专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008078100A2 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：WO2008078100A2
公开(公告)日：2008-07-03
申请号：PCT/GB2007/004960
申请日：2007-12-21
申请人： ASTEX THERAPEUTICS LIMITED , BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
发明人： BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译：本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。癌症。

2. 发明申请

WO2008078091A1 BICYCLIC HETEROCYCLIC COMPOUNDS AS FGFR INHIBITORS 审中-公开
标题翻译：作为FGFR抑制剂的双相杂环化合物
公开(公告)号：WO2008078091A1
公开(公告)日：2008-07-03
申请号：PCT/GB2007/004934
申请日：2007-12-21
申请人： ASTEX THERAPEUTICS LIMITED , BERDINI, Valerio , BESONG, Gilbert, Ebai , CALLAGHAN, Owen , CARR, Maria, Grazia , CONGREVE, Miles, Stuart , GILL, Adrian, Liam , GRIFFITHS-JONES, Charlotte, Mary , MADIN, Andrew , MURRAY, Christopher, William , NIJJAR, Rajdeep, Kaur , O'BRIEN, Michael, Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard, David , VICKERSTAFFE, Emma
发明人： BERDINI, Valerio , BESONG, Gilbert, Ebai , CALLAGHAN, Owen , CARR, Maria, Grazia , CONGREVE, Miles, Stuart , GILL, Adrian, Liam , GRIFFITHS-JONES, Charlotte, Mary , MADIN, Andrew , MURRAY, Christopher, William , NIJJAR, Rajdeep, Kaur , O'BRIEN, Michael, Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard, David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/437 , C07D471/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译：本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。癌症。

3. 发明申请

WO2008009954A1 MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS 审中-公开
标题翻译：环孢霉素依赖性激酶抑制剂的医学应用
公开(公告)号：WO2008009954A1
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002753
申请日：2007-07-20
申请人： ASTEX THERAPEUTICS LIMITED , PIKE, Andrew , LYONS, John, Francis
发明人： PIKE, Andrew , LYONS, John, Francis
IPC分类号： A61K31/415 , A61K31/44 , A61P13/12 , A61P29/00 , A61P25/00 , A61P9/10 , A61P9/12 , A61P3/10
CPC分类号： A61K31/415 , A61K31/44
摘要： The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0) : or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R 1 -A-NR 4 - or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO 2 , C=O, NR 9 (C=O) or O(C=O) wherein R 9 is hydrogen or C 1-4 hydrocarbyl optionally substituted by hydroxy or C 1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R 1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C 1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C 1-4 hydrocarbyloxy, amino, mono- or di-C 1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO 2 ; R 2 is hydrogen; halogen; C 1-4 alkoxy; or a C 1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C 1-4 alkoxy (e.g. methoxy); R 3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R 4 is hydrogen or a C 1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C 1-4 alkoxy. The invention also provides the use of the compounds of the formula (0) for the treatment of stroke and for the treatment of polycystic kidney disease.
摘要翻译：本发明提供化合物在制备用于治疗疼痛的药物中的用途，其中所述化合物是式（O）的化合物：或其盐或互变异构体或N-氧化物或其溶剂化物; 其中X是基团R 1 -A-NR 4 - 或5或6元碳环或杂环; A是一个键，SO 2，C = O，NR 9（C = O）或O（C = O），其中R 9，是任选被羟基或C 1-4烷氧基取代的氢或C 1-4烃基; Y是长度为1,2或3个碳原子的键或亚烷基链; R 1是氢; 具有3至12个环成员的碳环或杂环基; 或任选被一个或多个选自卤素，羟基，C 1-4烷氧基，氨基，一或二-C 1的取代基取代的C 1-8烃基，具有3至12个环成员的碳环或杂环基团，并且其中烃基的1或2个碳原子可以任选地被选自下列的原子或基团取代：O， S，NH，SO，SO 2; R 2是氢; 卤素; C 1-4烷氧基; 或任选被卤素，羟基或C 1-4烷氧基（例如甲氧基）取代的C 1-4烷基; R 3选自具有3至12个环成员的氢和碳环和杂环基; 和R 4是氢或任选被卤素（例如氟），羟基或C 1-4烷氧基取代的C 1-4烷基。本发明还提供式（O）化合物用于治疗中风和治疗多囊肾病的用途。

4. 发明公开

EP2121687A2 TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS 有权
标题翻译：三环AMIN衍生物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：EP2121687A2
公开(公告)日：2009-11-25
申请号：EP07848681.8
申请日：2007-12-21
申请人： Astex Therapeutics Limited
发明人： BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.

5. 发明公开

EP2046327A1 MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS 审中-公开
标题翻译：激酶抑制剂细胞周期蛋白的医疗用途
公开(公告)号：EP2046327A1
公开(公告)日：2009-04-15
申请号：EP07766316.9
申请日：2007-07-20
申请人： Astex Therapeutics Limited
发明人： PIKE, Andrew , LYONS, John Francis
IPC分类号： A61K31/415 , A61K31/44 , A61P13/12 , A61P29/00 , A61P25/00 , A61P9/10 , A61P9/12 , A61P3/10
CPC分类号： A61K31/415 , A61K31/44
摘要： The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0) : or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NR9(C=O) or O(C=O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy. The invention also provides the use of the compounds of the formula (0) for the treatment of stroke and for the treatment of polycystic kidney disease.

6. 发明授权

EP2121687B1 TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS 有权
标题翻译：三环AMIN衍生物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：EP2121687B1
公开(公告)日：2015-10-14
申请号：EP07848681.8
申请日：2007-12-21
申请人： Astex Therapeutics Limited
发明人： BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04

7. 发明公开

EP2114941A1 BICYCLIC HETEROCYCLIC COMPOUNDS AS FGFR INHIBITORS 有权转让
标题翻译：双环杂环化合物作为抑制剂FGFR
公开(公告)号：EP2114941A1
公开(公告)日：2009-11-11
申请号：EP07848659.4
申请日：2007-12-21
申请人： Astex Therapeutics Limited
发明人： BERDINI, Valerio , BESONG, Gilbert, Ebai , CALLAGHAN, Owen , CARR, Maria, Grazia , CONGREVE, Miles, Stuart , GILL, Adrian, Liam , GRIFFITHS-JONES, Charlotte, Mary , MADIN, Andrew , MURRAY, Christopher, William , NIJJAR, Rajdeep, Kaur , O'BRIEN, Michael, Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard, David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/437 , C07D471/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

9. 发明申请

WO2002075417A1 SUPPORT FOR AN OPTICAL FIBRE 审中-公开
标题翻译：支持光纤
公开(公告)号：WO2002075417A1
公开(公告)日：2002-09-26
申请号：PCT/GB2002/001241
申请日：2002-03-18
申请人： BOOKHAM TECHNOLOGY PLC , PIKE, Andrew , MOODY, Michael
发明人： PIKE, Andrew , MOODY, Michael
IPC分类号： G02B6/44
CPC分类号： G02B6/444
摘要： A support for optical fibre having a first anchor lug (2) adapted to anchor the support to a base and four further lugs (3, 4, 5, 6), the free ends of which lugs extend in a direction remote from the free end of the first lug (2), the four further lugs (3, 4, 5, 6), being spatially arranged so as to provide a bearing surface for an optical fibre and being adapted to receive a brace for the optical fibre.
摘要翻译：一种光纤支撑件，其具有适于将支撑件固定到底座和四个另外的凸耳（3,4,5,6）的第一锚耳（2），其中，所述凸耳的自由端在远离自由端的方向上延伸第一凸耳（2）的四个另外的凸耳（3,4,5,6）在空间上布置成为光纤提供支承表面，并且适于接收光纤支架。

10. 发明申请

WO2007039773A1 USE OF FUSED PYRROLE CARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES AS D-AMINO ACID OXIDASE INHIBITORS 审中-公开
标题翻译：用于治疗作为D-氨基酸氧化酶抑制剂的神经营养因子和心理疾病的融合的吡咯羧酸的用途
公开(公告)号：WO2007039773A1
公开(公告)日：2007-04-12
申请号：PCT/GB2006/050317
申请日：2006-10-05
申请人： MERCK SHARP & DOHME LIMITED , MERCK & CO., INC. , BRANDISH, Philip E. , BRANDON, Nicholas , CAMPBELL, Alister , PIKE, Andrew , SPAREY, Timothy , ZHENG, Wei
发明人： BRANDISH, Philip E. , BRANDON, Nicholas , CAMPBELL, Alister , PIKE, Andrew , SPAREY, Timothy , ZHENG, Wei
IPC分类号： A61K31/33 , A61P25/00
CPC分类号： A61K31/33
摘要： The present invention provides the use of fused pyrrole carboxylic acids of formula (I) for the manufacture of a medicament to inhibit D-amino acid oxidase, particularly for the treatment of neurodegenerative and psychiatric disorders or diseases; certain compounds of formula I being novel, pharmaceutical compositions containing them, their use in medicine and methods of treatment using them are also disclosed.
摘要翻译：本发明提供式（I）的稠合吡咯羧酸用于制备抑制D-氨基酸氧化酶，特别是用于治疗神经变性和精神疾病或疾病的药物的用途; 某些式I化合物是新的，含有它们的药物组合物，它们在医药中的用途以及使用它们的治疗方法也被公开。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式