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2. 发明专利

DE60133758D1 未知
公开(公告)号：DE60133758D1
公开(公告)日：2008-06-05
申请号：DE60133758
申请日：2001-10-23
申请人： AMGEN INC , HOFFMANN LA ROCHE
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADA S , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P , LABELLE MARC
IPC分类号： A61K31/535 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D221/00 , C07D233/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D471/00 , C07D471/04 , C12N15/25 , C12N15/28
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

3. 发明专利

DE60133758T2 未知
公开(公告)号：DE60133758T2
公开(公告)日：2009-07-02
申请号：DE60133758
申请日：2001-10-23
申请人： AMGEN INC , HOFFMANN LA ROCHE
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADA S , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P , LABELLE MARC
IPC分类号： A61K31/535 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D221/00 , C07D233/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D471/00 , C07D471/04 , C12N15/25 , C12N15/28
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

4. 发明专利

ES2305125T3 AGENTES ANTI-INFLAMATORIOS. 未知
公开(公告)号：ES2305125T3
公开(公告)日：2008-11-01
申请号：ES01987605
申请日：2001-10-23
申请人： AMGEN INC , HOFFMANN LA ROCHE
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO
IPC分类号： A61K31/535 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D221/00 , C07D233/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D471/00 , C07D471/04 , C12N15/25 , C12N15/28
摘要： Un compuesto que tiene la fórmula (Ver fórmula) o una sal del mismo farmacéuticamente aceptable, en la que W es N; X es CH; Y es O o S; Z es seleccionada del grupo que consiste en H, alquilo (C1-C10), cicloalquilo (C3-C10), cicloalquilo (C4-C10) alquilo, alquenilo (C2-C10), alquinilo (C2-C10) y NR 2 R 3 ; R 1 , R 2 y R 3 son seleccionados independientemente del grupo que consiste en H, alquilo (C1-C10), alquenilo (C3-C10), alquinilo (C2-C10), heteroalquilo (C1-C10), cicloalquilo (C3-C10), cicloalquil (C4-C10) alquilo, cicloheteroalquil (C3-C10) alquilo, cicloheteroalquilo (C3-C10), arilo, aril alquilo (C1-C4), aril heteroalquilo (C1-C4), heteroaril alquilo (C1-C6), heteroaril heteroalquilo (C1-C4) y perfluoro alquilo (C1-C6); y en el que Z es NR 2 R 3 . R 2 y R 3 pueden ser combinados para formar un anillo heterocíclico de 5 a 7 miembros; R 4 es seleccionado del grupo que consiste en H, alquilo (C1-C6), ciclo alquilo (C3-C6), ciclo alquil alquilo (C4-C7), alquenilo (C2-C6) y alquinilo (C2-C6); A es seleccionado del grupo que consiste en: (Ver fórmula) en el que R 5 , R 6 , R 7 y R 8 son seleccionados independientemente del grupo que consiste en halógeno H, CF3, alquilo (C1-C6), alquenilo (C2-C6), alquinilo (C2-C6), heteroalquilo (C1-C6), alcoxi (C1-C6), tioalcoxi (C1-C6), amino, alquilamino (C1-C6), dialquilamino (C1-C6), cicloalquilo (C3-C10). Cicloalquil alquilo (C4-C10), cicloheteroalquilo (C3-C10), cicloheteroalquil alquilo (C3-C10), ciano, nitro, acilo (C1-C6), acilamino (C1-C6), alcoxicarbonilo (C1-C6), alcoxicarbonil (C1-C6) alquilo (C1-C6), CONH2, CO-NH alquilo (C1-C6), CO-NH [alquilo (C1-C6)]2, SO3NH2, SO2NH-alquilo (C1-C6), SO2N u [alquilo (C1-C6)]2 y heteroalcoxi (C1-C6); o dos grupos R adyacentes seleccionados a partir de R 5 , R 6 , R 7 y R 8 pueden ser unidos juntos para formar un nuevo anillo heterocíclico o carbocíclico de 5 ó 6 miembros; y en el que cualquiera de los grupos R 5 , R 6 , R 7 y R 8 son sustituidos opcionalmente mediante los sustituyentes de 1 a 3 seleccionados a partir del CN, alquilo (C1-C6)-SO2, heteroalquilo (C1-C6) u SO2 CONH2, CO-NH alquilo (C1-C6), CO-N [alquilo (C1-C6)]2, SO2NH2, SO2NH-alquilo (C1-C6) o SO2N [alquilo (C1-C6)]2 y B es seleccionado a partir del grupo que consiste en imidazol sustituido o sin sustituir, tiazolilo sustituido o sin sustituir y triazolilo sustituido o sin sustituir.

5. 发明申请

WO0241843A3 ANTIINFLAMMATION AGENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：WO0241843A3
公开(公告)日：2003-02-06
申请号：PCT/US0151403
申请日：2001-10-23
申请人： TULARIK INC , HOFFMANN LA ROCHE , BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADA S , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P C
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADA S , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P C
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K31/535 , A61K31/415 , A61K31/44 , A61K31/47 , C07D221/00 , C07D233/00 , C07D413/00 , C07D471/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有稠合的碳环或杂环。

6. 发明申请

WO03048152A3 INFLAMMATION MODULATORS 审中-公开
标题翻译：炎症调节剂
公开(公告)号：WO03048152A3
公开(公告)日：2003-10-16
申请号：PCT/US0239134
申请日：2002-12-04
申请人： TULARIK INC , HOFFMANN LA ROCHE , CUSHING TIMOTHY D , HE XIAO , SMITH MARIE-LOUISE , DEGRAFFENREID MICHAEL R , POWERS JAY , TOMOOKA CRAIG S , CLARK DAVID L , HAO XIAOLIN , JAEN JUAN C , LABELLE MARC , WALKER NIGEL P C , GILL ADRIAN L , TALAMAS FRANCISCO X , LABADIE SHARADA S
发明人： CUSHING TIMOTHY D , HE XIAO , SMITH MARIE-LOUISE , DEGRAFFENREID MICHAEL R , POWERS JAY , TOMOOKA CRAIG S , CLARK DAVID L , HAO XIAOLIN , JAEN JUAN C , LABELLE MARC , WALKER NIGEL P C , GILL ADRIAN L , TALAMAS FRANCISCO X , LABADIE SHARADA S
IPC分类号： A61K31/4709 , A61P29/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D403/10
CPC分类号： C07D401/04 , A61K31/4709 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖病症或疾病的化合物，组合物和方法。特别地，本发明提供了调节涉及炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有喹啉或喹唑啉环。

8. 发明专利

AU2002365611A1 INFLAMMATION MODULATORS 未知
公开(公告)号：AU2002365611A1
公开(公告)日：2003-06-17
申请号：AU2002365611
申请日：2002-12-04
申请人： TULARIK INC , HOFFMANN LA ROCHE
发明人： TOMOOKA CRAIG S , CLARK DAVID L , HAO XIAOLIN , JAEN JUAN C , LABELLE MARC , WALKER NIGEL P C , GILL ADRIAN L , TALAMAS FRANCISCO X , LABADIE SHARADA S , CUSHING TIMOTHY D , HE XIAO , SMITH MARIE-LOUISE , DEGRAFFENREID MICHAEL R , POWERS JAY
IPC分类号： A61K31/4709 , A61P29/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D403/10
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.

9. 发明专利

PL366114A1 ANTIINFLAMMATION AGENTS 未知
公开(公告)号：PL366114A1
公开(公告)日：2005-01-24
申请号：PL36611401
申请日：2001-10-23
申请人： TULARIK INC , HOFFMANN LA ROCHE
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADA S , LABELLE MARC , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P C
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , C07D221/00 , A61K31/535
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

10. 发明专利

NO20031869D0 未知
公开(公告)号：NO20031869D0
公开(公告)日：2003-04-25
申请号：NO20031869
申请日：2003-04-25
申请人： HOFFMANN LA ROCHE
发明人： BROWNER MICHELLE F , CLARK DAVID L , CUSHING TIMOTHY D , HAO XIAOLIN , HAWLEY RONALD C , HE XIAO , JAEN JUAN C , LABADIE SHARADNA SHENVI , SMITH MARIE-LOUISE , TALAMAS FRANCISCO X , WALKER NIGEL P C , LABELLE MARC
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

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