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1. 发明专利

HK1244005B 5-HT2C受體激動劑和組合物和使用方法未知
公开(公告)号：HK1244005B
公开(公告)日：2020-04-17
申请号：HK18103485
申请日：2018-03-13
申请人： ARENA PHARM INC
发明人： REN ALBERT S , SEMPLE GRAEME , ZHU XIUWEN , SAGE CARLETON R
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

2. 发明专利

DOP2014000096A MODULADORES DEL RECEPTOR MAS ACOPLADO A LA PROTEÍNA G Y EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON EL MISMO 未知
公开(公告)号：DOP2014000096A
公开(公告)日：2014-07-15
申请号：DO2014000096
申请日：2014-05-07
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , BLACKBURN ANTHONY C , KRAMER BRYAN A , NAGURA MAIKO , SAGE CARLETON R , SHIN YOUNG-JUN , ZOU NING
IPC分类号： A61K31/496 , A61P9/00 , C07D241/04
摘要： La presente invención se refiere a compuestos de Fórmula (I) y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos: que son útiles en métodos para tratar y aliviar enfermedades y trastornos del corazón, cerebro, riñón, sistema inmune y reproductivo que resultan de isquemia o reperfusión posterior a isquemia y cualquier complicación o complicaciones posteriores relacionadas con los mismos. La presente invención se refiere, además, a métodos para tratar y aliviar enfermedades y trastornos de la vasculatura que resultan de vasoconstricción o hipertensión y cualquier complicación o complicaciones posteriores que resultan de presión arterial elevada y/o perfusión tisular reducida.

3. 发明专利

SG11201401743RA MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO 未知
公开(公告)号：SG11201401743RA
公开(公告)日：2014-05-29
申请号：SG11201401743R
申请日：2012-11-07
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , BLACKBURN ANTHONY C , KRAMER BRYAN A , NAGURA MAIKO , SAGE CARLETON R , SHIN YOUNG-JUN , ZOU NING
IPC分类号： A61K31/496 , C07D241/04 , A61P9/00
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof: that are useful in methods of treatment and alleviation of diseases and disorders of the heart, brain, kidney, immune, and reproductive system resulting from ischemia, or reperfusion subsequent to ischemia, and any downstream complication(s) related thereto. The present invention further relates to methods of treatment and alleviation of diseases and disorders of the vasculature resulting from vasoconstriction or hypertension and any downstream complication(s) resulting from elevated blood pressure and/or reduced tissue perfusion.

4. 发明专利

CA2853833A1 MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO 未知
公开(公告)号：CA2853833A1
公开(公告)日：2013-05-16
申请号：CA2853833
申请日：2012-11-07
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , BLACKBURN ANTHONY C , KRAMER BRYAN A , NAGURA MAIKO , SAGE CARLETON R , SHIN YOUNG-JUN , ZOU NING
IPC分类号： C07D241/04 , A61K31/496 , A61P9/00
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof that are useful in methods of treatment and alleviation of diseases and disorders of the heart, brain, kidney, immune, and reproductive system resulting from ischemia, or reperfusion subsequent to ischemia, and any downstream complication(s) related thereto. The present invention further relates to methods of treatment and alleviation of diseases and disorders of the vasculature resulting from vasoconstriction or hypertension and any downstream complication(s) resulting from elevated blood pressure and/or reduced tissue perfusion.

5. 发明专利

AU2004257267B2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 未知
公开(公告)号：AU2004257267B2
公开(公告)日：2009-12-03
申请号：AU2004257267
申请日：2004-07-13
申请人： ARENA PHARM INC
发明人： XIONG YIFENG , CHOI JIN SUN KAROLINE , CALDERON IMELDA , SHIN YOUNG-JUN , JONES ROBERT M , SEMPLE GRAEME , SAGE CARLETON R , REN ALBERT S , FIORAVANTI BEATRIZ
IPC分类号： A61P3/00 , A61P3/10 , C07D215/22 , C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

6. 发明专利

BRPI0412689A 未知
公开(公告)号：BRPI0412689A
公开(公告)日：2006-10-03
申请号：BRPI0412689
申请日：2004-07-13
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , SEMPLE GRAEME , XIONG YIFENG , SHIN YOUNG-JUN , REN ALBERT S , CALDERON IMELDA , SAGE CARLETON R , FIORAVANTI BEATRIZ , CHOI JIN SUN KAROLINE
IPC分类号： A61P3/00 , A61P3/10 , C07D215/22 , C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

7. 发明专利

ECSP066284A ARIL Y HETEROARIL DERIVADOS FUSIONADOS COMO MODULADORES DEL METABOLISMO Y LA PREVENCIÓN Y TRATAMIENTO DE TRASTORNOS RELACIONADOS CON EL MISMO 未知
公开(公告)号：ECSP066284A
公开(公告)日：2006-07-28
申请号：ECSP066284
申请日：2006-01-13
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , SEMPLE GRAEME , FIORAVANTI BEATRIZ , CALDERON IMELDA , CHOI JIN SUN KAROLINE , XIONG YIFENG , SHIN YOUNG-JUN , REN ALBERT , SAGE CARLETON R
IPC分类号： A61K31/4375 , A61K31/47 , A61K31/519 , A61K31/52 , A61P3/00 , A61P3/10 , C07D215/22 , C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04
摘要： La presente invención se refiere a ciertos derivados arilo y heteroarilo fusionados de la Fórmula (I) que son moduladores del metabolismo. En consecuencia, los compuestos de la presente invención son útiles para la prevención o el tratamiento de trastornos metabólicos y sus complicaciones, tales como diabetes y obesidad.

8. 发明专利

ES2757922T3 Agonistas y composiciones del receptor 5-HT2C y métodos de uso 未知
公开(公告)号：ES2757922T3
公开(公告)日：2020-04-30
申请号：ES16721320
申请日：2016-04-26
申请人： ARENA PHARM INC
发明人： REN ALBERT S , SEMPLE GRAEME , ZHU XIUWEN , SAGE CARLETON R
IPC分类号： C07D487/06 , A61K31/407 , A61P25/00
摘要： Un compuesto seleccionado de los siguientes compuestos, y las sales, hidratos y solvatos farmacéuticamente aceptables de los mismos: N-(2,2-difluoroetil)-7-metil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 1); (S)-N-(2,2-difluoroetil)-7-metil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 2); (R)-N-(2,2-difluoroetil)-7-metil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 3); (S)-N-(2,2-difluoroetil)-7-etil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 4); (R)-N-(2,2-difluoroetil)-7-etil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 5); N-(2,2-difluoroetil)-7,7-dimetil-1,2,3,4,6,7-hexahidro-[1,4]diazepino [6,7,1-hi]indol-8-carboxamida (Compuesto No. 6); N-(2,2-difluoroetil)-2,3,4,6-tetrahidro-1H-espiro-[[1,4]diazepino [6,7,1-hi]indol-7,1'-ciclobutano]-8-carboxamida (Compuesto No. 7); (S)-N-(2,2-difluoroetil)-7-(2,2,2-trifluoroetil)-1,2,3,4,6,7-hexahidro-[1,4]diazepino[6,7,1-hi]indol-8-carboxamida (Compuesto No. 8); y (R)-N-(2,2-difluoroetil)-7-(2,2,2-trifluoroetil)-1,2,3,4,6,7-hexahidro-[1,4]diazepino[6,7,1-hi]indol-8-carboxamida (Compuesto No. 9).

9. 发明专利

EA034446B1 АГОНИСТЫ РЕЦЕПТОРА 5-HTИ ИХ КОМПОЗИЦИИ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ 未知
公开(公告)号：EA034446B1
公开(公告)日：2020-02-10
申请号：EA201792356
申请日：2016-04-26
申请人： ARENA PHARM INC
发明人： REN ALBERT S , SEMPLE GRAEME , ZHU XIUWEN , SAGE CARLETON R
IPC分类号： C07D487/06 , A61K31/407 , A61P25/00
摘要： Изобретениенаправленонарядсоединений, обладающихактивностьюв отношениирецептора 5-HTипригодныхдляпримененияв способахсниженияпотребленияпищи, индуцированиячувствасытости, леченияи/илипредотвращенияожирения, контролямассы, леченияи/илипредотвращениядиабета II типа, лечениялекарственнойи алкогольнойзависимостей, леченияпароксизмальногонарушенияи лечениянедержаниямочи. Такжепредставленыфармацевтическаякомпозиция, содержащаясоединение, испособееполучения.

10. 发明专利

CA3002544A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE 未知
公开(公告)号：CA3002544A1
公开(公告)日：2016-11-03
申请号：CA3002544
申请日：2016-04-26
申请人： ARENA PHARM INC
发明人： REN ALBERT S , SEMPLE GRAEME , ZHU XIUWEN , SAGE CARLETON R
IPC分类号： C07D487/06 , A61K31/5517 , A61P25/00
摘要： Provided in some embodiments are compounds herein. Also provided in some embodiments are methods for weight management, inducing satiety, and decreasing food intake, and for preventing and treating obesity, antipsychotic-induced weight gain, type 2 diabetes, Prader-Willi syndrome, tobacco/nicotine dependence, drug addiction, alcohol addiction, pathological gambling, reward deficiency syndrome, and sex addiction), obsessive-compulsive spectrum disorders and impulse control disorders (including nail-biting and onychophagia), sleep disorders (including insomnia, fragmented sleep architecture, and disturbances of slow-wave sleep), urinary incontinence, psychiatric disorders (including schizophrenia, anorexia nervosa, and bulimia nervosa), Alzheimer disease, sexual dysfunction, erectile dysfunction, epilepsy, movement disorders (including parkinsonism and antipsychotic-induced movement disorder), hypertension, dyslipidemia, nonalcoholic fatty liver disease, obesity-related renal disease, and sleep apnea. Also provided in some embodiments are compositions comprising a compound herein, optionally in combination with a supplemental agent, and methods for reducing the frequency of smoking tobacco in an individual attempting to reduce frequency of smoking tobacco; aiding in the cessation or lessening of use of a tobacco product in an individual attempting to cease or lessen use of a tobacco product; aiding in smoking cessation and preventing associated weight gain; controlling weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco; reducing weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco; treating nicotine dependency, addiction and/or withdrawal in an individual attempting to treat nicotine dependency, addiction and/or withdrawal; or reducing the likelihood of relapse use of nicotine by an individual attempting to cease nicotine use comprising administering a compound herein, optionally in combination with a supplemental agent.

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