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1. 发明专利

AU2035101A New tri-substituted phenyl derivatives and analogues 未知
公开(公告)号：AU2035101A
公开(公告)日：2001-06-12
申请号：AU2035101
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： BOIJE MARIA , FAGERHAG JONAS , ALSTERMARK EVA-LOTTE LINDSTEDT , OHLSSON BENGT
IPC分类号： A61P3/06 , A61K31/192 , A61K31/255 , A61K31/27 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/12 , C07C59/64 , C07C59/68 , C07C69/734 , C07C271/28 , C07C309/66
摘要： The present invention relates to certain tri-substituted phenyl derivatives and analogues of formula (I), to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

2. 发明专利

CA2392035A1 NEW PHENALKYLOXY-PHENYL DERIVATIVES 未知
公开(公告)号：CA2392035A1
公开(公告)日：2001-06-07
申请号：CA2392035
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： LINDSTEDT ALSTERMARK EVA-LOTTE , LI LANNA , FAGERHAG JONAS
IPC分类号： A61P3/10 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/137 , A61K31/165 , A61K31/255 , A61K31/27 , A61K31/275 , A61K31/277 , A61P3/00 , A61P5/48 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C309/66 , C07C309/68 , C07C317/22 , C07C323/16 , A61K31/136 , A61K31/192 , A61K31/325
摘要： The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, having t he utility in clinical conditions associated with insulin resistance, to method s for their therapeutic use and to pharmaceutical compositions containing them .

3. 发明专利

IL149517A TRI-SUBSTITUTED PHENYL DERIVATIVES AND ANALOGUES 未知
公开(公告)号：IL149517A
公开(公告)日：2007-07-04
申请号：IL14951702
申请日：2002-05-07
申请人： ASTRAZENECA AB , ALSTERMARK EVA-LOTTE LINDSTEDT , OHLSSON BENGT , FAGERHAG JONAS , BOIJE ANNA MARIA PERSDOTTER
发明人： ALSTERMARK EVA-LOTTE LINDSTEDT , OHLSSON BENGT , FAGERHAG JONAS , BOIJE ANNA MARIA PERSDOTTER
IPC分类号： A61P3/06 , A61K31/192 , A61K31/255 , A61K31/27 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/12 , C07C59/64 , C07C59/68 , C07C69/734 , C07C271/28 , C07C309/66
摘要： The present invention relates to certain tri-substituted phenyl derivatives and analogues of formula (I), to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

4. 发明专利

MY124727A TRI-SUBSTITUTED PHENYL DERIVATIVES AND ANALOGUES. 未知
公开(公告)号：MY124727A
公开(公告)日：2006-06-30
申请号：MYPI20005602
申请日：2000-11-30
申请人： ASTRAZENECA AB
发明人： BOIJE MARIA , LINDSTEDT ALSTERMARK EVA-LOTTE , OHLSSON BENGT , FAGERHAG JONAS
IPC分类号： A61P3/06 , C07C309/63 , A61K31/192 , A61K31/255 , A61K31/27 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/12 , C07C59/64 , C07C59/68 , C07C69/734 , C07C271/28 , C07C309/66
摘要： THE PRESENT INVENTION RELATES TO CERTAIN TRI-SUBSTITUTED PHENYL DERIVATIVES AND ANALOGUES OF FORMULA (I), TO A PROCESS FOR PREPARING SUCH COMPOUNDS, HAVING THE UTILITY IN CLINICAL CONDITIONS ASSOCIATED WITH INSULIN RESISTANCE, TO METHODS FOR THEIR THERAPEUTIC USE AND TO PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

5. 发明专利

ES2219425T3 NUEVOS DERIVADOS DE FENILO TRI-SUSTITUIDOS Y ANALOGOS. 未知
公开(公告)号：ES2219425T3
公开(公告)日：2004-12-01
申请号：ES00983619
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： BOIJE MARIA , FAGERHAG JONAS , LINDSTEDT ALSTERMARK EVA-LOTTE , OHLSSON BENGT
IPC分类号： A61P3/06 , A61K31/192 , A61K31/255 , A61K31/27 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/12 , C07C59/64 , C07C59/68 , C07C69/734 , C07C271/28 , C07C309/66
摘要： Un compuesto seleccionado de: ácido 3-[4-bencil-3-({4-[(metilsulfonil)oxi]fenetil}-oxi)fe nil]-2-etoxipropanoico; 3-[4-bencil-3-({4-[(metilsulfonil)oxi]fenetil}oxi)-fe nil]-2-etoxipropanoato de etilo; 3-[4-bencil-3-({4-[(metilsulfonil)oxi]fenetil}oxi)-fe nil]-2-etoxipropanoato de isopropilo; ácido 3-[3-bencil-4-({4-[(metilsulfonil)oxi]fenetil}-oxi)fe nil]-2-etoxipropanoico; ácido (2S)-3-[3-bencil-4-({4-[(metilsulfonil)oxi]-fenetil}o xi)fenil]-2-etoxipropanoico; ácido (2R)-3-[3-bencil-4-({4-[(metilsulfonil)oxi]-fenetil}o xi)fenil]-2-etoxipropanoico; 3-[3-bencil-4-({4-[(metilsulfonil)oxi]fenetil}oxi)-fe nil]-2-etoxipropanoato de etilo; (2S)-3-[3-bencil-4-({4-[(metilsulfonil)oxi]fenetil}-o xi)fenil]-2-etoxipropanoato de etilo; (2R)-3-[3-bencil-4-({4-[(metilsulfonil)oxi]fenetil}-o xi)fenil]-2-etoxipropanoato de etilo; ácido 3-[3-terc-butil-4-(2-{4-[(metilsulfonil)oxi]-fenil}et oxi)fenil]-2-etoxipropanoico; 3-[3-terc-butil-4-(2-{4-[(metilsulfonil)oxi]fenil}-et oxi)fenil]-2-etoxipropanoato de etilo; ácido 3-[(3-terc-butoxicarbonil)amino]-4-(2-{4-[(metilsulfo nil)oxi]fenil}etoxi)fenil]-2-etoxipropan-oico; 3-[(3-terc-butoxicarbonil)amino]-4-(2-{4-[(metilsul-f onil)oxi]fenil}etoxi)fenil]-2-etoxipropanoato de etilo; ácido 2-etoxi-3-{4-(2-(4-hidroxifenil)etoxi]-3-metilfenil}p ropanoico; 2-etoxi-3-[3-metil-4-(2-{4-[(metilsulfonil)oxi]fen-il }etoxi)fenil]propanoato de etilo; ácido 3-[3-bencil-4-(2-{4-[(terc-butoxicarbonil)-amino]feni l}etoxi)fenil]-2-etoxipropanoico; 3-[3-bencil-4-(2-{4-[(terc-butoxicarbonil)amino]-feni l}etoxi)fenil]-2-etoxipropanoato de etilo; ácido 2-etoxi-3-[4-metoxi-3-(2-{4-[(metilsulfonil)-oxi]feni l}etoxi)fenil]propanoico; o ácido 2-etoxi-3-[3-metoxi-4-(2-{4-[(metilsulfonil)-oxi]feni l}etoxi)fenil]propanoico; y sus estereoisómeros e isómeros ópticos y racematos de los mismos, así como sales, solvatos y formas profármaco farmacéuticamente aceptables de los mismos.

6. 发明专利

NZ518922A Phenalkyloxy-phenyl derivatives useful for treating conditions associated with insulin resistance 未知
公开(公告)号：NZ518922A
公开(公告)日：2003-11-28
申请号：NZ51892200
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： FAGERHAG JONAS , LI LANNA , LINDSTEDT ALSTERMARK EVA-LOTTE
IPC分类号： A61P3/10 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/137 , A61K31/165 , A61K31/255 , A61K31/27 , A61K31/275 , A61K31/277 , A61P3/00 , A61P5/48 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C309/66 , C07C309/68 , C07C317/22 , C07C323/16 , A61K31/192 , A61K31/325 , A61K31/136
摘要： Phneylalkyloxy-phenyl derivatives of formula (I) may be used to treat conditions associated with insulin resistance. A compound of formula (I) where: A is situated in ortho, meta and para positions and is represented by formula A(I) and A(II) where is cyano, when X is 0, and when X is 1 then R is - BRa or SCORa, where O,S, SO or SO2, where Ra represents hydrogen, alkyl, aryl or alkylaryl group is optionally substituted one or more times by Rb represents alkyl, aryl, alkylaryl, cyano, -NRcRc, =O, halogen, alkyl, aryl or alkylaryl and Rd represents alkyl, aryl or alkylaryl - BB1Ra where B1 is O when B is S, SO or SO2, or B1 is S, So or SO2 when B is O, and wherein B and Ra are defined as above. Alternatively, R is NRaRa, where each Ra is the same or different, and defined as above. R2 represents alkyl, halogen, aryl, alkylaryl, alknenyl, alkynyl (which may be optionally substituted by Rb as defined above), nitro or cyano, -BRa where B and Ra is defined above. R2 may also: - SO2NRaRf where Rf represents hydrogen, alkylacyl, aryl or alkylaryl, SO2ORa, -OCONRfRa where Rf and Ra are defined, -NRcCOORd, NRcCORa, -CONRcRa, NRcCORa, NRcSO2Rd, NRcCORNaRk (where Rk represents hydrogen, alkyl, aryl or alkylaryl). Ra, Rf, Rc, Rd are defined as above. - Alternatively, T2 is -NRcRa, where Rc and Ra are defined above. R1, R3 and R4 are the same or different and each represents hydrogen, alkyl, aryl, alkenyl, alkynyl, cyano, halogen or alkyl, where these groups may be optionally substituted by Rb. n is an integer from 1 to 6, X is an ineger 0 or 1, m is an integer 0 or 1. D is situated in ortho, meta or para positions and represents alkyl, acyl, aryl, alkylaryl, halogen or alkylaryl group is optionally substituted by Rb; - NRcCOORa, -NRcCORa, -NRcRa, -NRcSO2Rd, -NRcCONRaRk, - ORa, -OSO2Rd, -SORd, -SRc, -SO2Rd, -SORd, -SRc, -SO2NRaRf, -SO2ORa, -CONRcRa, -OCONRfRa, where Rc, Ra, Rd, Rf are defined above. D' is situated in ortho, meta or para positions and represents hydrogen, alkyl, acyl, aryl, alkylaryl, halogen, -CN, -NO2, -NRfRb, -ORf, -OSO2Rd where Rf, Rb amd Rd are defined above.

7. 发明专利

AU766547B2 New phenalkyloxy-phenyl derivatives 未知
公开(公告)号：AU766547B2
公开(公告)日：2003-10-16
申请号：AU2240101
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： FAGERHAG JONAS , LI LANNA , ALSTERMARK EVA-LOTTE LINDSTEDT
IPC分类号： A61P3/10 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/137 , A61K31/165 , A61K31/255 , A61K31/27 , A61K31/275 , A61K31/277 , A61P3/00 , A61P5/48 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C309/66 , C07C309/68 , C07C317/22 , C07C323/16 , A61K31/136 , A61K31/192 , A61K31/325
摘要： The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I)and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

8. 发明专利

ES2222261T3 NUEVOS DERIVADOS DE FENALQUILOXI-FENILO. 未知
公开(公告)号：ES2222261T3
公开(公告)日：2005-02-01
申请号：ES00986106
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： FAGERHAG JONAS , LI LANNA , LINDSTEDT ALSTERMARK EVA-LOTTE
IPC分类号： A61P3/10 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/137 , A61K31/165 , A61K31/255 , A61K31/27 , A61K31/275 , A61K31/277 , A61P3/00 , A61P5/48 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C309/66 , C07C309/68 , C07C317/22 , C07C323/16 , A61K31/192 , A61K31/325 , A61K31/136
摘要： Un compuesto de la **fórmula** y estereoisómeros e isómeros ópticos y racematos de la misma así como sales, profármacos, solvatos y formas cristalinas farmacéuticamente aceptables de aquéllos, en cuya fórmula A está situado en la posición meta o para y representa en donde R es -ORa, -SRa, -SCORa o -OSO2Ra, en donde Ra es hidrógeno, alquilo o alquilarilo; R2 es ciano, -ORa en donde Ra es como se define arriba; -NRcCORa en donde Ra es como se define arriba; -CONRcRa en donde Ra es como se define arriba; R1, R3, y R4 se seleccionan independientemente de hidrógeno o alquilo; D está situado en la posición orto, meta o para y representa alquilo sustituido opcionalmente con Rb en donde Rb representa alquilo, arilo, alquilarilo, ciano, -NRcRc, =O, halógeno, -OH, -SH, -Oalquilo, -Oarilo, -Oalquilarilo, -CORc, -SRd, -SORd, o -SO2Rd; ciano; -ORa, en donde Ra es como se define arriba; -NRcCORa, en donde Ra es como se define arriba; -CONRcRa, en donde Ra es como se define arriba; -NRcCOORa, en donde Raes como se define arriba; -OSO2Rd, en donde Rd se define más adelante; -SO2Rd; D'' es hidrógeno; D" es hidrógeno; n es un número entero de 1 a 2; m es un número entero 0 o 1 en donde Rc representa hidrógeno, alquilo, arilo o alquilarilo y Rd representa alquilo, arilo o alquilarilo.

9. 发明专利

TR200402529T4 未知
公开(公告)号：TR200402529T4
公开(公告)日：2004-12-21
申请号：TR200402529
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： FAGERHAG JONAS , LI LANNA , ALSTERMARK EVA-LOTTE LINDSTEDT
IPC分类号： A61P3/10 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/137 , A61K31/165 , A61K31/255 , A61K31/27 , A61K31/275 , A61K31/277 , A61P3/00 , A61P5/48 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C309/66 , C07C309/68 , C07C317/22 , C07C323/16 , A61K31/192 , A61K31/325 , A61K31/136
摘要： The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I)and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

10. 发明专利

PT1237856E 未知
公开(公告)号：PT1237856E
公开(公告)日：2004-08-31
申请号：PT00983619
申请日：2000-11-29
申请人： ASTRAZENECA AB
发明人： BOIJE MARIA , ALSTERMARK EVA-LOTTE LINDSTEDT , OHLSSON BENGT , FAGERHAG JONAS
IPC分类号： A61P3/06 , A61K31/192 , A61K31/255 , A61K31/27 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/12 , C07C59/64 , C07C59/68 , C07C69/734 , C07C271/28 , C07C309/66
摘要： The present invention relates to certain tri-substituted phenyl derivatives and analogues of formula (I), to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

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