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1. 发明申请

WO2018027117A1 ULTRA-SOFT COATINGS FOR INTERFACES WITH BRAIN AND OTHER SOFT TISSUES 审中-公开
标题翻译： ULTRA-SOFT涂层用于与脑和其他软组织接口
公开(公告)号：WO2018027117A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045470
申请日：2017-08-04
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： SRIDHARAN, Arati , MUTHUSWAMY, Jitendran
IPC分类号： C01B32/174 , C01B32/15 , C08K7/24 , C09D1/00 , H01B1/04
摘要： A soft conductive composition can include: a crosslinked silicone composition; and single-walled or multi-walled carbon nanotubes in the silicone composition. A neural probe or other implant can include the soft conducive composition on a least a portion of the implant body. A method of making an implant can include: selecting PDMS precursors; cross-linking the PDMS precursor to obtain an elastic modulus of about 3-9 kPa or +/- 1%, 5%, 10%, 20%, or 50%; selecting the carbon nanotubes; introducing the carbon nanotubes into the crosslinked PDMS to form a soft conductive composite composition; and coating the soft conductive composite composition onto at least a portion of an implant. A method of measuring properties at a neural interface can include: providing a neural probe having a soft conductive composition; implanting the neural probe having the soft conductive composition at a neural interface; and measuring a property with the neural probe.
摘要翻译：软导电组合物可以包括：交联的硅氧烷组合物; 以及硅氧烷组合物中的单壁或多壁碳纳米管。神经探针或其他植入物可以在植入物本体的至少一部分上包括软导组合物。制造植入物的方法可以包括：选择PDMS前体; 交联PDMS前体以获得约3-9kPa或+/- 1％，5％，10％，20％或50％的弹性模量; 选择碳纳米管; 将碳纳米管引入交联的PDMS中以形成软导电复合材料组合物; 和将软导电复合组合物涂覆到植入物的至少一部分上。测量神经界面处的特性的方法可以包括：提供具有软导电组合物的神经探针; 将具有软导电组合物的神经探针植入神经界面; 并用神经探针测量性质。

2. 发明申请

WO2022256741A1 SENSOR FOR DETECTING BIOMARKERS IN A FLUID SAMPLE AND METHODS OF USE 审中-公开
公开(公告)号：WO2022256741A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/032379
申请日：2022-06-06
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , AMERICAN UNIVERSITY OF BEIRUT
发明人： MUTHUSWAMY, Jitendran , SRIDHARAN, Arati , KHRAICHE, Massoud
IPC分类号： C12Q1/68 , G01N33/50 , A61B5/157
摘要： The invention relates to a diagnostic platform for detection of biomarkers associated with a particular condition, disease, or disorder and methods of making and using the same. In various embodiments, the diagnostic platform includes a sensing device and an electronic reading platform. Aspects of the invention are directed to a diagnostic platform for detection of at least one biomarker in a fluid sample. In embodiments, the diagnostic platform comprises a sensing device configured to receive the fluid sample. The platform can further comprise an electronic reading platform and a computing device. The electronic reading platform can be configured to activate the sensor.

3. 发明申请

WO2015156862A3 INTEGRATED HIGH-RESOLUTION UNTETHERED FLEXIBLE NEURAL IMPLANT 审中-公开
公开(公告)号：WO2015156862A3
公开(公告)日：2015-10-15
申请号：PCT/US2015/011092
申请日：2015-01-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： SMITH, Joseph , O'BRIEN, Barry , LEE, Yong-Kyn , BAWOLEK, Edward , CHRISTEN, Jennifer, Blain , GORYLL, Michael , MUTHUSWAMY, Jitendran , KUNNEN, George , ALLEE, David
IPC分类号： A61N5/06
摘要： Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

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