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1. 发明申请

WO2008012071A3 PHARMACEUTICAL COMPOSITIONS OF NICOTINE AND METHODS OF USE THEREOF 审中-公开
标题翻译：尼古丁的药物组合物及其使用方法
公开(公告)号：WO2008012071A3
公开(公告)日：2008-03-13
申请号：PCT/EP2007006579
申请日：2007-07-24
申请人： ANTARES PHARMA IPL AG , R CARRARA DARIO NORBERTO , GRENIER ARNAUD , BESSE CELINE
发明人： R CARRARA DARIO NORBERTO , GRENIER ARNAUD , BESSE CELINE
IPC分类号： A61K9/06 , A61P25/34
CPC分类号： A61K9/0014 , A61K9/7015 , A61K47/10
摘要： The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between about pH 5.5 and about pH 6.5. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.
摘要翻译：本发明包括用于经皮递送尼古丁的非闭塞组合物，更具体地是其药学上可接受的盐，以及制备它们的方法。组合物可以例如是适合于透皮或经粘膜应用的凝胶。本发明的组合物通常包含水和醇的混合物，以及具有二甘醇单体烷基醚和二醇以特定比例和特定量存在的溶剂体系，其中凝胶的pH通常在约pH 5.5和约pH 6.5。组合物可以包括另外的组分，例如，水醇载体可以进一步包含另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂。本发明还涉及一种用于持续递送尼古丁药学上可接受的盐以治疗多种病症和病症的方法。

2. 发明申请

WO2004080413A3 USES AND FORMULATIONS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION OF ACTIVE AGENTS 审中-公开
标题翻译：用于活性剂的透皮或透射应用的用途和制剂
公开(公告)号：WO2004080413A3
公开(公告)日：2006-07-20
申请号：PCT/US2004007291
申请日：2004-03-11
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
IPC分类号： A61K9/70 , A01N45/00 , A61K20060101 , A61K9/00 , A61K9/06 , A61K31/56 , A61K47/10 , A61K47/32 , A61K47/38
CPC分类号： A61K31/56 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/32 , A61K47/38
摘要： Uses and formulations for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods treat symptoms of hormonal disorders including hypogonadism, female sexual desire disorder, female menopausal disorder, and adrenal insufficiency.
摘要翻译：用于将活性剂透皮或经粘膜递送至有需要的受试者的用途和制剂。制剂和方法治疗激素失调症状，包括性腺机能减退，女性性欲障碍，女性绝经障碍和肾上腺功能不全。

3. 发明申请

WO2007022924A3 PHARMACEUTICAL COMPOSITIONS WITH MELTING POINT DEPRESSANT AGENTS AND METHOD OF MAKING SAME 审中-公开
标题翻译：含有熔点抑制剂的药物组合物及其制备方法
公开(公告)号：WO2007022924A3
公开(公告)日：2007-08-09
申请号：PCT/EP2006008170
申请日：2006-08-18
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
发明人： CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
IPC分类号： A61K9/00 , A61K9/06 , A61K31/00 , A61K47/14 , A61K47/32 , A61K47/34
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/00 , A61K47/10 , A61K47/24 , A61K47/32 , A61K47/44
摘要： The invention relates to the use of chemical fragrance ingredient to lower the melting point of active agents, thereby changing crystalline active agents into an amorphous state. The invention also relates to methods of enhancing the transdermal or transmucosal skin permeation or skin penetration of pharmacologically active agents to patients in need thereof. The compositions of the present invention present the additional benefits of being substantially alcohol-free and having a pleasant olfactory profile.
摘要翻译：本发明涉及使用化学香料成分来降低活性剂的熔点，从而将结晶活性剂变为无定形状态。本发明还涉及增强药理活性剂对需要其的患者的透皮或透粘膜皮肤渗透或皮肤渗透的方法。本发明的组合物具有基本不含酒精并具有令人愉快的嗅觉特征的额外益处。

4. 发明申请

WO2005105059B1 PERMEATION ENHANCER COMPRISING GENUS CURCUMA OR GERMACRONE FOR TRANSDERMAL AND TOPICAL ADMINISTRATION OF ACTIVE AGENTS 审中-公开
标题翻译：渗透性增强剂包括基因曲霉或灭活剂用于活性代谢物的超导和局部给药
公开(公告)号：WO2005105059B1
公开(公告)日：2006-02-02
申请号：PCT/EP2005004594
申请日：2005-04-28
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , ALBERTI INGO , HENRY LAETITIA
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , ALBERTI INGO , HENRY LAETITIA
IPC分类号： A61K9/00 , A61K9/70 , A61K31/121 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/46
CPC分类号： A61K9/0014 , A61K31/121 , A61K36/9066 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/46 , A61K2300/00
摘要： A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus
摘要翻译：用于局部，透皮或经粘膜给药治疗有效活性剂的制剂，方法和系统。特别地，本发明提供了用于增强活性剂穿过哺乳动物受试者的皮肤或粘膜表面的渗透或渗透的制剂，系统和方法。所述制剂包括所述植物提取物

5. 发明申请

WO2007022924B1 PHARMACEUTICAL COMPOSITIONS WITH MELTING POINT DEPRESSANT AGENTS AND METHOD OF MAKING SAME 审中-公开
公开(公告)号：WO2007022924B1
公开(公告)日：2007-10-18
申请号：PCT/EP2006008170
申请日：2006-08-18
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
发明人： CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
IPC分类号： A61K9/00 , A61K9/06 , A61K31/00 , A61K47/14 , A61K47/32 , A61K47/34
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/00 , A61K47/10 , A61K47/24 , A61K47/32 , A61K47/44
摘要： The invention relates to the use of chemical fragrance ingredient to lower the melting point of active agents, thereby changing crystalline active agents into an amorphous state. The invention also relates to methods of enhancing the transdermal or transmucosal skin permeation or skin penetration of pharmacologically active agents to patients in need thereof. The compositions of the present invention present the additional benefits of being substantially alcohol-free and having a pleasant olfactory profile.

6. 发明专利

IL170454A Transdermal or transmucosal formulations of active agents and uses thereof 未知
公开(公告)号：IL170454A
公开(公告)日：2014-02-27
申请号：IL17045405
申请日：2005-08-23
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/70 , A61K31/56 , A61K47/10 , A61K47/32 , A61K47/38
摘要： Methods, formulations, and kits for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods treat symptoms of hormonal disorders including hypogonadism, female sexual desire disorder, female menopausal disorder, and adrenal insufficiency.

7. 发明专利

JP2011236250A Use and formulation for transdermal or transmucosal application of active agent 有权
标题翻译：用于活化剂的透皮或透射应用的使用和配方
公开(公告)号：JP2011236250A
公开(公告)日：2011-11-24
申请号：JP2011179079
申请日：2011-08-18
申请人： Antares Pharma Ipl Ag , アンタレスファルマイーペーエルアクチェンゲゼルシャフト
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
IPC分类号： A61K31/568 , A61J1/00 , A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/127 , A61K9/70 , A61K31/56 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/38 , A61P5/24 , A61P5/38 , A61P15/08 , A61P15/12 , C07J1/00
CPC分类号： A61K31/56 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/32 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide formulations for treating symptoms of hypogonadism, female menopausal symptoms, female sexual dysfunction, hypoactive sexual desire disorder, and adrenal insufficiency.SOLUTION: The formulation includes an active agent comprising androgen, estrogen, progestin, or a combination thereof and a delivery vehicle including an alkanol, a polyalcohol and permeation enhancers. The formulation is free of chain fatty alcohols, long chain fatty acids and long-chain fatty esters and avoids undesirable odors and irritation during use of the formulation.
摘要翻译：要解决的问题：提供用于治疗性腺机能减退症，女性绝经期症状，女性性功能障碍，性欲降低障碍和肾上腺功能不全的制剂。解决方案：该制剂包括包含雄激素，雌激素，孕激素或其组合的活性剂和包含链烷醇，多元醇和渗透促进剂的递送载体。该制剂不含链状脂肪醇，长链脂肪酸和长链脂肪酸酯，并避免在使用制剂期间不希望的气味和刺激性。版权所有（C）2012，JPO＆INPIT

8. 发明专利

AU2004283431B2 Transdermal pharmaceutical formulation for minimizing skin residues 未知
公开(公告)号：AU2004283431B2
公开(公告)日：2009-09-10
申请号：AU2004283431
申请日：2004-10-06
申请人： ANTARES PHARMA IPL AG
发明人： GRENIER ARNAUD , BESSE CELINE , CARRARA DARIO NORBERTO R
IPC分类号： A61K9/00 , A61K9/06 , A61K47/10 , A61K47/32 , A61K47/38
摘要： This invention relates to novel transdermal or transmucosal pharmaceutical formulation having an active agent of testosterone which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The solvent system of the formulation includes a monoalkylether of diethylene glycol and a glycol present in specified ratios, and a mixture of water and alcohol. The invention also relates to a method for inhibiting or delaying crystallization of the active agent in a pharmaceutical formulation.

9. 发明专利

CA2538856A1 TRANSDERMAL PHARMACEUTICAL FORMULATION FOR MINIMIZING SKIN RESIDUES 未知
公开(公告)号：CA2538856A1
公开(公告)日：2005-05-06
申请号：CA2538856
申请日：2004-10-06
申请人： ANTARES PHARMA IPL AG
发明人： GRENIER ARNAUD , BESSE CELINE , CARRARA DARIO NORBERTO R
IPC分类号： A61K9/06 , A61K9/00 , A61K47/10 , A61K47/32 , A61K47/38
摘要： This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically active ingredient, and a solvent system having a monoalkylether of diethylene gycol and a gycol prese nt in specified ratios, and a mixture of water and alcohol. The invention also relates to a method for inhibiting or delaying crystallization of an active agent in a pharmaceutical formulation.

10. 发明专利

CA2515426C USES AND FORMULATIONS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION OF ACTIVE AGENTS 未知
公开(公告)号：CA2515426C
公开(公告)日：2012-01-24
申请号：CA2515426
申请日：2004-03-11
申请人： ANTARES PHARMA IPL AG
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , SIMES STEPHEN M , LEHMAN LEAH M
IPC分类号： A61K31/57 , A61K20060101 , A61K9/00 , A61K9/06 , A61K9/70 , A61K31/56 , A61K31/565 , A61K47/10 , A61K47/32 , A61K47/38
摘要： Uses and formulations for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods treat symptoms of hormonal disorders including hypogonadism, female sexual desire disorder, female menopausal disorder, and adrenal insufficiency.

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