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1. 发明专利

IL252836D0 (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors 未知
公开(公告)号：IL252836D0
公开(公告)日：2017-08-31
申请号：IL25283617
申请日：2017-06-11
申请人： ASTRAZENECA AB , LONN HANS ROLAND , CONNOLLY STEPHEN , SWALLOW STEVEN , KARLSSON STAFFAN PO , AURELL CARL JOHAN , PONTEN JOHN FRITIOF , DOYLE KEVIN JAMES , VAN DE POEL AMANDA JANE , JONES GRAHAM PETER , WATSON DAVID WYN , MACRITCHIE JAQUELINE ANNE , PALMER NICHOLAS JOHN
发明人： LONN HANS ROLAND , CONNOLLY STEPHEN , SWALLOW STEVEN , KARLSSON STAFFAN PO , AURELL CARL-JOHAN , PONTEN JOHN FRITIOF , DOYLE KEVIN JAMES , VAN DE POEL AMANDA JANE , JONES GRAHAM PETER , WATSON DAVID WYN , MACRITCHIE JAQUELINE ANNE , PALMER NICHOLAS JOHN
IPC分类号： C07D20060101
摘要： The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

2. 发明申请

WO2009024585A2 IMIDAZOPYRAZINE COMPOUNDS 审中-公开
标题翻译：咪唑并吡嗪化合物
公开(公告)号：WO2009024585A2
公开(公告)日：2009-02-26
申请号：PCT/EP2008060896
申请日：2008-08-20
申请人： BIOFOCUS DPI LTD , MACLEOD ANGUS , MITCHELL DALE ROBERT , PALMER NICHOLAS JOHN , PARSY CHRISTOPHE CLAUDE , GOLDSMITH MICHAEL DANIEL , HARRIS CLIFFORD JOHN
发明人： MACLEOD ANGUS , MITCHELL DALE ROBERT , PALMER NICHOLAS JOHN , PARSY CHRISTOPHE CLAUDE , GOLDSMITH MICHAEL DANIEL , HARRIS CLIFFORD JOHN
IPC分类号： C07D487/04 , A61K31/4985 , A61P31/00
CPC分类号： C07D487/04
摘要： Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.
摘要翻译：公开了具有由下式表示的式的新型咪唑并吡嗪化合物：式（I）。化合物可以制备成药物组合物，并且可用于预防和治疗有需要的患者中的病毒感染，特别是HCV，HRV，Sb和/或CVB。

3. 发明专利

GB2354418A Fishing rod holder 未知
公开(公告)号：GB2354418A
公开(公告)日：2001-03-28
申请号：GB0100345
申请日：2000-04-05
申请人： PALMER NICHOLAS JOHN
发明人： PALMER NICHOLAS JOHN
IPC分类号： A01K97/10 , A01K97/00
摘要： An angler's rest for use with fishing pole, whip or rod, the rest comprising a body (10), an arm member (11) from which an arm projects, a spindle (12) on which the arm member is biased to rotate in one direction relative to the body, a spring (14) biasing the arm and the body axially apart on the spindle, at least one protrusion (17) on each of the body and the arm, the protrusions engaging each other when the arm and body are close together on the spindle to prevent rotation of the arm in said one direction and being out of engagement when they are apart to allow the rotation.

4. 发明专利

GB2281180A A fishing reel anti-reverse release arrangement 未知
公开(公告)号：GB2281180A
公开(公告)日：1995-03-01
申请号：GB9416230
申请日：1994-08-11
申请人： PALMER NICHOLAS JOHN
发明人： PALMER NICHOLAS JOHN
IPC分类号： A01K89/01
摘要： A release arrangement in or for fishing reel anti-reverse mechanism e.g. of the pawl and ratchet wheel type comprises a pawl actuator (9) arranged to be tripped by the ratchet wheel (7) whereby the pawl (8) is disengaged from anti-reverse engagement with the ratchet wheel (7) on rotation of the latter by forward line retrieval rotation of the reel handle (3) (Fig. 1) to permit line back winding as well as line retrieval operation of the reel in an automatic manner. A projection (72) may trip the actuator (9) or a projection (83) (Fig. 5) on the latter may engage between adjacent teeth of the ratchet wheel (7). Where ratchet teeth (77) (Fig. 10) are provided within the bail rotor drum (40) a pin (20) on the drum end face (43) trips the actuator (9) to disengage the pawl (8) from the ratchet teeth (77). The pin (20) may be retractable to render the release arrangement inoperative. The release arrangement can be provided as a kit of parts for conversion of the anti-reverse mechanism.

7. 发明专利

CA2935625C (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS 未知
公开(公告)号：CA2935625C
公开(公告)日：2022-10-18
申请号：CA2935625
申请日：2015-01-23
申请人： ASTRAZENECA AB
发明人： LONN HANS ROLAND , CONNOLLY STEPHEN , SWALLOW STEVEN , PO KARLSSON STAFFAN , AURELL CARL-JOHAN , PONTEN JOHN FRITIOF , DOYLE KEVIN JAMES , VAN DE POEL AMANDA JANE , JONES GRAHAM PETER , WATSON DAVID WYN , MACRITCHIE JAQUELINE ANNE , PALMER NICHOLAS JOHN
IPC分类号： C07D267/10 , A61K31/553 , A61P11/00 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), (Formula (I)) that inhibit dipeptidyl peptidase 1(DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

10. 发明专利

NZ722063A (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors 未知
公开(公告)号：NZ722063A
公开(公告)日：2017-09-29
申请号：NZ72206315
申请日：2015-01-23
申请人： ASTRAZENECA AB
发明人： LÖNN HANS ROLAND , CONNOLLY STEPHEN , SWALLOW STEVEN , KARLSSON STAFFAN PO , AURELL CARL-JOHAN , PONTÉN JOHN FRITIOF , DOYLE KEVIN JAMES , VAN DE POËL AMANDA JANE , JONES GRAHAM PETER , WATSON DAVID WYN , MACRITCHIE JAQUELINE ANNE , PALMER NICHOLAS JOHN
IPC分类号： C07D267/10 , A61K31/553 , A61P11/00 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), (Formula (I)) that inhibit dipeptidyl peptidase 1(DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

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