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1. 发明专利

JP2014128292A Thermal cycling apparatus and method for providing thermal uniformity 审中-公开
标题翻译：热循环装置和提供热均匀性的方法
公开(公告)号：JP2014128292A
公开(公告)日：2014-07-10
申请号：JP2014079210
申请日：2014-04-08
申请人： Applied Biosystems Llc , アプライドバイオシステムズリミテッドライアビリティーカンパニー
发明人： SHIN HON SIU , NGUI JEW KWEE , LIM CHEE KIONG , LAU CHING ONG , TAN LIM HI , KEE YANG HOOI
IPC分类号： C12M1/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and method for rapid thermal cycling including a thermal diffusivity plate.SOLUTION: A thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling. Specifically an apparatus for thermally cycling biological samples comprises the followings: a thermal block assembly for receiving the biological samples; a thermoelectric module coupled to the thermal block assembly; and a heat sink, wherein the heat sink is coupled to the thermoelectric module, the heat sink comprises a base plate, fins, and a thermal diffusivity plate, and the thermal diffusivity plate comprises a different material than the base plate and fins. In the heat sink, the thermal diffusivity plate provides substantial temperature uniformity to the thermal block assembly during thermal cycling.
摘要翻译：要解决的问题：提供一种包括热扩散板的快速热循环的装置和方法。解决方案：热扩散板可以通过热电模块在热循环期间在整个热块组件中提供显着的温度均匀性。边缘加热器可以在热循环期间在整个热块组件中提供显着的温度均匀性。具体地，用于热循环生物样品的装置包括以下：用于接收生物样品的热块组件; 耦合到热块组件的热电模块; 和散热器，其中所述散热器耦合到所述热电模块，所述散热器包括基板，散热片和热扩散板，并且所述热扩散板包括与所述基板和散热片不同的材料。在散热器中，热扩散板在热循环期间为热块组件提供了显着的温度均匀性。

2. 发明专利

JP2011115185A Thermal cycling apparatus and method for providing temperature uniformity 审中-公开
标题翻译：热循环装置和提供温度均匀性的方法
公开(公告)号：JP2011115185A
公开(公告)日：2011-06-16
申请号：JP2011063395
申请日：2011-03-22
申请人： Applied Biosystems Llc , アプライドバイオシステムズリミテッドライアビリティーカンパニー
发明人： SHIN HON SIU , NGUI JEW KWEE , LIM CHEE KIONG , LAU CHING ONG , TAN LIM HI , KEE YANG HOOI
IPC分类号： C12M1/00 , B01L7/00 , C12Q1/68
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and a method for a rapid thermal cycling including a thermal diffusion plate. SOLUTION: A thermal diffusion plate provides a substantially temperature uniformity of an overall heater block assembly during thermal cycling by a thermoelectric module. An edge heater provides a substantially temperature uniformity of an overall heater block assembly during thermal cycling. Particularly, a device for thermally cycling a biological sample includes: a heater block assembly to receive a biological sample; a thermoelectric module coupled with the heater block assembly; and a heat sink. Thereby, the heat sink is coupled with the thermoelectric module; wherein the heat sink includes a base plate, a fin and a thermal diffusion plate; wherein a thermal diffusion plate includes a material differing from the base plate and the fine; and wherein a thermal diffusion plate provides the substantially temperature uniformity to the heater block assembly during thermal cycling. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种包括热扩散板的快速热循环的装置和方法。解决方案：热扩散板通过热电模块在热循环期间提供总体加热器块组件的基本上温度均匀性。边缘加热器在热循环期间提供总体加热器块组件的基本上温度均匀性。特别地，用于热循环生物样品的装置包括：用于接收生物样品的加热器块组件; 与所述加热器组件联接的热电模块; 和散热器。因此，散热器与热电模块耦合; 其中所述散热器包括基板，翅片和热扩散板; 其特征在于，热扩散板包括与所述基板不同的材料，并且其中热扩散板在热循环期间向加热器块组件提供基本上温度均匀性。版权所有（C）2011，JPO＆INPIT

3. 发明专利

AU3661001A Apparatus and method for ejecting sample well trays 未知
公开(公告)号：AU3661001A
公开(公告)日：2001-08-14
申请号：AU3661001
申请日：2001-02-01
申请人： APPLIED BIOSYSTEMS LLC
发明人： SHIN HON S , NGUI JEW KWEE , FAWCETT ADRIAN , CHAO KENNETH P , BORDENKIRCHER GARY L , BARZILAI JESSICA E , SANDELL DONALD R
IPC分类号： G01N33/48 , B01L3/00 , B01L7/00 , C12M1/00 , G01N35/00 , G01N35/02 , C12Q1/68
摘要： The invention includes a heating apparatus for biological samples. The heating apparatus of the present invention includes a cover, a sample block having a plurality of openings in a top portion thereof for receiving a sample well tray having a plurality of sample wells, and an urging mechanism. The urging mechanism is positionable between the sample block and the sample well tray to urge the sample well tray away from the sample block when the cover is moved from a closed position toward an open position. The cover imparts a downward force on the top of the sample well tray to press the sample wells into the openings of the sample block when the heated cover is moved toward a closed position. The urging mechanism imparts an upward force on the sample well tray. The downward force imparted by the heated cover is sufficient to retain the sample well tray against the sample block when the cover is in the closed position.

4. 发明专利

DE602004024882D1 未知
公开(公告)号：DE602004024882D1
公开(公告)日：2010-02-11
申请号：DE602004024882
申请日：2004-05-28
申请人： APPLIED BIOSYSTEMS LLC
发明人： SHIN HON , NGUI JEW KWEE , LIM CHEE KIONG , LAU CHING ONG , TAN LIM HI , KEE YANG HOOI
IPC分类号： B01L7/00 , C12Q1/68

5. 发明专利

AT453452T 未知
公开(公告)号：AT453452T
公开(公告)日：2010-01-15
申请号：AT04753774
申请日：2004-05-28
申请人： APPLIED BIOSYSTEMS LLC
发明人： SHIN HON SIU , NGUI JEW KWEE , LIM CHEE KIONG , LAU CHING ONG , TAN LIM HI , KEE YANG HOOI
IPC分类号： B01L7/00 , C12Q1/68

6. 发明专利

AU2007292329A1 Device for carrying out chemical or biological reactions 未知
公开(公告)号：AU2007292329A1
公开(公告)日：2008-03-13
申请号：AU2007292329
申请日：2007-09-06
申请人： APPLIED BIOSYSTEMS LLC
发明人： KEE YANG HOOI , KHOO HOCK LAI , LAU CHING ONG , SOH UI LENG , HEIMBERG WOLFGANG , TAN LIM HI , NGUI JEW KWEE , SHIN HOU SIU , REED MARK T
IPC分类号： C12M1/34 , C12M1/00 , C12M1/38 , C12P19/34 , G01K7/00
摘要： A device for processing biological or chemical samples may include a reaction vessel receiving element, one or more temperature equalization plates, one or more Peltier elements, and a cooling element. The reaction vessel receiving element has one or more segments each of which has a plurality of reaction vessel holders. Each of the one or more temperature equalization plates is provided in the area beneath one of the one or more segments, is a flat element with a surface corresponding to the basic surface of the segment beneath which it is provided, is a hollow body with a small amount of fluid, and works on the same principle as a heat pipe. At least one Peltier element is provided in the area beneath each of the one or more segments. The cooling element extends over the area of the one or more segments.

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