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1. 发明专利

EA030259B1 ЧЕЛОВЕЧЕСКИЕ НЕЙТРАЛИЗУЮЩИЕ АНТИТЕЛА К ФАКТОРУ РОСТА НЕРВОВ (NGF) В КАЧЕСТВЕ СЕЛЕКТИВНЫХ ИНГИБИТОРОВ МЕТАБОЛИЧЕСКОГО ПУТИ NGF 未知
公开(公告)号：EA030259B1
公开(公告)日：2018-07-31
申请号：EA201000245
申请日：2004-07-15
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D JR , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： C07K16/22 , A61K39/395 , A61P37/00 , C12N1/21 , C12N5/12 , C12N15/13 , G01N33/53
摘要： Визобретениипредложеноантитело, котороесвязываетсяс факторомростанервов (NGF) человекаи посредствомэтогонейтрализуетфункцию NGF. Визобретениитакжепредложенафармацевтическаякомпозицияуказанногоантителаи ееприменениедляпроизводствалекарствадлялечениясвязанныхс NGF расстройств. Такжепредложенспособобнаружения NGF вбиологическомобразцес использованиемуказанногоантитела.

2. 发明专利

SG10201603945RA HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS 未知
公开(公告)号：SG10201603945RA
公开(公告)日：2016-07-28
申请号：SG10201603945R
申请日：2010-10-08
申请人： MEDAREX LLC , AMGEN INC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

3. 发明专利

NZ625391A Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors 未知
公开(公告)号：NZ625391A
公开(公告)日：2016-02-26
申请号：NZ62539110
申请日：2010-10-08
申请人： AMGEN INC , MEDAREX LLC
发明人： TREANOR JAMES J S , MARTIN FRANK , WILD KENNETH D , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J
IPC分类号： A61K39/395 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , C07K16/22 , C12N5/10 , C12N15/68 , G01N33/53
摘要： Discloses use of an NGF antibody in the manufacture of a medicament for treating pain that is associated with a condition caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF, wherein the antibody is to be administered in a pharmaceutical composition comprising: a pharmaceutically acceptable carrier and the isolated antibody, wherein the antibody comprises a light chain comprising SEQ ID NO: 44 and a heavy chain comprising SEQ ID NO: 40; wherein the NGF antibody is to be administered by subcutaneous injection, wherein the subcutaneous injection comprises multiple subcutaneous injections; wherein the NGF antibody dose is from 3 mg to 30 mg per subcutaneous injection, wherein the sequences are as defined in the complete specification.

4. 发明专利

NZ599431A Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors 未知
公开(公告)号：NZ599431A
公开(公告)日：2014-07-25
申请号：NZ59943110
申请日：2010-10-08
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： A61K39/395 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , C07K16/22 , C12N5/10 , C12N15/68 , G01N33/53
摘要： Disclosed is the use of an NGF antibody (4D4) in the manufacture of a medicament for treating a condition caused by increased expression of NGF or increased sensitivity to NGF, - wherein the NGF antibody comprises a light chain comprising SEQ ID. NO. 44 and a heavy chain comprising SEQ ID. NO. 40 as defined in the complete specification; - wherein the NGF antibody dose is selected from the group consisting of 3 mg, 10 mg, and 20 mg; - wherein the medicament is for use orally, through injection by intravenous, intraperitoneal, intracerebral, intra-parenchymal, intracerebroventricular, intramuscular, intra-ocular, intraarterial, intraportal, intralesional or subcutaneous routes, by sustained release systems, or by implantation devices; and - wherein the condition is osteoarthritis (OA) knee pain, acute pain, dental pain, pain from trauma, surgical pain, pain resulting from amputation or abscess, causalgia, demyelinating diseases, trigeminal neuralgia, cancer, chronic alcoholism, stroke, thalamic pain syndrome, diabetes, acquired immune deficiency syndrome (”AIDS”), toxins, chemotherapy, general headache, migraine, cluster headache, mixed-vascular or non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, lupus, osteoarthritis, fibromyalgia, inflammatory bowel disorders, irritable bowel syndrome, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, sunburn, carditis, dermatitis, myositis, neuritis, collagen vascular diseases, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia or allodynia, diabetic neuropathy pain, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, colitis, gastric ulceration, duodenal ulcers, vasomotor or allergic rhinitis, or bronchial disorders, dysmenorrhoea, dyspepsia, gastroesophageal reflux, pancreatitis, or visceralgia.

5. 发明专利

TN2012000136A1 HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS 未知
公开(公告)号：TN2012000136A1
公开(公告)日：2013-09-19
申请号：TN2012000136
申请日：2012-03-27
申请人： AMGEN INC , MEDAREX LLC
发明人： TREANOR JAMES J S , WILD KENNETH D , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： A61K39/395 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , C07K16/22 , C12N5/10 , C12N15/68 , G01N33/53
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

6. 发明专利

CL2012000881A1 Uso de una composicion farmacéutica que comprende un anticuerpo anti-ngf util para tratar condicion causada por el incremento de la mayor expresión del factor de crecimiento nervioso (ngf) o mayor sensibilidad al ngf. 未知
公开(公告)号：CL2012000881A1
公开(公告)日：2013-02-08
申请号：CL2012000881
申请日：2012-04-05
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22 , C12N15/68
摘要： Uso de una composición farmacéutica que comprende un anticuerpo anti-NGF útil para tratar condición causada por el incremento de la mayor expresión del factor de crecimiento nervioso (NGF) o mayor sensibilidad al NGF.

7. 发明专利

HK1088534A1 HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS 未知
公开(公告)号：HK1088534A1
公开(公告)日：2006-11-10
申请号：HK06108730
申请日：2006-08-07
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D JR , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： A61K20060101 , A61K39/395 , A61P20060101 , C07K20060101 , C07K16/22 , C12N20060101 , G01N20060101 , G01N33/53
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

8. 发明专利

AU2014203316A1 Human Anti-NGF Neutralizing Antibodies as Selective NGF Pathway Inhibitors 未知
公开(公告)号：AU2014203316A1
公开(公告)日：2014-07-10
申请号：AU2014203316
申请日：2014-06-18
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： C07K16/22 , A61K39/395 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , C12N5/10 , C12N15/68 , G01N33/53
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby, The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing 5 NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

9. 发明专利

PE20121028A1 ANTICUERPOS NEUTRALIZANTES ANTI-NGF HUMANOS COMO INHIBIDORES SELECTIVOS DE LA RUTA DE NGF 未知
公开(公告)号：PE20121028A1
公开(公告)日：2012-08-06
申请号：PE2012000442
申请日：2010-10-08
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： C07K16/22 , A61K39/395 , A61P19/02 , A61P25/00
摘要： REFERIDA A UN ANTICUERPO FRENTE A NGF, EL CUAL ES UN ANTICUERPO Fab' QUE COMPRENDE UNA CADENA LIGERA DE SECUENCIA SEQ ID NO:44 Y UNA CADENA PESADA DE SEQ ID NO:40, DONDE LAS CADENAS PESADA Y LIGERA ESTAN CONECTADAS MEDIANTE UN LIGADOR FLEXIBLE PARA FORMAR UN ANTICUERPO DE CADENA SENCILLA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA QUE SE ADMINISTRA VIA ORAL, INTRAVENOSA, INTRAPERITONEAL, INTRACEREBRAL, INTRACEREBROVENTRICULAR, INTRAMUSCULAR, INTRAOCULAR, INTRAARTERIAL, INTRAPORTAL, INTRALESIONAL O SUBCUTANEA. DICHOS ANTICUERPOS INTERACCIONAN CON O SE UNEN AL FACTOR DE CRECIMIENTO NERVIOSO (NGF) HUMANO NEUTRALIZANDO SU FUNCION Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, TRASTORNOS INFLAMATORIOS, TRASTORNOS GASTROINTESTINALES, ENTRE OTROS

10. 发明专利

AU2010308418A1 Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 未知
公开(公告)号：AU2010308418A1
公开(公告)日：2012-05-10
申请号：AU2010308418
申请日：2010-10-08
申请人： AMGEN INC , MEDAREX LLC
发明人： WILD KENNETH D , TREANOR JAMES J S , HUANG HAICHUN , INOUE HEATHER , ZHANG TIE J , MARTIN FRANK
IPC分类号： C07K16/22 , A61K39/395 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , C12N5/10 , C12N15/68 , G01N33/53
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

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