two conductors. In one embodiment, an outer conductor and an outer conductor are separated by a gap. When a conducting element is applied to the corneal surface the area of the cornea at the periphery of the inner conductor is subject to an energy pattern with substantially the same shape and dimension as the gap between the inner and outer conductors. The inner and outer conductors may be positioned and shaped to form a gap having any desirable size and/or shape, including non-annular and asymmetrical shapes. The gap may be configured by altering the spatial relationships between the inner conductor and the outer conductor, by altering the size, shape, and/or position of the inner and/or outer conductors, or by forming one or more indentations or protrusions in or on the inner conductor and/or the outer conductor. Additionally or alternatively, energy is applied to the cornea in a customized pattern defined by a specific arrangement of one or more dielectric materials providing varying impedance.
摘要翻译： Thermokeratoplasty应用于实现角膜的定制重塑，特别是用于治疗散光。使用两个导体的特定配置，以定制的模式将角能量施加到角膜。在一个实施例中，外部导体和外部导体被间隙隔开。当将导电元件施加到角膜表面时，在内部导体的周边处的角膜的区域受到与内部和外部导体之间的间隙具有基本相同的形状和尺寸的能量图案。内导体和外导体可以定位和成形以形成具有任何期望的尺寸和/或形状的间隙，包括非环形和非对称形状。可以通过改变内导体和/或外导体的尺寸，形状和/或位置，或者通过在内导体和/或外导体中形成一个或多个凹陷或突起来改变内导体和外导体之间的空间关系来构造间隙在内部导体和/或外部导体上。附加地或替代地，以由提供变化的阻抗的一个或多个介电材料的特定布置限定的定制图案将能量施加到角膜。

6. 发明申请

WO2009012490A3 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2009012490A3
公开(公告)日：2009-03-05
申请号：PCT/US2008070640
申请日：2008-07-21
申请人： AVEDRO INC , MULLER DAVID
发明人： MULLER DAVID
IPC分类号： A61B18/04
CPC分类号： A61B18/14 , A61B18/1477 , A61B18/18 , A61B18/22 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00702 , A61B2018/00791 , A61B2018/1425 , A61B2018/1807 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872 , A61N1/36046 , A61N1/403
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and at least one coolant delivery element. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery elements are in communication with the coolant supply and are operable to deliver a micro-controlled pulse of coolant to the distal end.
摘要翻译：用于对眼睛施加治疗的系统选择性地将冷却剂施加到角膜表面以最小化热角膜成形术期间对角膜表面的与热相关的损伤。实施例可以包括能量源，导电元件，冷却剂供应装置和至少一个冷却剂输送元件。导电元件可操作地连接至能量源并且从近端延伸至远端。导电元件将能量从能量源引导至可定位在眼睛的远端。冷却剂输送元件与冷却剂供应源连通并且可操作以将微控制的冷却剂脉冲输送到远端。

7. 发明申请

WO2012167260A3 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 审中-公开
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：WO2012167260A3
公开(公告)日：2013-03-14
申请号：PCT/US2012040758
申请日：2012-06-04
申请人： AVEDRO INC , FRIEDMAN MARC D , KAMAEV PAVEL , MULLER DAVID , PERTAUB RADHA , SCHARF RONALD , SHERR EVAN , USHER DAVID
发明人： FRIEDMAN MARC D , KAMAEV PAVEL , MULLER DAVID , PERTAUB RADHA , SCHARF RONALD , SHERR EVAN , USHER DAVID
IPC分类号： A61B3/107 , A61B3/14
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像，以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

8. 发明申请

WO2008039252A3 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模态生物量系统
公开(公告)号：WO2008039252A3
公开(公告)日：2008-09-12
申请号：PCT/US2007011507
申请日：2007-05-14
申请人： RETICA SYSTEMS INC , FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
发明人： FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
IPC分类号： H04K1/10 , H04L9/00
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物识别系统捕获并处理虹膜和视网膜的图像以进行生物识别。另一个多峰视觉系统捕获并处理虹膜的图像和/或来自对象双眼的图像。基于这些系统提供的数据的生物识别技术比使用仅来自虹膜的数据或仅来自单眼的视网膜的生物识别技术更准确和鲁棒。示例性实施例将光子发射到虹膜和双眼视网膜，虹膜图像传感器，当虹膜反射发射的光时捕获虹膜的图像;视网膜图像传感器，其在视网膜反射时捕获视网膜的图像以及控制光圈和视网膜照明源的控制器，其中所述虹膜的捕获图像和所述捕获的视网膜的图像包含生物特征数据。

9. 发明申请

WO2008039252A9 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模式眼睛生物测量系统
公开(公告)号：WO2008039252A9
公开(公告)日：2008-06-19
申请号：PCT/US2007011507
申请日：2007-05-14
申请人： RETICA SYSTEMS INC , FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
发明人： FRIEDMAN MARC D , CASAVERDE PABLO , YANSEN DON , MCNERNEY TIM , TOSA YASUNARI , USHER DAVID , ACCOMANDO NICHOLAS A , MULLER DAVID , HEACOCK GREG , MARSHALL JOHN
IPC分类号： A61B3/14 , A61B3/15 , G06K9/62
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物识别系统捕获和处理虹膜和视网膜的图像以用于生物识别。另一种多模式眼部系统捕捉和处理虹膜和/或来自对象双眼的图像。基于这些系统提供的数据的生物特征识别比使用生物特征识别更加准确和可靠，这些生物特征包括仅来自虹膜或仅来自单眼的视网膜的数据。示例性实施例向双眼的虹膜和视网膜发射光子，当虹膜反射发射的光时捕获虹膜图像的虹膜图像传感器，视网膜图像传感器，其在视网膜反射时捕获视网膜的图像发出的光线以及控制虹膜和视网膜照射源的控制器，其中虹膜的拍摄图像和视网膜的拍摄图像包含生物统计数据。

10. 发明公开

EP2967995A4 CORNEAL IMPLANT SYSTEMS AND METHODS 有权
标题翻译： SYSTEME UND VERFAHRENFÜRHORNHAUTIMPLANTATE
公开(公告)号：EP2967995A4
公开(公告)日：2017-04-26
申请号：EP14769291
申请日：2014-03-14
申请人： MULLER DAVID
发明人： MULLER DAVID
IPC分类号： A61F9/007 , A61F2/14 , A61F2/16 , A61F9/008
CPC分类号： A61F2/142 , A61F2/145 , A61F9/0081 , A61F9/00812 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： According to one aspect of the present disclosure, an implant for correcting vision impairment is disclosed. The implant is made from a donor corneal tissue sized and shaped to provide a predetermined refractive correction and reshaping of a cornea. The donor corneal tissue includes a posterior surface and an anterior surface. The posterior surface has a surface profile that is configured to generally correspond to a shape of an implantation site of the cornea.
摘要翻译：根据本公开的一个方面，公开了一种用于矫正视力障碍的植入物。植入物由供体角膜组织制成，所述供体角膜组织被制成大小和形状以提供角膜的预定屈光矫正和重塑。供体角膜组织包括后表面和前表面。后表面具有表面轮廓，该表面轮廓被配置为大致对应于角膜的植入部位的形状。

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