专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011064300A1 ORTHOESTER DERIVATIVES OF CROWN ETHERS AS CARRIERS FOR PHARMACEUTICAL AND DIAGNOSTIC COMPOSITIONS 审中-公开
标题翻译：作为药物和诊断组合物的载体的其他药物的代谢物衍生物
公开(公告)号：WO2011064300A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/068224
申请日：2010-11-25
申请人： ARISGEN SA , BOTTI, Paolo , TCHERTCHIAN, Sylvie , THEURILLAT, Doriane
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie , THEURILLAT, Doriane
IPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10 , A61K31/365
CPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10
摘要： This invention relates to A crown ether of formula (I) wherein m is 4, 5, 6, 7, or 8 and i is, independently for each occurrence, 1 or 2; at least one occurrence in the crown ether of R 1 , R 2 and the carbon to which R 1 and R 2 are attached, said carbon being bound directly to an ether oxygen of formula (I), form together a group of formula (II) wherein L is a linker which is absent or selected from a covalent bond and (CR 5 R 6 ) n , useful as carriers for pharmaceutical and diagnostic compositions.
摘要翻译：本发明涉及式（I）的冠醚，其中m为4,5,6,7或8，i独立地为每次出现1或2; 在R 1，R 2和R 1和R 2连接的碳的至少一个存在下，所述碳直接键合到式（I）的醚氧上，一起形成式（II）的基团，其中L是不存在或选自共价键的接头和用作药物和诊断组合物的载体的（CR5R6）n。

2. 发明申请

WO2012160203A1 MUCOSAL DELIVERY OF DRUGS 审中-公开
标题翻译：药物输送
公开(公告)号：WO2012160203A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059890
申请日：2012-05-25
申请人： ARISGEN SA , BOTTI, Paolo , TCHERTCHIAN, Sylvie
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
IPC分类号： A61K47/14 , A61K47/24 , A61K47/28 , A61K38/00 , A61K47/48 , A61K9/00
CPC分类号： A61K47/22 , A61K9/0014 , A61K38/11 , A61K38/2278 , A61K38/23 , A61K38/26 , A61K38/28 , A61K38/29 , A61K47/14 , A61K47/24 , A61K47/28
摘要： The present invention provides a composition comprising or consisting of components (a) (i) at least one mono-alkanoyl glycerol ester, wherein alkanoyl is selected from C 4 to C 21 alkanoyl, preferably from octanoyl and decanoyl; and (b) (i) at least one compound selected from cholesterol, phosphatidyl cholines and phosphatidyl glycerols, wherein the acyl moieties of the phosphatidyl moieties are independently selected from C 6 to C 21 alkanoyi and C 6 to C 21 alkenoyl.
摘要翻译：本发明提供一种组合物，其包含或由组分（a）（i）组成，至少一种单烷酰基甘油酯，其中烷酰基选自C 4至C 21烷酰基，优选为辛酰基和癸酰基; 和（b）（i）至少一种选自胆固醇，磷脂酰胆碱和磷脂酰甘油的化合物，其中磷脂酰部分的酰基部分独立地选自C6至C21链烷酰基和C6至C21链烯酰基。

3. 发明申请

WO2006133962A1 SIDE-CHAIN EXTENDED LIGATION 审中-公开
标题翻译：侧链延长码
公开(公告)号：WO2006133962A1
公开(公告)日：2006-12-21
申请号：PCT/EP2006/005815
申请日：2006-06-16
申请人： GENEPROT INC. , BOTTI, Paolo , TCHERTCHIAN, Sylvie
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
IPC分类号： C07K1/04
CPC分类号： C07K1/04 , C07K1/026
摘要： The invention is directed to methods and compositions for chemical ligation of a first component that includes a carboxythioester and a second component that includes an amino-functionalized compound bearing a branched side chain that includes a removable thiol auxiliary, to give a ligation product having an amide bond at the ligation site. The reactants of the invention are chemoselective and the thiol moiety is removable from the ligation product. Removal of the thiol can be exploited to generate a native side chain at the ligation site. The methods and compositions of the invention are particularly useful for ligation of peptides and polypeptides. The ligation system of the invention is applicable to a wide variety of molecules, and thus can be exploited to generate peptides, polypeptides and other amino acid containing polymers.
摘要翻译：本发明涉及用于化学连接第一组分的方法和组合物，所述第一组分包括羧基硫酯和第二组分，所述第二组分包括带有支链侧链的氨基官能化化合物，其包含可除去的硫醇辅助剂，得到具有酰胺的连接产物结扎部位的结合。本发明的反应物是化学选择性的，硫醇部分可从连接产物中除去。可以利用硫醇的去除在结合位点产生天然侧链。本发明的方法和组合物特别适用于肽和多肽的连接。本发明的连接系统可应用于各种各样的分子，因此可用于产生肽，多肽和其它含氨基酸的聚合物。

4. 发明公开

EP2504019A2 MUCOSAL DELIVERY COMPOSITION COMPRISING A PEPTIDE COMPLEXED WITH A CROWN COMPOUND AND/OR A COUNTER ION 无效转让
标题翻译：组成行政黏膜到肽的复合物和冠连接和/或反离子
公开(公告)号：EP2504019A2
公开(公告)日：2012-10-03
申请号：EP10781909.6
申请日：2010-11-25
申请人： ArisGen SA , Tchertchian, Sylvie
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
IPC分类号： A61K38/00 , A61K47/48 , A61K9/00 , A61K9/12 , A61K47/22 , A61K38/26
CPC分类号： A61K9/006 , A61K9/12 , A61K38/02 , A61K38/26 , A61K47/22 , A61K47/545
摘要： Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a nonaqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.
摘要翻译：提供了肽粘膜递送的组合物和方法。该组合物包括与冠化合物和/或在从所述肽活性剂的等电点不同的pH值在所述的非水疏水性媒介物溶解的抗衡离子络合的稳定水合肽活性剂。该方法包括施用给在有效量的本公开的组合物的受试者。其他方面包括本发明的组合物的制备方法。因此，提供了组合物和试剂盒确实在实践公开的实施方案有用的。方法和组合物可用于各种各样的应用，包括各种不同的疾病症状的药物。

5. 发明申请

WO2011064316A2 MUCOSAL DELIVERY OF PEPTIDES 审中-公开
标题翻译：胶原蛋白交付
公开(公告)号：WO2011064316A2
公开(公告)日：2011-06-03
申请号：PCT/EP2010/068257
申请日：2010-11-25
申请人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
CPC分类号： A61K9/006 , A61K9/12 , A61K38/02 , A61K38/26 , A61K47/22 , A61K47/545
摘要： Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a nonaqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.
摘要翻译：提供组合物和方法用于肽的粘膜递送。组合物包括与不同于肽活性剂的pI的pH的与非水性疏水载体溶解的冠状化合物和/或抗衡离子配合的稳定水合的肽活性剂。所述方法包括向受试者施用有效量的本发明的组合物。其它方面包括制造本公开的组合物的方法。还提供了在实践本公开的实施方案中使用的组合物和试剂盒。所述方法和组合物可用于各种应用，包括治疗各种不同疾病状况。

6. 发明公开

EP2714088A1 MUCOSAL DELIVERY OF DRUGS 有权
标题翻译：粘膜释放药物的
公开(公告)号：EP2714088A1
公开(公告)日：2014-04-09
申请号：EP12726047.9
申请日：2012-05-25
申请人： ArisGen SA
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
IPC分类号： A61K47/14 , A61K47/24 , A61K47/28 , A61K38/00 , A61K47/48 , A61K9/00
CPC分类号： A61K47/22 , A61K9/0014 , A61K38/11 , A61K38/2278 , A61K38/23 , A61K38/26 , A61K38/28 , A61K38/29 , A61K47/14 , A61K47/24 , A61K47/28
摘要： The present invention provides a composition comprising or consisting of components (a) (i) at least one mono-alkanoyl glycerol ester, wherein alkanoyl is selected from C
4 to C
21 alkanoyl, preferably from octanoyl and decanoyl; and (b) (i) at least one compound selected from cholesterol, phosphatidyl cholines and phosphatidyl glycerols, wherein the acyl moieties of the phosphatidyl moieties are independently selected from C
6 to C
21 alkanoyi and C
6 to C
21 alkenoyl.

7. 发明授权

EP2504327B1 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions 有权转让
标题翻译：冠醚的原酸酯衍生物作为用于诊断和药物组合物的载体
公开(公告)号：EP2504327B1
公开(公告)日：2015-07-29
申请号：EP10784504.2
申请日：2010-11-25
申请人： ArisGen SA
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie , THEURILLAT, Doriane
IPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10 , A61K31/365
CPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10

8. 发明公开

EP2504327A1 ORTHOESTER DERIVATIVES OF CROWN ETHERS AS CARRIERS FOR PHARMACEUTICAL AND DIAGNOSTIC COMPOSITIONS 有权转让
标题翻译：冠醚的原酸酯衍生物作为用于诊断和药物组合物的载体
公开(公告)号：EP2504327A1
公开(公告)日：2012-10-03
申请号：EP10784504.2
申请日：2010-11-25
申请人： ArisGen SA
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie , THEURILLAT, Doriane
IPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10 , A61K31/365
CPC分类号： C07D323/00 , C07D493/10 , C07D493/20 , C07D495/10
摘要： This invention relates to A crown ether of formula (I) wherein m is 4, 5, 6, 7, or 8 and i is, independently for each occurrence, 1 or 2; at least one occurrence in the crown ether of R
1 , R
2 and the carbon to which R
1 and R
2 are attached, said carbon being bound directly to an ether oxygen of formula (I), form together a group of formula (II) wherein L is a linker which is absent or selected from a covalent bond and (CR
5 R
6 )
n , useful as carriers for pharmaceutical and diagnostic compositions.

9. 发明授权

EP2714088B1 MUCOSAL DELIVERY OF DRUGS 有权
标题翻译： MUKOSALE FREISETZUNG VON ARZNEIMITTELN
公开(公告)号：EP2714088B1
公开(公告)日：2015-11-25
申请号：EP12726047.9
申请日：2012-05-25
申请人： ArisGen SA
发明人： BOTTI, Paolo , TCHERTCHIAN, Sylvie
IPC分类号： A61K47/14 , A61K47/24 , A61K47/28 , A61K38/00 , A61K47/48 , A61K9/00
CPC分类号： A61K47/22 , A61K9/0014 , A61K38/11 , A61K38/2278 , A61K38/23 , A61K38/26 , A61K38/28 , A61K38/29 , A61K47/14 , A61K47/24 , A61K47/28

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式