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1. 发明申请

WO2007068894A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2007068894A2
公开(公告)日：2007-06-21
申请号：PCT/GB2006/004607
申请日：2006-12-12
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BONNERT, Roger, Victor , LUKER, Timothy, Jon , MOHAMMED, Rukhsana, Tasneem , THOM, Stephen , COOK, Andrew
发明人： BONNERT, Roger, Victor , LUKER, Timothy, Jon , MOHAMMED, Rukhsana, Tasneem , THOM, Stephen , COOK, Andrew
CPC分类号： C07C317/22 , C07C317/44 , C07C323/65 , C07D205/04 , C07D231/20 , C07D233/64 , C07D257/04 , C07D271/07 , C07D401/12 , C07D403/04
摘要： The invention relates to substituted aromatic compounds as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译：本发明涉及取代的芳族化合物作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。

2. 发明申请

WO2019200100A1 PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2019200100A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026992
申请日：2019-04-11
申请人： COOK, Andrew , REYNOLDS, Dominic , ZHONG, Cheng , BRAWN, Ryan , ELLERY, Shelby , SAMARAKOON, Thiwanka , LIU, Xiang , PRAJAPATI, Sudeep , SHEEHAN, Megan , LOWE, Jason T. , PALACINO, James
发明人： COOK, Andrew , REYNOLDS, Dominic , ZHONG, Cheng , BRAWN, Ryan , ELLERY, Shelby , SAMARAKOON, Thiwanka , LIU, Xiang , PRAJAPATI, Sudeep , SHEEHAN, Megan , LOWE, Jason T. , PALACINO, James
IPC分类号： C07D313/00 , C07D405/06 , C07D405/10 , C07D405/14 , C07D498/08 , C07D491/10 , A61K31/365 , A61K31/496 , A61K31/5377 , A61K31/416 , A61K31/4025 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04
摘要： The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.

3. 发明申请

WO2013131196A1 FLEXIBLE WATER TURBINE 审中-公开
标题翻译：柔性水轮机
公开(公告)号：WO2013131196A1
公开(公告)日：2013-09-12
申请号：PCT/CA2013/050177
申请日：2013-03-11
申请人： GENESIS GROUP INC. , MASEK, Vlastimil , COOK, Andrew
发明人： MASEK, Vlastimil , COOK, Andrew
IPC分类号： F03B13/10 , F03B13/26 , F03B17/06 , F03B3/04 , H02K7/18 , F04D29/18
CPC分类号： F03B13/10 , F03B3/04 , F03B13/26 , F03B13/264 , F03B17/061 , F05B2240/62 , F05B2240/97 , H02K7/1823 , Y02E10/28 , Y02E60/17
摘要： The invention relates to a water mill, power generator, for use underwater, having a flexible support shaft which permits the water current to orient the turbine axis substantially parallel to the direction of flow so that the force of the water on the blades is optimized for a given turbine, without the need for slip ring style connections between the generator at the turbine and the5 anchored base. Optionally, the design features fins or cowlings on the flexible support shaft to further improve reorientation of the turbine with the water current or flow acting as the source of power; and/or output power links or power conditioning systems at the anchored base. The generators may be selected to meet low rotation operating conditions, and the entire system may be designed for particular ocean bottom and/or current parameters applicable to the10 deployment. The power generator could be used to provide electrical power to underwater installations for military, security, oceanography, monitoring and oil & gas exploration purposes.
摘要翻译：本发明涉及一种用于水下的水磨机，发电机，其具有柔性支撑轴，其允许水流使涡轮机轴线基本上平行于流动方向定向，使得叶片上的水的力被优化用于给定的涡轮机，而不需要在涡轮机的发电机和5个锚定基座之间的滑环式连接。可选地，该设计特征在于柔性支撑轴上的翅片或整流罩，以进一步改善涡轮机的再定向，其中水流或流动充当动力源; 和/或在锚定基座处的输出功率链路或功率调节系统。可以选择发电机以满足低旋转操作条件，并且整个系统可以被设计用于适用于10部署的特定海底和/或当前参数。发电机可用于向军事，安全，海洋学，监测和石油和天然气勘探目的的水下装置提供电力。

4. 发明申请

WO2005121073A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2005121073A1
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002234
申请日：2005-06-07
申请人： UNIVERSITY OF LEEDS , GRIGG, Ronald , COOK, Andrew
发明人： GRIGG, Ronald , COOK, Andrew
IPC分类号： C07C237/40
CPC分类号： C07C237/40 , C07C237/42 , C07D295/155
摘要： The present invention relates to a benzamide derivative comprising a head, spacer and cap group wherein the spacer includes a benzene ring substituted with an additional spacer and wherein the additional spacer is an unsaturated group.
摘要翻译：本发明涉及包含头，间隔基和帽基团的苯甲酰胺衍生物，其中间隔基包括被附加间隔基取代的苯环，并且其中所述另外的间隔基是不饱和基团。

5. 发明申请

WO2019199667A3 PLADIENOLIDE COMPOUNDS AND THEIR USE 审中-公开
公开(公告)号：WO2019199667A3
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
申请人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC分类号： C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

6. 发明申请

WO2019199667A2 CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019199667A2
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
申请人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC分类号： C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

7. 发明申请

WO2013131197A1 DUAL FIBRE BRAGG GRATING ACCELEROMETER 审中-公开
标题翻译：双光纤加速度计
公开(公告)号：WO2013131197A1
公开(公告)日：2013-09-12
申请号：PCT/CA2013/050180
申请日：2013-03-11
申请人： GENESIS GROUP INC. , MASEK, Vlastimil , COOK, Andrew , PRESS, Adam
发明人： MASEK, Vlastimil , COOK, Andrew , PRESS, Adam
IPC分类号： G01P15/093 , G01P15/18 , G01V1/18
CPC分类号： G01P15/093 , G01P15/18 , G01V1/18 , G01V1/226
摘要： The invention relates to a multi-dimensional accelerometer using dual fibre Bragg grating (FBG) in each of 2 or 3 substantially orthogonal directions about a inertial mass suspending within a rigid frame, and wherein the optical detection method uses the Intensity Modulation-Direct Detection (IM-DD) technique for the dual FBGs having proximate frequencies; and to a novel5 means of pre-tensioning the fibres within the rigid frame. Means for testing and pre-tensioning the accelerometer are also provided.
摘要翻译：本发明涉及一种多维加速度计，该方法采用双重光纤布拉格光栅（FBG），每个2或3个基本正交的方向围绕悬挂在刚性框架内的惯性块，并且其中光学检测方法使用强度调制直接检测（ IM-DD）技术，具有接近频率的双FBG; 以及一种用于在刚性框架内预张紧纤维的新型装置。还提供了用于测试和预张紧加速度计的装置。

8. 发明申请

WO2007085855A1 A SYSTEM AND METHOD FOR PARALLEL EXECUTION OF A PROGRAM 审中-公开
标题翻译：一种并行执行程序的系统和方法
公开(公告)号：WO2007085855A1
公开(公告)日：2007-08-02
申请号：PCT/GB2007/000286
申请日：2007-01-26
申请人： CODEPLAY SOFTWARE LIMITED , RICHARDS, Andrew , COOK, Andrew , RILEY, Colin
发明人： RICHARDS, Andrew , COOK, Andrew , RILEY, Colin
IPC分类号： G06F9/45
CPC分类号： G06F8/456
摘要： A computer system for executing a computer program on parallel processors, the system having a compiler for identifying within a computer program concurrency markers that indicate that code between them can be executed in parallel and should be executed with delayed side-effects; and an execution system that is operable to execute the code identified by the concurrency markers to generate a queue of side-effects and after execution of that code is completed, sequentially execute the queue of side-effects.
摘要翻译：一种用于在并行处理器上执行计算机程序的计算机系统，所述系统具有用于在计算机程序内识别并发标记的编译器，所述并发标记指示它们之间的代码可以并行执行并且应当用延迟的副作用执行; 以及执行系统，其可操作以执行由并发标记识别的代码以生成副作用队列，并且在执行该代码之后，顺序执行副作用队列。

9. 发明申请

WO2008003930A2 TECHNIQUES FOR PROGRAM EXECUTION 审中-公开
标题翻译：计划执行技术
公开(公告)号：WO2008003930A2
公开(公告)日：2008-01-10
申请号：PCT/GB2007/002398
申请日：2007-06-27
申请人： ITI SCOTLAND LIMITED , RICHARDS, Andrew , COOK, Andrew , RUSSELL, George
发明人： RICHARDS, Andrew , COOK, Andrew , RUSSELL, George
IPC分类号： G06F9/45 , G06F9/44
CPC分类号： G06F11/3664 , G06F9/522 , G06F9/546
摘要： The present application relates to techniques for handling the execution of a computer software program comprising a plurality of distinct program components. In particular, the application describes techniques relating to the interaction between distinct components of a computer program and seeks to allow program components to execute with a high degree of determinism. An execution environment is described which is operable such that the execution of one or more components of a computer program is carried out in a plurality of sequential frames of execution, wherein the execution environment is further operable to: i) allow communication between one said component and another said component in different frames of execution; and ii) to prevent communication between one said component and another said component in the same frame of execution. A debugger which utilises the execution environment is also described.
摘要翻译：本申请涉及用于处理包括多个不同程序组件的计算机软件程序的执行的技术。特别地，本申请描述了与计算机程序的不同组件之间的相互作用相关的技术，并试图允许程序组件以高度确定性执行。描述了可操作的执行环境，使得在多个顺序的执行帧中执行计算机程序的一个或多个组件的执行，其中执行环境还可操作以：i）允许一个所述组件另一个在不同执行帧中的组件; 以及ii）防止在同一执行帧中的一个所述组件与另一个所述组件之间的通信。还描述了利用执行环境的调试器。

10. 发明公开

EP1963259A2 SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE 有权
标题翻译：取代的二苯醚，胺，硫化物，和甲烷呼吸系统疾病的治疗
公开(公告)号：EP1963259A2
公开(公告)日：2008-09-03
申请号：EP06820474.2
申请日：2006-12-12
申请人： AstraZeneca AB
发明人： BONNERT, Roger, Victor , LUKER, Timothy, Jon , MOHAMMED, Rukhsana, Tasneem , THOM, Stephen , COOK, Andrew
IPC分类号： C07C311/03 , C07C317/22 , C07C323/65 , C07D205/04 , C07D231/20 , C07D233/54 , C07D257/04 , C07D271/06 , C07D403/04 , C07C311/51 , C07C317/32 , C07C317/36
CPC分类号： C07C317/22 , C07C317/44 , C07C323/65 , C07D205/04 , C07D231/20 , C07D233/64 , C07D257/04 , C07D271/07 , C07D401/12 , C07D403/04
摘要： The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory- disorders, pharmaceutical compositions containing them, and processes for their preparation.

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