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1. 发明申请

WO2008140859A1 DEUTERATED VENLAFAXINES AND 0-DESMETYLVENLAFAXINES WITH SEROTONINERGIC AND / OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
标题翻译：去饱和的维生素和0-DESMETYLVENLAFAXINES具有丝氨酸和/或肾上腺素活性
公开(公告)号：WO2008140859A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/056780
申请日：2008-03-13
申请人： AUSPEX PHARMACEUTICALS, INC. , GANT, Thomas, G. , SEPEHR, Sarshar , WOO, Soon, Hyung
发明人： GANT, Thomas, G. , SEPEHR, Sarshar , WOO, Soon, Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/06 , C07B59/00
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
摘要翻译：用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途，强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症，尿失禁，厌食症，神经性贪食症，肥胖症，缺血，头部损伤，脑细胞中的钙超载，药物依赖，注意缺陷多动障碍，纤维肌痛，肠易激综合征和/或早泄。

2. 发明申请

WO2010011868A2 PYRIDINE SULFONAMIDE MODULATORS OF ENDOTHELIN-A-RECEPTOR 审中-公开
标题翻译：内啡肽受体的吡啶磺酰胺调节剂
公开(公告)号：WO2010011868A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051594
申请日：2009-07-23
申请人： AUSPEX PHARMACEUTICALS , GANT, Thomas, G. , SEPEHR, Sarshar
发明人： GANT, Thomas, G. , SEPEHR, Sarshar
IPC分类号： C07D401/14 , A61K31/501 , A61P9/12 , A61P9/00
CPC分类号： C07D401/14
摘要： The present invention relates to new pyridine sulfonamide modulators of endothelin- A receptor, pharmaceutical compositions thereof, and methods of use thereof Formula (I).
摘要翻译：本发明涉及内皮素-A受体的新的吡啶磺酰胺调节剂，其药物组合物及其使用方法式（I）。

3. 发明公开

EP3130580A1 PREPARATION OF DEUTERATED VENLAFAXINES 无效
标题翻译： HERSTELLUNG VON DEUTERIERTEM VENLAFAXINE
公开(公告)号：EP3130580A1
公开(公告)日：2017-02-15
申请号：EP16183223.3
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas G , SEPEHR, Sarshar , WOO, Soon, Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/16 , C07B59/00 , C07C211/64
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： Processes for preparaing deuterated venlafaxines whcih can be used as inhibitors of the uptake of monoamine neurotransmitters.
摘要翻译：制备氘代文拉法辛的方法可用作摄取单胺神经递质的抑制剂。

4. 发明公开

EP2125698A1 DEUTERATED VENLAFAXINES AND 0-DESMETHYLVENLAFAXINES WITH SEROTONINERGIC AND /OR NOREPINEPHRINERGIC ACTIVITY 有权
标题翻译： DEUTERIERTES d9-VENLAFAXINE
公开(公告)号：EP2125698A1
公开(公告)日：2009-12-02
申请号：EP08732084.2
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas, G. , SEPEHR, Sarshar , WOO, Soon, Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/06 , C07B59/00
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
摘要翻译：用于治疗和/或治疗精神障碍，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途，强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁，阻塞性睡眠呼吸暂停，精神障碍，经前焦虑症，社交恐惧症，社交焦虑症，尿失禁，厌食症，神经性贪食症，肥胖症，缺血，头部损伤，脑细胞中的钙超载，药物依赖，注意缺陷多动障碍，纤维肌痛，肠易激综合征和/或早泄。

5. 发明授权

EP3103790B1 SUBSTITUTED PHENETHYLAMINE WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 失效转让
标题翻译：具有血清素能和/或去甲肾上腺素能力的取代的苯乙胺
公开(公告)号：EP3103790B1
公开(公告)日：2018-05-09
申请号：EP16179352.6
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas G. , SEPEHR, Sarshar , WOO, Soon Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/16 , C07B59/00
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.

6. 发明公开

EP3103790A1 SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 失效转让
标题翻译：具有血清素和/或去甲肾上腺素能力的取代的苯乙胺
公开(公告)号：EP3103790A1
公开(公告)日：2016-12-14
申请号：EP16179352.6
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas G. , SEPEHR, Sarshar , WOO, Soon Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/16 , C07B59/00
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： d 9 -1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride for use in the treatment of a monoamine-related disorder.
This novel inhibitor of the uptake of monoamine neurotransmitters is used for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
摘要翻译： d9-1- [2-二甲基氨基-1-（4-甲氧基苯基） - 乙基] - 环己醇盐酸盐，用于治疗单胺相关疾病。这种新颖的单胺类神经递质摄取抑制剂用于治疗和/或治疗精神障碍，焦虑症，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症，恐慌症，潮热，老年性痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病，双相抑郁症，阻塞性睡眠呼吸暂停，精神病性障碍，经前烦躁症，社交恐怖症，社交焦虑症，尿失禁，厌食症，神经性贪食症，肥胖症，描述了局部缺血，头部损伤，脑细胞中的钙超载，药物依赖，注意力缺陷多动症，纤维肌痛，肠易激综合征和/或早泄。

7. 发明公开

EP3269706A1 DEUTERATED O-DESMETHYLVENLAFAXINE WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
标题翻译：具有血清素和/或去甲肾上腺素能活性的氘代去甲基维拉帕嗪
公开(公告)号：EP3269706A1
公开(公告)日：2018-01-17
申请号：EP17169980.4
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas, G. , SEPEHR, Sarshar , WOO, Soon Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/16 , C07B59/00
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16
摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
摘要翻译：用于治疗和/或处理精神障碍，焦虑症，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的神经递质的新型单胺神经递质抑制剂及其药学上可接受的盐和前药的化学合成和医学用途，惊恐障碍，潮热，老年性痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，痛性糖尿病性视网膜病，双相抑郁症，阻塞性睡眠呼吸暂停，精神病，经前烦躁症，社交恐惧症，社交焦虑症，尿失禁，厌食症，神经性贪食症，肥胖症，缺血，头部损伤，脑细胞中的钙超载，药物依赖性，注意力缺陷多动症，纤维肌痛，肠易激综合征和/或早泄。

8. 发明授权

EP2125698B1 DEUTERATED d9-VENLAFAXINE 有权
标题翻译：氘化D9-文拉法辛
公开(公告)号：EP2125698B1
公开(公告)日：2016-08-31
申请号：EP08732084.2
申请日：2008-03-13
申请人： Auspex Pharmaceuticals, Inc.
发明人： GANT, Thomas, G. , SEPEHR, Sarshar , WOO, Soon, Hyung
IPC分类号： C07C217/74 , C07C215/64 , C07D265/16 , C07B59/00 , C07C211/64
CPC分类号： C07C211/64 , C07B59/00 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C215/64 , C07C217/74 , C07C2601/14 , C07D265/16

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