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1. 发明申请

WO2007001309A2 PREPARATION AND APPLICATIONS OF STABILIZED METAL NANOPARTICLES FOR DECHLORINATION OF CHLORINATED HYDROCARBONS IN SOILS, SEDIMENTS AND GROUNDWATER 审中-公开
标题翻译：稳定金属纳米粒子在土壤，沉积物和地下水中氯化烃类脱氯的研究和应用
公开(公告)号：WO2007001309A2
公开(公告)日：2007-01-04
申请号：PCT/US2005/023384
申请日：2005-06-30
申请人： AUBURN UNIVERSITY , ZHAO, Dongye , HE, Feng
发明人： ZHAO, Dongye , HE, Feng
IPC分类号： C02F1/58
CPC分类号： C02F1/705 , B09C1/002 , B09C1/08 , C02F2101/36 , C02F2103/06 , Y10T428/12028
摘要： Stabilized, chemically reactive, metallic nano-material effective for degradation of chlorinated organic compounds in soils, sediments and groundwater. The nano-material is composed of a magnetic metal nanoparticle and a carbohydrate stabilizer bound to the nanoparticle. The preferred metal nanoparticle is iron and the preferred carbohydrate stabilizer is either a starch or a water soluble cellulose such as sodium carboxymethyl cellulose. The nanoparticle may be either mono-metallic, bi-metallic or multi-metallic in nature, but is preferably bi-metallic wherein it is coated with a secondary catalytic metal coating, preferably palladium. A method of making the metallic nano-material is further disclosed wherein a solution of the metal nanoparticle and carbohydrate stabilizer is prepared, and the nanoparticle is then reduced under inert conditions. A process for reductive dechlorination of chlorinated organic compounds is also disclosed wherein the reduced magnetic metal nanoparticle is prepared, and then contacted with a chlorinated organic compound to dechlorinate the compound. Preferably, the nano-material is injected into a site such as oil subsurface or groundwater contaminated with a chlorinated organic compound to provide in-situ dechlorination.
摘要翻译：稳定的化学反应性金属纳米材料，有效降解土壤，沉积物和地下水中的氯化有机化合物。纳米材料由磁性金属纳米颗粒和与纳米颗粒结合的碳水化合物稳定剂组成。优选的金属纳米颗粒是铁，优选的碳水化合物稳定剂是淀粉或水溶性纤维素，例如羧甲基纤维素钠。纳米粒子本质上可以是单金属，双金属或多金属，但优选是双金属，其中它被涂覆有次级催化金属涂层，优选钯。进一步公开了制备金属纳米材料的方法，其中制备金属纳米粒子和碳水化合物稳定剂的溶液，然后在惰性条件下还原纳米粒子。还公开了还原脱氯氯化有机化合物的方法，其中制备还原的磁性金属纳米粒子，然后与氯化有机化合物接触以脱氯化合物。优选地，将纳米材料注入诸如被氯化有机化合物污染的油下表面或地下水的位置以提供原位脱氯。

2. 发明申请

WO2013038362A1 6 - SUBSTITUTED 3 - (QUINOLIN- 6 - YLTHIO) - [1,2,4] TRIAZOLO [4, 3 -A] PYRADINES AS TYROSINE KINASE 审中-公开
标题翻译： 6 - 取代3 - （喹啉-6-基） - [1,2,4]三唑并[4,3-a]吡啶类似于酪氨酸激酶
公开(公告)号：WO2013038362A1
公开(公告)日：2013-03-21
申请号：PCT/IB2012/054775
申请日：2012-09-13
申请人： NOVARTIS AG , CHEN, Chao , DENG, Haibing , GUO, Haibing , HE, Feng , JIANG, Lei , LIANG, Fang , MI, Yuan , WAN, Huixin , XU, Yao-Chang , YU, Hongping , ZHANG, Ji Yue (Jeff)
发明人： CHEN, Chao , DENG, Haibing , GUO, Haibing , HE, Feng , JIANG, Lei , LIANG, Fang , MI, Yuan , WAN, Huixin , XU, Yao-Chang , YU, Hongping , ZHANG, Ji Yue (Jeff)
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00 , A61P29/00
CPC分类号： A61K31/551 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D471/04 , C07D491/107 , C07D519/00
摘要： The invention relates to compounds of formula (I) and salts thereof: Formula (I) wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）化合物及其盐：式（I）其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

3. 发明申请

WO2006020082A1 INHIBITORS OF HCV REPLICATION 审中-公开
标题翻译： HCV复制抑制剂
公开(公告)号：WO2006020082A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025234
申请日：2005-07-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , HUDYMA, Thomas, W. , ZHENG, Xiaofan , HE, Feng , DING, Min , BERGSTROM, Carl, P. , HEWAWASAM, Piyasena , MARTIN, Scott, W. , GENTLES, Robert, G.
发明人： HUDYMA, Thomas, W. , ZHENG, Xiaofan , HE, Feng , DING, Min , BERGSTROM, Carl, P. , HEWAWASAM, Piyasena , MARTIN, Scott, W. , GENTLES, Robert, G.
IPC分类号： C07D491/14 , C07D487/04 , C07D498/14 , C07D471/14 , C07D471/04 , C07D487/14 , C07D513/14 , A61K31/55 , A61P31/14
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula (I) are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
摘要翻译：描述了式（I）的吲哚化合物。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。还描述了包含化合物的不同形式和组合物以及制备化合物的方法。

4. 发明申请

WO2014201665A1 BONDED ARTICLE OF THIN GLASS ON SUPPORT SUBSTRATE, PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译：支撑基板上的薄玻璃粘结物品，制备方法及其用途
公开(公告)号：WO2014201665A1
公开(公告)日：2014-12-24
申请号：PCT/CN2013/077585
申请日：2013-06-20
申请人： SCHOTT GLASS TECHNOLOGIES (SUZHOU) CO. LTD. , QIAN, Pengxiang , WANG, Chong , HE, Feng , HOU, James , LIEBALD, Rainer
发明人： QIAN, Pengxiang , WANG, Chong , HE, Feng , HOU, James , LIEBALD, Rainer
IPC分类号： B32B37/00
CPC分类号： B32B17/06 , B32B7/04 , B32B9/005 , B32B37/003 , B32B37/10 , B32B38/10 , B32B43/006 , B32B2037/1063 , B32B2255/20 , B32B2310/025 , B32B2315/08 , B32B2457/08 , B32B2457/10 , B32B2457/16 , B32B2457/206
摘要： The invention is related to a method for making a bonded article, wherein a thin glass substrate is bonded on a support substrate in the absence of any interlayer by an electrostatic adhesion process with the assistance of external pressure, the pressure is applied constantly or stepwise during the adhesion process by use of a tool such as a roll or a wheel or other movable device with curved surface. The bonded article has no defects, e.g. bubbles or inclusions, in the bonded interface, which benefits transportation of the thin glass substrate and its post-processing as well. Such defect-free bonded article is also disclosed. Pressure supported electrostatic adhesion, initiated by electrostatic charges adhesion of a two members, e.g. a substrate member and a support member, is enabled to minimize, prevent and exclude defects, distortion between the adhered surfaces.
摘要翻译：本发明涉及一种制造接合制品的方法，其中在外部压力的帮助下，通过静电粘附工艺在不存在任何夹层的情况下将薄玻璃基板粘结在支撑基板上，在压力作用下不断地或逐步地施加压力通过使用诸如辊或车轮的工具或具有弯曲表面的其它可移动装置的粘合过程。粘合制品没有缺陷，例如粘结界面中的气泡或夹杂物，这有利于薄玻璃基板的输送及其后处理。还公开了这种无缺陷的粘合制品。由两个构件的静电电荷附着引起的压力支持的静电粘附，例如。衬底构件和支撑构件能够最小化，防止和排除缺陷，粘附表面之间的变形。

5. 发明申请

WO2011020861A1 HETEROCYCLIC OXIME COMPOUNDS 审中-公开
标题翻译：杂环氧化合物
公开(公告)号：WO2011020861A1
公开(公告)日：2011-02-24
申请号：PCT/EP2010/062057
申请日：2010-08-18
申请人： NOVARTIS AG , DAI, Miao , FU, Xingnian , HE, Feng , JIANG, Lei , LI, Yue , LIANG, Fang , LIU, Lei , MI, Yuan , XU, Yao-chang , XUN, Guoliang , YAN, Xiaoxia , YU, Zhengtian , ZHANG, Ji, Yue
发明人： DAI, Miao , FU, Xingnian , HE, Feng , JIANG, Lei , LI, Yue , LIANG, Fang , LIU, Lei , MI, Yuan , XU, Yao-chang , XUN, Guoliang , YAN, Xiaoxia , YU, Zhengtian , ZHANG, Ji, Yue
IPC分类号： C07D471/04 , A61K31/52 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）化合物及其盐，其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

6. 发明申请

WO2012129775A1 AGGREGATING PRODUCT REVIEW INFORMATION FOR ELECTRONIC PRODUCT CATALOGS 审中-公开
标题翻译：电子产品目录的产品回顾信息
公开(公告)号：WO2012129775A1
公开(公告)日：2012-10-04
申请号：PCT/CN2011/072248
申请日：2011-03-29
申请人： GOOGLE INC. , HE, Feng
发明人： HE, Feng
IPC分类号： G06F17/30 , G06Q30/00
CPC分类号： G06F17/30489
摘要： [0051] A product catalog includes information regarding products for sale online by various merchants, including product review information. An analysis module collects product reviews and determines whether each product review includes a product identifier, such as a Global Trade Item Number ("GTIN"). For product reviews having a product identifier, the module adds the product review to the product catalog and associates the product review with the product identifier. For product reviews lacking a product identifier, the module initiates an Internet search using information from the product review and analyzes search results to identify a product identifier for the product review. If the analysis module identifies a product identifier for the product review, the analysis module adds the product review to the product catalog and associates the product review with the identified product identifier. The analysis module may discard product reviews that are not associated with a product identifier.
摘要翻译：产品目录包括关于各种商家在线销售的产品的信息，包括产品审查信息。分析模块收集产品评论，并确定每个产品评估是否包含产品标识符，例如全球贸易项目编号（“GTIN”）。对于具有产品标识符的产品评论，模块将产品评估添加到产品目录中，并将产品评估与产品标识相关联。对于缺少产品标识符的产品评论，模块使用产品评论中的信息启动Internet搜索，并分析搜索结果，以识别产品评估的产品标识。如果分析模块识别产品评估的产品标识符，则分析模块将产品评估添加到产品目录中，并将产品评估与标识的产品标识相关联。分析模块可以丢弃与产品标识符不相关联的商品评论。

7. 发明申请

WO2008110611A1 ORGANIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：有机化合物及其用途
公开(公告)号：WO2008110611A1
公开(公告)日：2008-09-18
申请号：PCT/EP2008/053040
申请日：2008-03-13
申请人： NOVARTIS AG , DAI, Miao , HE, Feng , JAIN, Rishi Kumar , KARKI, Rajesh , KELLEHER, Joseph, III , LEI, John , LLAMAS, Luis , MCEWAN, Michael A. , MILLER-MOSLIN, Karen , PEREZ, Lawrence Blas , PEUKERT, Stefan , YUSUFF, Naeem
发明人： DAI, Miao , HE, Feng , JAIN, Rishi Kumar , KARKI, Rajesh , KELLEHER, Joseph, III , LEI, John , LLAMAS, Luis , MCEWAN, Michael A. , MILLER-MOSLIN, Karen , PEREZ, Lawrence Blas , PEUKERT, Stefan , YUSUFF, Naeem
IPC分类号： C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07F9/58 , C07D405/14 , C07D417/14 , C07D487/04 , C07D491/048 , C07D498/14 , C07D237/30 , A61K31/502 , A61K31/4545
CPC分类号： C07D401/12 , C07D237/30 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14 , C07D487/04 , C07D491/048 , C07D498/14 , C07F9/65583
摘要： The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula (I).
摘要翻译：本公开涉及与涉及Hedgehog途径的病理学的诊断和治疗有关的化合物，包括但不限于肿瘤形成，癌症，瘤形成和非恶性过度增殖性疾病; 具体涉及式（I）化合物。

8. 发明申请

WO2008045905A1 PYRROLYDINE DERIVATIVES AS IAP INHIBITORS 审中-公开
标题翻译：吡咯啉衍生物作为IAP抑制剂
公开(公告)号：WO2008045905A1
公开(公告)日：2008-04-17
申请号：PCT/US2007/080875
申请日：2007-10-10
申请人： NOVARTIS AG , CHAREST, Mark G. , CHEN, Christine Hiu-tung , CHEN, Ming , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , STRAUB, Christopher , WANG, Run-Ming David , ZAWEL, Leigh
发明人： CHAREST, Mark G. , CHEN, Christine Hiu-tung , CHEN, Ming , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , STRAUB, Christopher , WANG, Run-Ming David , ZAWEL, Leigh
IPC分类号： C07K5/06 , A61K38/05 , A61P35/00
CPC分类号： C07K5/06191
摘要： The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译：本发明涉及式（I）的新型IAP抑制剂化合物。

9. 发明申请

WO2011063378A3 REFRACTORY POROUS CERAMICS 审中-公开
公开(公告)号：WO2011063378A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/057738
申请日：2010-11-23
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , PETUSKEY, William , HE, Feng
发明人： PETUSKEY, William , HE, Feng
IPC分类号： C04B35/185 , C04B35/447 , C04B38/00 , C04B35/50 , C04B35/64
摘要： A refractory, porous ceramic composite including crystalline mullite (3Al 2 O 3 +2SiO 2 or 3Al 6 Si 2 O 11 ) and a crystalline phase of LaPO 4 is formed from a mullite-LaPO 4 sol-gel by annealing the dried gel. During the annealing process, particle sintering and self-foaming occur in the glassy state, and pores are produced due at least in part to the release of entrapped gases that form during the pyrolysis of the gel. The resulting crystalline composite, or crystalline nanocomposite, has a high porosity and is dimensionally and chemically stable at high temperatures. The composite also has a high degree of structural (e.g., mechanical) stability, related at least in part to the fine texturing and mixing of the mullite and LaPO 4 during preparation of the sol. The resulting ceramic composite shows little or no shrinkage or expansion between about 1000C and about 1200°C.

10. 发明申请

WO2011018454A1 HETEROCYCLIC HYDRAZONE COMPOUNDS AND THEIR USES TO TREAT CANCER AND INFLAMMATION 审中-公开
标题翻译：杂环氢化合物及其用于治疗癌症和炎症的用途
公开(公告)号：WO2011018454A1
公开(公告)日：2011-02-17
申请号：PCT/EP2010/061609
申请日：2010-08-10
申请人： NOVARTIS AG , FU, Xingnian , HE, Feng , LI, Yue , LIU, Lei , MI, Yuan , XU, Yao-chang , XUN, Guoliang , YU, Zhengtian , ZHANG, Ji Yue (Jeff) , DAI, Miao
发明人： FU, Xingnian , HE, Feng , LI, Yue , LIU, Lei , MI, Yuan , XU, Yao-chang , XUN, Guoliang , YU, Zhengtian , ZHANG, Ji Yue (Jeff) , DAI, Miao
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00 , A61P29/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

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