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1. 发明申请

WO2005058804A1 PROCESS FOR THE PREPARATION OF TERTIARY AMINES ATTACHED TO A SECONDARY CARBON CENTRE 审中-公开
标题翻译：制备连接到二级碳中心的仲胺的方法
公开(公告)号：WO2005058804A1
公开(公告)日：2005-06-30
申请号：PCT/GB2004/005199
申请日：2004-12-08
申请人： AVECIA PHARMACEUTICALS LIMITED , FIELDHOUSE, Robin
发明人： FIELDHOUSE, Robin
IPC分类号： C07C269/06
CPC分类号： C07C29/143 , C07B2200/07 , C07C269/06 , C07C271/42 , C07C33/20 , C07C33/24
摘要： There is provided a process for the preparation of a compound of Formula: (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R 1 , R 2 and R 3 each independently represent an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group; said process comprising: a) reducing a compound of Formula: (2) to form a compound of Formula: (3) b) activating the compound of Formula: (3) to form a compound of Formula: (4) wherein X represents a leaving group; and c) coupling the compound of Formula: (4) to a compound of Formula: (5) to form a compound of Formula: (1). Stereoselective processes are also provided.
摘要翻译：提供了制备式（1）化合物的方法，其中Ar表示任选取代的烃基或任选取代的包含芳族部分的杂环基; 且R 1，R 2和R 3各自独立地表示任选取代的烃基或任选取代的杂环基; 所述方法包括：a）还原式（2）的化合物以形成式（3）的化合物：b）活化式（3）的化合物以形成式（4）的化合物，其中X表示离开组和c）将式（4）的化合物与式（5）的化合物偶联以形成式（1）的化合物。还提供了立体选择性方法。

2. 发明申请

WO2009089593A8 PROCESS FOR PREPARING NUTRITIONAL, THERAPEUTIC OR ORGANOLEPTIC PRODUCTS FROM CRUDE GLYCEROL 审中-公开
公开(公告)号：WO2009089593A8
公开(公告)日：2009-07-23
申请号：PCT/AU2009/000053
申请日：2009-01-16
申请人： BIO PROCESSING AUSTRALIA PTY LTD , FIELDHOUSE, Robin , MACLENNAN, Donald, Finlay , MACLENNAN, Mary, Elizabeth , MACLENNAN, David, Graham
发明人： FIELDHOUSE, Robin , MACLENNAN, Donald, Finlay , MACLENNAN, Mary, Elizabeth , MACLENNAN, David, Graham
IPC分类号： C12N1/16 , A23J1/18 , A23L1/28
摘要： The present invention relates to a process for preparing a nutritional, therapeutic or organoleptic product by growing non-recombinant yeast under aerobic conditions, in a medium that includes crude glycerol, as one possible carbon source to produce a yeast product. The yeast product can be processed to obtain such nutritional, therapeutic or organoleptic products as yeast paste, yeast metabolites, carbohydrates, proteins functional proteins, nucleotides, yeast autolysates, yeast extract, yeast cell walls, beta-glucans, mannans or a product derived from a mineralized yeast product.

3. 发明申请

WO2006010885A1 PALLADACYLES, THEIR PREPARATION AND CATALYTIC PROCESSES INVOLVING THEIR USE AS CATALYST, ESPECIALLY CATALYTIC CARBONYLATION PROCESSES 审中-公开
标题翻译：吡咯烷酮，其制备和催化方法涉及其作为催化剂的用途，特别是催化羰化方法
公开(公告)号：WO2006010885A1
公开(公告)日：2006-02-02
申请号：PCT/GB2005/002738
申请日：2005-07-13
申请人： HERIOT-WATT UNIVERSITY , PRESTON, Peter, Norman , LINDSELL, William, Edward , WHITTON, Alan , PALMER, Daniel , JONES, Raymond , FIELDHOUSE, Robin
发明人： PRESTON, Peter, Norman , LINDSELL, William, Edward , WHITTON, Alan , PALMER, Daniel , JONES, Raymond , FIELDHOUSE, Robin
IPC分类号： C07C51/10
CPC分类号： C07C67/36 , C07C45/49 , C07C51/10 , C07C205/56 , C07D307/88 , C07D311/76 , C07F15/006 , C07C69/614 , C07C69/616 , C07C69/612
摘要： The present invention relates to palladium compounds and their use as catalysts for improved catalytic processes. Specifically there is disclosed an improved catalytic carbonylation process and improved carbonylation catalysts. Catalysts in dimer form are also disclosed, as is their catalytic activity and methods of making the compounds.
摘要翻译：本发明涉及钯化合物及其用作改进催化方法的催化剂。具体地，公开了改进的催化羰基化方法和改进的羰基化催化剂。还公开了二聚体形式的催化剂，以及它们的催化活性和制备化合物的方法。

4. 发明申请

WO2005023737A1 PROCESS FOR THE HYDROGENATION OF ESTERS OF ALPHA-SUBSTITUTED CARBOXYLIC ACIDS 审中-公开
标题翻译：羟基取代的羧酸的加氢过程
公开(公告)号：WO2005023737A1
公开(公告)日：2005-03-17
申请号：PCT/GB2004/003884
申请日：2004-09-10
申请人： AVECIA LIMITED , MOODY, David, John , HÄRRÖD, Magnus , FIELDHOUSE, Robin
发明人： MOODY, David, John , HÄRRÖD, Magnus , FIELDHOUSE, Robin
IPC分类号： C07C29/149
CPC分类号： C07C29/149 , C07C67/31 , Y02P20/544 , C07C69/675 , C07C31/22 , C07C31/205
摘要： There is provided a process for the hydrogenation of esters of alpha-substituted carboxylic acids which comprises reacting an ester of an alpha-substituted carboxylic acid with hydrogen in the presence of a catalyst under substantially homogeneous supercritical conditions. Preferably, the ester of an alpha-substituted carboxylic acids is an ester of formula (1): wherein: R 1 and R 2 are each independently an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; and Y is a heteroatom or an optionally substituted heteroatom group. More preferably, the ester of an alpha-substituted is carboxylic acids is an ester of formula (2): wherein: R 3 is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; R 4 and R 5 are each independently hydrogen, an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; Y is a heteroatom or an optionally substituted heteroatom group; Q is a functional group; and n 1. Most preferably, the ester of an alpha-substituted carboxylic acids is an ester of formula (3): wherein: R 3 and R 6 are each independently an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; R 4 and R 5 are each independently hydrogen, an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; Y is a heteroatom or an optionally substituted heteroatom group; and n 1.
摘要翻译：提供了α-取代羧酸酯的氢化方法，其包括在催化剂存在下，在基本上均匀的超临界条件下使α-取代的羧酸的酯与氢反应。优选地，α-取代的羧酸的酯是式（1）的酯：其中：R 1和R 2各自独立地为任选取代的烃基或任选取代的杂环基; 并且Y是杂原子或任选取代的杂原子基团。更优选地，α-取代的酯是羧酸是式（2）的酯：其中：R 3是任选取代的烃基或任选取代的杂环基; R 4和R 5各自独立地为氢，任选取代的烃基或任选取代的杂环基; Y是杂原子或任选取代的杂原子基团; Q是功能组; 最优选地，α-取代的羧酸的酯是式（3）的酯：其中：R 3和R 6各自独立地是任选取代的烃基或任选取代的杂环基 ; R 4和R 5各自独立地为氢，任选取代的烃基或任选取代的杂环基; Y是杂原子或任选取代的杂原子基团; 和n 1。

5. 发明申请

WO2007057703A2 PROCESS AND COMPOUND 审中-公开
标题翻译：方法和化合物
公开(公告)号：WO2007057703A2
公开(公告)日：2007-05-24
申请号：PCT/GB2006/004331
申请日：2006-11-21
申请人： NPIL PHARMACEUTICALS (UK) LIMITED , BLACKER, John , FIELDHOUSE, Robin
发明人： BLACKER, John , FIELDHOUSE, Robin
IPC分类号： C07C229/22 , C07C229/30 , C07D207/34 , C07D319/06
CPC分类号： C07C229/30 , C07C229/22 , C07D207/34 , C07D319/06
摘要： A process for preparing intermediate compounds useful in the preparation of statins. The process is particularly useful for the preparation of atorvastatin. The process involves the reduction of two ketone groups at the same time using either a chiral transition metal catalyst or an enzyme based system.
摘要翻译：制备可用于制备他汀类药物的中间体化合物的方法。该方法对于阿托伐他汀的制备特别有用。该方法包括使用手性过渡金属催化剂或基于酶的体系同时还原两个酮基团。

6. 发明申请

WO2006067416A1 CHEMICAL PROCESSES AND INTERMEDIATES 审中-公开
标题翻译：化学工艺和中间体
公开(公告)号：WO2006067416A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004941
申请日：2005-12-19
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BROADY, Simon, Daniel , GOLDEN, Michael, David , LEONARD, John , MARTIN, David, Michael, Glanville , MUIR, James, Campbell , FIELDHOUSE, Robin , MAUDET, Mickael, Louis, Pierre
发明人： BROADY, Simon, Daniel , GOLDEN, Michael, David , LEONARD, John , MARTIN, David, Michael, Glanville , MUIR, James, Campbell , FIELDHOUSE, Robin , MAUDET, Mickael, Louis, Pierre
IPC分类号： C07C47/575 , C07C49/755 , C07C231/10 , C07C251/44 , A61K31/16 , A61P9/00
CPC分类号： C07C231/10 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/63 , C07C45/71 , C07C47/575 , C07C49/755 , C07C49/84 , C07C49/86 , C07C251/44 , C07C2603/32 , C07F9/142 , Y02P20/55 , C07C233/41
摘要： The present invention provides a process for the formation of an enamide (III) wherein each R is independently selected from (1-6C)alkyl, benzyl and C(O)(1-6C)alkyl, or two RO groups together form a (1-4C)alkylenedioxy group, comprising the steps of reductive acylation of an oxime of formula (IX) wherein each R is independently selected from (1-6C)alkyl, benzyl and C(O)(1-6C)alkyl, or two RO groups together form a (1-4C)alkylenedioxy group, and the hydroxy group may optionally be protected by a hydroxy protecting group; and thereafter if necessary, removal of any protecting groups. Intermediates to the enamide (III) and methods for their preparation are also described.
摘要翻译：本发明提供一种形成烯酰胺（III）的方法，其中每个R独立地选自（1-6C）烷基，苄基和C（O）（1-6C）烷基，或两个RO基团一起形成（ 1-4C）亚烷基二氧基，其包括如下步骤：还原酰化式（Ⅸ）的肟，其中每个R独立地选自（1-6C）烷基，苄基和C（O）（1-6C）烷基或二 RO基团一起形成（1-4C）亚烷基二氧基，羟基可任选被羟基保护基保护; 然后必要时，除去任何保护基。也描述了烯酰胺（III）的中间体及其制备方法。

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