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1. 发明申请

WO2008002609A2 HYDROQUINONE COMPOSITIONS FOR SKIN LIGHTENING 审中-公开
标题翻译：用于皮肤护理的水合物组合物
公开(公告)号：WO2008002609A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014910
申请日：2007-06-27
申请人： APPLIED GENETICS INCORPORATED DERMATICS , YAROSH, Daniel, B. , BURCH, Kimberly
发明人： YAROSH, Daniel, B. , BURCH, Kimberly
IPC分类号： A61K8/34
CPC分类号： A61K8/347 , A61K8/4946 , A61K8/66 , A61K8/97 , A61Q19/004 , A61Q19/02
摘要： Compositions for lightening skin color (or for reducing skin darkening) and for repairing DNA damage are provided. The compositions comprise (a) one or more skin lightening agents (e.g., hydroquinone) in a combined amount effective to lighten skin (or to reduce darkening), (b) one or more DNA repair agents (e.g., one or more DNA repair enzymes in pH-sensitive liposomes) in a combined amount effective to repair DNA damage by ultraviolet light, and (c) a cosmetically or pharmaceutically acceptable vehicle. Methods for preparing and using the compositions are also provided.
摘要翻译：提供了减轻皮肤颜色（或减少皮肤变黑）和修复DNA损伤的组合物。组合物包含（a）一种或多种有效减轻皮肤（或减少变暗）的组合量的一种或多种皮肤增亮剂（例如氢醌），（b）一种或多种DNA修复剂（例如一种或多种DNA修复酶在pH敏感的脂质体中）以有效修复由紫外线的DNA损伤的组合量，和（c）化妆品或药学上可接受的载体。还提供了制备和使用组合物的方法。

2. 发明申请

WO2003027238A2 STABILIZATION OF T4 ENDONUCLEASE V 审中-公开
标题翻译： T4内切酶V的稳定性
公开(公告)号：WO2003027238A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/029885
申请日：2002-09-20
申请人： APPLIED GENETICS INCORPORATED DERMATICS , BROWN, Anne, B. , BROWN, David, A. , YAROSH, Daniel, B.
发明人： BROWN, Anne, B. , BROWN, David, A. , YAROSH, Daniel, B.
IPC分类号： C12N
CPC分类号： C12N9/96 , C12Q1/37 , C12Q1/44
摘要： The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods for detecting cryptic protease activity and methods for reducing such activity are also provided.
摘要翻译：本发明提供T4内切核酸酶V组合物，其通过降低隐性蛋白酶的活性而显示出增强的稳定性，包括在非冷藏温度下的稳定性。还提供了检测隐性蛋白酶活性的方法和降低这种活性的方法。

3. 发明申请

WO2006023377A2 BIOMIMETIC OF EVODIA RUTAECARPA FRUIT EXTRACT FOR AMELIORATION OF INFLAMMATION 审中-公开
标题翻译： EVODIA RUTAECARPA水果提取物促进炎症改善的生物效应
公开(公告)号：WO2006023377A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/028630
申请日：2005-08-11
申请人： APPLIED GENETICS INCORPORATED DERMATICS , YAROSH, Daniel, B. , BROWN, David, A. , CANNING, Matthew, T.
发明人： YAROSH, Daniel, B. , BROWN, David, A. , CANNING, Matthew, T.
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K9/0014 , A61K47/10
摘要： Compositions and methods are provided for reversing and/or inhibiting inflammation, e.g., by inhibiting prostaglandin and/or COX-2 production, using one or more indolequinazoline alkaloids, preferably in combination with butylated hydroxytoluene. The preferred indolequinazoline alkaloids are rutaecarpine, evodiamine, and dehydroevodiamine, which are naturally found in unpurified form in the traditional Chinese medicine Wu Chu Yu made from the fruit of the herb, Evodia rutaecarpa.
摘要翻译：提供组合物和方法用于逆转和/或抑制炎症，例如通过使用一种或多种吲哚喹唑啉生物碱抑制前列腺素和/或COX-2产生，优选与丁基化羟基甲苯联合使用。优选的吲哚喹唑啉生物碱是吴茱萸次碱，吴茱萸碱和脱氢伏牛胺，它们是从草药果实吴茱萸果实制成的中药吴楚玉中以未纯化的形式天然存在的。

4. 发明申请

WO2005123953A2 GENETIC SCREENING FOR POLYMORPHISMS IN HUMAN GENES THAT INCREASE OR DECREASE SENSITIVITY TO TOXIC AGENTS 审中-公开
标题翻译：人类基因多态性的遗传筛选，增加或降低对毒性的敏感性
公开(公告)号：WO2005123953A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/020055
申请日：2005-06-07
申请人： APPLIED GENETICS INCORPORATED DERMATICS , YAROSH, Daniel, B. , BROWN, David, A.
发明人： YAROSH, Daniel, B. , BROWN, David, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K9/127 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , C12Q1/6888 , C12Q2600/106 , C12Q2600/142 , G06Q50/22
摘要： Methods are disclosed for genetically counseling a person based on one or more polymorphisms in his or her genes that sensitize him or her to toxic agents. Methods are also disclosed for genetically screening a group of individuals and/or a human population, based on, for example, ethnicity, race, religion. or geographic region, to identify individuals with such polymorphisms for counseling. The methods can be used to counsel a person who has not been genetically tested for polymorphisms but who might have increased risk for sensitivity to toxic agents due to his or her membership in a particular group and/or population. The methods use correlations between genotypes of polymorphic alleles in a panel of cell lines and sensitivity of the cell lines to toxic agents. As examples, the methods are used to identify genotypes of allelic forms of the genes TP53, OGG1, ERCC2, XRCC1, and NOS3 that increase sensitivity or resistance of cells to toxic agents.
摘要翻译：公开了基于他或她的基因中的一种或多种多态性使他或她感染有毒物质的个体的遗传咨询的方法。还公开了基于例如种族，种族，宗教的遗传筛选一组个体和/或人群的方法。或地理区域，以识别具有此类多态性的个体用于咨询。这些方法可用于为未经遗传测试的多态性的人提供咨询，但是由于他或她在某一特定群体和/或群体中的成员资格而可能增加对有毒物质的敏感性的风险。该方法使用一组细胞系中多态性等位基因的基因型与细胞系对毒性试剂的敏感性之间的相关性。作为实例，该方法用于鉴定增加细胞对毒性剂的敏感性或抗性的基因TP53，OGG1，ERCC2，XRCC1和NOS3的等位基因形式的基因型。

5. 发明申请

WO2003027238A3 STABILIZATION OF T4 ENDONUCLEASE V 审中-公开
公开(公告)号：WO2003027238A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/029885
申请日：2002-09-20
申请人： APPLIED GENETICS INCORPORATED DERMATICS , BROWN, Anne, B. , BROWN, David, A. , YAROSH, Daniel, B.
发明人： BROWN, Anne, B. , BROWN, David, A. , YAROSH, Daniel, B.
IPC分类号： C12Q1/37
摘要： The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods for detecting cryptic protease activity and methods for reducing such activity are also provided.

6. 发明申请

WO2007005596A2 PRODUCTION OF CPD GLYCOSYLASES 审中-公开
标题翻译： CPD糖基化物的生产
公开(公告)号：WO2007005596A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/025561
申请日：2006-06-29
申请人： APPLIED GENETICS INCORPORATED DERMATICS
发明人： YAROSH, Daniel, B. , ESTIS, Leonard, F. , KRAUS, Eliyahu
IPC分类号： C12P21/06 , C12N9/24
CPC分类号： C12N9/2497 , C12Y302/02017
摘要： Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene den V, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases.
摘要翻译：描述了能够以高水平表达的用于CPD糖基化酶的DNA序列的重组形式，包括噬菌体T4基因denV。活性CPD糖基化酶可以从使用例如采用流混合的均化过程的高表达产生的包涵体中回收，并且活性蛋白质可以用于例如用于治疗光敏性疾病的局部制剂。流混合也可用于溶解包含除CPD糖基化酶以外的蛋白质的包涵体。

7. 发明公开

EP1210075A1 COMPOSITIONS AND METHODS FOR MODIFICATION OF SKIN LIPID CONTENT 审中-公开
标题翻译：组合物和方法来改变皮肤的脂肪含量
公开(公告)号：EP1210075A1
公开(公告)日：2002-06-05
申请号：EP00961668.1
申请日：2000-09-08
申请人： Applied Genetics Incorporated Dermatics
发明人： BROWN, David, A. , YAROSH, Daniel, B.
IPC分类号： A61K31/19
CPC分类号： A61Q19/007 , A61K8/14 , A61K8/63 , A61K8/671 , A61K31/19 , A61Q19/00 , A61Q19/08
摘要： The topical use of ursolic acid compounds to alter the lipid content of mammalian skin is disclosed. The compounds can be encapsulated in liposomes and administered in this form to the skin in, for example, a lotion or a gel. The compounds are effective in, among other things, reducing the effects of aging, photoaging, and skin atrophy, including skin atrophy resulting from the topical use of retinoids and/or steroids. Compositions comprising a ursolic acid compound in combination with another therapeutically active topical compounds, such as, a retinoid or a steroid, are also disclosed.

8. 发明公开

EP1904643A2 PRODUCTION OF CPD GLYCOSYLASES 有权
标题翻译：生产CPD糖基化酶
公开(公告)号：EP1904643A2
公开(公告)日：2008-04-02
申请号：EP06785950.4
申请日：2006-06-29
申请人： Applied Genetics Incorporated Dermatics
发明人： YAROSH, Daniel, B. , ESTIS, Leonard, F. , KRAUS, Eliyahu
IPC分类号： C12P21/06 , C12N9/24
CPC分类号： C12N9/2497 , C12Y302/02017
摘要： Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases.

9. 发明授权

EP1784225B1 BIOMIMETIC OF EVODIA RUTAECARPA FRUIT EXTRACT FOR AMELIORATION OF INFLAMMATION 有权
标题翻译：吴茱萸果实提取物仿生败火
公开(公告)号：EP1784225B1
公开(公告)日：2016-10-05
申请号：EP05804278.9
申请日：2005-08-11
申请人： Applied Genetics Incorporated Dermatics
发明人： YAROSH, Daniel, B. , BROWN, David, A. , CANNING, Matthew, T.
IPC分类号： A61K9/00 , A61K47/10 , A61K31/519
CPC分类号： A61K31/519 , A61K9/0014 , A61K47/10

10. 发明公开

EP1430143A2 STABILIZATION OF T4 ENDONUCLEASE V 审中-公开
标题翻译： T4的稳定化切核酸酶V
公开(公告)号：EP1430143A2
公开(公告)日：2004-06-23
申请号：EP02778299.4
申请日：2002-09-20
申请人： Applied Genetics Incorporated Dermatics
发明人： BROWN, Anne, B. , BROWN, David, A. , YAROSH, Daniel, B.
IPC分类号： C12Q1/37 , C12N9/10 , C12N9/22
CPC分类号： C12N9/96 , C12Q1/37 , C12Q1/44
摘要： The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods for detecting cryptic protease activity and methods for reducing such activity are also provided.

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