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1. 发明申请

WO2006015373A3 ANTIBODIES TO DKK-1 审中-公开
标题翻译：抗体DKK-1
公开(公告)号：WO2006015373A3
公开(公告)日：2006-07-27
申请号：PCT/US2005027689
申请日：2005-08-04
申请人： AMGEN INC , LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
发明人： LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译：本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。

2. 发明专利

ZA202007088B PROFILED ARCHWIRE LOCKING DEVICE AND USAGE METHOD THEREFOR 未知
公开(公告)号：ZA202007088B
公开(公告)日：2021-08-25
申请号：ZA202007088
申请日：2020-11-13
申请人： GUANGZHOU OO MEDICAL SCIENTIFIC LIMITED , LI JI
发明人： LI JI
摘要： A profiled archwire locking device, comprising a profiled archwire (100), a bracket (500), and a locking element (300), wherein the bracket (500) comprises a bracket main body, a main bracket slot (200) is provided on an upper surface of the bracket main body, and a locking hole (400) is provided in a side surface of the bracket main body; the profiled archwire (100) comprises an inclined face or a face with a blind hole; the profiled archwire (100) is placed inside the main bracket slot (200); and one end of the locking element (300) passes through the locking hole (400), extends into the main bracket slot (200) and abuts against and comes into contact with the inclined face or a blind hole (153) in the face with a blind hole of the profiled archwire (100). The profiled archwire locking device can make the archwire (100) easily pass into the main bracket slot (200), and can also stably fix the archwire (100) in the main bracket slot (200) so same does not sway, so as to not lose the acting force of the archwire (100), and a torque can be very well conveyed, thereby facilitating a doctor's dental correction operation and simplifying the doctor's dental correction operation.

3. 发明专利

ZA202007086B STOP BRACKET AND USE METHOD THEREFOR 未知
公开(公告)号：ZA202007086B
公开(公告)日：2021-08-25
申请号：ZA202007086
申请日：2020-11-13
申请人： GUANGZHOU OO MEDICAL SCIENTIFIC LIMITED , LI JI
发明人： LI JI
摘要： An orthodontic stop bracket, comprising a main body portion (1) and a cover body portion (2) mounted on the main body portion (1) and a bottom plate (3) mounted on a bottom surface of the main body portion (1). A transverse arch wire slot is provided on the main body portion (1), an adjustment plate avoidance position (11) is provided on a side wall of the arch wire slot, a receiving position (12) is provided on the adjustment plate avoidance position (11), an adjustment plate (6) is movably mounted on the adjustment plate avoidance position (11), a drive rod (5) is connected to the adjustment plate (6), and the drive rod (5) fits with the receiving position (12). One end of the drive rod (5) is provided with a connector (51) which is fixedly connected to the adjustment plate (6). The stop bracket can adjust the size of the arch wire slot and stop an arch wire (4).

4. 发明专利

JP2011212022A Antibody to dkk-1 审中-公开
标题翻译：抗体DKK-1
公开(公告)号：JP2011212022A
公开(公告)日：2011-10-27
申请号：JP2011167756
申请日：2011-07-29
申请人： Amgen Inc , アムジェンインコーポレイテッド
发明人： LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P3/10 , A61P9/04 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , C07K16/18 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide a variety of binding agents that selectively bind Dkk-1.SOLUTION: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases, and skin diseases are also disclosed.
摘要翻译：要解决的问题：提供选择性结合Dkk-1的各种结合剂。解决方案：本发明提供特异性结合Dkk-1多肽的抗体及其免疫功能片段。受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。

5. 发明申请

WO2010015109A8 METHOD, BASE STATION AND MOBILE TERMINAL FOR IMPLEMENTING MULTICAST RETRANSMISSION BY USING NETWORK CODING 审中-公开
标题翻译：方法，基站和移动终端通过使用网络编码实现多播恢复
公开(公告)号：WO2010015109A8
公开(公告)日：2011-01-13
申请号：PCT/CN2008001442
申请日：2008-08-07
申请人： ALCATEL LUCENT SHANGHAI BELL , ALCATEL LUCENT , LI JI , HU ZHONGJI , WANG YONGGANG
发明人： LI JI , HU ZHONGJI , WANG YONGGANG
IPC分类号： H04W4/06
CPC分类号： H04L1/18 , H04L2001/0093
摘要： A method for implementing multicast retransmission by using network coding is provided, said method including: detecting the number of buffered packet numbers of packets to be network coded during one packet transmission time slot, wherein said packets to be network coded are those packets for which the cumulative number of negative responses (NACK) is larger than zero, wherein the NACK is from a mobile terminal; if the number of buffered packet numbers is larger than or equal to 2, two packet numbers from the buffered packet numbers are accessed randomly, and the packets corresponding to said two packet numbers are accessed; the accessed two packets are network-coded to form a network-coded packet; and said network-coded packets are multicast.
摘要翻译：提供了一种通过网络编码实现多播重传的方法，所述方法包括：检测在一个分组传输时隙期间要进行网络编码的分组的缓冲分组号的数量，其中所述要被网络编码的分组是那些分组负响应（NACK）的累积数大于零，其中NACK来自移动终端; 如果缓冲包号码数目大于或等于2，则从缓冲包编号中分配两个数据包，随机访问，对应于所述两个数据包号的数据包进行访问; 所访问的两个分组被网络编码以形成网络编码的分组; 并且所述网络编码的分组是多播的。

6. 发明申请

WO0139585A8 ADDITIVES WITH REDUCED RESIDUAL TIN CONTENT AND THERMOPLASTIC COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：具有降低残留含量的添加剂和含有其的热塑性组合物
公开(公告)号：WO0139585A8
公开(公告)日：2001-07-05
申请号：PCT/US0029276
申请日：2000-10-24
申请人： RHODIA , WO SHIMING , LI JI
发明人： WO SHIMING , LI JI
IPC分类号： C07C67/08 , C07B61/00 , C07C67/60 , C07C69/675 , C08K5/10 , C07C69/24
CPC分类号： C07C67/60 , C08K5/10
摘要： Additives obtained from the catalytically induced esterification reaction of a mono- or polyhydroxy alkanol and at least one carboxylic acid employing a complexing agent selected from dicarboxylic acid or anhydrides thereof to substantially reduce the residual tin content and thermoplastic compositions and articles produced thereby.
摘要翻译：通过单 - 或多羟基链烷醇和至少一种羧酸的催化诱导的酯化反应获得的添加剂，其使用选自二羧酸或其酸酐的络合剂，以显着降低残留的锡含量和由其制备的热塑性组合物和制品。

7. 发明申请

WO2011137325A3 METAL NANOPARTICLE STRUCTURES FOR ENHANCING FLUORESCENCE-BASED ASSAYS 审中-公开
标题翻译：用于增强基于荧光的测定的金属纳米结构
公开(公告)号：WO2011137325A3
公开(公告)日：2012-03-01
申请号：PCT/US2011034522
申请日：2011-04-29
申请人： PHARMASEQ INC , MANDECKI WLODEK , LI JI , WANG ZHUYING
发明人： MANDECKI WLODEK , LI JI , WANG ZHUYING
IPC分类号： G01N33/52 , G01N33/53
CPC分类号： G01N21/6486 , G01N33/587 , Y10T428/265
摘要： Provided, among other things, is a multiplex assay comprising: conducting a fluorescence-developing assay on microtabs having at least one surface that shows plasmonic enhancement, wherein a plurality of the microtabs have unique probes affixed to their plasmonically enhanced surfaces; and measuring the fluorescence associated with the substrates and identifying the correlated probe by for the microtab. The microtabs can be, for example, MTPs that send a unique identifier, and the correlated probe can be identified by querying the MTPs for their identifiers.
摘要翻译：除其他之外，提供多重测定，其包括：对具有至少一个表现出等离子体激增的表面的微切片进行荧光显影分析，其中多个微切片具有固定于其等离子体增强表面的独特探针; 并测量与底物相关的荧光，并通过microtab鉴定相关探针。微型计算机可以是例如发送唯一标识符的MTP，并且可以通过查询MTP的标识符来识别相关探测器。

8. 发明专利

AU2005267722B2 Antibodies to Dkk-1 未知
公开(公告)号：AU2005267722B2
公开(公告)日：2009-10-08
申请号：AU2005267722
申请日：2005-08-04
申请人： AMGEN INC
发明人： LU HSIENG SEN , SHEN WENYAN , RICHARDS WILLIAM GLEASON , LI JI
IPC分类号： C07K16/00 , A61K39/395 , C07K16/18
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

9. 发明专利

ES2414460T3 Anticuerpos para Dkk-1 未知
公开(公告)号：ES2414460T3
公开(公告)日：2013-07-19
申请号：ES05807469
申请日：2005-08-04
申请人： AMGEN INC
发明人： LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
IPC分类号： C07K16/18 , A61K39/395
摘要： Un anticuerpo aislado o un fragmento inmunológicamente funcional del mismo que se une específicamente a una proteína Dkk-1 humana madura, que consiste en los aminoácidos 32-266 del SEQ ID NO: 2, en donde dicho anticuerpo se une a un epítopo que comprende dos bucles, estando formados dichos bucles por enlaces disulfuro y encontrándose dichos bucles entre 220 y 237 del SEQ ID NO: 2 y entre los residuos de cisteína 245 y 263 del SEQ 5 ID NO: 2.

10. 发明专利

AU2009245850A1 Antibodies to DKK-1 未知
公开(公告)号：AU2009245850A1
公开(公告)日：2010-01-07
申请号：AU2009245850
申请日：2009-12-08
申请人： AMGEN INC
发明人： SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON , LI JI
IPC分类号： C07K16/00 , A61K39/395 , C07K16/18

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