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1. 发明申请

WO2008130321A3 NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN 审中-公开
公开(公告)号：WO2008130321A3
公开(公告)日：2008-10-30
申请号：PCT/SE2008/050460
申请日：2008-04-22
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , KERS, Inger , MACSARI, Istvan , NYLÖF, Martin , ROTTICCI, Didier
发明人： BESIDSKI, Yevgeni , KERS, Inger , MACSARI, Istvan , NYLÖF, Martin , ROTTICCI, Didier
IPC分类号： C07D405/12 , A61K31/341 , A61K31/353 , A61K31/357 , A61K31/4155 , A61K31/4192 , A61K31/428 , A61K31/4418 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61P29/00 , C07D213/82 , C07D249/06 , C07D295/135 , C07D307/68 , C07D311/20 , C07D417/12
摘要： The present invention relates to new compounds. The present invention relates to new compounds, to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.

2. 发明申请

WO2008130322A1 NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的新型5-环烷基氯代衍生物
公开(公告)号：WO2008130322A1
公开(公告)日：2008-10-30
申请号：PCT/SE2008/050461
申请日：2008-04-22
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , GRAVENFORS, Ylva , KERS, Inger , NYLÖF, Martin , ROTTICCI, Didier
发明人： BESIDSKI, Yevgeni , GRAVENFORS, Ylva , KERS, Inger , NYLÖF, Martin , ROTTICCI, Didier
IPC分类号： C07D405/12 , A61K31/353 , A61K31/381 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4433 , A61K31/506 , A61P29/00 , C07D311/04 , C07D409/12 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12 , C07D311/58 , C07D405/12 , C07D409/12 , C07D413/14
摘要： The present invention relates to new compounds and pharmaceutically-acceptable salts thereof,and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新化合物及其药学上可接受的盐，以及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

3. 发明申请

WO2004100865A2 NEW BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：新的苯并咪唑衍生物
公开(公告)号：WO2004100865A2
公开(公告)日：2004-11-25
申请号：PCT/SE2004/000738
申请日：2004-05-13
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , ROTTICCI, Didier , SLAITAS, Andis , SVENSSON, Mats
发明人： BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , ROTTICCI, Didier , SLAITAS, Andis , SVENSSON, Mats
IPC分类号： A61K
CPC分类号： C07D209/08 , C07C215/16 , C07C229/56 , C07C233/15 , C07C233/47 , C07C311/16 , C07C317/14 , C07C317/36 , C07D235/06 , C07D235/08 , C07D401/12 , C07D403/04 , C07D405/12 , C07D417/12
摘要： The present invention relates to new compounds of formula (I) wherein R 1 to R 9 are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新的式（I）化合物，其中R 1至R 9如式I中所定义，或其盐，溶剂合物或溶剂化盐，其制备方法和用于其制备方法，含有所述化合物的药物制剂和所述化合物在治疗中的用途。

4. 发明申请

WO2012039657A1 NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS 审中-公开
标题翻译：用于治疗疼痛病症的新型色素化合物
公开(公告)号：WO2012039657A1
公开(公告)日：2012-03-29
申请号：PCT/SE2010/051021
申请日：2010-09-22
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin
发明人： AURELL, Carl-Johan , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin
IPC分类号： C07D405/14 , A61K31/497 , A61P29/00
CPC分类号： C07D405/14 , C07D311/62 , C07D405/04 , C07F5/025
摘要： The present invention relates to the compound N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4- dihydro-2H-chromen-3-yl]-6-[(2,2,2-trifluoroethoxy)methyl]pyridine-3-carboxamide, or a pharmaceutical composition comprising said compound and to the use of said compounds in therapy.
摘要翻译：本发明涉及化合物N - [（3S）-5-（5-甲氧基吡嗪-2-基）-3,4-二氢-2H-色烯-3-基] -6 - [（2,2,2 - 三氟乙氧基）甲基]吡啶-3-甲酰胺，或包含所述化合物的药物组合物和所述化合物在治疗中的用途。

5. 发明申请

WO2006033620A1 NEW HETEROCYCLIC AMIDES 审中-公开
标题翻译：新的杂环化合物
公开(公告)号：WO2006033620A1
公开(公告)日：2006-03-30
申请号：PCT/SE2005/001364
申请日：2005-09-19
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , SLAITAS, Andis
发明人： BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , SLAITAS, Andis
IPC分类号： C07D401/04 , A61K31/4184 , A61K31/4439 , A61P29/00 , C07D235/06 , C07D405/12
CPC分类号： C07D235/08 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to new compounds (I) or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新化合物（I）或其盐，溶剂合物或溶剂化盐，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

6. 发明申请

WO2007073303A2 NEW COMPOUNDS III 审中-公开
标题翻译：新化合物III
公开(公告)号：WO2007073303A2
公开(公告)日：2007-06-28
申请号：PCT/SE2006/001467
申请日：2006-12-21
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , GRIFFIN, Andrew , LABRECQUE, Denis , JOHNSTONE, Shawn , JONES, Paul , KERS, Inger , NYLÖF, Martin , SKOGHOLM, Karin
发明人： BESIDSKI, Yevgeni , GRIFFIN, Andrew , LABRECQUE, Denis , JOHNSTONE, Shawn , JONES, Paul , KERS, Inger , NYLÖF, Martin , SKOGHOLM, Karin
IPC分类号： C07D235/08 , A61K31/4184 , A61K31/4439 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , C07D235/08 , C07D405/12 , C07D409/12
摘要： The present invention relates to new compounds [Chemical formula should be inserted here. Please see paper copy] (I) or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新化合物[化学式应在此插入。请参见纸本]（I）或其盐，溶剂合物或溶剂化盐，其制备方法和用于制备其的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

7. 发明申请

WO2008130320A2 NEW COMPOUNDS 806 审中-公开
标题翻译：新化合物806
公开(公告)号：WO2008130320A2
公开(公告)日：2008-10-30
申请号：PCT/SE2008/050459
申请日：2008-04-22
申请人： ASTRAZENECA AB , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , SANDBERG, Lars , SKOGHOLM, Karin
发明人： BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin , SANDBERG, Lars , SKOGHOLM, Karin
IPC分类号： C07D405/14 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/4418
CPC分类号： C07D405/14
摘要： The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.
摘要翻译：本发明涉及新的式（I）化合物和含有所述化合物的药物组合物和所述化合物在治疗中的用途。本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。

8. 发明申请

WO2012087237A1 COMPOUNDS AND THEIR USE AS BACE INHIBITORS 审中-公开
标题翻译：化合物及其作为BACE抑制剂的用途
公开(公告)号：WO2012087237A1
公开(公告)日：2012-06-28
申请号：PCT/SE2011/051555
申请日：2011-12-21
申请人： ASTRAZENECA AB , CSJERNYIK, Gabor , KARLSTRÖM, Sofia , KERS, Annika , KOLMODIN, Karin , NYLÖF, Martin , ÖHBERG, Liselotte , RAKOS, Laszlo , SANDBERG, Lars , SEHGELMEBLE, Fernando , SÖDERMAN, Peter , SWAHN, Britt-Marie , VON BERG, Stefan
发明人： CSJERNYIK, Gabor , KARLSTRÖM, Sofia , KERS, Annika , KOLMODIN, Karin , NYLÖF, Martin , ÖHBERG, Liselotte , RAKOS, Laszlo , SANDBERG, Lars , SEHGELMEBLE, Fernando , SÖDERMAN, Peter , SWAHN, Britt-Marie , VON BERG, Stefan
IPC分类号： C07D491/107 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/506 , A61P25/28 , C07D401/04 , C07D235/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D491/20
CPC分类号： A61K31/497 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/107 , C07D491/20
摘要： The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β- amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.
摘要翻译：本发明涉及式（I）化合物及其药物组合物。此外，本发明涉及用于治疗和/或预防β相关病理学的治疗方法，例如唐氏综合征，β-淀粉样变性血管病，例如但不限于脑淀粉样血管病或遗传性脑出血，与认知相关的疾病损伤例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默氏病或痴呆的疾病相关的神经变性，包括混合血管和退行性来源的痴呆，前老年痴呆症，老年痴呆症和与帕金森病相关的痴呆症。

9. 发明申请

WO2003082853A1 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：WO2003082853A1
公开(公告)日：2003-10-09
申请号：PCT/SE2003/000508
申请日：2003-03-28
申请人： ASTRAZENECA AB , BERG, Stefan , HELLBERG, Sven , NYLÖF, Martin , XUE, Yafeng
发明人： BERG, Stefan , HELLBERG, Sven , NYLÖF, Martin , XUE, Yafeng
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides new compounds of formula Ia and Ib: as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明提供新的式Ia和Ib化合物，以及其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

10. 发明授权

EP1025095B1 SUBSTITUTED CHROMAN DERIVATIVES 有权
标题翻译：取代的色素衍生物
公开(公告)号：EP1025095B1
公开(公告)日：2003-11-26
申请号：EP98944377.5
申请日：1998-09-09
申请人： AstraZeneca AB
发明人： BERG, Stefan , NYLÖF, Martin , ROSS, Svante , THORBERG, Seth-Olov
IPC分类号： C07D311/58 , A61K31/495 , A61K31/535
CPC分类号： C07D405/12 , C07D311/58 , C07D407/12
摘要： The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compounds having formula (I) wherein X is N or CH; Y is NR2CH2, CH2NR2, NR2CO, CONR2, NR2SO2 or NR2CONR2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5; and n is 0-4; as (R)-enantiomers, (S)-enantiomers or a racemate in the form of a free base or a pharmaceutically acceptable salt or solvate thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds.
摘要翻译：本发明涉及具有式（I）的新的哌啶基或哌嗪基取代的二氢-2H-1-苯并吡喃衍生物化合物，其中X是N或CH; Y是NR 2 CH 2，CH 2 NR 2，NR 2 CO，CONR 2，NR 2 SO 2或NR 2 CONR 2，其中R 2是H或C 1 -C 6烷基; R1是H，C1-C6烷基或C3-C6环烷基; R 3是C 1 -C 6烷基，C 3 -C 6环烷基或（CH 2）n - 芳基，其中芳基是苯基或含有一个或两个选自N，O和S的杂原子的杂芳族环，并且其可以单 - 或二 - 取代 R4和/或R5; 并且n是0-4; 作为（R） - 对映异构体，（S） - 对映异构体或游离碱形式的外消旋体或其药学上可接受的盐或溶剂合物，其制备方法，含有所述治疗活性化合物的药物组合物以及所述活性化合物。

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