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1. 发明申请

WO2012006475A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT 审中-公开
标题翻译：抑制磷酸盐运输的化合物和方法
公开(公告)号：WO2012006475A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043263
申请日：2011-07-07
申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric , DU, Xunxiang , OSLOB, Johan
发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric , DU, Xunxiang , OSLOB, Johan
IPC分类号： G01N33/48 , G01N31/00 , G01G23/01 , G06G7/58
CPC分类号： A61K33/24 , A61K31/19 , A61K31/415 , A61K31/4192 , A61K31/4418 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/465 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/522 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/706 , A61K31/785 , A61K33/10 , A61K45/06 , C07D213/81 , C07D295/155 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：具有作为磷酸盐转运抑制剂的活性的化合物，更具体地，公开了肠顶膜Na /磷酸盐共转运的抑制剂。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

2. 发明申请

WO2012006477A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT 审中-公开
标题翻译：抑制磷酸盐运输的化合物和方法
公开(公告)号：WO2012006477A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043266
申请日：2011-07-07
申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
IPC分类号： A01N43/38 , A61K31/405
CPC分类号： A61K31/5377 , A61K31/454 , A61K31/59 , A61K45/06 , C07D209/12 , C07D209/14
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, R 1 and R 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：具有作为磷酸盐转运抑制剂的活性的化合物，更具体地，公开了肠顶膜Na /磷酸盐共转运的抑制剂。所述化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中X，Y，R 1和R 2如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

3. 发明申请

WO2012006474A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT 审中-公开
标题翻译：用于抑制磷酸盐运输的化合物和方法
公开(公告)号：WO2012006474A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043262
申请日：2011-07-07
申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
IPC分类号： C07D403/02
CPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/59 , A61K45/06 , C07D239/42 , C07D241/20
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：具有作为磷酸盐转运抑制剂的活性的化合物，更具体地，公开了肠顶膜Na /磷酸盐共转运的抑制剂。该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中X，Y和A如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

4. 发明申请

WO2012054110A3 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT 审中-公开
公开(公告)号：WO2012054110A3
公开(公告)日：2012-04-26
申请号：PCT/US2011/043267
申请日：2011-07-07
申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
IPC分类号： A61K31/165
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R 1 and R 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

5. 发明申请

WO2012006473A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT 审中-公开
标题翻译：抑制磷酸盐运输的化合物和方法
公开(公告)号：WO2012006473A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043261
申请日：2011-07-07
申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
IPC分类号： A61K31/506 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D211/68 , C07D413/00
CPC分类号： A61K31/5377 , A61K31/415 , A61K31/454 , A61K31/4545 , A61K31/4965 , A61K31/505 , A61K31/59 , A61K45/06 , C07D211/68 , C07D231/40 , C07D233/88 , C07D249/14 , C07D255/02 , C07D277/46 , C07D285/135 , C07D401/12 , A61K2300/00
摘要： Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有作为磷酸盐转运抑制剂的活性的化合物，更具体地说，具有肠顶膜Na /磷酸盐共转运的抑制剂。所述化合物具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中X，Y和A如本文所定义。还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。

6. 发明申请

WO2002102791A1 PYRROLIDINE BICYCLIC COMPOUNDS 审中-公开
标题翻译：吡咯烷双环化合物
公开(公告)号：WO2002102791A1
公开(公告)日：2002-12-27
申请号：PCT/EP2002/006586
申请日：2002-06-14
申请人： VERSICOR, INC. , NOVARTIS AG , PATEL, Dinesh, V. , YUAN, Zhengyu , JAIN, Rakesh, K. , LEWIS, Jason, G. , JACOBS, Jeffrey
发明人： PATEL, Dinesh, V. , YUAN, Zhengyu , JAIN, Rakesh, K. , LEWIS, Jason, G. , JACOBS, Jeffrey
IPC分类号： C07D401/14
CPC分类号： C07D207/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： N -[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N -hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes, salts or prodrugs therof have interesting properties, e.g. in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.
摘要翻译： - [1-氧代（任选2-氮杂）-2-烷基-3-（羧基或硫醇或羟基氨基羰基或N - 羟基甲酰氨基） - 丙基] - （芳基或杂芳基） - 氮杂环烷-4-烷烃或噻唑烷-4-7烷烃，盐或前药具有有趣的性质，例如在治疗或预防由肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染。

7. 发明申请

WO2005007665A2 LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY 审中-公开
标题翻译：具有抗生素活性的LINCOMYCIN衍生物
公开(公告)号：WO2005007665A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/019497
申请日：2004-06-17
申请人： VICURON PHARMACEUTICALS INC. , LEWIS, Jason, G. , PATEL, Dinesh, V. , ANANDAN, Sampath, K. , GORDEEV, Mikhail, F.
发明人： LEWIS, Jason, G. , PATEL, Dinesh, V. , ANANDAN, Sampath, K. , GORDEEV, Mikhail, F.
IPC分类号： C07H15/00
CPC分类号： A61K31/7052 , C07H15/00 , C07H15/16 , Y02A50/473
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译：公开了新的林可霉素衍生物。这些林可霉素衍生物具有抗菌活性。由于本发明的化合物表现出对细菌（包括革兰氏阳性生物）的有效活性，因此它们是有用的抗微生物剂。还公开了化合物的合成和使用方法。

8. 发明申请

WO2003058341A1 IMAGE-RENDERING DEVICE 审中-公开
标题翻译：图像渲染设备
公开(公告)号：WO2003058341A1
公开(公告)日：2003-07-17
申请号：PCT/US2002/040725
申请日：2002-12-19
申请人： INFOCUS CORPORATION , OLSON, Jorell, A. , HOEYE, Robin, F. , LEWIS, Jason, G.
发明人： OLSON, Jorell, A. , HOEYE, Robin, F. , LEWIS, Jason, G.
IPC分类号： G03B21/00
CPC分类号： H04N9/3141 , G03B21/26
摘要： The present invention provides an image-rendering device (14) for an image projector (12). The image-rendering device includes a body (15) having an image receiver (24) adapted to alternatively receive a first interchangeable data transfer device and a second interchangeable data transfer devices (26). Each interchangeable data transfer device is adapted to enable transfer of an image to the image-rendering device. The body may further include a projector connector (16) adapted to operably couple the image-rendering device to the image projector and a processor (100) configured to automatically transmit the image from the image receiver to the image projector for display. In some embodiments, the image-rendering device includes a peripheral device connector (109) configured to enable at least one peripheral device to be operably linked to the image-rendering device. The peripheral device connector may be configured to transmit an image from the at least one peripheral device to the image projector, or vice versa.
摘要翻译：本发明提供了一种用于图像投影仪（12）的图像再现装置（14）。图像呈现设备包括具有适于交替地接收第一可互换数据传送设备和第二可互换数据传送设备（26）的图像接收器（24）的主体（15）。每个可互换的数据传送装置适于使得能够将图像传送到图像再现装置。身体还可以包括适于可操作地将图像呈现设备耦合到图像投影仪的投影仪连接器（16）和被配置为将图像从图像接收器自动发送到图像投影仪以用于显示的处理器（100）。在一些实施例中，图像呈现设备包括外围设备连接器（109），其被配置为使得至少一个外围设备能够可操作地链接到图像呈现设备。外围设备连接器可以被配置为将图像从至少一个外围设备传输到图像投影仪，反之亦然。

9. 发明申请

WO2006055070A3 NOVEL LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY 审中-公开
公开(公告)号：WO2006055070A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/031615
申请日：2005-09-01
申请人： VICURON PHARMACEUTICALS INC. , LEWIS, Jason, G. , ANANDAN, Sampath, K. , O'DOWD, Hardwin , GORDEEV, Mikhail , LI, Liansheng
发明人： LEWIS, Jason, G. , ANANDAN, Sampath, K. , O'DOWD, Hardwin , GORDEEV, Mikhail , LI, Liansheng
IPC分类号： C07H15/16
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

10. 发明申请

WO2005012320A2 NOVEL LINCOMYCIN DERIVATIVES POSSESSING ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：新兴的LINCOMYCIN衍生物抵抗抗生素活性
公开(公告)号：WO2005012320A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/019689
申请日：2004-06-17
申请人： VICURON PHARMACEUTICALS, INC. , LEWIS, Jason, G. , ANANDAN, Sampath, K. , O'DOWD, Hardwin , GORDEEV, Mikhail, F.
发明人： LEWIS, Jason, G. , ANANDAN, Sampath, K. , O'DOWD, Hardwin , GORDEEV, Mikhail, F.
IPC分类号： C07H15/16
CPC分类号： A61K31/7052 , C07D405/12 , C07H15/16 , Y02A50/411 , Y02A50/473
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use the compounds are also disclosed.
摘要翻译：公开了新的林可霉素衍生物。这些林可霉素衍生物具有抗菌活性。本发明的化合物可以表现出对细菌的有效活性，包括革兰氏阳性生物，并且可以是有用的抗微生物剂。还公开了合成和使用化合物的方法。

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