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1. 发明申请

WO2010030258A1 INSTILLATION ADMINISTRATION OF CAPSAICINOIDS FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的药物治疗药物的管理
公开(公告)号：WO2010030258A1
公开(公告)日：2010-03-18
申请号：PCT/US2008/010706
申请日：2008-09-12
申请人： ANESIVA, INC. , SANGAMESWARAN, Lakshmi , KRAMER, Susan
发明人： SANGAMESWARAN, Lakshmi , KRAMER, Susan
IPC分类号： A01N65/00
CPC分类号： A61K31/16
摘要： This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical compostion. In certain embodiments of the invention, the capsaicinoid is capsaicin.
摘要翻译：本发明涉及治疗或减轻患者疼痛的方法。具体而言，本发明提供了一种减轻开放伤口或手术切口部位附近的疼痛的方法，包括将包含辣椒素的药物组合物滴入伤口或切口中，使药物组合物停留预定时间段，以及抽吸伤口或切口以去除药物组合物。本发明还提供了一种减轻接近接近的疼痛的方法，包括将包含辣椒素的药物组合物关节内注射到关节中，使药物组合物停留预定时间段，并吸出关节以除去药物组合物。在本发明的某些实施方案中，辣椒素类是辣椒素。

2. 发明申请

WO2006010085A1 USE OF NEUROSTEROIDS TO TREAT NEUROPATHIC PAIN 审中-公开
标题翻译：使用神经病毒治疗神经病性疼痛
公开(公告)号：WO2006010085A1
公开(公告)日：2006-01-26
申请号：PCT/US2005/024451
申请日：2005-07-08
申请人： ROXRO PHARMA, LLC , WHITING, Roger , SANGAMESWARAN, Lakshmi
发明人： WHITING, Roger , SANGAMESWARAN, Lakshmi
IPC分类号： A61K31/57
CPC分类号： A61K31/57
摘要： Ganaxolone (3α -hydroxy-3β -methyl-5β -pregnan-20-one) and 3α -hydroxy-3β -methyl-5β -pregnan-20-one and their physiologically cleavable esters are useful for treating neuropathic pain. Compositions comprising a pharmaceutically acceptable excipient and an appropriate compound, along with methods for preparing the compositions are disclosed. Also disclosed are articles of manufacture wherein the composition is combine with labeling instructions for treating neuropathic pain.
摘要翻译： Ganaxolone（3a-羟基-3β-甲基-5β-孕甾-20-酮）和3a-羟基-3β-甲基-5β-孕甾-20-酮及其生理学上可切割的酯可用于治疗神经性疼痛。公开了包含药学上可接受的赋形剂和合适的化合物的组合物以及制备组合物的方法。还公开了制品，其中组合物与用于治疗神经性疼痛的标签说明书组合。

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