专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130244264A1 Measurement Method Using Enzyme 有权
标题翻译：使用酶的测定方法
公开(公告)号：US20130244264A1
公开(公告)日：2013-09-19
申请号：US13792798
申请日：2013-03-11
申请人： ARKRAY, INC. , KIKKOMAN BIOCHEMIFA COMPANY
发明人： Koji Sugiyama , Satoshi Yonehara , Kazuhiko Shimoji
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12Q1/54 , G01N33/526 , G01N33/683 , G01N33/723 , G01N33/92
摘要： A method for measuring an analyte is described that includes the steps of: i) preparing a reagent (D) in which an enzyme (A) and an enzyme (B) coexist in the absence of the analyte; ii) bringing the analyte into contact with the enzyme (A) and the enzyme (B) so that the enzyme (A) acts on the analyte to produce a product (E), on which the enzyme (B) does not substantially act, from the analyte; iii) producing a product (C) by allowing the enzyme (A) or an enzyme (F) that is different from the enzyme (A) that acts on the analyte to produce a product (C) to act on the analyte and/or the product (E); and iv) detecting the product (C) by the enzyme (B).
摘要翻译：描述了测量分析物的方法，其包括以下步骤：i）制备其中在不存在分析物的情况下酶（A）和酶（B）共存的试剂（D） ii）使分析物与酶（A）和酶（B）接触，使得酶（A）作用于分析物以产生酶（B）基本上不起作用的产物（E）来自分析物; iii）通过使酶（A）或不同于作用于分析物的酶（A）的酶（F））产生产物（C）以产生作用于分析物的产物（C）和/或产品（E）; 和iv）通过酶（B）检测产物（C）。

2. 发明授权

US08802366B2 Measurement method using enzyme 有权
标题翻译：使用酶的测定方法
公开(公告)号：US08802366B2
公开(公告)日：2014-08-12
申请号：US13792798
申请日：2013-03-11
申请人： ARKRAY, Inc. , Kikkoman Biochemifa Company
发明人： Koji Sugiyama , Satoshi Yonehara , Kazuhiko Shimoji
IPC分类号： C12Q1/00 , C12Q1/37 , C12Q1/26
CPC分类号： C12Q1/37 , C12Q1/54 , G01N33/526 , G01N33/683 , G01N33/723 , G01N33/92
摘要： A method for measuring an analyte is described that includes the steps of: i) preparing a reagent (D) in which an enzyme (A) and an enzyme (B) coexist in the absence of the analyte; ii) bringing the analyte into contact with the enzyme (A) and the enzyme (B) so that the enzyme (A) acts on the analyte to produce a product (E), on which the enzyme (B) does not substantially act, from the analyte; iii) producing a product (C) by allowing the enzyme (A) or an enzyme (F) that is different from the enzyme (A) that acts on the analyte to produce a product (C) to act on the analyte and/or the product (E); and iv) detecting the product (C) by the enzyme (B).
摘要翻译：描述了测量分析物的方法，其包括以下步骤：i）制备其中在不存在分析物的情况下酶（A）和酶（B）共存的试剂（D） ii）使分析物与酶（A）和酶（B）接触，使得酶（A）作用于分析物以产生酶（B）基本上不起作用的产物（E）来自分析物; iii）通过使酶（A）或不同于作用在分析物上的酶（A）的酶（F）产生产物（C）来产生产物（C）以作用于分析物和/或产品（E）; 和iv）通过酶（B）检测产物（C）。

3. 发明授权

US11313863B2 Measurement of glycoprotein 有权
公开(公告)号：US11313863B2
公开(公告)日：2022-04-26
申请号：US16148886
申请日：2018-10-01
申请人： ARKRAY, Inc.
发明人： Takuho Kasai , Satoshi Yonehara
IPC分类号： G01N33/00 , G01N33/68 , C12Q1/26 , G01N33/72 , C07K14/47 , C07K14/76 , C07K14/805 , G01N33/533
摘要： Abstract The disclosure provides a reagent comprising a leuco dye and a compound represented by Formula (I): where R represents a hydrocarbon chain having 8 to 17 carbon atoms, the reagent for measuring glycoprotein, a kit comprising the reagent and a second reagent, and methods of measuring hemoglobin A1c using the reagent.

4. 再颁专利

USRE46130E1 Method of selectively determining glycated hemoglobin 有权
标题翻译：选择性测定糖化血红蛋白的方法
公开(公告)号：USRE46130E1
公开(公告)日：2016-08-30
申请号：US14329019
申请日：2014-07-11
申请人： ARKRAY, Inc.
发明人： Satoshi Yonehara
IPC分类号： C12Q1/54 , C12Q1/26 , G01N33/72 , C12Q1/37
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725
摘要： A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG. 1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated α-amino group as a characteristic structure of HbA1c, an amount of HbA1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.
摘要翻译：提供了测定糖化血红蛋白的方法，通过该方法可以准确且容易地测定样品中糖化血红蛋白的比例。糖化血红蛋白的比例可以通过用蛋白酶选择性降解全血样品中的糖化血红蛋白来得到糖化血红蛋白降解产物; 引起糖化血红蛋白降解产物的糖化位点与果糖基氨基酸氧化还原酶之间的氧化还原反应; 并确定这种氧化还原反应。此外，如图1所示。如图1所示，在全血样品中，通过该方法测定的糖化血红蛋白的比例与HbA1c浓度存在相关性。因此，在不确定糖化α-氨基作为HbA1c的特征结构的情况下，可以从确定的糖化血红蛋白的比例准确，容易地测定HbA1c的量。

5. 再颁专利

USRE45626E1 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine 有权
标题翻译：预处理用于测定糖化胺的样品的方法和测定糖化胺的方法
公开(公告)号：USRE45626E1
公开(公告)日：2015-07-28
申请号：US14326697
申请日：2014-07-09
申请人： ARKRAY, Inc.
发明人： Satoshi Yonehara , Tsuguki Komori
IPC分类号： C12Q1/26 , C12Q1/37 , G01N33/68 , G01N33/00 , C12N9/06 , C12N9/52 , G01N33/72
CPC分类号： C12Q1/26 , C12N9/52 , C12Q1/37 , G01N33/68 , G01N33/723 , G01N2333/906
摘要： The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine. Then, the same FAOD further is added so that the FAOD acts on the degradation product obtained to cause a redox reaction, and the redox reaction is measured.
摘要翻译：本发明提供一种预处理含有糖化胺作为分析物的样品的方法，由此能够高度可靠地测量糖化胺。通过使果糖基氨基酸氧化酶（FAOD）在其上作用，使样品中的糖化氨基酸降解，此后，进一步使FAOD作为样品中的分析物作用于糖化胺以引起氧化还原反应。通过测量氧化还原反应来测定糖化胺的量。引起作用于糖化氨基酸的FAOD的底物特异性可以与引起作用于糖基化胺的FAOD的底物特异性相同或不同。当使用相同的FAOD时，使FAOD作用于糖化氨基酸以使其降解，然后用蛋白酶处理样品以使FAOD失活并降解糖化胺。然后，加入相同的FAOD，使得FAOD作用于所得到的降解产物以引起氧化还原反应，并测量氧化还原反应。

6. 发明申请

US20190137502A1 Measurement of Glycoprotein 审中-公开
公开(公告)号：US20190137502A1
公开(公告)日：2019-05-09
申请号：US16148889
申请日：2018-10-01
申请人： ARKRAY, Inc.
发明人： Satoshi Yonehara
IPC分类号： G01N33/58 , C07K14/805 , C07K14/76 , C07K14/47 , G01N33/52 , G01N33/68
摘要： Provided is a method for measuring a glycoprotein using an enzymatic method, and the method includes simplified steps.

7. 发明申请

US20190137509A1 Measurement of Glycoprotein 审中-公开
公开(公告)号：US20190137509A1
公开(公告)日：2019-05-09
申请号：US16148886
申请日：2018-10-01
申请人： ARKRAY, Inc.
发明人： Takuho Kasai , Satoshi Yonehara
IPC分类号： G01N33/68 , C07K14/76 , C07K14/47 , C07K14/805 , G01N33/533
摘要： Provided is a reagent that is suitable for measurement of a glycoprotein and contains a compound capable of stabilizing a leuco dye.

8. 再颁专利

USRE46105E1 Method of selectively determining glycated hemoglobin 有权
公开(公告)号：USRE46105E1
公开(公告)日：2016-08-16
申请号：US14521534
申请日：2014-10-23
申请人： ARKRAY, Inc.
发明人： Satoshi Yonehara
IPC分类号： C12Q1/54 , C12Q1/26 , G01N33/72 , C12Q1/37
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725
摘要： A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG. 1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated α-amino group as a characteristic structure of HbA1c, an amount of HbA1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.

9. 发明申请

US20150219595A1 Process for Analyzing Sample by Capillary Electrophoresis Method 审中-公开
标题翻译：通过毛细管电泳法分析样品的方法
公开(公告)号：US20150219595A1
公开(公告)日：2015-08-06
申请号：US14686366
申请日：2015-04-14
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , ARKRAY, Inc.
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows for high analytic precision and reduction in apparatus size, and can be readily carried out by electrophoresing a complex of a sample and an anionic group-containing compound in the capillary channel, wherein the capillary channel includes an A layer that is coated on an inner wall thereof and a B layer that is coated on the A layer, where the A and B layers are as described.
摘要翻译：提供了通过毛细管电泳方法分析样品的方法，其允许高分析精度和装置尺寸的降低，并且可以容易地通过在毛细通道中电泳样品和含阴离子基团的化合物的络合物来进行，其中毛细通道包括涂覆在其内壁上的A层和涂覆在A层上的B层，其中A层和B层如上所述。

10. 发明授权

US10989714B2 Measurement of glycoprotein 有权
公开(公告)号：US10989714B2
公开(公告)日：2021-04-27
申请号：US16148889
申请日：2018-10-01
申请人： ARKRAY, Inc.
发明人： Satoshi Yonehara
IPC分类号： C12Q1/26 , G01N33/52 , G01N33/58 , G01N33/68 , G01N33/72 , C07K14/47 , C07K14/76 , C07K14/805
摘要： Provided is a method for measuring a glycoprotein using an enzymatic method, and the method includes simplified steps.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式