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1. 发明申请

WO2004050126A3 COMPOSITIONS FOR TREATING OR PREVENTING ANGIOGENESIS-DEPENDENT SYMPTOMS 审中-公开
标题翻译：用于治疗或预防依赖于血液发生的症状的组合物
公开(公告)号：WO2004050126A3
公开(公告)日：2004-09-30
申请号：PCT/JP0315400
申请日：2003-12-02
申请人： ANGES MG INC , HIRAOKA KAZUYA , YAMAMOTO SEIJI , KANEDA YASUFUMI , MORISHITA RYUICHI , OGIHARA TOSHIO
发明人： HIRAOKA KAZUYA , YAMAMOTO SEIJI , KANEDA YASUFUMI , MORISHITA RYUICHI , OGIHARA TOSHIO
IPC分类号： A61K48/00 , A61P9/10
CPC分类号： C07K14/475 , A61K48/0016 , A61K48/0083 , C07K14/4753 , C12N9/0073
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemic heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.
摘要翻译：本发明提供了一种提高裸小质粒DNA在治疗和/或预防血管生成依赖性症状中的转染效率的方法。根据本方法，将适当的裸质粒DNA在肌肉或高压氧内加压肌内注射。可以通过本发明的方法治疗血管发生依赖性症状，包括伤口，炎性疾病，临界肢体缺血，缺血性心脏病，脑梗塞，糖尿病性神经病变，椎管狭窄等。

2. 发明专利

DE60333476D1 ZUSAMMENSETZUNGEN ZUR BEHANDLUNG ODER PRÄVENTION VON ANGIOGENESE-ABHÄNGIGEN SYMPTOMEN 未知
公开(公告)号：DE60333476D1
公开(公告)日：2010-09-02
申请号：DE60333476
申请日：2003-12-02
申请人： ANGES MG INC
发明人： HIRAOKA KAZUYA , YAMAMOTO SEIJI , KANEDA YASUFUMI , OGIHARA TOSHIO , MORISHITA RYUICHI
IPC分类号： A61K48/00 , A61P9/10

3. 发明专利

AU2003302590B2 Compositions for treating or preventing angiogenesis-dependent symptoms 未知
公开(公告)号：AU2003302590B2
公开(公告)日：2008-11-06
申请号：AU2003302590
申请日：2003-12-02
申请人： ANGES MG INC
发明人： YAMAMOTO SEIJI , OGIHARA TOSHIO , KANEDA YASUFUMI , MORISHITA RYUICHI , HIRAOKA KAZUYA
IPC分类号： A61K48/00 , A61P9/10
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemia heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.

4. 发明专利

CA2507534A1 COMPOSITIONS FOR TREATING OR PREVENTING ANGIOGENESIS-DEPENDENT SYMPTOMS 未知
公开(公告)号：CA2507534A1
公开(公告)日：2004-06-17
申请号：CA2507534
申请日：2003-12-02
申请人： ANGES MG INC
发明人： KANEDA YASUFUMI , OGIHARA TOSHIO , YAMAMOTO SEIJI , MORISHITA RYUICHI , HIRAOKA KAZUYA
IPC分类号： A61K48/00 , A61P9/10
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by th e present inventions. According to the present method, a suitable naked plasmi d DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemic heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.

5. 发明专利

CA2501701A1 CHEMOTHERAPEUTIC AGENT-INCORPORATED PHARMACEUTICAL PREPARATION 未知
公开(公告)号：CA2501701A1
公开(公告)日：2004-05-13
申请号：CA2501701
申请日：2003-10-29
申请人： ANGES MG INC , GENOMIDEA INC
发明人： KANEDA YASUFUMI , YAMAMOTO SEIJI , KOTANI HITOSHI
IPC分类号： A61K9/50 , A61K35/76 , A61K35/761 , A61K35/763 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , A61K38/08
摘要： It is intended to provide a medicinal preparation for transferring a chemotherapeutic (preferably an anticancer agent) into cells or the living body by using a virus envelope vector. Namely, a medicinal preparation containing a virus envelope vector having a chemotherapeutic encapsulated therein as the active ingredient. Examples of the anticancer agent include bleomycins, anthraquinone carcinostatic agents, mitomycins, actinomycins, taxane derivatives, camptothecins, cisplatins, staurosporines, vincristine, streptozotocin, 5-fluorouracil (5-FU) and its derivatives, pirarubicin, dolastatin and pharmacologically acceptable salts thereof. Examples of the virus include sendai virus, retro virus, adenovirus, adeno-associated virus, herpes virus, vaccinia virus, pox virus, influenza virus and so on.

6. 发明专利

AT474604T 未知
公开(公告)号：AT474604T
公开(公告)日：2010-08-15
申请号：AT03812366
申请日：2003-12-02
申请人： ANGES MG INC
发明人： HIRAOKA KAZUYA , YAMAMOTO SEIJI , KANEDA YASUFUMI , OGIHARA TOSHIO , MORISHITA RYUICHI
IPC分类号： A61K48/00 , A61P9/10
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemia heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.

7. 发明专利

AU2003302590A1 METHODS FOR TREATING OR PREVENTING ANGIOGENESIS-DEPENDENT SYMPTOMS 未知
公开(公告)号：AU2003302590A1
公开(公告)日：2004-06-23
申请号：AU2003302590
申请日：2003-12-02
申请人： ANGES MG INC
发明人： OGIHARA TOSHIO , HIRAOKA KAZUYA , YAMAMOTO SEIJI , KANEDA YASUFUMI , MORISHITA RYUICHI
IPC分类号： A61K48/00 , A61P9/10
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemia heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.

8. 发明专利

AU2003280604A8 Medicinal preparation having chemotherapeutic encapsulated therein 未知
公开(公告)号：AU2003280604A8
公开(公告)日：2004-05-25
申请号：AU2003280604
申请日：2003-10-29
申请人： ANGES MG INC
发明人： YAMAMOTO SEIJI , KOTANI HITOSHI , KANEDA YASUFUMI
IPC分类号： A61K9/50 , A61K35/76 , A61K35/761 , A61K35/763 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , A61K38/08
摘要： The present invention provides a pharmaceutical preparation used for transfecting a chemotherapeutic agent, preferably an anticancer agent by a virus envelope vector into a cell or living organism. The pharmaceutical preparation comprises, as an active ingredient, a virus envelope vector having a chemotherapeutic agent incorporated therein. The anticancer agent includes, for example, bleomycin and derivatives thereof, anthraquinone-based cancerocidal agents, mitomycin and derivatives thereof, actinomycin and derivatives thereof, taxane derivatives, camptothecin and derivatives thereof, cisplatin and derivatives thereof, staurosporine and derivatives thereof, vincristine, streptozotocin, 5-fluorouracil (5-FU) and derivatives thereof, viralbicin, dolastatin, and pharmacologically acceptable salts thereof. The virus includes, for example, Sendai virus, retrovirus, adenovirus, adeno-associated virus, herpes virus, vaccinia virus, poxvirus, influenza virus etc.

9. 发明专利

IT8667302D0 未知
公开(公告)号：IT8667302D0
公开(公告)日：1986-04-11
申请号：IT6730286
申请日：1986-04-11
申请人： YAMAMOTO SEIJI
发明人： YAMAMOTO SEIJI
IPC分类号： G03B9/08 , G03B9/10 , H01F7/122 , H01F7/14 , H01F7/16 , H01H51/22 , H01H51/24 , G05B
摘要： A magnetically operated actuator which comprises a generally elongated operating element displaceable between first and second positions, an electromagnet assembly for driving the operating element to displace between the first and second positions and comprising an iron core and a solenoid coil disposed around the iron core, a permanent magnet assembly rigidly mounted on the operating element and having a pair of opposite poles different in polarity from each other and having a magnetic field which is developed between the opposite poles, and a stopper member for restricting the stroke of movement of the operating element between the first and second positions. The electromagnet assembly is fixedly supported in position with one of the opposite ends of the iron core situated in the magnetic field developed between the poles of the permanent magnet assembly. The first and second positions are located in the vicinity of the opposite poles of the permanent magnet assembly.

10. 发明专利

GB2194100A MAGNETICALLY OPERATED ACTUATOR 未知
公开(公告)号：GB2194100A
公开(公告)日：1988-02-24
申请号：GB8718668
申请日：1987-08-06
申请人： YAMAMOTO SEIJI
发明人： YAMAMOTO SEIJI
IPC分类号： H01H51/22 , H01F7/08 , H01F7/14
摘要： A magnetically operated actuator comprises a support structure (10), a generally elongated operating element (14) mounted on the support structure for selective displacement between first and second positions, and at least one electromagnet assembly for driving the operating element (14) to displace the latter between the first and second positions under the influence of magnetism emanating therefrom. The electromagnet assembly comprises a first magnetic member (16) and a solenoid unit (20) around the first magnetic member (16) and adapted to develop a magnetic field when electrically energized. The first magnetic member (16) is then exposed in the magnetic field developed by the solenoid unit (20) when the solenoid unit (20) is electrically energized. There are at least two second magnetic members (33,34) cooperable with the first magnetic member (16). One of the first and second magnetic members is fixed to the support structure and the other of the first and second magnetic members is fixed to the operating element while the solenoid unit (20) is fixed to the support structure (10).

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