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1. 发明申请

WO2008064291A3 INTERMEDIATES AND METHODS FOR FORMING PASSIVATED SURFACES ON OXIDE LAYERS AND ARTICLES PRODUCED THEREBY 审中-公开
标题翻译：在氧化层上形成钝化表面的中间体和方法及其生产的制品
公开(公告)号：WO2008064291A3
公开(公告)日：2008-10-30
申请号：PCT/US2007085347
申请日：2007-11-21
申请人： APPLERA CORP , MENCHEN STEVEN M , INMAN CHRISTINA E , TAING MENG , LUONG KHAI , LI HANDONG
发明人： MENCHEN STEVEN M , INMAN CHRISTINA E , TAING MENG , LUONG KHAI , LI HANDONG
IPC分类号： G01N33/543 , G01N33/551
CPC分类号： G01N33/54393 , G01N33/551 , Y10T428/31678
摘要： Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Po l) m , where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and "Pol" represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
摘要翻译：描述了用于在氧化物层上形成钝化表面的中间体和方法以及由此制备的制品。氧化物表面上的羟基或氢氧基与式Y（L-Po 1）m的金属试剂反应，其中Y是过渡金属，镁或铝，L是氧，硫，硒或胺，“Pol”表示钝化剂，例如聚乙二醇，烃或碳氟化合物。所得到的改性表面可以进一步与具有磷酸酯官能团的钝化剂或包含钝化部分和多个与Y形成复合物的多个官能团的多价试剂反应。钝化剂还可以包括官能团例如生物素，以提供具有所需功能的表面。被钝化的表面表现出与生物分子的最小结合，并可用于单分子检测方案。

2. 发明申请

WO2009009408A3 DEVICES AND METHODS FOR THE DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析仪的装置和方法
公开(公告)号：WO2009009408A3
公开(公告)日：2009-04-16
申请号：PCT/US2008069126
申请日：2008-07-03
申请人： APPLIED BIOSYSTEMS , EASON ROBERT G , LAU ALDRICH N K , SCABOO KRISTIAN M , LI HANDONG
发明人： EASON ROBERT G , LAU ALDRICH N K , SCABOO KRISTIAN M , LI HANDONG
IPC分类号： G01N33/58
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译：描述了用于检测分析物如致病细胞的系统和方法。这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。

3. 发明申请

WO2007051032A3 CHEMICAL DERIVATIZATION, DETECTION, AND IDENTIFICATION OF PEPTIDE AND PROTEIN MODIFICATIONS 审中-公开
标题翻译：化学衍生物，肽和蛋白质修饰的检测和鉴定
公开(公告)号：WO2007051032A3
公开(公告)日：2007-06-14
申请号：PCT/US2006042334
申请日：2006-10-26
申请人： INTEL CORP , SUNDARARAJAN NARAYAN , LI HANDONG
发明人： SUNDARARAJAN NARAYAN , LI HANDONG
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of peptides using Surface Enhanced Raman Spectroscopy (SERS) and Raman spectroscopy. Additional embodiments provide strategies for chemically derivatizing post-translational modifications and detecting the chemically derivatized products using SERS. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供了使用表面增强拉曼光谱（SERS）和拉曼光谱法检测，鉴定，区分和定量肽的修饰状态的装置和方法。另外的实施方案提供了用于化学衍生翻译后修饰并使用SERS检测化学衍生化产物的策略。本发明实施方案的应用包括在疾病诊断，预后和药物疗效研究，酶活性分析和测定中的应用的蛋白质组广泛的修饰分析和分析。

4. 发明申请

WO2008086482B1 LATERAL COLLECTION PHOTOVOLTAICS 审中-公开
公开(公告)号：WO2008086482B1
公开(公告)日：2008-11-20
申请号：PCT/US2008050780
申请日：2008-01-10
申请人： SOLARITY INC , FONASH STEPHEN J , LI HANDONG , STONE DAVID
发明人： FONASH STEPHEN J , LI HANDONG , STONE DAVID
IPC分类号： H01L31/00
CPC分类号： H01L51/4213 , H01L31/022425 , H01L51/0037 , H01L51/4266 , Y02E10/549
摘要： Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.

5. 发明申请

WO2008016375A3 MODIFICATION OF METAL NANOPARTICLES FOR IMPROVED ANALYTE DETECTION BY SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) 审中-公开
标题翻译：改进金属纳米粒子用于表面增强拉曼光谱（SERS）改进分析物检测
公开(公告)号：WO2008016375A3
公开(公告)日：2008-08-14
申请号：PCT/US2006048009
申请日：2006-12-14
申请人： INTEL CORP , ZHANG JINGWU , SUNDARARAJAN NARAYAN , NGOLA SARAH M , LI HANDONG
发明人： ZHANG JINGWU , SUNDARARAJAN NARAYAN , NGOLA SARAH M , LI HANDONG
IPC分类号： G01N21/65
CPC分类号： G01N33/54373 , B82Y30/00 , G01N21/658 , G01N33/54346 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-metallic molecule, wherein the metal-containing particle is derivatized with the non-metallic molecule is disclosed. In addition, several methods of modifying the nanoparticles surfaces of a SERS active particle and of improving the interaction between the SERS active particle and an analyte are disclosed.
摘要翻译：公开了在含金属颗粒上具有含金属颗粒和阳离子涂层的SERS活性颗粒，其中SERS活性颗粒携带正电荷。此外，公开了具有含金属颗粒和非金属分子的SERS活性颗粒，其中含金属颗粒用非金属分子衍生化。另外，公开了修饰SERS活性颗粒的纳米颗粒表面并改善SERS活性颗粒与分析物之间的相互作用的几种方法。

6. 发明申请

WO2008085538A3 NEW ASSAY PLATFORMS AND DETECTION METHODOLOGY USING SURFACE ENHANCED RAMAN SCATTERING (SERS) UPON SPECIFIC BIOCHEMICAL INTERACTIONS 审中-公开
标题翻译：使用表面增强拉曼散射（SERS）与特定生化相互作用的新测定平台和检测方法学
公开(公告)号：WO2008085538A3
公开(公告)日：2008-11-20
申请号：PCT/US2007072298
申请日：2007-06-27
申请人： INTEL CORP , ZHANG JINGWU , LI HANDONG , SUNDARARAJAN NARAYAN , SU XING , SUN LEI
发明人： ZHANG JINGWU , LI HANDONG , SUNDARARAJAN NARAYAN , SU XING , SUN LEI
IPC分类号： G01N21/66 , G01J3/44 , G01N21/956
CPC分类号： G01N33/585 , C12Q1/6816 , G01N21/658 , G01N33/54373 , C12Q2563/155 , C12Q2565/632
摘要： The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.
摘要翻译：本发明的实施方案涉及包含至少部分被分析物分子包围的捕获颗粒的SERS簇，其中捕获颗粒和围绕捕获颗粒的分析物分子至少部分被增强剂颗粒包围，其中大部分的分析物分子夹在捕获和增强剂颗粒之间或位于增强剂颗粒的连接点之间。本发明的实施例还涉及制造和检测SERS群集的方法。本发明的实施方案还涉及包含标签分子的SERS活性颗粒，所述标签分子包含拉曼活性化合物和具有特定生物化学结合能力的探针或接头，并涉及使用SERS活性颗粒检测靶分子的方法，所述SERS活性颗粒具有标签分子，其包含拉曼活性化合物和探针或接头。

7. 发明申请

WO2008086482A3 LATERAL COLLECTION PHOTOVOLTAICS 审中-公开
标题翻译：横向收藏光伏
公开(公告)号：WO2008086482A3
公开(公告)日：2008-10-09
申请号：PCT/US2008050780
申请日：2008-01-10
申请人： SOLARITY INC , FONASH STEPHEN J , LI HANDONG , STONE DAVID
发明人： FONASH STEPHEN J , LI HANDONG , STONE DAVID
IPC分类号： H01L31/00
CPC分类号： H01L51/4213 , H01L31/022425 , H01L51/0037 , H01L51/4266 , Y02E10/549
摘要： Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.
摘要翻译：使用基于微纳米收集元件的侧向收集光伏（LCP）结构来收集光生载流子。在一组实施例中，集合元件排列在导电衬底上。在某些形式中，收集元件基本上垂直于导体。在另一组实施例中，微尺度或纳米级收集元件不具有与任何导电衬底的直接物理和电接触。在一个版本中，阳极和阴极电极都是横向排列的。在另一个版本中，一个电极的收集元件是复合材料，其中导体由驻留在基底上的相对电极的绝缘体分隔开，绝缘体是每个集电器元件的一部分。在另一个版本中，一个电极结构的集合是包含用于收集的阳极和阴极收集元件的复合物。活性物质位于收集器元件之间。

8. 发明申请

WO2008086482A2 LATERAL COLLECTION PHOTOVOLTAICS 审中-公开
标题翻译：横向收藏光伏
公开(公告)号：WO2008086482A2
公开(公告)日：2008-07-17
申请号：PCT/US2008050780
申请日：2008-01-10
申请人： SOLARITY INC , FONASH STEPHEN J , LI HANDONG , STONE DAVID
发明人： FONASH STEPHEN J , LI HANDONG , STONE DAVID
IPC分类号： B32B7/00
CPC分类号： H01L51/4213 , H01L31/022425 , H01L51/0037 , H01L51/4266 , Y02E10/549
摘要： Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.
摘要翻译：采用基于微米和纳米收集元件的横向收集光伏（LCP）结构来收集光生载流子。在一组实施例中，收集元件排列在导电基底上。在某些版本中，收集元件基本垂直于导体。在另一组实施例中，微米级或纳米级收集元件不具有与任何导电衬底的直接物理和电接触。在一个版本中，阳极和阴极都横向排列。在另一种形式中，一个电极的收集元件是复合物，其中导体由作为每个收集元件的一部分的绝缘体与位于基板上的相对电极分开。在又一个版本中，一个电极结构的集合是包含用于收集的阳极和阴极收集元件的复合物。活性材料位于收集器元件之间。

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