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1. 发明专利

SG159551A1 GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES 未知
公开(公告)号：SG159551A1
公开(公告)日：2010-03-30
申请号：SG2010009991
申请日：2006-02-10
申请人： AMYLIN PHARMACEUTICALS INC
发明人： LEVY ODILE ESTHER , HANLEY MICHAEL R , JODKA CAROLYN M , LEWIS DIANA Y , SOARES CHRISTOPHER J , GHOSH SOUMITRA S , DAESOUZA LAWRENCE J , PARKES DAVID G , MACK CHRISTINE M , SRIVASTAVA VED , JANSSEN SAMUEL , BARON ALAIN D , YOUNG ANDREW A , PITTNER RICHARD A , ERICKSON MARY
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin- resistance, obesity, and diabetes mellitus of any kind, including type I, type 2, and gestational diabetes.

2. 发明专利

NZ561361A GIP hybrid polypeptides with at least two hormonal activities 未知
公开(公告)号：NZ561361A
公开(公告)日：2010-02-26
申请号：NZ56136106
申请日：2006-02-10
申请人： AMYLIN PHARMACEUTICALS INC
发明人： LEVY ODILE ESTHER , HANLEY MICHAEL R , JODKA CAROLYN M , LEWIS DIANA Y , SOARES CHRISTOPHER J , GHOSH SOUMITRA S , DAESOUZA LAWRENCE J , PARKES DAVID G , MACK CHRISTINE M , SRIVASTAVA VED , JANSSEN SAMUEL , BARON ALAIN D , YOUNG ANDREW A , PITTNER RICHARD A , ERICKSON MARY
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00
摘要： Disclosed is a GIP hybrid polypeptide exhibiting at least two hormonal activities, said hybrid polypeptide comprising a first bio-active peptide hormone module covalently linked to at least one additional bio-active peptide hormone module; wherein: the bio-active peptide hormone modules are independently selected from the group consisting of: component peptide hormones, fragments of component peptide hormones that exhibit at least one hormonal activity of the component peptide hormones, analogs and derivatives of component peptide hormones that exhibit at least one hormonal activity of the component peptide hormones, and fragments of analogs and derivatives of component peptide hormones that exhibit at least one hormonal activity of the component peptide hormones; the component peptide hormone of the first bio-active peptide hormone module is a GIP; the component peptide hormone of the at least one additional bio-active peptide hormone modules are independently selected from the group consisting of: amylin, adrenomedullin (ADM), calcitonin (CT), calcitonin gene related peptide (CGRP), intermedin, cholecystokinin ("CCK"), leptin, peptide YY (PYY), glucagon-like peptideÀ1 (GLP-I), glucagon-like peptide 2 (GLP-2), oxyntomodulin (OXM), a natriuretic peptide, a urocortin family peptide, a neuromedin family peptide, exendin-3, and exendin-4; and at least both of the bio-active peptide hormone modules exhibits at least one hormonal activity of its component peptide hormone. The hybrid polypeptides are useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes

3. 发明专利

SG158141A1 PANCREATIC POLYPEPTIDE FAMILY MOTIFS, POLYPEPTIDES AND METHODS COMPRISING THE SAME 未知
公开(公告)号：SG158141A1
公开(公告)日：2010-01-29
申请号：SG2009083445
申请日：2005-12-12
申请人： AMYLIN PHARMACEUTICALS INC
发明人： LEVY ODILE ESTHER , JODKA CAROLYN M , GHOSH SOUMITRA S , PARKES DAVID , PITTNER RICHARD A , DAESOUZA LAWRENCE J , AHN JOHN S , PRICKETT KATHRYN S , ROTH JONATHAN DAVID , ADAMS SEAN H
摘要： The present invention provides novel Pancreatic Polypeptide Family ("PPF") polypeptides and methods for their use. Figure 51

4. 发明专利

NZ548978A Hybrid polypeptides with selectable properties 未知
公开(公告)号：NZ548978A
公开(公告)日：2009-10-30
申请号：NZ54897805
申请日：2005-02-11
申请人： AMYLIN PHARMACEUTICALS INC
发明人： LEVY ODILE ESTHER , HANLEY MICHAEL R , JODKA CAROLYN M , LEWIS DIANA Y , SOARES CHRISTOPHER J , GHOSH SOUMITRA S , DAESOUZA LAWRENCE J , PARKES DAVID G , MACK CHRISTINE M
IPC分类号： C07H21/04 , C07K14/47 , C07K14/575 , C07K14/595
摘要： Provided is a hybrid polypeptide exhibiting at least two hormonal activities, said hybrid polypeptide comprising a first bio-active peptide hormone module covalently linked to at least one additional bio-active peptide hormone module; wherein: the bio-active peptide hormone modules are independently selected from the group consisting of: component peptide hormones, fragments of component peptide hormones that exhibit at least one hormonal activity of the component peptide hormones, analogs and derivatives of component peptide hormones that exhibit at least one hormonal activity of the component peptide hormones, and fragments of analogs and derivatives of component peptide hormones that exhibit at least one hormonal activity of theÀ component peptide hormones; the component peptide hormones are independently selected from at least two of the group consisting of: amylin and exendin-4; and both of the bio-active peptide hormone modules exhibits at least one hormonal activity of a component peptide hormone.

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