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1. 发明申请

WO2005086661A2 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE IN TREATING METABOLIC DISORDERS 审中-公开
标题翻译：化合物，药物组合物和用于治疗代谢障碍的方法
公开(公告)号：WO2005086661A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/005815
申请日：2005-02-24
申请人： AMGEN INC. , AKERMAN, Michelle , HOUZE, Jonathan , LIN, Daniel, C., H. , LIU, Jiwen , LUO, Jian , MEDINA, Julio, C. , QIU, Wei , REAGAN, Jeffrey, D. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen, J. , SUN, Ying , ZHANG, Jian , ZHU, Liusheng
发明人： AKERMAN, Michelle , HOUZE, Jonathan , LIN, Daniel, C., H. , LIU, Jiwen , LUO, Jian , MEDINA, Julio, C. , QIU, Wei , REAGAN, Jeffrey, D. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen, J. , SUN, Ying , ZHANG, Jian , ZHU, Liusheng
IPC分类号： C07D277/24 , C07D277/30
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L 1 -P-L 2 -M-X-L 3 -A wherein the definitions of the variables Q, L 1 , P, L 2 , M, X, L 3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如调节受试者中胰岛素水平并具有通式QL 1 -PL 2 -MXL 3 -A的化合物，其中变量Q，L <1的定义 >，P，L 2，M，X，L 3和A。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

2. 发明申请

WO2008002591A3 METHODS FOR TREATING ATHEROSCLEROSIS 审中-公开
公开(公告)号：WO2008002591A3
公开(公告)日：2008-01-03
申请号：PCT/US2007/014873
申请日：2007-06-26
申请人： AMGEN INC , KAYSER, Frank , LABELLE, Marc , SHAN, Bei , ZHANG, Jian , ZHOU, Mingyue
发明人： KAYSER, Frank , LABELLE, Marc , SHAN, Bei , ZHANG, Jian , ZHOU, Mingyue
IPC分类号： A61K31/497 , A61P9/10 , A61P25/28 , A61P9/12 , A61P3/00 , A61P3/06
摘要： The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

3. 发明申请

WO2005103686A1 METHOD AND APPRATUS FOR PREDICTING AGGREGATION KINETICS OF A BIOLOGICALLY ACTIVE MATERIAL 审中-公开
标题翻译：用于预测生物活性材料的聚集动力学的方法和装置
公开(公告)号：WO2005103686A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/013928
申请日：2005-04-22
申请人： AMGEN INC. , REMMELE, Richard, L., Jr. , BALABAN, David, J. , ZHANG, Jian , SHOSHITAISHVILI, Alexander , DURST, Mark, J.
发明人： REMMELE, Richard, L., Jr. , BALABAN, David, J. , ZHANG, Jian , SHOSHITAISHVILI, Alexander , DURST, Mark, J.
IPC分类号： G01N33/48
CPC分类号： G01N33/6803 , G01N33/68 , G06F19/16
摘要： A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be used to predict stability or aggregation kinetics as a function of time and temperature.
摘要翻译：开发了一种从不可逆变性过程中提取有意义的热力学和动力学参数的机械模型。因此，已经创建了可用于数学确定预测生物活性材料的聚集动力学的参数的方法和计算机装置。这些参数随后可用于预测作为时间和温度的函数的稳定性或聚集动力学。

4. 发明申请

WO2012129344A1 FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3 审中-公开
标题翻译： CDK 4/6和FLT3的熔融TRICYCLIC双重抑制剂
公开(公告)号：WO2012129344A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/030007
申请日：2012-03-21
申请人： AMGEN INC. , CHEN, Xiaoqi , DAI, Kang , DUQUETTE, Jason , GRIBBLE, Michael W., Jr. , HUARD, Justin N. , KEEGAN, Kathleen S. , LI, Zhihong , LIVELY, Sarah E. , MCGEE, Lawrence R. , RAGAINS, Mark L. , WANG, Xianghong , WEIDNER, Margaret F. , ZHANG, Jian
发明人： CHEN, Xiaoqi , DAI, Kang , DUQUETTE, Jason , GRIBBLE, Michael W., Jr. , HUARD, Justin N. , KEEGAN, Kathleen S. , LI, Zhihong , LIVELY, Sarah E. , MCGEE, Lawrence R. , RAGAINS, Mark L. , WANG, Xianghong , WEIDNER, Margaret F. , ZHANG, Jian
IPC分类号： C07D471/14 , C07D519/00 , A61K31/519 , A61P35/00 , A61P35/02
CPC分类号： C07D519/00 , C07D471/14
摘要： Compounds of Formula (I) are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula (I) have the following structure: where R 1 is a group of Formula (IA), Formula (IB), Formula (IC), or Formula (ID) and the definitions of the other variables are provided herein.
摘要翻译：式（I）化合物是CDK4，CDK6和FLT3的有用抑制剂。这些化合物可用于治疗癌症和各种其他疾病状况。式（I）化合物具有以下结构：其中R1是式（IA），式（IB），式（IC）或式（ID）的基团，其他变量的定义在本文中提供。

5. 发明公开

EP4260962A1 ANGLE SHAPING DEVICE 审中-实审
公开(公告)号：EP4260962A1
公开(公告)日：2023-10-18
申请号：EP22729010.3
申请日：2022-01-27
申请人： Zhang, Jian , Wu, Wei
发明人： LI, Xuedong , ZHANG, Jian , WU, Wei
IPC分类号： B21F1/00 , A61M25/09
摘要： The present invention relates to a device for shaping an angle, including a support platform (2) and an angled cutter head (31). The support platform is configured to serve as a support surface for placing a guide wire. The angled cutter head is configured to press and bend the guide wire at an accurate angle. The present invention also relates to a method for shaping with a device for shaping an angle, including the following steps: placing a guide wire on a support platform, extending out the guide wire by a certain bending length, pressing down on the guide wire with an angled cutter head of which the bottom surface is provided with a certain angle, and preparing the guide wire of which one end has an angle of required accuracy. The present invention relates to a device for shaping a guide wire. A guide wire entry platform (4) is provided on a support platform. The guide wire entry platform is provided thereon with a guide wire entry hole (37) so that a guide wire is guided to be below an angled cutter head. The device for shaping the angle is capable of rapidly and reliably providing a guide wire having a certain bending angle according to requirements.

6. 发明申请

WO2021174545A1 SWITCH, CONTACT PROTECTION ASSEMBLY AND MANUFACTURING METHOD THEREOF 审中-公开
公开(公告)号：WO2021174545A1
公开(公告)日：2021-09-10
申请号：PCT/CN2020/078263
申请日：2020-03-06
申请人： ABB POWER GRIDS SWITZERLAND AG , ZHANG, Jian , LV, Zhangang , ZHANG, Weidong
发明人： ZHANG, Jian , LV, Zhangang , ZHANG, Weidong
IPC分类号： H01H31/02 , H01H31/28 , H01H1/64
摘要： Provided are a switch (200), a contact protection assembly (100) for a switch (200) and a manufacturing method thereof. The contact protection assembly (100) comprises a protection cover assembly (101) rotatably coupled to a moveable blade (201) of the switch (200), the moveable blade (201) being rotatable about a first shaft (203) of the switch (200) to change an engagement status of contact fingers (2011) of the moveable blade (201) with a fixed contact (202); a second shaft (103) arranged at a distance from the first shaft (203); and an actuation rod (102) coupled between the protection cover assembly (101) and the second shaft (103) and configured to be rotatable about the second shaft (103) with a rotation of the moveable blade (201), wherein the second shaft (103) is arranged parallel to the first shaft (203) to enable the actuation rod (102) to push or pull the protection cover assembly (101) to rotate between a covering position and an exposing position, wherein the protection cover assembly (101) covers the contact fingers (2011) at the covering position and exposes the contact fingers (2011) at the exposing position. With the contact protection assembly (100), foreign objects like ice covering the contact fingers (2011) can be easily removed with the rotation of the protection cover assembly (101). This arrangement makes the switch (200) such as an earthing switch meet requirements of relevant standards, which require that the engagement of contact fingers (2011) with the fixed contact (202) cannot be affected in a case where the contact fingers (2011) are covered by a 20mm ice layer. In this way, the stability of the switch (200) is improved.

7. 发明申请

WO2012065207A1 PEAK-TO-AVERAGE POWER RATIO REDUCTION FOR WIRELESS COMMUNICATION SYSTEMS 审中-公开
标题翻译：无线通信系统的平均功率比降低
公开(公告)号：WO2012065207A1
公开(公告)日：2012-05-24
申请号：PCT/AU2010/001562
申请日：2010-11-19
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , HUANG, Xiaojing , GUO, Yingjie Jay , ZHANG, Jian
发明人： HUANG, Xiaojing , GUO, Yingjie Jay , ZHANG, Jian
IPC分类号： H04W52/00
CPC分类号： H03G7/007 , H03G3/3042 , H04L27/2623
摘要： Disclosed is a wireless communication signal peak-to-average power ratio reduction, method. The method comprises calculating a peak envelope from an envelope of an input signal using a clipping threshold; smoothing the peak envelope using a window function; mapping the smoothed peak envelope to an attenuation function using the clipping threshold; and applying the attenuation function to the input signal.
摘要翻译：公开了一种无线通信信号峰均功率比的降低方法。该方法包括使用限幅阈值从输入信号的包络计算峰值包络; 使用窗口函数对峰值包络进行平滑; 使用限幅阈值将平滑的峰值包络映射到衰减函数; 并将衰减函数应用于输入信号。

8. 发明申请

WO2011079313A1 NOVEL ERGOLINE ANALOGS 审中-公开
标题翻译：新的胆固醇类似物
公开(公告)号：WO2011079313A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/062098
申请日：2010-12-23
申请人： MAP PHARMACEUTICALS, INC. , COOK, Robert, O. , ARMER, Thomas, A. , KOSAREV, Sergey, A. , ZHANG, Jian , XIE, Dejian
发明人： COOK, Robert, O. , ARMER, Thomas, A. , KOSAREV, Sergey, A. , ZHANG, Jian , XIE, Dejian
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are novel ergoline derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT 1D and or 5-HT 1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT 2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了新的麦角灵衍生物及其药物组合物。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

9. 发明申请

WO2011033475A1 METHOD AND DEVICE FOR PROCESSING AUDIO DATA 审中-公开
标题翻译：用于处理音频数据的方法和设备
公开(公告)号：WO2011033475A1
公开(公告)日：2011-03-24
申请号：PCT/IB2010/054200
申请日：2010-09-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WANG, Gang , ZHANG, Jian
发明人： WANG, Gang , ZHANG, Jian
IPC分类号： G11B20/10 , G11B27/036 , G11B27/34
CPC分类号： G11B20/10527 , G11B27/034 , G11B2020/00057 , G11B2020/10546
摘要： To allow users to share visual effects associated with music, the invention provides devices and methods for processing audio data. In an embodiment, a device (3) for providing visual effects is proposed, which comprises a first unit (31) for obtaining information defining a visual effect associated with the audio data, and a second unit (32) for combining the information with audio data to generate a combined data. In another embodiment, a device for extracting visual effects is proposed, comprising: an interface (50) for receiving the combined data and a first unit (51) for extracting the information defining visual effects from the combined data. Users could share their visual effects by communicating the audio data, since the information defining the visual effects is combined with the audio data.
摘要翻译：为了允许用户共享与音乐相关的视觉效果，本发明提供了用于处理音频数据的设备和方法。在一个实施例中，提出了一种用于提供视觉效果的设备（3），其包括用于获得定义与音频数据相关联的视觉效果的信息的第一单元（31）和用于将该信息与音频组合的第二单元（32）数据生成组合数据。在另一个实施例中，提出了一种用于提取视觉效果的设备，包括：用于接收组合数据的接口（50）和用于从组合数据中提取定义视觉效果的信息的第一单元（51）。用户可以通过传达音频数据来共享视觉效果，因为定义视觉效果的信息与音频数据相结合。

10. 发明申请

WO2009108923A1 INSTANT MESSAGING METHOD AND SYSTEM 审中-公开
标题翻译：即时消息传递方法和系统
公开(公告)号：WO2009108923A1
公开(公告)日：2009-09-03
申请号：PCT/US2009/035692
申请日：2009-03-02
申请人： ALIBABA GROUP HOLDING LIMITED , ZHANG, Jian
发明人： ZHANG, Jian
IPC分类号： G06F15/16
CPC分类号： H04L51/043 , H04L51/14
摘要： Disclosed is a method and system for transmitting an instant message from a message sending end to a message receiving end which has a primary instant messaging account and multiple auxiliary instant messaging accounts associated with the primary instant messaging account. The method selects a preferred target account from the primary account and the associated auxiliary accounts for receiving the message. The preferred target account satisfies a precedent-messaging condition and/or has a current online presence, such as having been recently contacted by the same message sending end according to a message delivery history. The method determines a backup target account according to a preset rule if no preferred target account is found. The method and the system optimize resource allocation by allowing a message to be selectively sent to a preferred account among the primary account and its associated auxiliary accounts.
摘要翻译：公开了一种用于将即时消息从消息发送端发送到消息接收端的方法和系统，该消息接收端具有主要即时消息账户和与主即时消息账户相关联的多个辅助即时消息账户。该方法从主帐户和相关辅助账户中选择一个首选目标帐户，以接收该消息。优选的目标帐户满足先前消息传递条件和/或具有当前在线存在，诸如最近根据消息传递历史被同一消息发送端所接触。如果没有找到首选目标帐户，该方法将根据预设规则确定备份目标帐户。该方法和系统通过允许将消息选择性地发送到主账户及其相关辅助账户中的优选帐户来优化资源分配。

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