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1. 发明专利

CA2334952A1 ANALYZER FOR DETERMINING COMPONENTS IN A FLUID SAMPLE 未知
公开(公告)号：CA2334952A1
公开(公告)日：1999-12-16
申请号：CA2334952
申请日：1999-06-14
申请人： ASAHI CHEMICAL IND
发明人： KIGUCHI AKIRA , MUKAIYAMA SHIGEMI , SHIMOIDE KOJI , KUROKAWA HIROSHI
IPC分类号： G01N33/48 , G01N21/41 , G01N21/94 , G01N21/95 , G01N25/16 , G01N27/447
摘要： An analyzer characterized by comprising a chip and a detector, wherein the chip is an organic polymer member having a fine capillary through which a fluid sample or a fluid sample and a fluid reagent flow and can perform a chemical reaction on the sample in the capillary without using a separate weighing means, and the detector is a photo-thermal conversion detector for measuring a physical quantity change such as a refractive index change cause d by a partial temperature change of the sample and the reagent by applying an excitation light to a substance to be measured produced by the chemical reaction, thereby providing a small analyzer excellent in chip waste-disposa l, capable of analyzing inexpensively, simply and in a short time and being suitable for a POC analysis.

2. 发明专利

AU746051B2 Analyzer 未知
公开(公告)号：AU746051B2
公开(公告)日：2002-04-11
申请号：AU4165899
申请日：1999-06-14
申请人： ASAHI CHEMICAL IND
发明人： SHIMOIDE KOJI , KIGUCHI AKIRA , MUKAIYAMA SHIGEMI , KUROKAWA HIROSHI
IPC分类号： G01N33/48 , G01N21/41 , G01N21/94 , G01N21/95 , G01N25/16 , G01N27/447
摘要： An analyzer characterized by comprising a chip and a detector, wherein the chip is an organic polymer member having a fine capillary through which a fluid sample or a fluid sample and a fluid reagent flow and can perform a chemical reaction on the sample in the capillary without using a separate weighing means, and the detector is a photothermal conversion detector for measuring a physical quantity change such as a refractive index change caused by a partial temperature change of the sample and the reagent by applying an excitation light to a substance to be measured produced by the chemical reaction, thereby providing a small analyzer excellent in chip waste-disposal, capable of analyzing inexpensively, simply and in a short time and being suitable for a POC analysis.

3. 发明公开

EP1087223A4 ANALYZER 审中-公开
标题翻译：分析单元
公开(公告)号：EP1087223A4
公开(公告)日：2004-06-16
申请号：EP99925313
申请日：1999-06-14
申请人： ASAHI CHEMICAL IND
发明人： SHIMOIDE KOJI , KIGUCHI AKIRA , MUKAIYAMA SHIGEMI , KUROKAWA HIROSHI
IPC分类号： G01N33/48 , G01N21/41 , G01N21/94 , G01N21/95 , G01N25/16 , G01N27/447 , G01N21/17 , B01L3/00
CPC分类号： G01N21/41 , G01N21/05 , G01N2021/0346 , G01N2021/056 , G01N2021/1712
摘要： An analyzer characterized by comprising a chip and a detector, wherein the chip is an organic polymer member having a fine capillary through which a fluid sample or a fluid sample and a fluid reagent flow and can perform a chemical reaction on the sample in the capillary without using a separate weighing means, and the detector is a photo-thermal conversion detector for measuring a physical quantity change such as a refractive index change caused by a partial temperature change of the sample and the reagent by applying an excitation light to a substance to be measured produced by the chemical reaction, thereby providing a small analyzer excellent in chip waste-disposal, capable of analyzing inexpensively, simply and in a short time and being suitable for a POC analysis.

4. 发明专利

CA2334952C ANALYZER FOR DETERMINING COMPONENTS IN A FLUID SAMPLE 未知
公开(公告)号：CA2334952C
公开(公告)日：2006-03-14
申请号：CA2334952
申请日：1999-06-14
申请人： ASAHI CHEMICAL IND
发明人： KIGUCHI AKIRA , SHIMOIDE KOJI , KUROKAWA HIROSHI , MUKAIYAMA SHIGEMI
IPC分类号： G01N25/16 , G01N33/48 , G01N21/41 , G01N21/94 , G01N21/95 , G01N27/447
摘要： An analyzer characterized by comprising a chip and a detector, wherein the chip is an organic polymer member having a fine capillary through which a fluid sample or a fluid sample and a fluid reagent flow and can perform a chemical reaction on the sample in the capillary without using a separate weighing means, and the detector is a photothermal conversion detector for measuring a physical quantity change such as a refractive index change caused by a partial temperature change of the sample and the reagent by applying an excitation light to a substance to be measured produced by the chemical reaction, thereby providing a small analyzer excellent in chip waste-disposal, capable of analyzing inexpensively, simply and in a short time and being suitable for a POC analysis.

5. 发明专利

AU4165899A Analyzer 未知
公开(公告)号：AU4165899A
公开(公告)日：1999-12-30
申请号：AU4165899
申请日：1999-06-14
申请人： ASAHI CHEMICAL IND
发明人： SHIMOIDE KOJI , KIGUCHI AKIRA , MUKAIYAMA SHIGEMI , KUROKAWA HIROSHI
IPC分类号： G01N33/48 , G01N21/41 , G01N21/94 , G01N21/95 , G01N25/16 , G01N27/447
摘要： An analyzer characterized by comprising a chip and a detector, wherein the chip is an organic polymer member having a fine capillary through which a fluid sample or a fluid sample and a fluid reagent flow and can perform a chemical reaction on the sample in the capillary without using a separate weighing means, and the detector is a photothermal conversion detector for measuring a physical quantity change such as a refractive index change caused by a partial temperature change of the sample and the reagent by applying an excitation light to a substance to be measured produced by the chemical reaction, thereby providing a small analyzer excellent in chip waste-disposal, capable of analyzing inexpensively, simply and in a short time and being suitable for a POC analysis.

6. 发明专利

JP2000002677A ANALYZER 失效
公开(公告)号：JP2000002677A
公开(公告)日：2000-01-07
申请号：JP16760398
申请日：1998-06-15
申请人： ASAHI CHEMICAL IND
发明人： MUKOYAMA SHIGEMI , SHIMOIDE KOJI
IPC分类号： G01N25/16 , G01N21/41 , G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To obtain an analyzer whose disposability and mass productivity are excellent and which is low-cost and small by forming a groove on the surface of an organic polymer flat board, irradiating a liquid inside the groove with exciting light, and measuring a change in physical quantity due to the partial temperature change of the liquid. SOLUTION: An organic polymer flat board 25 in which grooves 17 to 21 for capillary molding are provided on the surface and which is 120 cm long, 80 cm wide and 5 mm thick, is molded, and liquid reservoirs 13 to 16 are formed on the opposite side of the grooves 17 to 21. A resin sheet 26 is pasted onto the flat board 25, interconnections 22 and an electrode 24 are formed, and a capillary device is formed. Then, a buffer solution is dropped into the liquid reservoir 16, and the grooves 17 to 21 are filled with the buffer solution. After that, a reagent is dropped into the liquid reservoirs 14, 15, and a specimen is dropped into the liquid reservoir 13. Then, the capillary device is placed on the stage of an inverter microscope, a voltage is applied to the electrode 24, an electroosmotic flow is generated to the liquid reservoir 16 from the liquid reservoirs 13 to 15, the specimen and the reagent are mixed and reacted in the grooves 17 to 19 so as to be guided to a detection part 23, a laser for excitation is irradiated, and the specimen is detected by a photothermal conversion method.

7. 发明专利

JP2000002675A CAPILLARY PHOTOTHERMAL CONVERSION ANALYZER 失效
公开(公告)号：JP2000002675A
公开(公告)日：2000-01-07
申请号：JP18158798
申请日：1998-06-12
申请人： ASAHI CHEMICAL IND
发明人： SHIMOIDE KOJI , KUROKAWA HIROSHI
IPC分类号： G01N25/00 , G01N21/41 , G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To analyze a component in a trace amount while the flow rate is controlled with high accuracy and continuously with a simple, small and low-cost analyzer by a liquid sample inside a capillary (a groove) formed on a chip is changed into an electroosmotic flow, it is irradiated with exciting light and a change in a physical quantity due to the partial temperature change of the liquid sample is measured. SOLUTION: Fine groves 5 to 9 are formed, by an etching work or the like, on the surface of a chip-material flat board 31 such as a glass flat board, a resin flat board or the like. A cover plate 32 is bonded to the flat board 31 which contains the grooves 5 to 9, and a chip which is 12 cm long, 8 cm wide and 3 mm thick is formed. Then, a buffer solution is dropped into a liquid reservoir 4, and the grooves 5 to 9 are filled wholly with the buffer solution. After that, a reagent is dropped into liquid reservoirs 2, 3, and a specimen is dropped into a liquid reservoir 1. The chip is set on an inverted microscope, a high voltage is applied to electrodes 30 in the liquid reservoirs 1 to 3, an electroosmotic flow is generated to the liquid reservoir 4 from the liquid reservoirs 1 to 3, the specimen and the reagent are mixed and reacted in the grooves 5 to 9 so as to be guided to a detection part 12, a laser beam for excitation is radiated, and the specimen is detected by a photothermal conversion method.

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