专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011106703A3 CXCR4 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CXCR4受体化合物
公开(公告)号：WO2011106703A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026322
申请日：2011-02-25
申请人： ANCHOR THERAPEUTICS, INC. , LOOBY, Richard, J. , TCHERNYCHEV, Boris
发明人： LOOBY, Richard, J. , TCHERNYCHEV, Boris
IPC分类号： A61K38/16
摘要： The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease ( e.g. , cancer), auto-immune disease ( e.g ., rheumatoid arthritis), fibrosis disease ( e.g ., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于基质衍生因子1（SDF-1）的G蛋白偶联受体的变构调节剂（例如，正向和负向变构调节剂和变构激动剂）的化合物，也是已知的作为CXCR4受体。 CXCR4受体化合物来源于CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症例如骨髓移植，化学增敏作用，癌症，转移性疾病（例如，癌症），自身免疫疾病（例如类风湿性关节炎），纤维化疾病（例如肺癌），AIDS感染，心血管疾病，葡萄膜炎，炎症疾病，腹腔疾病HIV感染和基于干细胞的再生医学。

2. 发明申请

WO2010053550A2 CXCR4 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CXCR4受体化合物
公开(公告)号：WO2010053550A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/005979
申请日：2009-11-04
申请人： ANCHOR THERAPEUTICS, INC. , KULIOPULOS, Athan , MCMURRY, Thomas, J. , COVIC, Lidija , TCHERNYCHEV, Boris
发明人： KULIOPULOS, Athan , MCMURRY, Thomas, J. , COVIC, Lidija , TCHERNYCHEV, Boris
IPC分类号： A61K38/08
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/7158
摘要： The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于间质衍生因子1（SDF-1）（也称为CXCR4受体）的G蛋白偶联受体的变构调节剂（例如，正和负变构调节剂和变构兴奋剂）的化合物。 CXCR4受体化合物衍生自CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症如骨髓移植，化学敏化，癌症，转移性疾病，炎性疾病，HIV感染和干细胞再生医学。

3. 发明公开

EP2362779A2 CXCR4 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CXCR4受体的化合物
公开(公告)号：EP2362779A2
公开(公告)日：2011-09-07
申请号：EP09825115.0
申请日：2009-11-04
申请人： Anchor Therapeutics, Inc.
发明人： KULIOPULOS, Athan , MCMURRY, Thomas, J. , COVIC, Lidija , TCHERNYCHEV, Boris
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/7158
摘要： The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.

4. 发明公开

EP2566494A2 CXCR4 RECEPTOR COMPOUNDS 有权
标题翻译： CXCR4-REZEPTORVERBINDUNGEN
公开(公告)号：EP2566494A2
公开(公告)日：2013-03-13
申请号：EP11748182.0
申请日：2011-02-25
申请人： Anchor Therapeutics, Inc.
发明人： LOOBY, Richard, J. , TCHERNYCHEV, Boris
IPC分类号： A61K38/16
CPC分类号： A61K47/48046 , A61K38/00 , A61K47/543 , A61K47/554 , C07K14/7158
摘要： The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease (
e.g. , cancer), auto-immune disease (
e.g ., rheumatoid arthritis), fibrosis disease (
e.g ., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于间质衍生因子1（SDF-1）（也称为CXCR4受体）的G蛋白偶联受体的变构调节剂（例如，正和负变构调节剂和变构兴奋剂）的化合物。 CXCR4受体化合物衍生自CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症如骨髓移植，化疗敏化，癌症，转移性疾病（例如癌症），自动化免疫性疾病（例如类风湿性关节炎），纤维化疾病（例如肺部），艾滋病感染，心血管疾病，葡萄膜炎，炎性疾病，腹腔疾病HIV感染和干细胞再生医学。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式