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1. 发明申请

WO2007136680A3 3-PYRAZ0LYL-BENZAMIDE-4-ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗与相关疾病有关的5-HT2A丝氨酸受体有用的调节剂的3-氨基吡啶-4-酮，其次级胺和衍生物
公开(公告)号：WO2007136680A3
公开(公告)日：2008-01-10
申请号：PCT/US2007011789
申请日：2007-05-17
申请人： ARENA PHARM INC , TEEGARDEN BRADLEY , CHAPMAN DENNIS , DECAIRE MARC , DOSA PETER I , FEICHTINGER KONRAD , JAYAKUMAR HONNAPPA , STRAH-PLEYNET SONJA , TRAN THUY-ANH , XU JINGDONG
发明人： TEEGARDEN BRADLEY , CHAPMAN DENNIS , DECAIRE MARC , DOSA PETER I , FEICHTINGER KONRAD , JAYAKUMAR HONNAPPA , STRAH-PLEYNET SONJA , TRAN THUY-ANH , XU JINGDONG
IPC分类号： C07D413/12 , A61K31/4192 , A61K31/42 , A61K31/427 , A61K31/454 , A61P7/02 , A61P9/10 , A61P25/00 , C07D231/12 , C07D231/16 , C07D403/12 , C07D411/12
CPC分类号： C07D231/12 , A61K31/415 , C07D207/335 , C07D207/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：本发明涉及某些调节5-HT2A 5-羟色胺受体活性的式（Ia）化合物及其药物组合物。化合物及其药物组合物涉及可用于治疗血小板凝集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，血块形成，哮喘或其症状，躁动或其症状的方法，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，睡眠障碍，睡眠障碍，糖尿病性精神病，精神病，精神病，精神病，相关疾病，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT2A 5-羟色胺受体相关疾病的方法。

2. 发明申请

WO2005095357A3 PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF 审中-公开
标题翻译：吡嗪衍生物及其使用相关的治疗方法
公开(公告)号：WO2005095357A3
公开(公告)日：2006-01-19
申请号：PCT/JP2005006582
申请日：2005-03-29
申请人： TAISHO PHARMA CO LTD , ARENA PHARM INC , SEKIGUCHI YOSHINORI , KANUMA KOSUKE , OMODERA KATSUNORI , TRAN THUY-ANH , SEMPLE GRAEME , KRAMER BRYAN A
发明人： SEKIGUCHI YOSHINORI , KANUMA KOSUKE , OMODERA KATSUNORI , TRAN THUY-ANH , SEMPLE GRAEME , KRAMER BRYAN A
IPC分类号： C07D239/48 , A61K31/505 , A61P3/04 , A61P3/10 , C07D239/00 , C07D239/42 , C07D239/54 , C07D239/545 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D473/34 , C07D487/04
CPC分类号： C07D239/42 , C07D239/48 , C07D239/545 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D473/34 , C07D487/04
摘要： The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.
摘要翻译：本发明包括式（I）的新型取代嘧啶化合物：其作为MCH受体拮抗剂。这些化合物可用于药物组合物，其用途包括预防或治疗改善记忆功能，睡眠和觉醒，焦虑，抑郁，情绪障碍，癫痫发作，肥胖症，糖尿病，食欲和进食障碍，心血管疾病，高血压，血脂异常，心肌梗死，包括贪食症，厌食症，包括躁狂抑郁症，精神分裂症，del妄，痴呆，压力，认知障碍，注意力缺陷障碍，药物滥用障碍和包括帕金森氏病，癫痫和成瘾在内的运动障碍的暴饮暴食症。

3. 发明申请

WO03028641A2 MCH RECEPTOR ANTAGONISTS 审中-公开
标题翻译： MCH受体拮抗剂
公开(公告)号：WO03028641A2
公开(公告)日：2003-04-10
申请号：PCT/US0231059
申请日：2002-09-30
申请人： TAISHO PHARMA CO LTD , SEKIGUCHI YOSHINORI , KANUMA KOSUKE , OMODERA KATSUNORI , TRAN THUY-ANH , KRAMER BRYAN AUBREY , BEELEY NIGEL ROBERT ARNOLD
发明人： SEKIGUCHI YOSHINORI , KANUMA KOSUKE , OMODERA KATSUNORI , TRAN THUY-ANH , KRAMER BRYAN AUBREY , BEELEY NIGEL ROBERT ARNOLD
IPC分类号： A61K31/18 , A61K31/381 , A61K31/517 , A61K31/5377 , A61K31/538 , A61P3/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07C311/18 , C07C311/29 , C07C311/41 , C07D239/95 , C07D333/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04 , A61K
CPC分类号： C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel compounds of the formula (I) which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of obesity, obesity related disorders, anxiety, or depression.
摘要翻译：本发明涉及作为MCH受体拮抗剂的新的式（I）化合物。这些组合物可用于其用途包括预防或治疗肥胖症，肥胖症相关病症，焦虑症或抑郁症的药物组合物中。

4. 发明公开

EP1611109A4 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF 审中-公开
标题翻译： NEW喹唑啉衍生物和治疗与IN相关使用方法
公开(公告)号：EP1611109A4
公开(公告)日：2009-06-24
申请号：EP04724424
申请日：2004-03-30
申请人： TAISHO PHARMA CO LTD , ARENA PHARM INC
发明人： SEKIGUCHI YOSHINORI , KANUMA KOSUKE , OMODERA KATSUNORI , BUSUJIMA TSUYOSHI , TRAN THUY-ANH , HAN SANGDON , CASPER MARTIN , KRAMER BRYAN A
IPC分类号： C07D239/84 , A61K31/517 , A61P3/00 , A61P3/04 , A61P9/00 , A61P9/12 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07D239/95 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D239/95 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to novel compounds of Formula (I): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

5. 发明专利

AU2021206809B2 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto 未知
公开(公告)号：AU2021206809B2
公开(公告)日：2023-01-05
申请号：AU2021206809
申请日：2021-07-20
申请人： ARENA PHARM INC
发明人： DO QUYEN-QUYEN , TRAN THUY-ANH , ULLMAN BRETT
IPC分类号： C07D491/107 , A61K31/4355 , A61P9/00
摘要： The present invention relates to compounds of Formula (la) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and/or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and/or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF

6. 发明专利

HK1257652A1 作為前列環素(PGI2)受體調節劑用於治療該受體相關病症的吡唑基取代的碳酸衍生物未知
公开(公告)号：HK1257652A1
公开(公告)日：2019-10-25
申请号：HK19100010
申请日：2019-01-02
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , IBARRA JASON B , SHIN YOUNG-JUN , ULLMAN BRETT , ZOU NING , ZENG XI
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

7. 发明专利

MA44037A1 Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci 未知
公开(公告)号：MA44037A1
公开(公告)日：2019-05-31
申请号：MA44037
申请日：2017-06-04
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , DO QUYEN-QUYEN , ULLMAN BRETT
IPC分类号： A61K31/4355 , A61P9/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/107
摘要： Cette invention concerne certains composés de formule (ia) et leurs compositions pharmaceutiques qui modulent l'activité du récepteur adrénergique bêta 3. Des composés de la présente invention et leurs compositions pharmaceutiques ciblent des procédés utiles dans le traitement d'un trouble médié par le récepteur adrénergique bêta 3, tel que l'insuffisance cardiaque, l'activité cardiaque dans l'insuffisance cardiaque, la mortalité, la récidive d'infarctus et/ou l'hospitalisation en relation avec l'insuffis

8. 发明专利

ECSP19001018A MODULADORES DEL RECEPTOR ADRENÉRGICO BETA -3 ÚTILES PARA EL TRATAMIENTO O PREVENCIÓN DE TRASTORNOS RELACIONADOS CON LOS MISMOS 未知
公开(公告)号：ECSP19001018A
公开(公告)日：2019-02-28
申请号：ECDI201901018
申请日：2019-01-07
申请人： ARENA PHARM INC
发明人： DO QUYEN-QUYEN , ULLMAN BRETT , TRAN THUY-ANH
IPC分类号： C07D491/107 , A61K31/4355 , A61P9/00
摘要： Compuestos de Fórmula(Ia) y composiciones farmacéuticas de los mismos que modulan la actividad del receptor adrenérgico beta-3.Compuestos de la presente invención y composiciones farmacéuticas de los mismos se dirigen a métodos útiles en el tratamiento de un trastorno mediado por receptor adrenérgico beta-3, tal como insuficiencia cardiaca;rendimiento cardíaco en insuficiencia cardiaca;mortalidad,infarto de miocardio y/o hospitalización en conexión con insuficiencia cardiaca;insuficiencia cardiaca aguda;insuficiencia cardiaca congestiva aguda;insuficiencia cardiaca congestiva;insuficiencia cardiaca congestiva severa;daño del órgano asociado con insuficiencia cardiaca(ejemplo Daño o falla del riñón,problemas de la válvula cardiaca,problemas del ritmo cardiaco y/o daño del hígado);fallo cardíaco debido a la disfunción ventricular izquierda;insuficiencia cardiaca con fracción de expulsión normal;mortalidad cardiovascular después de infarto de miocardio;mortalidad cardiovascular en pacientes con insuficiencia ventricular izquierda o disfunción ventricular izquierda;fallo ventricular izquierdo;disfunción del corazón de la clase II utilizando el sistema de clasificación de la Asociación de corazón de Nueva York (NYHA);insuficiencia cardiaca de la clase III utilizando la Nueva York heart Association(NYHA) sistema de clasificación;insuficiencia cardiaca de la clase IV utilizando la Nueva York heart Association(NYHA) sistema de clasificación;LVEF 40% mediante ventriculografía(sigue)

9. 发明专利

ES2525244T9 Moduladores del receptor de prostaciclina (PGI2) útiles para el tratamiento de trastornos relacionados con el mismo 未知
公开(公告)号：ES2525244T9
公开(公告)日：2016-03-23
申请号：ES09721284
申请日：2009-03-17
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU J M , SHYFRYNA HANNA L , SHIN YOUNG-JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61K31/17 , A61K31/27 , A61P43/00 , C07C271/08 , C07C275/18

10. 发明专利

PL2370413T3 Modulatory receptora prostacykliny (PGI2) użyteczne w leczeniu zaburzeń z nimi związanych 未知
公开(公告)号：PL2370413T3
公开(公告)日：2016-01-29
申请号：PL09775380
申请日：2009-12-07
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , HAYASHI RENA , IBARRA JASON B , ULLMAN BRETT , ZOU NING
IPC分类号： C07D237/14 , A61K31/50 , A61K31/501 , A61K31/53 , A61P11/08 , C07D253/07 , C07D401/04 , C07D403/04 , C07D409/04

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