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1. 发明申请

WO2017139603A1 HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS 审中-公开
标题翻译：卤素取代的哌啶作为OREXIN受体调节剂
公开(公告)号：WO2017139603A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/017408
申请日：2017-02-10
申请人： ASTRAZENECA AB , EOLAS THERAPEUTICS, INC.
发明人： KAMENECKA, Theodore, M. , HOLENZ, Jörg , WESOLOWSKI, Steven , HE, Yuanjun , BÜRLI, Roland
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/445 , A61K31/497 , A61K31/506 , A61K31/53 , A61P1/04 , A61P1/12 , A61P3/04 , A61P9/12 , A61P13/12 , A61P15/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D417/14 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.
摘要翻译：本申请涉及某些卤代哌啶化合物，含有它们的药物组合物及其使用方法，包括治疗物质成瘾，恐慌症，焦虑症，创伤后应激障碍，疼痛的方法，抑郁症，季节性情感障碍，进食障碍或高血压。

2. 发明申请

WO2015123355A1 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为OREXIN受体拮抗剂的替代制剂/哌啶
公开(公告)号：WO2015123355A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015500
申请日：2015-02-11
申请人： EOLAS THERAPEUTICS, INC.
发明人： KAMENECKA, Theodore, M. , HE, Yuanjun , JIANG, Rong , NGUYEN, William , SONG, Xinyi , HERR, Robert, Jason , BARNES, Keith , YOUNG, Steven, D. , JIANG, Qin
IPC分类号： C07D211/04 , C07D209/02 , A61K31/445 , C07D277/02
CPC分类号： C07D417/14 , C07D401/12 , C07D413/14 , C07D417/12
摘要： The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX 1 or OX 2 , or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention. For example, orexin receptor- modulatory compounds of the present invention can be used in treatment of an eating disorder, obesity, alcoholism or an alcohol-related disorder, drug abuse or addiction including addiction to cocaine, opiates, amphetamines, or nicotine, a sleep disorder, a cognitive dysfunction in a psychiatric or neurologic disorder, depression, anxiety, post-traumatic stress disorder, seasonal affective disorder, an eating disorder, panic disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, headache, migraine, pain, gastrointestinal diseases, epilepsy, inflammations, immune-related diseases, endocrine-related diseases, cancer, hypertension, behavior disorder, mood disorder, manic depression, dementia, sex disorder, psychosexual disorder, or renal disease.
摘要翻译：本发明涉及调节食欲肽受体如OX1或OX2或两者的生物活性的化合物; 涉及包含本发明化合物的药物组合物和组合; 涉及食管蛋白受体调节在医学上指示的患者中的病情治疗方法; 以及制备本发明化合物的方法。例如，本发明的食欲素受体调节化合物可用于治疗进食障碍，肥胖，酒精中毒或酒精相关疾病，药物滥用或成瘾，包括对可卡因，阿片剂，苯丙胺或尼古丁的成瘾，睡眠精神病或神经障碍的认知功能障碍，抑郁症，焦虑症，创伤后应激障碍，季节性情感障碍，进食障碍，恐慌症，精神分裂症，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，头痛，偏头痛，疼痛，胃肠道疾病，癫痫，炎症，免疫相关疾病，内分泌相关疾病，癌症，高血压，行为障碍，情绪障碍，躁狂抑郁，痴呆，性障碍，心理性功能障碍或肾脏疾病。

3. 发明申请

WO2016025669A1 DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS 审中-公开
标题翻译：作为OREXIN受体调节剂的二氟吡啶类
公开(公告)号：WO2016025669A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/044974
申请日：2015-08-13
申请人： EOLAS THERAPEUTICS, INC.
发明人： KAMENECKA, Theodore M. , HE, Yuanjun
IPC分类号： C07D403/14 , C07D401/14 , C07D417/14 , C07D413/14 , A61K31/4025 , A61P25/00 , A61P1/04 , A61P1/12 , A61P3/04 , A61P9/12 , A61P13/12 , A61P15/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/06 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/36 , A61P25/08 , A61P25/24 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D417/14 , C07D401/14 , C07D403/14
摘要： The present application relates to certain difluoropyrrolidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.
摘要翻译：本申请涉及某些二氟吡咯烷化合物，含有它们的药物组合物及其使用方法，包括治疗物质成瘾，恐慌症，焦虑症，创伤后应激障碍，疼痛，抑郁症，季节性情感障碍，进食障碍，或高血压。

4. 发明公开

EP3180332A1 DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS 有权
标题翻译：二氟吡咯烷作为OREXIN受体调节剂
公开(公告)号：EP3180332A1
公开(公告)日：2017-06-21
申请号：EP15832417.8
申请日：2015-08-13
申请人： Eolas Therapeutics Inc.
发明人： KAMENECKA, Theodore M. , HE, Yuanjun
IPC分类号： C07D403/14 , C07D401/14 , C07D417/14 , C07D413/14
CPC分类号： C07D417/14 , C07D401/14 , C07D403/14
摘要： The present application relates to certain difluoropyrrolidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.
摘要翻译：本申请涉及某些二氟吡咯烷化合物，含有它们的药物组合物及其使用方法，包括治疗物质成瘾，恐慌症，焦虑症，创伤后应激障碍，疼痛，抑郁症，季节性情感障碍，进食障碍，或高血压。

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