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1. 发明申请

WO2011001138A1 VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR OF BIOLOGICAL CELLS 审中-公开
标题翻译：用于表征生物细胞行为特性的振动微生物生物传感
公开(公告)号：WO2011001138A1
公开(公告)日：2011-01-06
申请号：PCT/GB2010/001252
申请日：2010-06-25
申请人： ASTON UNIVERSITY , MA, Xianghong , WU, Zhangming , BRETT, Peter, Nigel , WRIGHT, Michael,T , GRIFFITHS, Helen, R.
发明人： MA, Xianghong , WU, Zhangming , BRETT, Peter, Nigel , WRIGHT, Michael,T , GRIFFITHS, Helen, R.
IPC分类号： G01N27/00 , G01N33/487
CPC分类号： G01N29/036 , G01N2291/0256
摘要： There is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the microplate in a cell culture medium such that at least one biological cell to be characterised is in contact with the microplate; vibrating the microplate; providing a plurality of mutually spaced sensors coupled to the microplate; obtaining a respective sensory data time series from each sensor during vibration of the microplate, the microplate and the sensors being arranged such that the obtained sensory data time series are not independent from one another; and processing the sensory data time series so as to characterise a property or behaviour of the at least one biological cell. A corresponding system for characterising a property or behaviour of at least one biological cell is also described.
摘要翻译：描述了表征至少一个生物细胞的性质或行为的方法。该方法包括以下步骤：提供微板; 将微板的至少一个表面浸入细胞培养基中，使得要表征的至少一个生物细胞与微板接触; 振动微板; 提供耦合到所述微板的多个相互间隔的传感器; 在微板的振动期间从每个传感器获得相应的感觉数据时间序列，微板和传感器被布置成使得所获得的感觉数据时间序列彼此不独立; 以及处理所述感觉数据时间序列，以便表征所述至少一个生物细胞的性质或行为。还描述了用于表征至少一个生物细胞的性质或行为的相应系统。

2. 发明申请

WO2012123749A1 VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR BIOLOGICAL CELLS 审中-公开
标题翻译：用于表征行为生物细胞性质的振动微生物生物传感
公开(公告)号：WO2012123749A1
公开(公告)日：2012-09-20
申请号：PCT/GB2012/050571
申请日：2012-03-15
申请人： ASTON UNIVERSITY , MA, Xianghong , GRIFFITHS, Helen R
发明人： MA, Xianghong , GRIFFITHS, Helen R
IPC分类号： G01N33/487 , G01N29/036 , G01N29/02 , G01N33/543
CPC分类号： G01N33/54306 , G01N29/022 , G01N29/036 , G01N33/487 , G01N33/54366 , G01N2291/0256
摘要： There is described a system for testing a sample. The system comprises a microplate, at least one actuator, a plurality of mutually spaced sensors, and a processor. The microplate has a test portion including an interactive substance. The interactive substance is inherently interactive with a specified test substance. The microplate is arranged such that at least the test portion of the microplate may be brought into contact with the sample. The at least one actuator is operable to vibrate the microplate. The plurality of mutually spaced sensors are coupled to the microplate. Each sensor is operable to provide a respective sensory data time series during vibration of the microplate. The microplate and the sensors are arranged such that the provided sensory data time series are not independent from one another. The processor is operable to receive the sensory data time series from the sensors and to process the received sensory data time series so as to provide information about the test substance in the sample based on the sensed interaction between the test substance and the interactive substance on the test portion of the microplate. A corresponding method of testing a sample is also described.
摘要翻译：描述了一个用于测试样本的系统。该系统包括微板，至少一个致动器，多个相互间隔的传感器和处理器。微板具有包括交互物质的测试部分。互动物质与指定的测试物质本质上是互动的。微板被布置成使得至少微孔板的测试部分可以与样品接触。所述至少一个致动器可操作以使微孔板振动。多个相互间隔的传感器耦合到微板。每个传感器可操作以在微孔板的振动期间提供相应的感觉数据时间序列。微板和传感器布置成使得所提供的感觉数据时间序列彼此不独立。处理器可操作以从传感器接收感官数据时间序列并处理接收到的感觉数据时间序列，以便基于检测物质和相互作用物质之间的相互作用来提供关于样品中测试物质的信息微孔板的测试部分。还描述了测试样品的相应方法。

3. 发明申请

WO2008152402A1 AUTOMATIC DISCRIMINATION OF DYNAMIC BEHAVIOUR 审中-公开
标题翻译：动态行为的自动辨别
公开(公告)号：WO2008152402A1
公开(公告)日：2008-12-18
申请号：PCT/GB2008/002037
申请日：2008-06-16
申请人： ASTON UNIVERSITY , BRETT, Peter, Nigel , MA, Xianghong , ELLIOTT, Mark, T
发明人： BRETT, Peter, Nigel , MA, Xianghong , ELLIOTT, Mark, T
IPC分类号： A61B5/103
CPC分类号： A61B5/1038 , A61B5/7203
摘要： There is described a distributive sensing technology that is able to discriminate between the causes of dynamic disturbances. The system applies a limited number of sensing elements within a sensing medium. The sensing medium itself provides a nonlinear coupling between the dynamic disturbance and the sensors. By interpreting the simultaneous, collective sensed responses of the medium, the nature of the disturbance can be discriminated in such a way as to determine a description, class or category. In particular, there is described a method of categorising the dynamic behaviour of a body, the method comprising: providing a sensing medium coupled to the body during at least a period of the dynamic behaviour of the body; providing a plurality of mutually spaced sensors coupled to the sensing medium; obtaining a respective sensory data time series from each sensor during the dynamic behaviour of the body, the sensing medium and the sensors being arranged such that the obtained sensory data time series are not independent from one another; specifying a dynamic behaviour category; and processing the sensory data time series so as to determine whether the dynamic behaviour of the body is in the specified dynamic behaviour category. Apparatus for performing the method is also described.
摘要翻译：描述了能够区分动态干扰原因的分布式感测技术。该系统在感测介质内应用有限数量的感测元件。感测介质本身提供动态干扰和传感器之间的非线性耦合。通过解释介质的同时，集体感测的响应，可以以确定描述，类别或类别的方式来区分干扰的性质。特别地，描述了对身体的动态行为进行分类的方法，所述方法包括：在身体的动态行为的至少一段时间期间提供耦合到身体的感测介质; 提供耦合到所述感测介质的多个相互间隔的传感器; 在身体的动态行为期间从每个传感器获得各自的感觉数据时间序列，感测介质和传感器被布置成使得所获得的感觉数据时间序列彼此不相关; 指定动态行为类别; 并处理感觉数据时间序列，以便确定身体的动态行为是否在指定的动态行为类别中。还描述了用于执行该方法的装置。

4. 发明申请

WO2005005947A1 SYSTEM AND METHOD FOR SENSING AND INTERPRETING DYNAMIC FORCES 审中-公开
标题翻译：用于感测和解释动力的系统和方法
公开(公告)号：WO2005005947A1
公开(公告)日：2005-01-20
申请号：PCT/GB2004/002963
申请日：2004-07-09
申请人： ASTON UNIVERSITY , BRETT, Peter , MOLLOY, Anthony , MA, Xianghong
发明人： BRETT, Peter , MOLLOY, Anthony , MA, Xianghong
IPC分类号： G01L1/20
CPC分类号： A61B5/1038 , A61B5/4023 , A61B5/7264
摘要： The present invention relates to a sensing system which is capable of discriminating types of causes of changing loads on a surface, such as the type of motion of a human subject. The system has wide ranging applications including sports performance (e.g. golf club swing analysis). The system comprises a deformable load bearing surface (2), a plurality of mutually spaced sensors (6), a processor (8) and an output (10). The sensors (6) are coupled through the deformation response of the surface (2) to an applied load (4) to receive local sensory data from the surface (2). The processor (8) is operatively coupled to the sensors (6) and is arranged to transform the sensory data into information data relating to a load (4) applied to the surface (2), e.g. by means of a neural network algorithm. In an alternative embodiment, a housing including the deformable load bearing surface (2) contains a flowable material (e.g. liquid) which flows in response to the deformation of the surface.
摘要翻译：本发明涉及一种感测系统，其能够区分诸如人类对象的运动类型等改变表面上的负载的原因的种类。该系统具有广泛的应用，包括运动表现（例如高尔夫球杆挥杆分析）。该系统包括可变形负载表面（2），多个相互间隔的传感器（6），处理器（8）和输出（10）。传感器（6）通过表面（2）的变形响应耦合到施加的负载（4），以从表面（2）接收局部感觉数据。处理器（8）可操作地耦合到传感器（6）并且被布置成将感觉数据变换成与施加到表面（2）的负载（4）相关的信息数据，例如，通过神经网络算法。在替代实施例中，包括可变形载荷承载表面（2）的壳体包含响应于表面变形而流动的可流动材料（例如液体）。

5. 发明公开

EP2449367A1 VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR OF BIOLOGICAL CELLS 审中-公开
标题翻译：生物传感器充满活力的微盘生物细胞的行为的属性表征
公开(公告)号：EP2449367A1
公开(公告)日：2012-05-09
申请号：EP10730821.5
申请日：2010-06-25
申请人： Aston University
发明人： MA, Xianghong , WU, Zhangming , BRETT, Peter, Nigel , WRIGHT, Michael,T , GRIFFITHS, Helen, R.
IPC分类号： G01N27/00 , G01N33/487
CPC分类号： G01N29/036 , G01N2291/0256
摘要： There is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the microplate in a cell culture medium such that at least one biological cell to be characterised is in contact with the microplate; vibrating the microplate; providing a plurality of mutually spaced sensors coupled to the microplate; obtaining a respective sensory data time series from each sensor during vibration of the microplate, the microplate and the sensors being arranged such that the obtained sensory data time series are not independent from one another; and processing the sensory data time series so as to characterise a property or behaviour of the at least one biological cell. A corresponding system for characterising a property or behaviour of at least one biological cell is also described.

6. 发明公开

EP2686678A1 VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR BIOLOGICAL CELLS 审中-公开
标题翻译：利用生物传感一个充满活力的微孔板为表征的生物细胞行为的属性
公开(公告)号：EP2686678A1
公开(公告)日：2014-01-22
申请号：EP12716064.6
申请日：2012-03-15
申请人： Aston University
发明人： MA, Xianghong , GRIFFITHS, Helen R
IPC分类号： G01N33/487 , G01N29/036 , G01N29/02 , G01N33/543
CPC分类号： G01N33/54306 , G01N29/022 , G01N29/036 , G01N33/487 , G01N33/54366 , G01N2291/0256
摘要： There is described a system for testing a sample. The system comprises a microplate, at least one actuator, a plurality of mutually spaced sensors, and a processor. The microplate has a test portion including an interactive substance. The interactive substance is inherently interactive with a specified test substance. The microplate is arranged such that at least the test portion of the microplate may be brought into contact with the sample. The at least one actuator is operable to vibrate the microplate. The plurality of mutually spaced sensors are coupled to the microplate. Each sensor is operable to provide a respective sensory data time series during vibration of the microplate. The microplate and the sensors are arranged such that the provided sensory data time series are not independent from one another. The processor is operable to receive the sensory data time series from the sensors and to process the received sensory data time series so as to provide information about the test substance in the sample based on the sensed interaction between the test substance and the interactive substance on the test portion of the microplate. A corresponding method of testing a sample is also described.

7. 发明公开

EP2166944A1 AUTOMATIC DISCRIMINATION OF DYNAMIC BEHAVIOUR 审中-公开
标题翻译：动态特性自动识别
公开(公告)号：EP2166944A1
公开(公告)日：2010-03-31
申请号：EP08762366.6
申请日：2008-06-16
申请人： Aston University
发明人： BRETT, Peter, Nigel , MA, Xianghong , ELLIOTT, Mark, T
IPC分类号： A61B5/103
CPC分类号： A61B5/1038 , A61B5/7203
摘要： There is described a distributive sensing technology that is able to discriminate between the causes of dynamic disturbances. The system applies a limited number of sensing elements within a sensing medium. The sensing medium itself provides a nonlinear coupling between the dynamic disturbance and the sensors. By interpreting the simultaneous, collective sensed responses of the medium, the nature of the disturbance can be discriminated in such a way as to determine a description, class or category. In particular, there is described a method of categorising the dynamic behaviour of a body, the method comprising: providing a sensing medium coupled to the body during at least a period of the dynamic behaviour of the body; providing a plurality of mutually spaced sensors coupled to the sensing medium; obtaining a respective sensory data time series from each sensor during the dynamic behaviour of the body, the sensing medium and the sensors being arranged such that the obtained sensory data time series are not independent from one another; specifying a dynamic behaviour category; and processing the sensory data time series so as to determine whether the dynamic behaviour of the body is in the specified dynamic behaviour category. Apparatus for performing the method is also described.

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