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1. 发明申请

WO2009111676A8 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：含硼的小分子作为抗炎剂
公开(公告)号：WO2009111676A8
公开(公告)日：2010-09-30
申请号：PCT/US2009036250
申请日：2009-03-05
申请人： ANACOR PHARMACEUTICALS INC , AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
IPC分类号： A61K31/69
CPC分类号： C07F5/025
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译：公开了治疗抗炎症的化合物和方法。

2. 发明申请

WO2009111676A3 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：含有BORON的小分子作为抗炎剂
公开(公告)号：WO2009111676A3
公开(公告)日：2010-04-01
申请号：PCT/US2009036250
申请日：2009-03-05
申请人： ANACOR PHARMACEUTICALS INC , AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
IPC分类号： A61K31/69
CPC分类号： C07F5/025
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译：公开了治疗抗炎症状的化合物和方法。

3. 发明授权

EP2564857B1 Boron-containing small molecules as anti-inflammatory agents 有权
标题翻译： BoronhaltigeKleinmolekülealsentzündungshemmendeWirkstoffe
公开(公告)号：EP2564857B1
公开(公告)日：2017-05-03
申请号：EP12178640
申请日：2009-03-05
申请人： ANACOR PHARMACEUTICALS INC
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
IPC分类号： A61K31/69 , A61P29/00 , C07F5/02
CPC分类号： C07F5/025 , A61K31/69 , C07F5/04
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed. The compounds are benzoxaboroles and in particular are 5-phenoxy-1-hydroxy-2,1-benzoxaboroles and 5-pyridin-2-yloxy-1-hydroxy-2,1-benzoxaboroles.
摘要翻译：公开了治疗抗炎症的化合物和方法。这些化合物是苯并氧杂硼杂环戊烯，特别是5-苯氧基-1-羟基-2,1-苯并氧杂硼杂环戊烯和5-吡啶-2-基氧基-1-羟基-2,1-苯并氧杂硼杂环戊烯。

4. 发明专利

SG182219A1 BORON-CONTAINING SMALL MOLECULES 未知
公开(公告)号：SG182219A1
公开(公告)日：2012-07-30
申请号：SG2012045712
申请日：2008-06-19
申请人： ANACOR PHARMACEUTICALS INC
发明人： BAKER STEPHEN J , HERNANDEZ VINCENT S , SHARMA RASHMI , NIEMAN JAMES A , AKAMA TSUTOMA , ZHANG YONG-KANG , PLATTNER JACOB J , ALLEY MICHAEL RICHARD KEVIN , SINGH RAJESHWAR , XIA YI , ZHOU HUCHEN , MOHAMMAD RAHIM , KERAMANE EL MEHDI , LU XIAOSONG , HA MINH , PHILLIPS JAMES G
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Fig. 1A

5. 发明专利

NZ582706A 1-Hydroxy-1,3-dihydro-benzo[c][1,2]oxaboroles and their derivatives 未知
公开(公告)号：NZ582706A
公开(公告)日：2012-07-27
申请号：NZ58270608
申请日：2008-06-19
申请人： ANACOR PHARMACEUTICALS INC
发明人： PHILLIPS JAMES G , HA MINH , LU XIAOSONG , KERAMANE EL MEHDI , MOHAMMAD RAHIM , ZHOU HUCHEN , XIA YI , SINGH RAJESHWAR , ALLEY MICHAEL RICHARD KEVIN , PLATTNER JACOB J , ZHANG YONG-KANG , AKAMA TSUTOMA , NIEMAN JAMES A , SHARMA RASHMI , HERNANDEZ VINCENT S , BAKER STEPHEN J
IPC分类号： A01N55/08 , A61K31/69 , C07F5/02
摘要： Disclosed are 1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaboroles and their derivatives as represented by the general formula (I), wherein: R* is H; R3 is selected from H, cyano, substituted or unsubstituted nitroalkyl and substituted or unsubstituted aminoalkyl; Ra is YR5; wherein Y is O or S; R5 is selected from H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl; and with the proviso that when R3 is H, Ra is not unsubstituted benzyloxy, Ra is not -OCH2COOH, Ra is not -OCH3 or Ra is not -OCH2CH3; or a salt, hydrate or solvate or anhydride thereof. Of particular importance is the compound (S)-1-hydroxy-3-aminomethyl-7-(3-hydroxypropyloxy)-3H-benzo[c][1,2]oxaborole. Further disclosed is a pharmaceutical formulation which comprises: a compound as defined above, or a pharmaceutically acceptable salt, hydrate, solvate or anhydride thereof, and a pharmaceutically acceptable excipient; for killing or preventing the growth of a microorganism, or for treating a bacterial infection in a mammal.

6. 发明专利

CR11224A MOLECULAS PEQUENAS QUE CONTIENEN BORO 未知
公开(公告)号：CR11224A
公开(公告)日：2010-06-28
申请号：CR11224
申请日：2010-01-18
申请人： ANACOR PHARMACEUTICALS INC
发明人： BAKER STEPHEN J , HERNANDEZ VINCENT , SHARMA RASHMI , NIEMAN JAMES A , AKAMA TSUTOMA , ZHANG YONG-KANG , PLATTNER JACOB J , ALLEY MICHAEL RICHARD KEVIN , SINGH RAJESHWAR , XIA YI , ZHOU HUCHEN , MOHAMMAD RAHIM , KERAMANE EL MEHDI , LU XIAOSONG , HA MINH , PHILLIPS JAMES
IPC分类号： A01N55/08 , A61K31/69
摘要： Esta invencion proporciona, entre otras cosas, compuestos novedosos utiles para tratar infecciones bacterianas, composiciones farmaceuticas que contienen tales compuestos, asi como combinaciones de estos compuestos con al menos un agente terapeuticamente eficaz adicional.

7. 发明专利

AU2008265630A1 Boron-containing small molecules 未知
公开(公告)号：AU2008265630A1
公开(公告)日：2008-12-24
申请号：AU2008265630
申请日：2008-06-19
申请人： ANACOR PHARMACEUTICALS INC
发明人： ZHANG YONG-KANG , MOHAMMAD RAHIM , ALLEY MICHAEL RICHARD KEVIN , HERNANDEZ VINCENT S , SHARMA RASHMI , KERAMANE EL MEHDI , SINGH RAJESHWAR , ROCK FERNANDO , XIA YI , LU XIAOSONG , PHILLIPS JAMES G , NIEMAN JAMES A , PLATTNER JACOB J , AKAMA TSUTOMA , HA MINH , BAKER STEPHEN J , ZHOU HUCHEN
IPC分类号： A01N55/08 , A61K31/69
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

8. 发明专利

ES2655299T3 Moléculas pequeñas que contienen boro 未知
公开(公告)号：ES2655299T3
公开(公告)日：2018-02-19
申请号：ES08825921
申请日：2008-06-19
申请人： ANACOR PHARMACEUTICALS INC
发明人： BAKER STEPHEN , HERNANDEZ VINCENT , SHARMA RASHMI , NIEMAN JAMES , AKAMA TSUTOMU , ZHANG YONG KANG , PLATTNER JACOB , ALLEY MICHAEL , SINGH RAJESHWAR , PHILLIPS JAMES G , XIA YI , ZHOU HUCHEN , KERAMANE EL MEHDI , MOHAMMAD RAHIM , HA MINH , LU XIASONG
IPC分类号： A01N55/08 , A61K31/69 , C07F5/02
摘要： Un compuesto que tiene una estructura de acuerdo con la fórmula: **(Ver fórmula)** en la que R* es H o una carga negativa; C* es un átomo de carbono; y es un estereocentro que tiene una configuración que se selecciona de (R) y (S); R3 es -CH2NH2; Ra es H o -YR5; en la que Y es O o S; R5 se selecciona de alquilo sustituido o no sustituido, H y heteroalquilo sustituido o no sustituido; o R5 es: **(Ver fórmula)** en la que a es un número entero seleccionado de 1 a 10 y opcionalmente se selecciona de 1 a 5; cada R10 y cada R11 se selecciona independientemente de H, alquilo sustituido o no sustituido, OH y NH2; R12 se selecciona de H, R7, halógeno, ciano, amidino, OR7, NR7R8, SR7, -N(R7)S(O)2R8, -C(O)R7, -C(O)OR7, -C(O)NR7R8 en la que cada R7 y cada R8 se selecciona independientemente de H, alquilo sustituido o no sustituido, heteroalquilo sustituido o no sustituido, cicloalquilo sustituido o no sustituido, heterocicloalquilo sustituido o no sustituido, arilo sustituido o no sustituido y heteroarilo sustituido o no sustituido; y a condición de que Ra y R*, junto con los átomos a los que se unen, estén opcionalmente combinados para formar un anillo de heterocicloalquilo sustituido o no sustituido de 6 a 10 miembros; o una sal, hidrato, solvato o anhídrido del mismo; en el que el término "alquilo" significa alquilo C1-C10; y en el que los sustituyentes para radicales de alquilo se seleccionan cada uno independientemente del grupo que consiste en -R', -OR', >=O, >=NR', >=N-OR', -NR'R", -SR', -halógeno, -SiR'R"R"', -OC(O)R', -C(O)R', -CO2R', -CONR'R", -OC(O)NR'R", -NR"C(O)R', -NR'-C(O)NR"R"', -NR"C(O)2R', -NR""'-C(NR'R"R"')>=NR"", -NR""-C(NR'R")>=NR"', -S(O)R', -S(O)2R', -S(O)2NR'R", -NR"SO2R', -CN, -NO2, -N3, -CH(Ph)2, fluoro(C1-C4)alcoxi y fluoro(C1-C4)alquilo, en un número que varía de cero a (2m'+1), donde m' es el número total de átomos de carbono en el grupo "alquilo", y en el que R', R", R"', R"" y R''''' se refieren cada uno independientemente a grupos hidrógeno, heteroalquilo, arilo, alquilo, alcoxi, tioalcoxi o grupos arilalquilo.

9. 发明专利

DK2164331T3 BORHOLDIGE SMÅ MOLEKYLER 未知
公开(公告)号：DK2164331T3
公开(公告)日：2018-01-29
申请号：DK08825921
申请日：2008-06-19
申请人： ANACOR PHARMACEUTICALS INC
发明人： BAKER STEPHEN J , HERNANDEZ VINCENT S , SHARMA RASHMI , NIEMAN JAMES A , ZHANG YONG-KANG , ALLEY MICHAEL RICHARD KEVIN , SINGH RAJESHWAR , AKAMA TSUTOMU , PHILLIPS JAMES G , XIA YI , ZHOU HUCHEN , KERAMANE EL MEHDI , MOHAMMAD RAHIM , HA MINH , LU XIASONG , PLATTNER JACOB J
IPC分类号： A01N55/08 , A61K31/69 , C07F5/02

10. 发明专利

MA31675B1 Petites molecules contenant du bore 未知
公开(公告)号：MA31675B1
公开(公告)日：2010-09-01
申请号：MA32517
申请日：2010-01-15
申请人： ANACOR PHARMACEUTICALS INC
发明人： BAKER STEPHEN J , HERNANDEZ VINCENT S , SHARMA RASHMI , NIEMAN JAMES A , AKAMA TSUTOMA , ZHANG YONG-KANG , PLATTNER JACOB J , ALLEY MICHAEL RICHARD KEVIN , SINGH RAJESHWAR , XIA YI , ZHOU HUCHEN , MOHAMMAD RAHIM , KERAMANE EL MEHDI , LU XIAOSONG , HA MINH , PHILLIPS JAMES G
IPC分类号： A61K31/69 , A01N55/08
摘要： L'invention concerne, entre autres choses, de nouveaux composés utiles pour traiter des infections bactériennes, des compositions pharmaceutiques contenant de tels composés ainsi que des combinaisons de ces composés renfermant au moins un agent supplémentaire thérapeutiquement efficace.

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