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1. 发明申请

WO2005066372A3 QUANTITATIVE AMPLIFICATION AND DETECTION OF SMALL NUMBERS OF TARGET POLYNUCLEOTIDES 审中-公开
标题翻译：定量放大和检测目标多核苷酸的小数字
公开(公告)号：WO2005066372A3
公开(公告)日：2006-01-19
申请号：PCT/US2004044052
申请日：2004-12-30
申请人： APPLERA CORP , VANN CHARLES S , LAO KAIQIN , REED MARK , STERN SETH R , LEHTO DENNIS
发明人： VANN CHARLES S , LAO KAIQIN , REED MARK , STERN SETH R , LEHTO DENNIS
IPC分类号： B01L3/00 , B01L7/00 , C12M1/34 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/502707 , B01L3/502715 , B01L2300/0861 , B01L2300/18 , B01L2400/06 , C12Q1/686 , C12Q2527/125
摘要： Devices, assemblies, systems and methods described herein enable detection of as few as a single copy of a target nucleic acid molecule. Polynucleotides copied from a single or a small number of target nucleotide(s) within regions near to an initial copying site may be detected by optical or other methods as disclosed herein. Devices, assemblies and systems may comprise probes and/or primer molecules. Systems comprising optical assemblies, thermal assemblies and reaction assemblies (having reaction chambers for amplification of target nucleic acid molecules) are provided in which used reaction assemblies may be replaced to provide reusable devices. Systems comprising analytical assemblies and detection assemblies are provided in which an assay cartridge having assay chambers may engage a thermal assembly for amplification of target nucleic acid molecules. These devices, systems and methods offer the advantages of detection of as few as a single copy of a target nucleic acid molecule.
摘要翻译：本文描述的装置，组件，系统和方法能够检测目标核酸分子的单拷贝数。从初始复制部位附近的区域内单个或少数目标核苷酸复制的多核苷酸可以通过本文公开的光学或其它方法检测。装置，组件和系统可以包括探针和/或引物分子。提供了包括光学组件，热组件和反应组件（具有用于扩增靶核酸分子的反应室）的系统，其中可以更换所使用的反应组件以提供可重复使用的装置。提供了包括分析组件和检测组件的系统，其中具有测定室的测定盒可以接合热组件以扩增靶核酸分子。这些装置，系统和方法提供了检测目标核酸分子的单拷贝的优点。

2. 发明申请

WO2006116616A3 SYSTEMS AND METHODS FOR MULTIPLE ANALYTE DETECTION 审中-公开
标题翻译：用于多分析检测的系统和方法
公开(公告)号：WO2006116616A3
公开(公告)日：2007-09-27
申请号：PCT/US2006016060
申请日：2006-04-26
申请人： APPLERA CORP , YUE MIN , LIU DAVID M , CHIANG YUH-MIN , YANG JOON MO , LEHTO DENNIS , VANN CHARLES S , BEARD NIGEL P , HARDING IAN A , VAN CAMP JOHN , DROMARETSKY ALEXANDER , ERMAKOV SERGEY V , OLDHAM MARK F , ROY JOY , SHARIATI MARYAM , ULMANELLA UMBERTO
发明人： YUE MIN , LIU DAVID M , CHIANG YUH-MIN , YANG JOON MO , LEHTO DENNIS , VANN CHARLES S , BEARD NIGEL P , HARDING IAN A , VAN CAMP JOHN , DROMARETSKY ALEXANDER , ERMAKOV SERGEY V , OLDHAM MARK F , ROY JOY , SHARIATI MARYAM , ULMANELLA UMBERTO
IPC分类号： C12M1/38
CPC分类号： C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
摘要： Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要翻译：用于多个分析物检测的系统和方法包括用于分配包括衬底的生物样品的系统，其中所述衬底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止每个样品室中包含的样品从每个样品室流出。底物可以由检测兼容和测定相容的材料构成。

3. 发明申请

WO03045310A2 DIGITAL ASSAY 审中-公开
标题翻译：数字测定
公开(公告)号：WO03045310A2
公开(公告)日：2003-06-05
申请号：PCT/US0237499
申请日：2002-11-21
申请人： APPLERA CORP , VANN CHARLES S , LAO KAI QIN , REED MARK
发明人： VANN CHARLES S , LAO KAI QIN , REED MARK
IPC分类号： G01N33/53 , A61K20060101 , C07H21/02 , C12N9/22 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566 , A61K
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.
摘要翻译：本发明涉及用于检测样品中靶标的方法和组合物。

4. 发明申请

WO03045310A9 DIGITAL ASSAY 审中-公开
标题翻译：数字测定
公开(公告)号：WO03045310A9
公开(公告)日：2004-07-22
申请号：PCT/US0237499
申请日：2002-11-21
申请人： APPLERA CORP , VANN CHARLES S , LAO KAI QIN , REED MARK
发明人： VANN CHARLES S , LAO KAI QIN , REED MARK
IPC分类号： G01N33/53 , A61K20060101 , C07H21/02 , C12N9/22 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.
摘要翻译：本发明涉及用于检测样品中靶标的方法和组合物。

5. 发明申请

WO03045310A8 DIGITAL ASSAY 审中-公开
公开(公告)号：WO03045310A8
公开(公告)日：2004-05-27
申请号：PCT/US0237499
申请日：2002-11-21
申请人： APPLERA CORP , VANN CHARLES S , LAO KAI QIN , REED MARK
发明人： VANN CHARLES S , LAO KAI QIN , REED MARK
IPC分类号： G01N33/53 , A61K20060101 , C07H21/02 , C12N9/22 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.

6. 发明申请

WO2007061943A8 PORTABLE PREPARATION, ANALYSIS, AND DETECTION APPARATUS FOR NUCLEIC ACID PROCESSING 审中-公开
标题翻译：便携式制备，分析和检测装置用于核酸加工
公开(公告)号：WO2007061943A8
公开(公告)日：2008-09-12
申请号：PCT/US2006044878
申请日：2006-11-20
申请人： APPLERA CORP , VANN CHARLES S , GREENSTEIN MICHAEL , CHIANG YUH-MIN
发明人： VANN CHARLES S , GREENSTEIN MICHAEL , CHIANG YUH-MIN
IPC分类号： C12M3/00 , G01N27/26
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

7. 发明申请

WO2006028585A2 OPTICAL FIBER BUNDLE FOR DETECTING BINDING OF CHEMICAL SPECIES 审中-公开
标题翻译：用于检测化学物质结合的光纤组件
公开(公告)号：WO2006028585A2
公开(公告)日：2006-03-16
申请号：PCT/US2005026118
申请日：2005-07-22
申请人： APPLERA CORP , VANN CHARLES S
发明人： VANN CHARLES S
IPC分类号： C12Q1/68 , B01J19/00 , B01L3/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/64 , G01N21/77
CPC分类号： G01N21/7703 , B01J19/0046 , B01J2219/00326 , B01J2219/0043 , B01J2219/00495 , B01J2219/00515 , B01J2219/00524 , B01J2219/00572 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00657 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01L3/5023 , B01L3/5085 , B82Y30/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/6452 , G01N21/648 , G01N2201/0833
摘要： The system includes a bundle of elongate optical fibers, multiple probes, a well, a light source and a detector. The optical fibers each have a first end remote from a second end, Each of the multiple probes is attached to one of the optical fibers within a predetermined section between each of the optical fiber's first and second ends. The well is configured to hold a solution comprising a target and to receive at least the predetermined section of each of the optical fibers. The light source is configured to direct light into the first end of each of the optical fibers. Finally, the detector is configured to detect light emitted by the binding of the target to at least one of the multiple probes. In some embodiments, there are multiple bundles and multiple wells.
摘要翻译：该系统包括一束细长的光纤，多个探针，阱，光源和检测器。光纤各自具有远离第二端的第一端，多个探针中的每一个在光纤的第一和第二端中的每一个之间的预定部分内附接到光纤中的一个。井被配置为保持包括目标的解决方案并且接收每个光纤的至少预定部分。光源被配置为将光引导到每个光纤的第一端。最后，检测器被配置为检测由目标物与至少一个多个探针的结合发射的光。在一些实施例中，存在多个束和多个孔。

8. 发明申请

WO2007130434A3 VARIABLE VOLUME DISPENSER AND METHOD 审中-公开
标题翻译：可变体积分配器和方法
公开(公告)号：WO2007130434A3
公开(公告)日：2008-10-16
申请号：PCT/US2007010596
申请日：2007-05-02
申请人： APPLERA CORP , VANN CHARLES S
发明人： VANN CHARLES S
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01J2219/00459 , B01L2200/0605 , B01L2200/0657 , B01L2300/0681 , B01L2400/0487 , G01F11/18 , G01F15/001 , G01F15/125
摘要： A variable volume dispenser contains a set of one or more fill tubes (10), each having a rod (60) or other volume-limiting member slidably mounted therein. Suction pressure can aspirate supported oligonucleotide beads or other powder (140), grnulate, or other particlute material into the fill tubes (10) for dispensing selected volumes into wells or other containers. The rods (60) or other members can be constructed to comprise a filter (260) having a poresize smaller than the particulate matter to be manipulated so th the material cannot be lodged inside the fill tube (10). In various embodiments, the volume of powder (140) or other material to be aspirated can be selectively set by moving the rods (60) to different locations within the fill tubes (10) using electromagnets (210). various embodiments, individual rods (60) can be independently activated.
摘要翻译：可变体积分配器包含一组一个或多个填充管（10），每个填充管具有可滑动地安装在其中的杆（60）或其他容积限制构件。吸入压力可以将负载的寡核苷酸珠或其它粉末（140），颗粒或其它特定材料吸入填充管（10）中，以将选定的体积分配到孔或其它容器中。杆（60）或其它构件可以被构造成包括具有小于待操作的颗粒物质的孔的过滤器（260），使得材料不能被填充在填充管（10）内。在各种实施例中，通过使用电磁体（210）将棒（60）移动到填充管（10）内的不同位置，可以选择性地设置待吸入的粉末（140）或其它材料的体积。各种实施例中，单独的杆（60）可以被独立地激活。

9. 发明申请

WO2009006447A3 DETECTING AND MIXING IN A CONDUIT IN INTEGRATED BIOANALYSIS SYSTEMS 审中-公开
标题翻译：在一体化生物分析系统中的检测和混合
公开(公告)号：WO2009006447A3
公开(公告)日：2009-06-18
申请号：PCT/US2008068859
申请日：2008-06-30
申请人： APPLERA CORP , VANN CHARLES S
发明人： VANN CHARLES S
IPC分类号： B01L3/00 , B01F13/00 , B01L3/02
CPC分类号： C12Q1/686 , B01F3/088 , B01F11/0071 , B01F11/0074 , B01L3/0217 , B01L3/022 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2300/0654 , B01L2300/0832 , B01L2300/1805 , B01L2400/0478 , G01N21/64 , G01N21/76 , G01N35/1065 , G01N2035/1046 , G01N2035/1062
摘要： Apparatuses and methods in which detection is integrated with various liquid processing and environmental control functions to create integrated bioanalysis systems are disclosed. Though the various integrated bioanalysis systems are useful for any number of analysis formats, they are adaptable to high-throughput processing of samples.
摘要翻译：公开了将检测与各种液体处理和环境控制功能整合以产生集成的生物分析系统的装置和方法。尽管各种综合生物分析系统对于任何数量的分析格式都是有用的，但它们适用于样品的高通量处理。

10. 发明申请

WO2005071412A3 PHOSPHOR PARTICLE CODED BEADS 审中-公开
标题翻译：磷光颗粒编码珠
公开(公告)号：WO2005071412A3
公开(公告)日：2006-04-06
申请号：PCT/US2005000006
申请日：2005-01-06
申请人： APPLERA CORP , VANN CHARLES S , CONNELL CHARLES R , LAU ALDRICH N K , TAING MENG C , MENCHEN STEVEN M
发明人： VANN CHARLES S , CONNELL CHARLES R , LAU ALDRICH N K , TAING MENG C , MENCHEN STEVEN M
IPC分类号： C12Q1/68 , C40B20/04 , C40B70/00 , G01N33/53 , G01N33/533 , G01N33/543 , G01N33/58
CPC分类号： B82Y5/00 , C12Q2563/155 , G01N33/54346 , G01N33/587
摘要： Beads coded with phosphor particles and methods of making and using them are provided.
摘要翻译：提供用磷光体颗粒编码的珠子，并制作和使用它们的方法。

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