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1. 发明授权

US3828090A Alkylsulfonic acid esters of 1,3,2-oxazaphospha-cyclic compounds 失效
标题翻译： 1,3,2-OXAZAPHOSPHA-CYCLIC化合物的烷基磺酸酯
公开(公告)号：US3828090A
公开(公告)日：1974-08-06
申请号：US22527372
申请日：1972-02-10
申请人： ASTA WERKE AG CHEM FAB
发明人： ARNOLD H , BOURSEAUX F , POTEL J , BROCK N
IPC分类号： C07F9/6584 , C07D105/02
CPC分类号： C07F9/65844 , C07F9/65846 , Y10S514/885
摘要： NEW ALKYL SULFONIC ACID ESTERS OF 1,3,1-OXAZAPHOSHPACYCLIC COMPOUNDS OF FORMULA 1

R-ALK-N(-R1)-P(=X)
O-)

THESE NEW COMPOUNDS PRODUCE A HIGH IMMUNSUPPRESSING ACTIVITY IN HUMANS.

4. 发明专利

BR6912200D0 未知
公开(公告)号：BR6912200D0
公开(公告)日：1973-05-10
申请号：BR21220069
申请日：1969-09-05
申请人： ASTA WERKE AG CHEM FAB
发明人： ARNOLD H , BROCK N
IPC分类号： C07C217/04 , C07D207/04 , C07D207/09
摘要： The present invention is related to certain new basic alpha -nortricyclyl-(3)-benzyl ethers and salts, quaternary ammonium salts and N-oxides thereof, pharmaceutical composition comprising the same as active principle and a process for the treatment of spasm.

6. 发明专利

DK113291B 未知
公开(公告)号：DK113291B
公开(公告)日：1969-03-10
申请号：DK620966
申请日：1966-12-01
申请人： ASTA WERKE AG CHEM FAB
发明人： ARNOLD H , PAHLS K , REBLING R , BROCK N , LENKE H
IPC分类号： A61K31/495 , C07D243/08 , C07D245/02 , C07D295/10 , C07D53/02
摘要： Novel basic esters (and acid addition salts thereof), of the general formula wherein R is an alkoxy group with 1 to 4 carbon atoms, n is 1, 2 or 3, m is 2 or 3, x is 2, 3 or 4, y is 2 or 3 and x together with y is from 5 to 7, are prepared by the interaction of: (a) a N,N1-bis-o -hydroxyalkyl compound containing the desired heterocyclic nucleus with an alkoxy substituted benzoyl halide, (b) a N,N1-bis-omega -halogenoalkyl compound having the desired heterocyclic nucleus with an alkali or silver salt of an alkoxy substituted benzoic acid, or (c) the desired unsubstituted heterocyclic compound and the desired haloalkyl benzoate. N,N1 - bis - (3 - hydroxypropyl) homopiperazine, N,N1 - bis - (3 - bromopropyl) homopiperazine dihydrobromide and N,N1 - bis - (3 -hydroxypropyl) - 1,5 - diazacyclooctane are prepared by reacting the desired diamine and dihalopropane. Pharmaceutical compositions which produce coronary dilatation contain as the active ingredient the above novel compounds and are administered intravenously and orally.

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