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1. 发明申请

WO2011002406A1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 审中-公开
标题翻译：用于在空气流中加入粉末的分配器和方法
公开(公告)号：WO2011002406A1
公开(公告)日：2011-01-06
申请号：PCT/SE2010/050749
申请日：2010-06-30
申请人： ASTRAZENECA AB , KJELLGREN, Per Arne , LASTOW, Orest , REMMELGAS, Johan , SVENSSON, Mårten
发明人： KJELLGREN, Per Arne , LASTOW, Orest , REMMELGAS, Johan , SVENSSON, Mårten
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0025 , A61M15/0043 , A61M15/0048 , A61M2202/064 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2209/02
摘要： The invention relates to a device (1) for inhalation of at least one air stream carrying a dose of medicament powder (2). The device comprises a powder-containing cavity (5) which opens into a flow passage (4). The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity (5) by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage (4).
摘要翻译：本发明涉及用于吸入携带一定剂量的药物粉末（2）的至少一个气流的装置（1）。该装置包括通向流道（4）的含粉末的空腔（5）。流动通道布置成将吸入空气流引导通过腔开口。因此，通过剪切驱动腔流动的现象在空腔（5）中引起循环流动。粉末被夹带在循环流中，并在离开空腔之前解聚，并沿着流动通道（4）夹带在空气流中。

2. 发明申请

WO2012010877A2 NEW DEVICE 审中-公开
标题翻译：新设备
公开(公告)号：WO2012010877A2
公开(公告)日：2012-01-26
申请号：PCT/GB2011/051349
申请日：2011-07-19
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , ARVIDSSON, Lars, Rune, Gustav , BAKEWELL, William , BRIANT, John, Philip , CAMPBELL, Patrick , COOKE, Charles , GROOMBRIDGE, Christopher , JOHN, James, Daniel , LASTOW, Orest , PENHALLURICK, Trevor, John , SMARTT, Nicholas , SVENSSON, Mårten , ULLBRAND, Björn
发明人： ARVIDSSON, Lars, Rune, Gustav , BAKEWELL, William , BRIANT, John, Philip , CAMPBELL, Patrick , COOKE, Charles , GROOMBRIDGE, Christopher , JOHN, James, Daniel , LASTOW, Orest , PENHALLURICK, Trevor, John , SMARTT, Nicholas , SVENSSON, Mårten , ULLBRAND, Björn
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0043 , A61M15/0048 , A61M15/0075 , A61M15/0081 , A61M15/0091 , A61M15/08 , A61M2202/064
摘要： A dry powder inhaler comprises a disc-shaped assembly (14) having cavities (16) filled with medicament powder for inhalation. The assembly is rotatably mounted in a housing (6, 8) on which is mounted a rotatable external casing (11, 12). A mouthpiece (10) is movably mounted on the housing (6, 8) allowing it to be brought into and out of engagement with the edge of the disc (14) whereby the mouthpiece acts as a brake to prevent or permit rotational movement of the disc (14). The inhaler is opened by rotating the housing with respect to the casing (11, 12) to expose the mouthpiece (10). As the inhaler is opened and closed, cam followers (105) on the mouthpiece move along cam tracks (109) in the casing (11, 12), causing the mouthpiece to move against or away from the disc (14). A gap is defined between the disc and mouthpiece to allow a flow of bypass air to enter the mouthpiece.
摘要翻译：干粉吸入器包括具有填充有用于吸入的药物粉末的空腔（16）的盘形组件（14）。组件可旋转地安装在壳体（6,8）中，其上安装有可旋转的外壳（11,12）。吸嘴（10）可移动地安装在壳体（6,8）上，允许其与盘（14）的边缘进入和离开接合，由此接口作为制动器来防止或允许光盘（14）。通过相对于壳体（11,12）旋转壳体来打开吸入器以暴露接口（10）。当吸入器打开和关闭时，口部上的凸轮从动件（105）沿壳体（11,12）中的凸轮轨道（109）移动，使得接口件能够抵靠或远离盘片（14）移动。在盘和接口之间限定间隙，以允许旁路空气流进入接口。

3. 发明申请

WO2009102275A1 INHALER COMPRISING A BASE HAVING AT LEAST ONE SEALED CAVITY CONTAINING MEDICAMENT 审中-公开
标题翻译：吸入包含至少一个含有药物的密封囊的基底
公开(公告)号：WO2009102275A1
公开(公告)日：2009-08-20
申请号：PCT/SE2009/050143
申请日：2009-02-11
申请人： ASTRAZENECA AB , LASTOW, Orest
发明人： LASTOW, Orest
IPC分类号： A61M15/00 , B65D75/32
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： The invention relates to an inhaler which comprises a base having at least one sealed cavity containing medicament and a foil portion comprising two sides, one side being attached to the base for sealing the medicament within the cavity. A separating element is attached to the other side of the foil portion for separating the foil portion from the cavity, the separating element having a first e nd and an opposite second end, wherein the separating element is movable to an intermediate tilted position in which said first end is moved-away from the cavity. The separating element is further movable from the intermediate tilted position to a removed position in which also said second end is moved-away from the cavity so that the foil portion is removed from the cavity which is thereby uncovered so that medicament contained therein is enabled to be come entrained in a fluid flow.
摘要翻译：本发明涉及一种吸入器，其包括具有包含药物的至少一个密封空腔的基座和包括两侧的箔片部分，一个侧面附接到基座上，以密封腔内的药物。分离元件附接到箔部分的另一侧，用于将箔片部分与空腔分离，分离元件具有第一和第二端，其中分离元件可移动到中间倾斜位置，其中所述第一端离开空腔。分离元件还可以从中间倾斜位置移动到去除位置，其中所述第二端也从空腔移开，使得箔部分从空腔移除，从而使其不被覆盖，使得其中包含的药物能够被被夹带在流体流中。

4. 发明申请

WO2006000758A1 A SUPPORT STRUCTURE FOR A MEDICAMENT 审中-公开
标题翻译：药物支持结构
公开(公告)号：WO2006000758A1
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002440
申请日：2005-06-21
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LASTOW, Orest
发明人： LASTOW, Orest
IPC分类号： B65D81/26
CPC分类号： B65D81/266 , A61M15/0045 , A61M15/0048 , A61M2202/062 , A61M2202/064 , B65D2585/56
摘要： A support structure (1) for a medicament comprising a base (2) with at least one cavity (3) for the medicament and a lid (4) for sealing the medicament within the cavity (3). Each moisture permeable region of the structure (6) is protected against the ingress of moisture by locating a moisture absorbing sink (7) between that region and the ambient air outside the structure (1).
摘要翻译：一种用于药物的支撑结构（1），其包括具有用于药物的至少一个空腔（3）的基部（2）和用于密封腔（3）内的药物的盖（4）。结构（6）的每个透湿区域通过在该区域和结构（1）外部的周围空气之间设置吸湿槽（7）来防止湿气进入。

5. 发明申请

WO2009082343A1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 537 审中-公开
标题翻译：用于在气流中加入粉末的分配器和方法537
公开(公告)号：WO2009082343A1
公开(公告)日：2009-07-02
申请号：PCT/SE2008/051490
申请日：2008-12-18
申请人： ASTRAZENECA AB , BRIANT, John , LASTOW, Orest
发明人： BRIANT, John , LASTOW, Orest
IPC分类号： A61M15/00 , F15D1/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by means of an obstacle in a flow passage. The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The invention also relates to a medical dispenser, for instance an inhaler, in which said method may be performed.
摘要翻译：本发明涉及一种用于在气流中携带包含在具有空腔开口的空腔中的药物粉末的方法。例如，通过流动通道中的障碍物提供大气流涡流。具有大涡流的气流布置成绕过空腔开口，从而在空腔中产生涡流，这有助于将粉末夹带在所述气流中。本发明还涉及一种医疗分配器，例如吸入器，其中可以执行所述方法。

6. 发明申请

WO2009008832A1 MEDICAMENT CONTAINING STRUCTURE, METHOD AND INHALATION DEVICE COMPRISING SUCH STRUCTURE 审中-公开
标题翻译：包含这种结构的包含结构，方法和吸入装置的药物
公开(公告)号：WO2009008832A1
公开(公告)日：2009-01-15
申请号：PCT/SE2008/050857
申请日：2008-07-10
申请人： ASTRAZENECA AB , LASTOW, Orest
发明人： LASTOW, Orest
IPC分类号： A61M15/00 , B65D83/04
CPC分类号： A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M2202/064
摘要： The invention relates to a method of manufacturing a medicament-containing structure. A base having a plurality of cavities is provided, such that neighbouring cavities are located at a first distance from each other.The shape of the base is changed so that neighbouring cavities are located at a second distance from each other, said second distance being shorter than said first distance. The cavity openings are contained in a common geometrical plane. The cavities are provided with medicament and sealed. The invention also relates to a medicament-containing structure as such and to a method of designing a medicament-containing structure. The invention further relates to an inhalation device.
摘要翻译：本发明涉及制药含药结构的方法。提供具有多个空腔的基座，使得相邻的空腔彼此相隔第一距离。底座的形状被改变，使得相邻的空腔彼此相隔第二距离，所述第二距离较短比第一个距离。空腔开口被包含在共同的几何平面中。空腔设有药物并密封。本发明还涉及一种药物含有结构，以及一种设计含药物结构的方法。本发明还涉及吸入装置。

7. 发明申请

WO2009102276A1 INHALER COMPRISING A BASE HAVING A PLURALITY OF MEDICAMENT CONTAINING SEALED CAVITIES 审中-公开
标题翻译：吸收包含密封CAID的药物多样性的基础
公开(公告)号：WO2009102276A1
公开(公告)日：2009-08-20
申请号：PCT/SE2009/050148
申请日：2009-02-11
申请人： ASTRAZENECA AB , LASTOW, Orest
发明人： LASTOW, Orest
IPC分类号： A61M15/00 , B65D75/32
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： The invention relates to an inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. The invention also relates to a method in an inhaler.
摘要翻译：本发明涉及一种吸入器，其包括具有包含药物的多个连续的密封空腔的底座。箔部分在一侧附接到基部，用于将药物密封在相应的相关空腔内。多个分离元件附接到箔片部分的另一侧，每个分离元件与相应的腔体相关联，用于将箔片部分与该腔体分离。每个分离元件可以从其相关联的空腔移开，使得密封箔片部分与空腔分离，由此未被覆盖，使得其中容纳的药物能够被夹带在流体流中，然后与附着的箔片部分一起返回覆盖其相关腔。本发明还涉及一种吸入器中的方法。

8. 发明申请

WO2009102273A1 INHALER COMPRISING A PLURALITY OF CONSECUTIVE SEALED CAVITIES CONTAINING MEDICAMENTS 审中-公开
标题翻译：吸收包含药物的大量相关密封性
公开(公告)号：WO2009102273A1
公开(公告)日：2009-08-20
申请号：PCT/SE2009/050140
申请日：2009-02-11
申请人： ASTRAZENECA AB , BAKEWELL, William , BRIANT, John , COOKE, Charles , GROOMBRIDGE, Chris , HARRISON, Nick , LASTOW, Orest , SMARTT, Nick
发明人： BAKEWELL, William , BRIANT, John , COOKE, Charles , GROOMBRIDGE, Chris , HARRISON, Nick , LASTOW, Orest , SMARTT, Nick
IPC分类号： A61M15/00 , B65D83/04
CPC分类号： A61M15/0045 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0096 , A61M2202/064
摘要： The invention relates to an inhaler, comprising a base having a plurality of consecutive sealed cavities containing medicament. A foil is attached to the base for sealing the medicament within the cavities, wherein the width of the foil is defined by a first edge and a second edge of the foil. A plurality of separating elements, one for each cavity, are attached to the foil for separating a foil portion from a respective cavity. Between each pair of neighbouring separating elements, the foil is provided with an indication of fracture at said first edge, wherein when a separating element is moved away from the base, the foil starts to tear at said indication of fracture and continues to tear between the moving separating element and its neighbouring separating element until the foil has torn to said second edge.
摘要翻译：本发明涉及一种吸入器，其包括具有包含药物的多个连续密封空腔的底座。箔片附接到基座上，以密封空腔内的药物，其中箔片的宽度由箔片的第一边缘和第二边缘限定。多个分离元件（每个空腔一个）附接到箔片上，用于将箔片部分与相应的空腔分离。在每对相邻的分离元件之间，箔片在所述第一边缘处被提供有断裂的指示，其中当分离元件移动离开基部时，箔片在所述断裂指示处开始撕裂，并且继续在第移动分离元件及其相邻的分离元件，直到箔片撕裂到所述第二边缘。

9. 发明申请

WO2009082341A1 DEVICE AND METHOD FOR DEAGGREGATING POWDER 854 审中-公开
标题翻译：用于去除粉末的装置和方法854
公开(公告)号：WO2009082341A1
公开(公告)日：2009-07-02
申请号：PCT/SE2008/051488
申请日：2008-12-18
申请人： ASTRAZENECA AB , LASTOW, Orest
发明人： LASTOW, Orest
IPC分类号： A61M15/00 , F15D1/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a device (1) for inhalation of at least one air stream carrying a dose of medicament powder (2). The device comprises a flow passage (4) passing a powder-containing cavity (5). A part of said flow passage (4) propagates along a flat surface region (7). The flat surface region (7) comprises a cavity opening (20) into said powder- containing cavity (5). The passing of an air stream along said flat surface region (7) and outside said cavity (5) generates an eddy in the cavity (5) and the generated eddy contributes to deaggregation of the powder (2) in said cavity (5) and emptying of the powder (2) from said cavity (5). Furthermore, the invention relates to the use of a shear driven cavity principle on such a device (1) and a method of releasing medicament powder (2).
摘要翻译：本发明涉及用于吸入携带一定剂量的药物粉末（2）的至少一个气流的装置（1）。该装置包括通过含粉末的腔（5）的流动通道（4）。所述流动通道（4）的一部分沿着平坦表面区域（7）传播。平表面区域（7）包括到所述含粉末的空腔（5）中的空腔开口（20）。沿着所述平坦表面区域（7）和所述空腔（5）外部的空气流的通过在空腔（5）中产生涡流，并且产生的涡流有助于粉末（2）在所述空腔（5）中的解聚和从所述腔（5）中排出粉末（2）。此外，本发明涉及在这种装置（1）上使用剪切驱动腔原理和释放药物粉末（2）的方法。

10. 发明申请

WO2010042033A1 INHALATION DEVICE AND METHOD OF DISPENSING MEDICAMENT 审中-公开
标题翻译：吸入装置和药物分配方法
公开(公告)号：WO2010042033A1
公开(公告)日：2010-04-15
申请号：PCT/SE2009/051110
申请日：2009-10-07
申请人： ASTRAZENECA AB , BAKEWELL, William , BRIANT, John , CAMPBELL, Patrick , COOKE, Charles , GROOMBRIDGE, Chris , HARRISON, Nick , JOHN, James Daniel , LASTOW, Orest , SMARTT, Nick
发明人： BAKEWELL, William , BRIANT, John , CAMPBELL, Patrick , COOKE, Charles , GROOMBRIDGE, Chris , HARRISON, Nick , JOHN, James Daniel , LASTOW, Orest , SMARTT, Nick
IPC分类号： A61M15/00 , B65D83/04
CPC分类号： A61M15/0091 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to an inhaler, comprising a base having at least one air-tight, foil-sealed cavity containing medicament. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. The invention also relates to a method of dispensing a medicament from a sealed cavity inside an inhaler.
摘要翻译：吸入器技术领域本发明涉及一种吸入器，其包括具有至少一个包含药物的气密的箔密封空腔的底座。致动器可接合附接到箔的分离元件，致动器具有通电位置，在该位置中，致动器被朝向卸载位置偏置，以使分离元件和附着的箔片远离腔体移动。闩锁具有第一位置，其中致动器在所述通电位置中锁定，其中闩锁至少部分地布置在流动路径中，使得通过流动路径的吸入流动影响闩锁从第一位置移动到第二名本发明还涉及从吸入器内部的密封空腔分配药物的方法。

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