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1. 发明专利

JP2011050381A NEW OLIGONUCLEOTIDE DERIVATIVE AND NF-κB DECOY COMPRISING THE SAME 有权
标题翻译：新的寡核苷酸衍生物和包含其的NF-kappaB
公开(公告)号：JP2011050381A
公开(公告)日：2011-03-17
申请号：JP2010178330
申请日：2010-08-09
申请人： Anges Mg Inc , Gene Design Inc , アンジェスMg株式会社 , 株式会社ジーンデザイン
发明人： YOSHINO MASAFUMI , YUYAMA KAZUHIKO , UENO NOBUHIRO , KONO HIROKAZU , GENBAN GAKUSEN
IPC分类号： C12N15/09 , A61K31/7088 , A61K48/00 , A61P1/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To provide such a new oligonucleotide derivative that, when used as an NF-κB decoy, the linkage affinity for NF-κB is further higher than that of well-known NF-κB decoys, to provide an NF-κB decoy comprising the same, and to provide a pharmaceutical containing the same as an active ingredient. SOLUTION: The new oligonucleotide derivative, which is such a hairpin-type double-stranded oligonucleotide in which an oligonucleotide having a specific base sequence and a complementary strand thereof are linked to each other via a specific linker, exhibits further higher linkage affinity for NF-κB than well-known NF-κB decoys. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供这样一种新的寡核苷酸衍生物，当用作NF-κB诱饵时，NF-κB的连接亲和力比已知的NF-κB诱饵更高，提供了一种包含其的NF-κB诱饵，并提供含有其作为活性成分的药物。解决方案：将具有特定碱基序列和互补链的寡核苷酸通过特异性接头相互连接的发夹型双链寡核苷酸的新的寡核苷酸衍生物显示出更高的连接亲和力 NF-κB比NF-κB诱饵更好。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010090103A NEW OLIGONUCLEOTIDE DERIVATIVE AND NF-κB DECOY COMPOSED OF THE SAME 有权
标题翻译：新的寡核苷酸衍生物和NF-κB复合物
公开(公告)号：JP2010090103A
公开(公告)日：2010-04-22
申请号：JP2009030915
申请日：2009-02-13
申请人： Anges Mg Inc , Gene Design Inc , アンジェスMg株式会社 , 株式会社ジーンデザイン
发明人： YOSHINO MASAFUMI , YUYAMA KAZUHIKO , UENO NOBUHIRO , KONO HIROKAZU , GENBAN GAKUSEN
IPC分类号： A61K31/7125 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/08 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new oligonucleotide derivative which has a higher bonding affinity with an NF-κB than the known NF-κB decoys, when used as an NF-κB decoy, an NF-κB decoy composed of the derivative and a drug containing the derivative as an effective ingredient.
SOLUTION: A hairpin type double-stranded oligonucleotide in which an oligonucleotide having a specific base sequence and its complementary chain are bonded with a specific linker exhibits a higher NF-κB bonding affinity than the known NF-κB decoys.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供与已知NF-κB诱饵相比具有比NF-κB更高的结合亲和力的新的寡核苷酸衍生物，当用作NF-κB诱饵时，由以下组成的NF-κB诱饵衍生物和含有该衍生物作为有效成分的药物。解决方案：其中具有特异性碱基序列及其互补链的寡核苷酸与特异性接头结合的发夹型双链寡核苷酸表现出比已知NF-κB诱饵更高的NF-κB结合亲和力。版权所有（C）2010，JPO＆INPIT

3. 发明专利

CA2614295A1 TRANSCRIPTION FACTOR DECOY 未知
公开(公告)号：CA2614295A1
公开(公告)日：2006-12-14
申请号：CA2614295
申请日：2006-06-06
申请人： ANGES MG INC
发明人： UENO NOBUHIRO , GEMBA TAKEFUMI
IPC分类号： C12N15/09 , A61K31/713 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/08 , A61P41/00 , A61P43/00 , C07H21/00
摘要： Disclosed are: a double-stranded oligonucleotide which is useful as a decoy oligonucleotide having a high ability to bind to a transcription factor and a reduced cytotoxicity; and use of the double-stranded oligonucleotide for medical purposes. A double-stranded oligonucleotide composed of a hybrid of a sense oligonucleotide having a nucleotide sequence depicted by the formula A with an anti-sense oligonucleotide which is complementary to the sense oligonucleotide: 5'-N(m)-G-(consensus sequence)-C-N(n)-3' (A) wherein N(m) represents a sequence which is added to the 5'-terminus and is composed of m units of N's and N(n) represents a sequence which is added to the 3'-terminus and is composed of n units of N's, wherein all of N's independently represent a nucleotide A, G, T, C or U; m and n independently represent an integer of 0 to 20; and the term "consensus sequence" means a consensus sequence to which a transcription factor is to be bound.

4. 发明公开

EP1892293A4 TRANSCRIPTION FACTOR DECOY 审中-公开
标题翻译： TRANSKRIPTIONSFAKTORKÖDER
公开(公告)号：EP1892293A4
公开(公告)日：2008-12-10
申请号：EP06757008
申请日：2006-06-06
申请人： ANGES MG INC
发明人： GEMBA TAKEFUMI , UENO NOBUHIRO
IPC分类号： C12N15/09 , A61K31/713 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , C07K14/47
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3521
摘要： Disclosed are: a double-stranded oligonucleotide which is useful as a decoy oligonucleotide having a high ability to bind to a transcription factor and a reduced cytotoxicity; and use of the double-stranded oligonucleotide for medical purposes. A double-stranded oligonucleotide composed of a hybrid of a sense oligonucleotide having a nucleotide sequence depicted by the formula A with an anti-sense oligonucleotide which is complementary to the sense oligonucleotide: 5'-N(m)-G-(consensus sequence)-C-N(n)-3' (A) wherein N(m) represents a sequence which is added to the 5'-terminus and is composed of m units of N's and N(n) represents a sequence which is added to the 3'-terminus and is composed of n units of N's, wherein all of N's independently represent a nucleotide A, G, T, C or U; m and n independently represent an integer of 0 to 20; and the term 'consensus sequence' means a consensus sequence to which a transcription factor is to be bound.
摘要翻译：公开了：用作具有与转录因子结合的高能力和降低的细胞毒性的诱饵寡核苷酸的双链寡核苷酸; 并将双链寡核苷酸用于医疗目的。由具有式A所示的碱基序列的有义寡核苷酸与与有义寡核苷酸5'-N（m）-G-（共有序列）互补的反义寡核苷酸的杂交体构成的双链寡核苷酸， -CN（n）-3'（A）其中N（m）代表加到5'-末端并由N个m单元组成的序列，N（n）代表加到3 ' - 末端并且由n个单位的N组成，其中所有N独立地代表核苷酸A，G，T，C或U; m和n独立地表示0至20的整数; 并且术语“共有序列”意指转录因子将与之结合的共有序列。

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