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1. 发明申请

WO2007051995A3 TERT-BUTYLAMMONIUM SALT OR ADAMNTYLAMMONIUM SALT OF ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES 审中-公开
标题翻译：正丁基取代苯甲酸衍生物的叔丁基铵盐或亚氨基磺酸盐
公开(公告)号：WO2007051995A3
公开(公告)日：2007-07-12
申请号：PCT/GB2006004035
申请日：2006-10-31
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , DAHLSTROM MIKAEL ULF JOHAN , OHLSSON BENGT
发明人： DAHLSTROM MIKAEL ULF JOHAN , OHLSSON BENGT
IPC分类号： C07C235/34 , C07C323/62
CPC分类号： C07C235/34 , C07C323/62 , C07C2603/74
摘要： A tert-butylammonium salt or an adamantylammonium salt of a compound of formula I wherein n is 0, 1 or 2 and R 1 represents halo, a C 1-4 alkyl group which is optionally substituted by one or more fluoro, a C 1-4 alkoxy group which is optionally substituted by one or more fluoro and wherein when n is 2 the substituents R 1 may be the same or different; R 2 represents a C 2-8 alkyl group which is optionally interrupted by oxygen; Y is absent or represents methylene; and X is O or S.
摘要翻译：式I化合物的叔丁基铵盐或金刚烷基铵盐，其中n为0,1或2，R 1为卤素，C 1-4烷基其任选被一个或多个氟任选被一个或多个氟取代的C 1-4烷氧基取代，并且其中当n是2时，取代基R 1〜可能相同或不同; R 2表示任选被氧中断的C 2-8 C烷基; Y不存在或代表亚甲基; X是O或S.

2. 发明专利

IL160691A BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICAMENTS FOR INHIBITING ILEAL BILE ACID TRANSPORT (IBAT) IN A WARM BLOODED ANIMAL 未知
公开(公告)号：IL160691A
公开(公告)日：2011-11-30
申请号：IL16069104
申请日：2004-03-02
申请人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID , ALENFALK SUZANNE , SKJARET TORE , LEMURELL MALIN , ALBIREO AB , ASTRAZENECA AB
发明人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID , ALENFALK SUZANNE , SKJARET TORE , LEMURELL MALIN
IPC分类号： A61K20060101 , A61K31/192 , A61K31/397 , A61K31/40 , A61K31/505 , A61K31/554 , A61K31/695 , A61K31/785 , A61P20060101 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P17/02 , A61P31/00 , A61P43/00 , C07D20060101 , C07D281/02 , C07D281/10 , C07D285/36 , C07D417/12 , C07F7/10 , C07K20060101
摘要： The present invention relates to compounds of formula (I) wherein R v , R 1 , R 2 , R x , R y , M, R z , v, R 3 , R 4 , R 5 and R 6 are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

3. 发明专利

IL156341A BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF MEDICAMENTS AND AS MEDICAMENTS FOR THE PRODUCTION OF AN IBAT INHIBITORY EFFECT IN A WARM-BLOODED ANIMAL 未知
公开(公告)号：IL156341A
公开(公告)日：2009-09-22
申请号：IL15634103
申请日：2003-06-08
申请人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID , ALBIREO AB , ASTRAZENECA AB
发明人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID
IPC分类号： A61K31/192 , A61K31/255 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/505 , A61K31/554 , A61K31/675 , A61K31/785 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P17/00 , A61P17/02 , A61P29/00 , A61P31/00 , A61P43/00 , C07D281/10 , C07D417/12 , C07F9/6536 , C07K5/065
摘要： The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described

4. 发明专利

JP2006045240A Therapeutic agent 审中-公开
标题翻译：治疗剂
公开(公告)号：JP2006045240A
公开(公告)日：2006-02-16
申请号：JP2005253346
申请日：2005-09-01
申请人： Astrazeneca Ab , アストラゼネカアクチボラグ
发明人： ALSTERMARK EVA-LOTTE LINDSTEDT , OLSSON ANNA CHRISTINA , LI LANNA , AURELL CARL-JOHAN , MINIDIS ANNA , YOUSEFI-SALAKDEH ESMAIL , DAHLSTROM MIKAEL ULF JOHAN
IPC分类号： C07C235/06 , A61K31/16 , A61K31/192 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , C07C231/12 , C07C235/20
CPC分类号： A61K31/16 , C07C235/20
摘要： PROBLEM TO BE SOLVED: To provide a certain new intermediate of a (2S)-3-(4-ä2-[amino]-2-oxoethoxy}phenyl)-2-ethoxypropanoic acid derivative and a method for producing the derivative; and to provide a pharmaceutical composition containing the derivative in combination with another therapeutic agent useful in treatment of disorder (e.g. hypertension, hyperlipidemia, dyslipidemia, diabetic and obesity) associated with the onset or progress of atherosclerosis. SOLUTION: The medicinal composition contains the S enantiomer of a compound of formula (I) (wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy; R 2 represents H or fluoro; and R 3 represents a 2-4C alkyl group) as well as a pharmaceutically acceptable salt, solvate and prodrug thereof, and another therapeutic agent of the disorder associated with the onset or the progress of the atherosclerosis, another PPAR regulator, a depressant of cholesterol, an HMG-CoA reductase inhibitor or an IBAT inhibitor. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供（2S）-3-（4-2- [氨基] -2-氧代乙氧基}苯基）-2-乙氧基丙酸衍生物的某种新的中间体及其衍生物的制备方法 ; 并提供含有该衍生物与可用于治疗与动脉粥样硬化发作或进展相关的病症（例如高血压，高脂血症，血脂异常，糖尿病和肥胖）的另一治疗剂的药物组合物。药物组合物含有式（I）化合物的S对映异构体（其中R 1表示氯，三氟甲基或三氟甲氧基; R 2表示H或氟代; R 3代表2-4C烷基）以及其药学上可接受的盐，溶剂合物和前药，以及与动脉粥样硬化发作或进展相关的病症的另一种治疗剂，另一种PPAR调节剂，胆固醇抑制剂，HMG-CoA还原酶抑制剂或IBAT抑制剂。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2004210794A Benzothiazepine and benzothiadiazepine derivatives with inhibition activity for ileum bile acid transport (ibat) for treating hyperlipemia 审中-公开
公开(公告)号：JP2004210794A
公开(公告)日：2004-07-29
申请号：JP2004038919
申请日：2004-02-16
申请人： Astrazeneca Ab , アストラゼネカアクチボラグ
发明人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID , ALENFALK SUZANNE , SKJARET TORE , LEMURELL MALIN
IPC分类号： A61K20060101 , A61K31/192 , A61K31/397 , A61K31/40 , A61K31/505 , A61K31/554 , A61K31/695 , A61K31/785 , A61P20060101 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P17/02 , A61P31/00 , A61P43/00 , C07D20060101 , C07D281/02 , C07D281/10 , C07D285/36 , C07D417/12 , C07F7/10 , C07K20060101
CPC分类号： C07D417/12 , C07D285/36
摘要： PROBLEM TO BE SOLVED: To provide an ileum bile acid transport (IBAT) inhibitor useful for treating hyperlipemia.
SOLUTION: A pharmaceutical composition comprises a compound represented by formula (I) (wherein, for example, M denotes -N- or -CH-; R
V , R
X , R
Y , R
3 and R
6 each denote a hydrogen; R
1 and R
2 each denote a butyl group; R
4 denotes a bromine; V=0; R
5 denotes a -OCH
2 NHCOCH(-C
6 H
5 )CONHCH
2 COOH group), a pharmaceutically acceptable salt, solvate and solvate of the salt thereof, and a prodrug thereof, and is used for treating hyperlipemia.
COPYRIGHT: (C)2004,JPO&NCIPI

6. 发明专利

PL377144A1 Środki terapeutyczne 未知
公开(公告)号：PL377144A1
公开(公告)日：2006-01-23
申请号：PL37714403
申请日：2003-12-19
申请人： ASTRAZENECA AB
发明人： LINDSTEDT ALSTERMARK EVA-LOTTE , OLSSON ANNA CHRISTINA , LI LANNA , AURELL CARL-JOHAN , MINIDIS ANNA , YOUSEFI-SALAKDEH ESMAIL , DAHLSTROM MIKAEL ULF JOHAN
IPC分类号： C07C235/20 , A61K31/16

7. 发明专利

NZ531798A Benzothiepine ileal bile acid transport inhibitors 未知
公开(公告)号：NZ531798A
公开(公告)日：2005-11-25
申请号：NZ53179802
申请日：2002-09-05
申请人： ASTRAZENECA AB
发明人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , BLOMBERG DAVID
IPC分类号： A61K31/255 , A61K31/366 , A61K31/38 , A61K31/381 , A61K31/40 , A61K45/00 , A61P1/00 , A61P3/00 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P17/02 , A61P29/00 , A61P31/04 , C07D337/08 , C07D409/12
摘要： Compounds of formula (I), pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia are disclosed, wherein Rx, Ry, Rz, v, R1, R2, R3, R4, R5 and R6 are as defined in the specification. Processes for their manufacture and pharmaceutical compositions containing them are also disclosed.

8. 发明专利

ZA200408548B Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them. 未知
公开(公告)号：ZA200408548B
公开(公告)日：2005-11-14
申请号：ZA200408548
申请日：2004-10-21
申请人： ASTRAZENECA AB
发明人： STARKE INGEMAR , NORDBERG MATS PETER , WALLBERG ANDREAS CHRISTER , DAHLSTROM MIKAEL ULF JOHAN , ALENFALK SUZANNE , BOSTROM STIG JONAAS
IPC分类号： A61K31/255 , A61K31/40 , A61K31/505 , C07D239/42 , A61K31/554 , A61K45/00 , A61P1/12 , A61P3/06 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/00 , A61P41/00 , A61P43/00 , C07D207/34 , C07D285/36 , C07D417/12 , C07D , A61K , A61P
摘要： The present invention relates to compounds of formula (I): wherein R v , R 1 , R 2 , R x , R y , R 3 , R 4 , R 5 , R 6 , R z and v are as defined within; pharmaceutically acceptable salts, solvates, solvates or such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

9. 发明专利

PL372998A1 BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：PL372998A1
公开(公告)日：2005-08-08
申请号：PL37299803
申请日：2003-04-23
申请人： ASTRAZENECA AB
发明人： STARKE INGEMAR , DAHLSTROM MIKAEL ULF JOHAN , NORDBERG MATS PETER , ALENFALK SUZANNE , WALLBERG ANDREAS CHRISTER , BOSTROM STIG JONAS
IPC分类号： C07D239/42 , A61K31/255 , A61K31/40 , A61K31/505 , A61K31/554 , A61K45/00 , A61P1/12 , A61P3/06 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/00 , A61P41/00 , A61P43/00 , C07D207/34 , C07D285/36 , C07D417/12
摘要： The present invention relates to compounds of formula (I): wherein R v , R 1 , R 2 , R x , R y , R 3 , R 4 , R 5 , R 6 , R z and v are as defined within; pharmaceutically acceptable salts, solvates, solvates or such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

10. 发明专利

NO20050016L 未知
公开(公告)号：NO20050016L
公开(公告)日：2005-03-01
申请号：NO20050016
申请日：2005-01-03
申请人： ASTRAZENECA AB
发明人： STARKE INGEMAR , LINDQVIST ANN-MARGRET , SKJARET TORE , LEMURELL MALIN , NORDBERG MATS PETER , DAHLSTROM MIKAEL ULF JOHAN
IPC分类号： C07D205/08 , A61P3/06 , A61P9/10 , C07D409/12 , A61K31/397
摘要： Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described

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