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1. 发明申请

WO2018204918A1 TREATMENT OF HEPATIC DISORDERS 审中-公开
公开(公告)号：WO2018204918A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/031400
申请日：2018-05-07
申请人： ARDELYX, INC. , FINN, Patricia , KING, Andrew , LEWIS, Jason
发明人： FINN, Patricia , KING, Andrew , LEWIS, Jason
IPC分类号： A61K38/26 , A61P1/16
CPC分类号： A61P1/16 , A61K38/26
摘要： The invention relates to the use of GLP-2 or an analog thereof in the treatment of hepatic diseases and disorders. In particular, GLP-2 or GLP-2 analogs are used to treat diseases and disorders associated with fat accumulation in the liver such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis and liver cirrhosis.

2. 发明申请

WO2018129556A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS 审中-公开
公开(公告)号：WO2018129556A1
公开(公告)日：2018-07-12
申请号：PCT/US2018/013025
申请日：2018-01-09
申请人： ARDELYX, INC.
发明人： CHARMOT, Dominique , NAVRE, Marc , CARRERAS, Christopher , BELL, Noah , LEADBETTER, Michael R. , JACOBS, Jeffrey W. , DOTSENKO, Irina , DRAGOLI, Dean , HE, Ying , KING, Andrew , LEWIS, Jason , SIEGEL, Matthew
IPC分类号： C07C311/29 , C07D401/12 , C07D217/04 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/62 , A61K31/18 , A61K31/472 , A61K31/4725 , A61K31/517 , A61K31/662 , A61K31/675 , A61K45/06 , C07D215/14 , C07D217/14 , C07D217/16 , C07F9/576 , C07F9/6558
CPC分类号： C07C311/29 , A61K31/18 , A61K31/472 , A61K31/4725 , A61K31/517 , A61K31/662 , A61K31/675 , A61K45/06 , C07D215/14 , C07D217/04 , C07D217/14 , C07D217/16 , C07D401/12 , C07F9/3808 , C07F9/3834 , C07F9/3882 , C07F9/4021 , C07F9/4056 , C07F9/5765 , C07F9/62 , C07F9/65583 , Y02A50/414
摘要： The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. The methods generally comprise administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that is designed to be substantially active in the gastrointestinal (GI) tract to inhibit NHE-mediated antiport of sodium ions and hydrogen ions therein. More particularly, the method comprises administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that inhibits NHE-3, -2 and/or -8 mediated antiport of sodium and/or hydrogen ions in the GI tract and is designed to be substantially impermeable to the layer of epithelial cells, or more specifically the epithelium of the GI tract. As a result of the compound being substantially impermeable, it is not absorbed and is thus essentially systemically non-bioavailable, so as to limit the exposure of other internal organs (e.g., liver, heart, brain, etc.) thereto. The present disclosure is still further directed to a method wherein a mammal is administered such a compound with a fluid-absorbing polymer, such that the combination acts as described above and further provides the ability to sequester fluid and/or salt present in the GI tract.

3. 发明申请

WO2020237096A1 COMBINATION FOR LOWERING SERUM PHOSPHATE IN A PATIENT 审中-公开
公开(公告)号：WO2020237096A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/034090
申请日：2020-05-21
申请人： ARDELYX, INC.
发明人： KING, Andrew
IPC分类号： A61K31/4725 , A61K31/785 , A61K45/06 , A61K47/55 , A61P3/00 , A61P3/12
摘要： The present invention relates to methods for lowering serum phosphate in a mammal comprising administering an epithelial phosphate transport inhibitor, such as an NHE3 inhibitor, in combination with a phosphate binder as well as pharmaceutical compositions comprising such epithelial phosphate transport inhibitors and phosphate binders.

4. 发明申请

WO2014040161A1 BRAKE RELEASE DEVICE FOR A BRAKING ARRANGEMENT 审中-公开
标题翻译：用于制动装置的制动释放装置
公开(公告)号：WO2014040161A1
公开(公告)日：2014-03-20
申请号：PCT/CA2012/000848
申请日：2012-09-13
申请人： BOMBARDIER TRANSPORTATION GMBH , ASLANIAN, George , KING, Andrew
发明人： ASLANIAN, George , KING, Andrew
IPC分类号： B60T15/54 , B60T15/02 , B60T7/08 , B61H13/02 , B61H13/34
CPC分类号： B60T7/102 , B60T15/02 , B60T15/54 , B61H13/02 , B61H13/34
摘要： The invention provides a brake release device for a braking arrangement. The braking arrangement includes friction pads, a friction surface and a first fluid path to convey fluid for controlling the application of the friction pads against the friction surface. The brake release device comprises a second fluid path to convey fluid for releasing the friction pads from the friction surface. The brake release device also comprises a selector valve coupled with the first and second fluid paths. The selector valve is capable to selectively acquire a first mode, a second mode and an intermediate mode. The first mode establishes fluid communication between the first fluid path and the braking arrangement. The second mode establishes fluid communication between the second fluid path and the braking arrangement. The selector valve is movable from the first mode to the second mode via the intermediate mode in which pressurized fluid in the first fluid path is relieved before entering the second mode. The brake release device may also comprise a pressure responsive interlock which controls switching between the first mode and the second mode when pressure in the second fluid path is above a threshold.
摘要翻译：本发明提供一种用于制动装置的制动器释放装置。制动装置包括摩擦垫，摩擦表面和第一流体路径以输送流体以控制摩擦垫对摩擦表面的施加。制动器释放装置包括用于输送流体以从摩擦表面释放摩擦垫的第二流体路径。制动器释放装置还包括与第一和第二流体路径联接的选择阀。选择阀能够选择性地获取第一模式，第二模式和中间模式。第一模式建立第一流体路径和制动装置之间的流体连通。第二模式建立第二流体路径和制动装置之间的流体连通。选择阀可以通过中间模式从第一模式移动到第二模式，其中第一流体路径中的加压流体在进入第二模式之前被释放。制动器释放装置还可以包括压力响应联锁装置，当第二流体路径中的压力高于阈值时，控制第一模式和第二模式之间的切换。

5. 发明公开

EP3972599A1 COMBINATION FOR LOWERING SERUM PHOSPHATE IN A PATIENT 审中-实审
公开(公告)号：EP3972599A1
公开(公告)日：2022-03-30
申请号：EP20730955.0
申请日：2020-05-21
申请人： Ardelyx, Inc.
发明人： KING, Andrew
IPC分类号： A61K31/4725 , A61K31/785 , A61K45/06 , A61K47/55 , A61P3/00 , A61P3/12

6. 发明申请

WO2008109057A1 ORGANIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：有机化合物及其用途
公开(公告)号：WO2008109057A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/002831
申请日：2008-03-03
申请人： DANA-FARBER CANCER INSTITUTE, INC. , KING, Andrew , ZIEGLER, David
发明人： KING, Andrew , ZIEGLER, David
IPC分类号： G01N33/574
CPC分类号： A61K45/06 , A61K31/506 , A61K2300/00
摘要： The present invention relates to methods of treating neoplasms, particularly involving brain tumors, including gliomas and glioblastomas, comprising the combination of a growth factor receptor inhibitor with a compound that inhibits the binding of the second mitochondria-derived activator of caspase (Smac) protein to inhibitor of apoptosis (IAPs) (IAP inhibitor), and one or more pharmaceutically active agents; pharmaceutical compositions comprising said combination; and a commercial package comprising said combination.
摘要翻译：本发明涉及治疗肿瘤的方法，特别涉及包括神经胶质瘤和成胶质细胞瘤在内的脑肿瘤的方法，其包括生长因子受体抑制剂与抑制第二线粒体衍生的半胱天冬酶（Smac）蛋白激活剂结合的化合物的组合，凋亡抑制剂（IAP）（IAP抑制剂）和一种或多种药物活性剂; 包含所述组合的药物组合物; 以及包括所述组合的商业包装。

7. 发明申请

WO2003009973A1 TOOL FOR APPLYING CLIPS 审中-公开
标题翻译：适用于CLIPS的工具
公开(公告)号：WO2003009973A1
公开(公告)日：2003-02-06
申请号：PCT/GB2002/003290
申请日：2002-07-17
申请人： J. & H. ROSENHEIM LIMITED , PICKUP, Raymond, Allan , KING, Andrew
发明人： PICKUP, Raymond, Allan , KING, Andrew
IPC分类号： B25B27/14
CPC分类号： B25B27/146 , Y10T29/5148 , Y10T29/53783
摘要： A closure tool (10, 40) is provided that is convenient to use in any location that has no power source available, for closing heavy-duty clips (11) as used for example in the building trade and in agriculture. The tool (10,40) has a body (13), a pair of handles (14) mounted on the body (13) on pivots (15) and a pair of anvils (18, 20) movable relative to each other from a spaced position to closure position in response to relative movement of the handles (14) and the body (13). A moving member (17) is engaged by the handles (14) and is movable therewith, and one of the anvils (18) is connected to and movable with the moving member (17). The handles (14) may have spigots (44) engaged in a slot (43) in a cylindrical moving member (17) in a barrel part (41) of the body (13), or each handle (14) may have a quadrant shaped first gear (16) engaging a rack second gear moving member (17) slidably mounted in the body (13).
摘要翻译：提供一种闭合工具（10,40），其便于在没有电源的任何位置使用，用于关闭例如在建筑行业和农业中使用的重型夹子（11）。工具（10,40）具有主体（13），安装在枢轴（15）上的主体（13）上的一对手柄（14）和一对相对于彼此移动的砧座（18,20）响应于手柄（14）和主体（13）的相对运动，将其间隔开到关闭位置。移动构件（17）由手柄（14）接合并且可移动构件（17），并且其中一个砧座（18）连接并可移动构件（17）移动。把手（14）可以具有接合在主体（13）的筒部（41）中的圆柱形移动构件（17）中的槽（43）中的插口（44），或者每个手柄（14）可以具有象限（16）接合可滑动地安装在主体（13）中的齿条第二齿轮移动构件（17）。

8. 发明申请

WO2011085007A1 TREATMENT METHOD 审中-公开
标题翻译：治疗方法
公开(公告)号：WO2011085007A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020231
申请日：2011-01-05
申请人： GLAXO WELLCOME MANUFACTURING PTE LTD , DAMIAN-IORDACHE, Valeriu , KING, Andrew , MCLAUGHLIN, Megan M , SUTTLE, Albert B
发明人： DAMIAN-IORDACHE, Valeriu , KING, Andrew , MCLAUGHLIN, Megan M , SUTTLE, Albert B
IPC分类号： A61K31/52
CPC分类号： A61K31/52
摘要： The present invention is directed to methods of treating disorders of ocular angiogenesis or vascular leakage in a patient by administration of suitable inhibitors, including pazopanib or pharmaceutically acceptable salts or hydrates thereof.
摘要翻译：本发明涉及通过给予合适的抑制剂（包括吡罗他尼或其药学上可接受的盐或水合物）来治疗患者眼血管发生或血管渗漏的疾病的方法。

9. 发明申请

WO2009090381A3 GLYCOSYL HYDROLASE POLYPEPTIDES 审中-公开
公开(公告)号：WO2009090381A3
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000095
申请日：2009-01-15
申请人： THE UNIVERSITY OF YORK , KING, Andrew , GRAHAM, Ian, Alexander , MQUEEN MASON, Simon , BRUCE, Neil , BOWLES, Dianna, Joy
发明人： KING, Andrew , GRAHAM, Ian, Alexander , MQUEEN MASON, Simon , BRUCE, Neil , BOWLES, Dianna, Joy
IPC分类号： C12N9/42 , C12N15/82
摘要： We disclose nucleic acid molecules that encode glycosyl hydrolase polypeptides; polypeptides encoded by said nucleic acids, transgenic cells and plants transfected with said nucleic acids and uses thereof.

10. 发明申请

WO2009090379A2 PHENOL OXIDASE POLYPEPTIDES 审中-公开
标题翻译：酚醛氧化物多糖
公开(公告)号：WO2009090379A2
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000093
申请日：2009-01-15
申请人： THE UNIVERSITY OF YORK , KING, Andrew , GRAHAM, Ian, Alexander , MQUEEN MASON, Simon , BRUCE, Neil , BOWLES, Dianna, Joy
发明人： KING, Andrew , GRAHAM, Ian, Alexander , MQUEEN MASON, Simon , BRUCE, Neil , BOWLES, Dianna, Joy
IPC分类号： C07K14/435
CPC分类号： C12N9/0059 , C12N9/001 , C12P7/10 , D21C5/005 , Y02E50/16
摘要： We disclose nucleic acid molecules that encode haemocyanin polypeptides that have phenol oxidase activity; polypeptides encoded by said nucleic acids, transgenic cells transfected with said nucleic acids and uses thereof in the manufacture of biofuels and modification of lignocellulose materials.
摘要翻译：我们公开了编码具有酚氧化酶活性的血蓝蛋白多肽的核酸分子; 由所述核酸编码的多肽，用所述核酸转染的转基因细胞及其在制备生物燃料中的用途以及木质纤维素材料的改性。

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